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Results for “FIBROSITIS”

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Factors influencing the development and maintenance of aerobic fitness: lessons applicable to the fibrositis syndrome.

Exercise may have therapeutic benefits in the treatment of fibrositis/fibromyalgia. However, little is known concerning what type of exercise best serves patients with this condition, their capacity for exercise or the identity of the physiological or psychological alterations elicited by increased activity that might be responsible for the positive effects. We discuss these issues from the perspective of the classical responses reported in healthy subjects. In addition, since the benefits of exercise programs are dependent upon continual participation. strategies for initiating activity and maximizing compliance are discussed.

Adaptation, Physiological↗

[Fibrosing interstitial pneumonia and idiopathic pulmonary fibrosis].

The most reasonable classification for diffuse interstitial pneumonia/fibrosis is described according to the clinical course, histopathological findings and responses to steroids. Idiopathic pulmonary fibrosis (IPF) represents the most prevalent, most chronic form of the disease with the worst prognosis. The histopathological findings of IPF are usual interstitial pneumonia (UIP) which microscopically is recognized as patchy lesions. In UIP diffuse alveolar inflammation does not change to diffuse alveolar fibrosis, rather the disease progresses via an increase in the number of localized fibrosis lesions. Steroids are ineffective in the treatment of IPF. Lung transplantation is the only effective treatment. The question of when such transplantation should be undertaken constitutes the subject of further study.

Fibrosis↗

Is there an immunologic component to the fibrositis syndrome?

PFS is an enigmatic disorder whose etiology remains largely unknown. Its clinical spectrum probably encompasses a heterogeneous group of patients displaying multifactorial symptomatology. Recent evaluation of PFS patients, on both a clinical and laboratory basis, suggests that there is a subpopulation of these patients who exhibit a low grade connective tissue disorder. This group of patients exhibit many of the clinical features expected with rheumatic diseases such as SLE and Sjögren's syndrome. They can be distinguished on a clinical basis from other PFS patients and from patients with the CEBV syndrome. Their disease may be disablingly painful and resistant to many therapeutic modalities. Results of newer information reviewed here suggests that these patients may have EVP on the basis of a peripheral, low grade, quasi-inflammatory process that may have a neurologic and an immune dysregulatory component. The implications of such a mechanism of injury are profound and potentially impact on the treatment of this group of patients.

Antibody Formation↗

New concepts in primary fibrositis syndrome.

PFS is a painful rheumatologic disorder that may be detected by the wary clinician attuned to the presence of seven or more tender points. This common disorder may be seen at any age, including childhood, and may be associated with secondary symptoms of depression and other affective disorders. It may also be associated with findings of disturbed sleep, hearing and vestibular abnormalities, and profound complaints of fatigue. The vagueness of this latter complaint means that PFS must be distinguished from the newly described CEBV syndrome. Although the etiology of PFS remains unknown, recent investigations suggest that these patients may suffer a disorder with a central nervous system component as well as a subtle peripheral tissue lesion. Newer PFS studies demonstrate tissue changes that may be consistent with altered microvascular permeability and blood flow, tissue hypoxia, and chronic muscle spasm. An immunologic abnormality, or even a previously undescribed connective tissue disease, may be important as a pathogenic factor in some PFS patients.

Depression↗

[Fibrositis].

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Adult↗

Altered sympathetic nervous system response in patients with fibromyalgia (fibrositis syndrome).

Twenty-seven female patients with fibromyalgia and 29 female healthy controls underwent an auditive stimulation test and a left hand cold pressor test at 10 and 4 degrees C. The microcirculatory changes observed, indicate that, as a response to 80 dB, 1000 Hz, 2 seconds sounds and cooling with associated pain, the vasoconstrictory responses are less in patients with fibromyalgia than in normal controls. This could indicate altered sympathetic nervous activity in patients with fibromyalgia and that the cutaneous manifestations previously interpreted as Raynaud's phenomenon should be reconsidered.

Acoustic Stimulation↗

[Anatomical study of the fibrosing action of Corynebacterium parvum in malignant pleural effusion].

Intrapleural injection of Corynebacterium parvum (CBP) has recently been used for the treatment of recurrent neoplastic pleural effusions and its mechanism of action has been suggested to be either a local fibrosis-stimulating effect or immunostimulation. The case is reported of a patient with pleuritis secondary to metastases of mammary carcinoma, treated with CBP plus methylprednisolone, who died five days after the treatment because of an acute myocardial infarction. The pathologic examination showed fibrinous pleuritis with an interconnecting network between the visceral and parietal pleura.

Breast Neoplasms↗