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PubMed2004

Consciousness and quantum information processing: uncovering the foundation for a medicine of light.

Great progress has been made by Russian and German researchers in recent years (Popp, Voeikov, and others) to examine the biophysical aspects of biophotonic processes in humans. This paper suggests that there is a many-body reality to the way biophysical light interacts with the human self-organization of information that may be achieved by means of biomolecular, metabolic, or neural communication. These systems may merge as mobile energy relay systems similar to what is seen as qi processes in acupuncture science, suggesting a "holomovement" that seeks to confirm itself and increasingly retrieves and uses only the information that serves its exchanges with the environment. This coevolution of evolutionary process levels, expressed in process terms, can be seen as a foundation for a Medicine of Light integrating hidden variables in consciousness studies with functional differentiation and new findings in the biologic sciences.

Acupuncture Therapy↗
PubMed2002

Tamoxifen and toremifene impair retrieval, but not acquisition, of spatial information processing in mice.

The present study examines the effects of tamoxifen (TAM) or toremifene (TOR), two triphenylethylene antiestrogen agents, on spatial information in mice by using Morris water maze. In a 30-s free swim trial, the TAM- or TOR-treated mice (intraperitoneally, 30 min before test) spent shorter time than the blank control mice in target quadrant. Compared to saline control group, animals exposed to TAM (1-10 mg/kg i.p., once a day for 5 days) or TOR (3-30 mg/kg i.p., once a day for 5 days) did not show significant difference on the acquisition of place task in Morris water maze. These results suggest that TAM, at the doses of 1-10 mg/kg, and TOR, at the doses of 3-30 mg/kg, impair the retrieval, but not the acquisition, of spatial information task in Morris water maze. It seems, however, that TOR is more potent than TAM on impairing memory retrieval.

Animals↗
PubMed2000

Triplex-forming molecules for modulation of DNA information processing.

The design of specific DNA ligands is an important challenge in biological and biomedical sciences. Targeting the source of genetic information may allow highly efficient gene-directed modulation of cell function. Triplex-forming molecules specifically recognize oligopyrimidine/oligopurine sequences by hydrogen bonding interactions. In cell cultures they have been used successfully to downregulate or upregulate transcription in a gene-specific manner or to induce site-directed mutagenesis and recombination. For biotechnological applications, triplex-forming molecules are powerful tools for gene-specific chemistry.

Animals↗
PubMed1997

Health care information processing: how accurate are the data?

Managed health care providers, governmental agencies, lawmakers, and the general public are now relying on informational databases to influence health care decisions. This information is also used to derive efficiency profiles for both the individual physician and the institution. However, database reporting procedures are not standardized or monitored. Further, the ICD-9-CM coding system lacks specificity. Consequently, the accuracy of the information in a typical informational database is questionable. As a result, credentialing of physicians and institutions may be based on erroneous information from inaccurate databases. The objective of our study was to document the accuracy of a local informational database. We did a retrospective review of 40 randomly selected charts with surgical procedure codes (ICD-9-CM) for decompression or diskectomy. We compared the diagnosis, procedures, comorbid events, and complications as originally recorded by the surgeon with results of our chart review. We also compared the procedure codes as originally recorded by a hospital recorder with results of our chart review. Results indicated that the information actually reported to the hospital database was lacking or inaccurate in 70% of cases. Discrepancies were not the fault of hospital coders; the coding accuracy rate was 95%. Discrepancies were largely the result of two problems. First, the primary procedure code (ie, the first code on the list recorded by the hospital medical records personnel) did not always match the actual primary procedure (ie, the most complex procedure) done by the surgeon. Second, the ICD-9-CM code was not specific enough to accurately describe the actual surgery done. We conclude that critical discrepancies were recorded into the informational database.

Adult↗
PubMedDate not supplied

Interviewing for a deanship in nursing--an informed process.

This article has been written to assist those individuals who aspire to administration in nursing education. Being interviewed for a Deanship is an exacting experience during which the candidate must make an impression, as well as, collect enough data upon which an informed decision can be made. Good preparation for the process is essential. Data is gathered about the School, the people in the School (faculty, students and staff), the position (and the University and the professional community), as well as, the community. No one School of Nursing is perfect but the informed candidate will be more able to decide which risks are worth taking.

Decision Making↗
PubMed1990

Effects of aging on the dynamics of information processing and synaptic weight changes in the mammalian hippocampus.

It is clear that the properties of LTE make it a plausible mechanism for associative information storage at some synapses in the central nervous system. While many of the factors that regulate LTE's induction and expression have been discovered and a strong case is being developed for its role in learning and memory processes, until we understand more clearly the mechanisms underlying both the expression and maintenance of LTE, an understanding of its change with age will be difficult. Judging by the progress that has been made over the past several years in uncovering some of the molecular events that are critical for LTE's expression, one may be optimistic that answers will be forthcoming reasonably soon. Of particular importance to aging mammals, such answers may provide insights into why older organisms show faster forgetting. This may have a profound impact on therapeutic strategies for memory disorders in both normal and pathological conditions of aging.

Aging↗
PubMedDate not supplied

Information processing for the analysis of metabolic pathways and inborn errors.

Methods of biotechnology allow the analysis of molecular structures and molecular processes. Different molecular database systems are available which allow worldwide data access. Methods and concepts of bioinformatics are important for the analysis of these molecular data, which represent complex regulatory networks. The detection of metabolic diseases is one application of information systems, which represents molecular and medical data and allows the stimulation of metabolic processes. In this paper we present the architecture of our molecular information system.

Database Management Systems↗
PubMed2006

Information processing in human parieto-frontal circuits during goal-directed bimanual movements.

It is known that, in macaques, movements guided by somatosensory information engage anterior parietal and posterior precentral regions. Movements performed with both visual and somatosensory feedback additionally activate posterior parietal and anterior precentral areas. It remains unclear whether the human parieto-frontal circuits exhibit a similar functional organization. Here, we employed a directional interference task requiring a continuous update of sensory information for the on-line control of movement direction, while brain activity was measured by functional magnetic resonance imaging (fMRI). Directional interference arises when bimanual movements occur along different directions in joint space. Under these circumstances, the presence of visual information does not substantially alter performance, such that we could vary the amount and type of sensory information used during on-line guidance of goal-directed movements without affecting motor output. Our results confirmed that in humans, as in macaques, movements guided by somatosensory information engages anterior parietal and posterior precentral regions, while movements performed with both visual and somatosensory information activate posterior parietal and anterior precentral areas. We provide novel evidence on how the interaction of specific portions of the dorsal parietal and precentral cortex in the right hemisphere might generate spatial representations by integrating different sensory modalities during goal-directed movements.

Adult↗