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PubMed2006

Associations between risk behavior and injury and the protective roles of social environments: an analysis of 7235 Canadian school children.

OBJECTIVE: The social etiology of adolescent injury remains poorly understood. The Population Health Framework suggests that the etiology of adolescent injury involves interactions between individual risk factors and the natures of adolescent environments. The purpose of this study was to apply this framework to examination of relationships between adolescent risk taking and injury, and the potential modifying effects of supportive home and school environments. METHODS: The analysis was conducted in a representative sample of 7235 males and females (10-16 years old) from Canada. Results were based on records from the 2001/02 World Health Organization Health Behaviour in School-Aged Children Survey. Individual items and factor analytically derived scales were used to describe and then model injury outcomes, risk behaviors, perceived home, and school climates, and the relationships between these variables in a theory driven etiological analysis. RESULTS: Adolescents with supportive home and school environments experienced lower relative odds of engagement in risk taking behavior and lower relative odds of injury. Gradients were observed between the extent of adolescent risk taking and the occurrence of injury. Interactions were not observed between risk taking behavior, perceived support in home and school climates, and injury. CONCLUSIONS: Risk taking is common among adolescents and plays a role in the etiology of injury. Supportive social climates clearly protect adolescents from engaging in these behaviors, and also the occurrence of some forms of injury. However, once an adolescent chooses to engage in risk taking behaviour, a supportive environment may not protect them from injury.

Adolescent↗
PubMed2006

Lesions of the anteroventral third ventricle region exaggerate neuroendocrine and thermogenic but not behavioral responses to a novel environment.

Mild psychological stressors provoke an acute rise in core temperature (T(C)), stimulate the hypothalamo-pituitary-adrenocortical (HPA) axis, and induce various stress-related behaviors. In the present study, we examined the effect of ablation of the anteroventral third ventricle region (AV3V) on both physiological and behavioral responses to a novel environment. T(C) was monitored in male Sprague-Dawley rats, with either sham or AV3V lesions, during a 5-h exposure to a novel environment. Trunk blood was collected, in a second group of rats, for the assessment of plasma levels of ACTH and corticosterone. Novelty-induced grooming and rearing behaviors were assessed in a third group of animals. T(C) was elevated in all animals after 30 min in the novel environment, but the rise was exaggerated in rats with AV3V lesions ( approximately 0.5 degrees C). AV3V-lesion rats maintained a higher core temperature for 2 h before it returned to the same level as the control group. Plasma levels of ACTH and corticosterone were also exaggerated in the AV3V lesion group after 30 min in a novel environment. In contrast to the physiological responses, the behavioral measures of grooming and rearing revealed no differences between the groups. The results from the current study suggest that neurons within the AV3V region exert an inhibitory influence on the HPA axis and fever developed in response to stressful psychological stimuli. They also confirm that the physiological and hormonal components of the stress response are independent of certain behavioral measures of stress.

Adrenocorticotropic Hormone↗
PubMed2005

The controlled-environment chamber: a new mouse model of dry eye.

PURPOSE: To develop a controlled-environment chamber (CEC) for mice and verify the effects of a low-humidity setting on ocular surface signs in normal mice. METHODS: Eight- to 12-week-old BALB/c mice were used in a controlled-environment chamber (CEC) where relative humidity (RH), temperature (T), and airflow (AF) are regulated and monitored. Mice were placed into the CEC and exposed to specific environmentally controlled conditions (RH = 18.5% +/- 5.1%, AF = 15 L/min, T = 21-23 degrees C) for 3, 7, 14, and 28 days. Control mice were kept in a normal environment (RH = 50%-80%, no AF, T = 21-23 degrees C) for the same duration. Aqueous tear production by means of the cotton thread test, corneal fluorescein staining (score, 0-15), and goblet cell density in the superior and inferior conjunctiva were measured by a masked observer. RESULTS: No statistically significant differences between the groups were found at baseline. Decreased tear secretion and increased corneal fluorescein staining were significantly present on day 3, 7, 14, and 28 in animals kept in the CEC. Goblet cell density was significantly decreased in the superior conjunctiva on day 7, and on day 3, 7, and 14 in the inferior conjunctiva in the CEC-kept mice compared with control animals. CONCLUSIONS: This study indicates that exposure of normal mice to a low-humidity environment in a CEC can lead to significant alterations in tear secretion, goblet cell density, and acquisition of dry eye-related ocular surface signs.

Air↗
PubMed1996

Differences in social environment between inpatient and day hospital-crisis respite settings.

OBJECTIVE: The study compared the social environment of a conventional psychiatric inpatient setting with that of a combined acute day hospital and crisis respite program that functions as an alternative to hospitalization for patients judged appropriate for acute inpatient admission. METHODS: As part of a randomized controlled study comparing the clinical effectiveness and cost-effectiveness of the two settings, the quality of the social environment in the two settings was assessed using the Multiphasic Environmental Assessment Procedure, an empirical measure of established reliability and validity that is based on objective ratings and perceptions of staff members and patients. RESULTS: Compared with the inpatient setting, the day hospital-crisis respite program had higher expectations for patients' functioning, a lower tolerance for deviance, and more flexibility in patients' choice of activities. The day hospital-crisis respite program also had a more attractive physical environment, and respondents rated its social milieu as more cohesive, less conflictual, and more comfortable. This setting also promoted higher levels of patient functioning and activity and more utilization of health services, assistance with daily living skills, and social and recreational resources and encouraged fuller integration of patients in the community. CONCLUSIONS: The social environment of the community-based day hospital-crisis respite program embodied several principles of community support systems, including provision of treatment in a less restrictive setting, avoiding disruption of patients' ongoing involvement in the community, promoting activities in the community, offering patients respect and opportunities for self-determination, and enhancing their dignity.

Activities of Daily Living↗
PubMedDate not supplied

The role of environment in the development of reading skills: a longitudinal study of preschool and school-age measures.

The purpose of this study was to extend previous studies on the influence of environmental measures on intelligence scores by examining how proximal and distal measures of children's environments in the preschool period and in the primary-grade period are related to their performance on reading achievement tests. Reading performance was explored using two approaches. The first approach involved the identification of children within a longitudinal sample who had poor reading skills at 8 years of age. The second approach used the full range of reading scores to explore whether factors influencing poor reading were different from those influencing good reading. Participants were 113 children, including 35 children with poor reading skills, who were part of a longitudinal study of cognitive development. Socioeconomic status (SES), Home Observation for Measurement of the Environment (HOME) scores at 3 and 10 years of age, and school-administered and individually administered reading achievement scores were obtained. Both SES and HOME scores were found to be related to reading abilities, but preschool environment measures were more strongly and consistently related to and predictive of reading scores. Differences in the patterns of correlations and the results of the predictive models were found between the full sample and the poor readers. Variables other than proximal and distal measures of the environment are involved in the development of reading skills.

Achievement↗
PubMed2005

Adult shyness: the interaction of temperamental sensitivity and an adverse childhood environment.

This article examines the relation between adult shyness and sensory-processing sensitivity and posits a new model in which the interaction of sensitivity and adverse childhood environment leads to negative affectivity (with the highly sensitive being more impacted), which in turn leads to shyness. Consistent with this model, two questionnaire studies (Ns = 96 and 213) supported three hypotheses: (a) sensory-processing sensitivity interacts with recalled quality of childhood parental environment to predict shyness, (b) sensory-processing sensitivity interacts in the same way with childhood environment to predict negative affectivity, and (c) the interaction effect on negative affectivity mediates the effect on shyness. Hypothesis 2 was tested and supported in an additional questionnaire study (N = 393) and also in an experiment (N = 160) that manipulated negative contemporaneous experience as an analog for adverse childhood environment.

Adolescent↗
PubMedDate not supplied

Postpartum women's perceptions of the hospital environment.

OBJECTIVE: To describe postpartum women's perceptions of the hospital environment and how it affects their postpartum experiences. METHOD: Descriptive study using content analysis of interview transcripts. SETTING: Participants were interviewed in their homes within the first 3 postpartum weeks about their postpartum experiences. PARTICIPANTS: Thirty-one primiparous women who gave birth vaginally to full-term newborns. They were recruited from two large childbirth education programs in the Pacific Northwest. RESULTS: The categories addressing the hospital environment were context, physical conditions, sociocultural conditions, contingencies, and consequences. Overall, these women had more negative perceptions than positive ones of the hospital environment. Women's perceptions seemed to be most influenced by the context of care. Women with mother/baby care had a greater proportion of positive perceptions than women with other care modalities. CONCLUSION: Nurses need to modify or change the hospital environment to promote more positive experiences for new mothers.

Adolescent↗
PubMed1999

Perceiving and representing both health and the environment: an exploratory investigation.

This article describes an exploratory study that examined the perceptions of both health and environment among men and women in higher and lower status areas in Hamilton, Canada. Situated in the literatures on health perceptions and environmental concerns, it not only describes health and environment perceptions, but also explores their interconnections, arguing that concern for self is more salient than that for any other, including environment, and that this salience is predicated on notions of control and responsibility. The article concludes by speculating on reasons for these findings by suggesting an empirically derived cultural model for representation of health-environment relations and the bases of information processing in this arena.

Attitude to Health↗
PubMed2005

Assessing the policy environment.

This article proposes a basic framework for assessing the policy environment. Environment is a key concept in nursing's much-discussed "metaparadigm," but the policy environment is rarely considered. Too often, bedside nurses do not recognize the policy dimensions of clinical practice issues. Yet nursing assessment involves identifying and appraising aspects of patients' situations that are salient to their responses to actual or potential health problems. Policy may be such a salient factor, as it shapes the physical aspects of patients' surroundings; the relationships possible between practitioners and patients; the institutions in which health care is offered; and, on a broader scale, the prospects for global survival. This article proposes a question-based framework for clinical practice nurses to use in assessing the policy environment.

Health Policy↗
PubMed2005

Nurses' work environment perceptions when employed in states with and without mandatory staffing ratios and/or mandatory staffing plans.

Multiple stakeholders have sought regulatory and nonregulatory strategies to address nursing workforce and patient safety concerns. This study examines differences in nurses' work environment perceptions. Approximately 4,000 nurses employed in 10 states provided their perceptions of key characteristics of their work environment using the Individual Workload Perception Scale. Univariate statistics were used to characterize mean values of the nurses' work environment perceptions by state of employment and whether these perceptions changed if employed in states with versus without mandatory staffing ratios and/or mandatory staffing plans. This study provides preliminary evidence that mandatory staffing plan legislation may be linked with the most positive nurse work environment perceptions when compared with implementation of mandatory staffing ratios or no workforce regulation. Based on this preliminary observation, further analysis comparing the relative benefits and costs of workforce regulation may be warranted.

Adult↗
PubMed2002

Genes and environment in arthritis: can RA be prevented?

Understanding of how interactions between genes and environment contribute to the development of arthritis is a central issue in understanding the etiology of rheumatoid arthritis (RA), as well as for eventual subsequent efforts to prevent the disease. In this paper, we review current published data on genes and environment in RA as well as in certain induced animal models of disease, mainly those in which adjuvants only or adjuvants plus organ-specific autoantigens are used to induce arthritis. We refer to some new data on environmental and genetic factors of importance for RA generated from a large case-control study in Sweden (1200 patients, 1200 matched controls). We found an increased risk of seropositive but not of seronegative RA in smokers, and there are indications that this effect may be due to a gene-environment interaction involving MHC class II genes. We also found an increased risk of RA in individuals heavily exposed to mineral oils. This was of particular interest because mineral oils are strong inducers of arthritis in certain rodent strains and because polymorphisms in human genetic regions syntenic with genes predisposing for oil-induced arthritis in rats have now been shown to associate with RA in humans. Taken together, our data support the notion that concepts and data on gene-environment interactions in arthritis can now be taken from induced animal models of arthritis to generate new etiological hypotheses for RA.

Animals↗
PubMed2003

Institutionalisation and schizophrenia in Japan: social environments and negative symptoms: Nationwide survey of in-patients.

BACKGROUND: The number of psychiatric beds per capita in Japan is the highest in the world, and a replication of earlier British research is needed to identify possible means of improving the mental health system. Aims To describe the current situation of psychiatric hospitals in Japan and to examine the relationship between negative symptoms of schizophrenia and social environments. METHOD: In-patients with schizophrenia were randomly selected from 139 hospitals. Data were obtained for 2758 participants using several scales, including the Manchester Scale and social environment scales. RESULTS: Negative symptom scales showed a significant correlation with understimulating social environments in hospitals. CONCLUSIONS: This study confirms the results from the UK and provides evidence for the importance of community-based care and for providing more-stimulating rehabilitation environments.

Attitude of Health Personnel↗
PubMed1993

Biomedical applications of simulated environments.

Environmental physiology assumes great significance in our national context in view of the diverse climatic conditions prevailing in different regions. Troops have to operate in diverse environmental conditions guarding the frontiers. Hence, the research in this area has been focused on the usage of field studies in the natural environments or simulated environments in the laboratory. Besides, the application of the simulation chambers in the research on the physiological effects of diverse environments, these studies may have applications in the control and management of certain clinical disorders. Some simulation chambers and specialised set-ups have been designed and developed at the Defence Institute of Physiology and Allied Sciences to carry out simulation studies. This paper describes these developments and the potentials of these biomedical applications of simulated environments.

Acclimatization↗
PubMed2002

Influence of enriched environment on spatial learning following cerebral insult.

The fact that our brain is continuously shaped by the environment and experience presents many challenges. It was noted several decades ago that exposure of a laboratory rat to a complex environment alters its brain and improves problem solving in complex tasks. Rats that are housed in an enriched environment can better compensate for brain lesion-induced deficits and resist neurodegeneration. In this article, the role of an enriched environment on brain plasticity following experimentally-induced lesions is discussed.

Animals↗
PubMed2004

Novel environments enhance the induction and maintenance of long-term potentiation in the dentate gyrus.

The induction of long-term potentiation (LTP) in the hippocampal formation can be modulated by different behavioral states. However, few studies have addressed modulation of LTP during behavioral states in which the animal is likely acquiring new information. Here, we demonstrate that both the induction and the longevity of LTP in the dentate gyrus are enhanced when LTP is induced during the initial exploration of a novel environment. These effects are independent from locomotor activity, changes in brain temperature, and theta rhythm. Previous exposure to the novel environment attenuated this enhancement, suggesting that the effects of novelty habituate with familiarity. LTP longevity also was enhanced when induced in familiar environments containing novel objects. Together, these data indicate that both LTP induction and maintenance are enhanced when LTP is induced while rats investigate novel stimuli. We suggest that novelty initiates a transition of the hippocampal formation to a mode that is particularly conducive to synaptic plasticity, a process that could allow for new learning while preserving the stability of previously stored information. In addition, LTP induced in novel environments elicited a sustained late LTP. This suggests that a single synaptic population can display distinct profiles of LTP maintenance and that this depends on the animal's behavioral state during its induction. Furthermore, the duration of LTP enhanced by novelty parallels the time period during which the hippocampal formation is thought necessary for memory, consistent with the view that dentate LTP is of a duration sufficient to sustain memory in the hippocampal formation.

Animals↗
PubMed2006

Genotype-by-environment interactions influencing the emergence of rpoS mutations in Escherichia coli populations.

Polymorphisms in rpoS are common in Escherichia coli. rpoS status influences a trade-off between nutrition and stress resistance and hence fitness across different environments. To analyze the selective pressures acting on rpoS, measurement of glucose transport rates in rpoS+ and rpoS bacteria was used to estimate the role of F(nc), the fitness gain due to improved nutrient uptake, in the emergence of rpoS mutations in nutrient-limited chemostat cultures. Chemostats with set atmospheres, temperatures, pH's, antibiotics, and levels of osmotic stress were followed. F(nc) was reduced under anaerobiosis, high osmolarity, and with chloramphenicol, consistent with a reduced rate of rpoS enrichment in these conditions. F(nc) remained high, however, with alkaline pH and low temperature but rpoS sweeps were diminished. Under these conditions, F(sp), the fitness reduction due to lowered stress protection, became significant. We also estimated whether the fitness need for the gene was related to its regulation. No consistent pattern emerged between the level of RpoS and the loss of rpoS function in particular environments. This dissection allows an unprecedented view of the genotype-by-environment interactions controlling a mutational sweep and shows that both F(nc) and F(sp) are influenced by individual stresses and that additional factors contribute to selection pressure in some environments.

Bacterial Proteins↗
PubMed2005

[Brazilian public health research output related to the environment].

Although there are few scientific studies on the environment in the Brazilian public health literature, there are indications of recent growth in this theme in research and graduate programs in Brazil, thus tending to consolidate the scientific output in this area. The objective of this study was to contribute to the understanding and characterization of this theme in public health, offering backing for establishing research focused on sustainability of the environment and health. We identified and analyzed the research output on the environment in the most important Brazilian scientific journals in public health (1992-2002), using as the reference Chapter 35 of Agenda 21 (science for sustainability). The results showed: research output highly concentrated in the more affluent Southeast region of the country; predominance of the biological concept of health and the biophysical concept of environment; prevalence of diagnoses versus the search for solutions; and few studies involving stakeholders' participation.

Bibliometrics↗
PubMed2005

Family environment of individuals with oral clefts in Argentina.

OBJECTIVE: The purpose of this investigation was to study the social environment of families of children with different types of nonsyndromic oral clefts (OC) and to compare these groups with a control population of families of children without clefts. DESIGN: The study compared three nonsyndromic oral cleft groups and the control group using the Moos Family Environment Scale, which examines cohesion, expressiveness, conflict, independence, achievement-orientation, intellectual-cultural orientation, active-recreational orientation, moral-religious emphasis, organization, and control. SETTING: All parents of children with nonsyndromic oral clefts from a large craniofacial clinic in Buenos Aires, Argentina, were identified and were enrolled in this study between June 2000 and August 2001. Control families were ascertained from the pediatrics service of a hospital located in the vicinity of the craniofacial clinic. PARTICIPANTS: One hundred and sixty-five parents were selected, based on having a child with nonsyndromic unilateral cleft lip with or without cleft palate (UCL/P), bilateral cleft lip with or without cleft palate (BCL/P), or isolated cleft palate (ICP). One hundred and eighty control parents with no family history of congenital anomalies were selected, as well. RESULTS: There was no major difference in the social environment of families of children with different types of nonsyndromic oral clefts. When compared with families in the control group, families of children with nonsyndromic oral clefts scored better in all three subdimensions of family relationship, revealed a high level of independence, and showed better structure and organization than control families did; however, families of children with nonsyndromic oral clefts reported participating in fewer recreational activities. CONCLUSIONS: Overall, families of children with nonsyndromic oral clefts displayed a good social environment. Efforts should be focused to involve them in recreational activities.

Adaptation, Psychological↗