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At least 1,135 records · Page 63Linked to original sources
PubMed1989

[Treatment of upper genital infections in women. Multicenter study of the comparative efficacy and tolerance of an amoxicillin-clavulanic acid combination and of a triple antibiotic combination].

Eighty-two patients with laparoscopically confirmed salpingitis were randomly divided into two groups in a multicentre and prospective trial. Single drug therapy with the amoxicillin-clavulanic acid combination was used in 42 patients (group A). The other 40 patients were given a combination of penicillin, aminoside and metronidazole (group B). For each case a secondary prescription for a tetracycline was discussed. Clinical results were comparable in both groups: sooner (at the end of the hospitalization period) in group A: 10 cured, 30 improved and 2 failures against 9 cured, 30 improved in group B. Later (evaluation after 5 to 8 weeks) a relapse was noted in five patients in group A and included one case of angioedema in group B. It is concluded that amoxicillin-clavulanic acid combination is a satisfactory alternative to the penicillin-aminoside-metronidazole combination, especially as it is simpler to use.

Adolescent↗
PubMed1985

A non-absorbable rifamycin for treatment of hepatic encephalopathy.

Ammonia (NH3) plays a role in hepatic encephalopathy (HE). Agents affecting colonic ammonia production, such as non-absorbable antibiotics, decrease plasma levels of NH3 and findings of HE. The short-term efficacy of a non-absorbable rifamycin, rifaximin, was studied in comparison with paramomycin in 20 cirrhotic patients with high levels of NH3 and impaired number connection test (NCT). Both antibiotics significantly decreased ammonia-producing colonic bacteria. Rifaximin proved to be active on both aerobic and anaerobic bacteria and is thus effective, even at the dosage used, in the treatment of HE.

Absorption↗
PubMed1986

Different alterations of the ribosomal protein S7 lead to opposite effects on translational fidelity in the fungus Podospora anserina.

In the fungus Podospora anserina, the su12-1 mutation was previously found to decrease translational accuracy and to alter the ribosomal protein S7. The mutant protein is more basic than the wild type. Among the revertants of the two ribosomal mutations su12-1 and su12-2, 29 contained a second mutation very closely linked to su12. Biochemical analysis of these revertants by functional poly(U) tests and electrophoretical study of the ribosomes led to two conclusions. First, some revertant strains contain new mutant forms of S7. This suggests that su12 is the structural gene for the ribosomal protein S7. Second, the su12-2 revertants display antisuppressor properties in vivo and in vitro (i.e. increased translational accuracy). The electrophoretical patterns of their ribosomal proteins show new, more acidic, forms of S7. Therefore, su12 can be mutated towards either a lower or a greater translational accuracy corresponding to two opposite modifications of the global charge of the ribosomal protein S7. A more acidic form than wild type leads to increased accuracy and a more basic form to decreased accuracy.

Ascomycota↗
PubMed1985

Giardiasis.

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Female↗