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An audio-video system for automated data acquisition in the clinical environment. LOTAS Group.

OBJECTIVE: Our objective was to develop an audiovideo data acquisition system that facilitates studying the activities of anesthesia care providers in the clinical environment. METHOD: Ceiling-mounted miniature video cameras, vital sign monitors, and videocassette recorders (VCRs) were interfaced to digital computers in two patient admitting areas and two operating rooms of a trauma center. This video data acquisition system network (VASNET) is simple to operate. Insertion of a videotape activates the system and begins video overlay of updated vital signs onto the video image every 5 sec. Recorded data is passed via a local area network, allowing remote monitoring of the data acquisition process. To facilitate analysis of the video at a later time, the image, soundtrack, and vital signs data are stamped with the same time code. Each tape is initialized by recording the data file name and wall clock time for 30 sec at the start of taping. This initialization enables comparison of the video recordings with anesthesia, surgical, and nursing records. RESULTS: During 2 years of operation, VASNET was used to record over 100 cases of acute trauma management. Vital signs overlaid onto the video image identified when patient monitors were in use and providing data. Participants found videotape review useful in assessing their own performance. VASNET was nonintrusive and acquired data with minimum user interaction. In one operating room, separate from the trauma center, VASNET was installed to function as a remote monitor, with the option of videotaping. Although users were aware of when videotaping occurred, once patient management was underway, the activities of the anesthesia care providers did not appear to be influenced by the videocassette recording. Equipment maintenance was not excessive. The most frequent problems were changes to the VCR control settings and disconnection of the power supply or interface connections. CONCLUSIONS: Videotapes of the process of anesthetizing and resuscitating trauma patients provided a record of the activities of anesthesia care providers. Video vignettes may be useful training tools. Excerpts from real scenarios can be incorporated into anesthesia stimulators. The soundtrack and timing of real events from such video acquisition may be useful in the development of multimedia simulations of trauma patient resuscitation. The data collection may be useful for research into human performance, ergonomics, training techniques, quality assurance, and certification of anesthesia care providers in trauma patient management. Potential additional applications of VASNET include remote monitoring of patients in the operating room, in the intensive care unit, during transportation, in hazardous environments, and in the field. Such VASNET telemetry may facilitate the availability of expert opinions during medical and other consultations.

Anesthesia↗

Reducing the risk of cardiovascular disease: effects of a community-based campaign on knowledge and behavior.

In 1972 the Stanford Heart Disease Prevention Program launched a three-community field study. A multimedia campaign was conducted for two years in two California communities (Watsonville and Gilroy), in one of which (Watsonville) it was supplemented by an intensive-instruction program with high-risk subjects. A third community (Tracy) was used as a control. The campaigns were designed to increase participants' knowledge of the risk factors for cardiovascular disease, to change such risk-producing behavior as cigarette smoking, and to decrease the participants' dietary intake of calories, salt, sugar, saturated fat, and cholesterol. Results of a sample survey indicate that substantial gains in knowledge, in behavioral modification, and in the estimated risk of cardiovascular disease can be produced by both methods of intervention. The intensive-instruction program, when combined with the mass-medica campaign, emerged as the most effective for those participants who were initially evaluated to be at high risk. The results after two years of intervention are reported for effects on knowledge and behavioral change for the total participant samples and for the high-risk subsamples in each of the three communities.

Attitude to Health↗

[Continuous evaluation of the general effect of the campaign against AIDS in Switzerland].

Since 1985 the Swiss Federal Office of Public Health and the Swiss AIDS Foundation are promoting AIDS prevention campaigns. A multimedia information campaign with the main slogan "STOP-AIDS" began in Feb. 1987 and is still under way. Multiplying effects are stimulated. An evaluation program is following continuously these campaigns, examines knowledge, attitude and behaviour changes in several groups of the population and analyses the conditions of these changes. The evaluation shows that the campaign and its objectives reached the general population and the target groups. Noticeable changes in attitudes and behaviors are taking place in the way of better protection in various observed groups, moderately or strongly exposed to HIV infection.

Acquired Immunodeficiency Syndrome↗

Medical knowledge systems: applications to telemedicine.

The application and form of electronically stored medical knowledge has a direct impact on the design of any healthcare delivery system. For those who plan for remote medical care or who work at the disaster relief level, there are specific requirements which will dictate the type of knowledge required and the vehicle best suited to deliver that information. The PC based multimedia biomedical library developed for NASA was originally intended for long-term space missions where complete isolation from each support was a distinct possibility. The library is a combination of traditional references and secondary databases structured within a primary care physician's workstation. The integration of the library and a point-of-care system allows optimal use of both resources and provides a basic building block for telemedicine networking.

Artificial Intelligence↗

Dynamic and quantitative evaluation of eyelid motion using image analysis.

Evaluation of facial movement, especially eyelid movement, has depended on the subjective judgment of trained clinicians. Recently, a few objective methods have been reported, but they required uncomfortable markers to be attached to the eyelids and a special-purpose, high-speed video camera. This study had two aims: one was to develop a new device for measuring eyelid motion dynamically and quantitatively, without eyelid markers or a high-speed camera; the other was to devise feasible parameters for eyelid motion. The system consisted of a personal computer with a general-purpose multimedia board and a software program that the authors named blepharokymography. A sequence of blinking eyes was recorded with a video camera. After the capturing process of the video, kymograms were produced from the movie file. Kymograms were converted to binary images by threshold filtering. The lower margin of the upper eyelid was traced, and displacement and velocity curves were obtained. Some parameters were devised and verified in preliminary clinical data. The analysis revealed that the displacement (8 mm in normal compared with 5.2 mm in paralysis), average closing velocity (74 mm s(-1) in normal compared with 30.6 mm s(-1) in paralysis) and peak closing velocity (154 mm s(-1) in normal against 63.4 mm s(-1) in paralysis) were useful parameters for differentiating the normal and facial-paralysis states.

Adolescent↗

The role of TGF-beta 1 in mice hepatic fibrosis by Schistosomiasis Japonica.

To investigate the role of transforming growth factor-beta 1 (TGF-beta 1) in mice with hepatic fibrosis caused by Schistosomiasis Japonica, ELISA, VG staining and multimedia color hieroglyph quantitative analysis were used to study the change of the serum TGF-beta 1, liver collagen fiber and reticular fiber in mice. The level of serum TGF-beta 1 in experimental group was significantly higher than that in control group (P < 0.01 or P < 0.05) 8, 10, 12 weeks after infected by schistosomiasis. After infection, the level of liver collagen fiber and reticular fiber, and that of TGF-beta 1 increased over time (P < 0.01 or P < 0.05). In mice infected by Schistosomiasis Japonica, the level of TGF-beta 1 increased with prolongation of infection time, and with the increase of liver collagen fiber and reticular fiber. TGF beta 1 plays an important role of immunomodulation in hepatic fibrosis formation caused by Schistosomiasis Japonica.

Animals↗

Study on IL-4, IL-5 and IL-10 in liver and bone marrow of mice infected with Schistosomiasis Japonica.

To compare Th2 cytokines levels in livers and bone marrow of mice infected with Schistosomiasis Japonica and understand their implication, ABC immunohistochemical staining technique and multimedia pathologic pictures analysis were used to detect the IL-4, IL-5 and IL-10 derived from livers and bone marrow of infected mice. Results showed that in the livers of infected mice, IL-4, IL-5 and IL-10 were obviously increased over time. The level of IL-4 was increased most among the 3 indicators. In bone marrow of infected mice, however, even though IL-4 was slowly increased over time, it was lower than that of livers in 10th and 12th week. The level of IL-5 was higher than that of livers during 12th weeks. Before 10th weeks IL-10 was elevated. After 12th week IL-10 was decreased and obviously lower than that of livers. It is concluded that in mice infected with Schistosomiasis Japonica, the immune response occurred mainly in the liver. Therefore, in bone marrow, IL-5 showed obvious auto-secretion. It might be related to its biological ability to induce B cell division and eosinophil differentiation.

Animals↗

Dynamic observation of liver fibrosis in mice infected with Schistosoma japonica.

The expression of TNF-alpha in the liver at different periods post Schistosoma japonica infection and the effect on liver fibrosis after supplementary injection of these cytokines were investigated. The mice infected with schistosome cercariae were divided into 3 groups: normal control group, TNF-alpha-untreated infection group and TNF-alpha-treated infection group. ABC immunohistochemistry and pathologic image multimedia quantification system were applied to dynamically detect the activity of TNF-alpha. The results showed that the levels of TNF-alpha in the liver in TNF-alpha-untreated infection group were slowly decreased with prolongation of infection time (from 8th, 11th, 14th to 18th week), while in the TNF-alpha-treated infection group, those were increased significantly after intraperitoneal injection of TNF-alpha at 6th week after infection. At first to 8th week after the final injection of TNF-alpha, the intrahepatic TNF-alpha levels in the TNF-alpha-treated infection group were significantly higher than in the other two groups (P < 0.01), and the granulomatous inflammation and fibrosis in the liver were also milder in the normal control group. It was concluded that at the early stage of Schistosoma japonica infection mouse liver mainly released Th1 cytokine and TNF-alpha from Th1 activated macrophages. Six weeks after infection (post egg deposition), exogenous supplement with intraperitoneal injection of TNF-alpha could induce the enhanced expression of Th1 cytokines and alleviate the liver granulomatous inflammation and fibrosis.

Animals↗

Enhancing the expressiveness of structured reporting systems.

The overall goal of this research is to build a structured reporting system that reduces the cost, delays, and inconvenience associated with conventional dictation and speech recognition systems. We have implemented such a structured reporting system for radiology that replaces current dictation and transcription processes by allowing radiologists and other imaging professionals to select imaging findings from a medical lexicon. The system uses an imaging-specific information model, called a "description set,' to organize selected terms in a relational database. Unique features of the knowledge representation that enhance its expressiveness include its ability to codify uncertainty about an imaging observation and to represent explicitly the logical relationships among imaging findings. In addition, the system does not require the user to fill in "blanks' in a static text template. Instead, it allows entry of terms in arbitrary order and uses automated text-generation techniques to create a text report that referring physicians are accustomed to receiving. In parallel, the system also produces a multimedia report that the referring physician can use as a quick reference. Unlike the results of conventional dictation or speech recognition, each finding is coded in a relational database for later information processing. Thus, the structured report database can be used to index images by content, to provide real-time decision support, to enhance radiologists' performance, to conduct exploratory clinical research, and to transmit imaging report data to computer-based patient record systems.

Abstracting and Indexing↗

Hardware and software requirements for a picture archiving and communication system's diagnostic workstations.

Electronic systems (picture archiving and communications systems [PACS]) for image and multimedia data distribution, archiving, and transmission, represent the future of radiology. The workstation is the point of contact between a PACS and the radiologist or referring physician. Therefore, the acceptance of PACS is highly dependent on workstation functionality and performance. This paper, based on our experience in evaluating commercial workstations and on a review of recent literature, describes hardware and software requirements for diagnostic workstations that could be used for making primary diagnoses in a radiology department. Requirements for PACS workstations for use in referring clinics are also briefly described. These workstations must be able to handle the large volume of images to be viewed efficiently, add new functionality to improve the productivity of physicians, technologists, and other health care providers, and provide enough flexibility to allow the electronic systems to grow as medical imaging technology evolves.

Computer Systems↗

Hypermedia in radiology: computer-assisted education.

Hypertext is a new computer-based method of presenting information that provides greater flexibility than conventional methods of continuing education. With a hypertext system, an individual using the computer can acquire more information on a word or concept that needs to be pursued in depth. Hypermedia is an expanded concept which uses the computer's ability to incorporate images, sounds, and video images in addition to text. This interactive, multimedia approach customizes information for more effective learning. The authors devised a prototype hypermedia textbook of nuclear medicine using a personal computer with hypermedia software that contains text, graphs, tables, figures, literature citations, and an easily persuable image database. All the information is organized with multiple cross-references, allowing instant branching to relevant facts, in different levels of detail. The system's applications and the ease of expansion or modification by the user are described.

Computer-Assisted Instruction↗

Digital video applications in radiologic education: theory, technique, and applications.

Computer-assisted instruction (CAI) has great potential in medical education. The recent explosion of multimedia platforms provides an environment for the seemless integration of text, images, and sound into a single program. This article discusses the role of digital video in the current educational environment as well as its future potential. An indepth review of the technical decisions of this new technology is also presented.

Computer-Assisted Instruction↗

Interfacing aspects between the picture archiving communications systems, radiology information systems, and hospital information systems.

Information relevant to radiological applications is commonly managed by several autonomous medical information systems including hospital information systems (HIS), radiological information systems (RIS), and picture archiving and communications systems (PACS). In this report, we explain the need to coordinate these systems and to provide some framework in which they can exchange information. In the first half of this report, we describe the integration of a PACS system into a hospital operation. Next, we present the interfacing methods between the HIS and the RIS, and between the RIS and the PACS. Two methods are further detailed for the communication between the RIS and the PACS (1) the triggered database to database transfer, and (2) the query protocol. The implementation of the first method successfully allows RIS reports, procedure and patient demographic information to be displayed at the request of the user along with the associated images at a PACS workstation. The query protocol allows a PACS to dynamically query RIS information. It will be eventually integrated into the design of a scientific multimedia distributed medical database system built on top of the HIS, the RIS, and the PACS.

Academic Medical Centers↗

Real-time telediagnosis of radiological images through an asynchronous transfer mode network: the ARTeMeD project.

The ARTeMeD project aims to solve problems of interactivity and real-time in teleradiology. It integrates personal multimedia facilities and patient data access in a common platform that allows radiologists to collaborate from remote sites through a suitable communication support. ARTeMeD is based on asynchronous transfer mode (ATM) network technology and an optimized manipulation of medical image material. The ARTeMeD system opens interesting perspectives in the area of collaborative teleradiology.

Computer Systems↗

Image organization and navigation strategies for a radiological work station.

One can distinguish two distinct preliminary phases in the "analog" radiographs reading process. The first phase deals with the film selection and placement on viewboxes (image organization), and the second with the actual film reading (involving image navigation, ie, the means for accessing the individual images). Our multimedia radiological work station will replace the view boxes with a low-resolution control monitor and a single high-resolution image monitor for viewing the radiographic images of the patient. These are organized by body area and examination view, and are associated with a sketch of a human body on the control monitor. This "anthropomorphic" organization of the images helps the radiologist create a mental picture of the entire patient radiographic file. We expect that together with the requisition information, a proper representation of the file will improve the search for relevant radiographic images. The work station supports image navigation by means of a "soft" representation of the physical viewboxes. In the same manner that radiographic films can be placed onto physical viewboxes, image labels can be dragged with the mouse onto soft viewboxes embedded on the image monitor. Evaluation of results from tests conducted with 15 physicians are presented.

Data Display↗

Higher order statistical analysis of /x/ in male speech.

This paper presents a study of kurtosis analysis for the sound /x/ in male speech, /x/ is the sound of the 'o' at the end of words such as 'ago'. The sound analysed for this paper came from the Australian National Database of Spoken Language, more specifically the male speaker 17. The /x/ was isolated and extracted from the database by the author in a quiet booth using standard multimedia software. A 5 millisecond window was used for the analysis as it was shown previously by the author to be the most appropriate size for speech phoneme analysis. The significance of the research presented here is shown in the results where a majority of coefficients had a platykurtic (kurtosis between 0 and 3) value as opposed to the previously held leptokurtic (kurtosis > 3) belief.

Algorithms↗

Beyond the electronic textbook model: software techniques to make on-line educational content dynamic.

OBJECTIVE: We describe a working software technology that enables educators to incorporate their expertise and teaching style into highly interactive and Socratic educational material for distribution on the world wide web. MATERIALS/METHODS: A graphically oriented interactive authoring system was developed to enable the computer novice to create and store within a database his or her domain expertise in the form of electronic knowledge. The authoring system supports and facilitates the input and integration of several types of content, including free-form, stylized text, miniature and full-sized images, audio, and interactive questions with immediate feedback. The system enables the choreography and sequencing of these entities for display within a web page as well as the sequencing of entire web pages within a case-based or thematic presentation. Images or segments of text can be hyperlinked with point-and-click to other entities such as adjunctive web pages, audio, or other images, cases, or electronic chapters. Miniature (thumbnail) images are automatically linked to their full-sized counterparts. The authoring system contains a graphically oriented word processor, an image editor, and capabilities to automatically invoke and use external image-editing software such as Photoshop. The system works in both local area network (LAN) and internet-centric environments. An internal metalanguage (invisible to the author but stored with the content) was invented to represent the choreographic directives that specify the interactive delivery of the content on the world wide web. A database schema was developed to objectify and store both this electronic knowledge and its associated choreographic metalanguage. A database engine was combined with page-rendering algorithms in order to retrieve content from the database and deliver it on the web in a Socratic style, assess the recipient's current fund of knowledge, and provide immediate feedback, thus stimulating in-person interaction with a human expert. RESULTS: This technology enables the educator to choreograph a stylized, interactive delivery of his or her message using multimedia components assembled in virtually any order, spanning any number of web pages for a given case or theme. An educator can thus exercise precise influence on specific learning objectives, embody his or her personal teaching style within the content, and ultimately enhance its educational impact. CONCLUSION: The described technology amplifies the efforts of the educator and provides a more dynamic and enriching learning environment for web-based education.

Computer-Assisted Instruction↗

Empowering radiologic education on the Internet: a new virtual website technology for hosting interactive educational content on the World Wide Web.

OBJECTIVE: We describe a virtual web site hosting technology that enables educators in radiology to emblazon and make available for delivery on the world wide web their own interactive educational content, free from dependencies on in-house resources and policies. MATERIALS/METHODS: This suite of technologies includes a graphically oriented software application, designed for the computer novice, to facilitate the input, storage, and management of domain expertise within a database system. The database stores this expertise as choreographed and interlinked multimedia entities including text, imagery, interactive questions, and audio. Case-based presentations or thematic lectures can be authored locally, previewed locally within a web browser, then uploaded at will as packaged knowledge objects to an educator's (or department's) personal web site housed within a virtual server architecture. This architecture can host an unlimited number of unique educational web sites for individuals or departments in need of such service. Each virtual site's content is stored within that site's protected back-end database connected to Internet Information Server (Microsoft Corp, Redmond WA) using a suite of Active Server Page (ASP) modules that incorporate Microsoft's Active Data Objects (ADO) technology. Each person's or department's electronic teaching material appears as an independent web site with different levels of access--controlled by a username-password strategy--for teachers and students. There is essentially no static hypertext markup language (HTML). Rather, all pages displayed for a given site are rendered dynamically from case-based or thematic content that is fetched from that virtual site's database. The dynamically rendered HTML is displayed within a web browser in a Socratic fashion that can assess the recipient's current fund of knowledge while providing instantaneous user-specific feedback. Each site is emblazoned with the logo and identification of the participating institution. Individuals with teacher-level access can use a web browser to upload new content as well as manage content already stored on their virtual site. Each virtual site stores, collates, and scores participants' responses to the interactive questions posed on line. CONCLUSION: This virtual web site strategy empowers the educator with an end-to-end solution for creating interactive educational content and hosting that content within the educator's personalized and protected educational site on the world wide web, thus providing a valuable outlet that can magnify the impact of his or her talents and contributions.

Computer-Assisted Instruction↗