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Local treatment of carcinoma of the rectum.

LE is a management modality offered, at present, to less than 5 per cent of all patients with carcinoma of the rectum. It is indicated, as a primary curative procedure, in the subgroup of patients with early lesions of a favorable histologic grade. It has also been used, for palliation, in patients with overt disseminated malignant disease or in patients too old or too ill, or both, to withstand a radical operation or unwilling to accept a colostomy. Various techniques have been described and can be divided into two categories: excision of the intact tumor, best suited for a curative procedure when tumor characteristics can be accurately determined, and tumor destruction therapy, more generally used for palliation. The results of local excision, compared with those of radical operations, are very good when a strict selection policy is implemented and coupled with adequate patient follow-up study.

Adenocarcinoma↗

[Adenocarcinoma of an extraperitoneal rectum in a 17-year-old female].

A 17-year-old female with an adenocarcinoma of the extraperitoneal rectum, which was diagnosed correctly by preoperative intrarectal ultrasonography as being in Dukes' A stage, was operated on, this surgery performed adhering to function preserving procedures. Histologically, the tumor uncovered was found to be a well differentiated adenocarcinoma and, as had been expected, in Dukes' A stage. An absolute curative operation was achieved. The operative procedure for juvenile rectal cancer must be planned to achieve both tumor removal and bodily function preservation to assure the best possible quality of postoperative life. We recommend intrarectal ultrasonography at the preoperative stage, the results to be used in deciding on the operative procedure.

Adenocarcinoma↗

Non-neoplastic stenoses of the rectum.

Rectal stenoses, often accompanied by a simple, non-specific symptomatology, have multiple and varied causes. The clinical picture is far from specific and can go from absolute latency to the full picture of a distinct colic occlusion. The clinical examination mainly relies on the data from the proctologic examination and, in particular, the rectal touch that enables detection of the lesion. This proctologic examination is completed with a uro-genital clinical check-up. The complementary endoscopic, X-ray and biological examinations are dominated by rectoscopy, barium enema and, if necessary, scanner, ultrasonography and anatomopathology. The etiological forms comprise stenoses by extrinsic compression; inflammatory or non-inflammatory pseudo-tumoral stenoses; inflammatory cryptogenetic (RCH, Crohn) or specific (infectious, parasitic and venereal) stenoses; ischaemic stenoses; traumatic stenoses by internal or external traumatism and medical iatrogenic, post-physiotherapeutic or post-surgical stenoses. The therapeutic problems depend on the type, age and size of the evolution as well as the cause (etiology) of the lesions. Depending on the case, we have to "make do with it", circumvent the problem, force or remove the obstacle.

Constriction, Pathologic↗

Colitis: radiographic features and differentiation of idiopathic inflammatory bowel disease.

It is important clinically to be able to differentiate ulcerative colitis from Crohn's colitis because they differ considerably in the nature of complications and prognoses. Radiographically, it is possible to render a specific diagnosis in the vast majority of cases using criteria described in this article. The problem of the underlying process in inflammatory bowel disease in elderly patients and indeterminate colitis is also discussed.

Aged↗

Fulminant colitis complicating antibiotic-associated pseudomembranous colitis: case report and review of the clinical manifestations and treatment.

A middle-aged man presented with diarrhea, fever, and leukocytosis 7 days after discontinuation of clindamycin therapy for a urinary tract infection. Proctosigmoidoscopy showed adherent, raised plaques studding the bowel wall consistent with antibiotic-associated pseudomembranous colitis. Vancomycin therapy was begun, but progressive abdominal distension, nausea, vomiting, and loss of bowel sounds occurred. Serial abdominal radiographs demonstrated colonic wall edema without dilatation. Subtotal colectomy was performed and resulted in complete resolution of symptoms.

Clindamycin↗

[Concerning the malignancy of villous tumors of the large intestine].

The analysis of a personal series of 83 villous tumors of the rectum and the colon showed that half of them were degenerated. Malignancy was, once out of twice, at the intraepithelial stage ("in situ" epithelioma) or at the intramucous stage (micro-carcinoma) and once out of twice invasive. No more than the rectal touch or the endoscopic aspect, biopsy enables a regular recognition of this degeneration, nor of its invasion degree. Therefore villous tumor must be removed surgically, to give to the anatomopathologist a whole and well-oriented specimen, which allows him to say if this excision is enough or if it must be completed. In no case, a villous tumor must be removed endoscopically by any physical means, nor even resected with the diathermical ansa if it is pedonculated.

Carcinoma in Situ↗

[Transitory bacteremia in rectoscopy].

A prospective study was undertaken to determine the frequency of transient bacteremia on recto-sigmoidoscopy. Blood specimens were drawn for aerobic and anaerobic bacterial culture immediately before, and 1, 5, 10, 15, 20, 25 and 30 min after the beginning of recto-sigmoidoscopy. 19 blood cultures were supposed to be contaminated. In 3 patients (6%) a positive blood culture was found with the following types of organisms: enterococci, Escherichia coli and nonhemolytic streptococci. The need for antibiotic prophylaxis in patients with valvular heart diseases or prosthetic valves is discussed. In such cases the authors propose prophylaxis with 1 g streptomycin i.m. and 3 g ampicillin by mouth 30 min before recto-sigmoidoscopy.

Anti-Bacterial Agents↗