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PubMedDate not supplied

Perioperative serum procalcitonin concentrations in patients with acute aortic dissection.

We investigated the perioperative serum procalcitonin (PCT) concentrations in 5 consecutive patients who underwent surgery for acute aortic dissection (2 men, 3 women; mean age 72 +/- 9 years, age range 52-81 years). Surgery used cardiopulmonary bypass with deep hypothermic circulatory arrest. Blood samples were taken prior to surgery, upon arrival in the intensive care unit, and 6, 12, 18, 24, and 48 h after intensive care unit arrival. Prior to surgery, the PCT level was 4.2 +/- 3.4 (range 0.8-8.3) ng/ml. The PCT increase was greatest at 24 h (5.8 +/- 4.5 ng/ml). Preoperatively, the C-reactive protein concentration was 8.0 +/- 8.3 (range 0.9-23.8) mg/dl, and the white blood cell count was 8.5 +/- 3.1 x 10(3). C-reactive protein continued to increase at 48 h, while the white blood cell count peaked at 24 h. In spite of no symptoms of infectious diseases or septicemia, all patients had a significant preoperative PCT elevation. This finding may have something to do with the specific preoperative condition of acute aortic dissection. However, more clinical investigation is needed to clarify the PCT changes during and after surgery for acute aortic dissection.

Acute Disease↗
PubMedDate not supplied

Acute aortic dissection in a patient with Marfan's syndrome complicated by gestational hypertension.

OBJECTIVE: To present a case of aortic dissection in a pregnant woman with Marfan's syndrome. CLINICAL FEATURES: A 34-year-old woman with Marfan's syndrome developed gestational hypertension and Type III aortic dissection during the third trimester. The diagnosis was confirmed by computed tomography and aortography. OUTCOME: Although the dissection progressed, the woman was treated successfully. Elective caesarean section was performed. At follow-up the dissection had healed. CONCLUSION: Marfan's syndrome introduces a high risk of aortic dissection during pregnancy and the treatment chosen is crucial. As dilatation of the aorta is progressive, patients with Marfan's syndrome should be followed up closely and offered prophylactic surgery if necessary.

Adult↗
PubMed1991

Intravascular ultrasound imaging of an acute dissecting aortic aneurysm: a case report.

A case of acute dissecting aortic aneurysm is described in which intravascular ultrasonography was used at the time of aortography to produce real-time, 360 degree cross-sectional images of the aorta. The transmural vessel morphology visualized by this new catheter-based technology allowed confirmation of the diagnosis and identification of distal extension to the aortic bifurcation. The case demonstrates the unique potential of this modality in diagnosis and possible therapy in vascular diseases.

Acute Disease↗
PubMed2006

Is primary hyperaldosteronism a risk factor for aortic dissection?

Primary hyperaldosteronism is a rare (<1%) and underdiagnosed cause of secondary hypertension. We present a case of aortic dissection in a patient with primary hyperaldosteronism. To our knowledge, there are six other reported cases of aortic dissection in patients with primary hyperaldosteronism. Our case strengthens the hypothesis that primary hyperaldosteronism is a potential independent risk factor for aortic dissection.

Aortic Dissection↗
PubMed2002

What is the best treatment for patients with acute type B aortic dissections--medical, surgical, or endovascular stent-grafting?

BACKGROUND: Controversy continues regarding treatment for patients with acute type B aortic dissection. METHODS: One hundred eighty-nine patients with acute type B aortic dissection managed over a 36-year period were analyzed retrospectively for three outcome endpoints: survival; freedom from reoperation, and freedom from late aortic-related complications or late death. Risk factors for death were identified using a multivariable Cox proportional hazards model. Then to account for patient selection bias, heterogeneity of the population, and continuous evolution in techniques, propensity score analysis was used to identify risk-matched cohorts (quintiles I and II) in which the results of medical (n = 111) or surgical (n = 31) therapy were compared more comprehensively. RESULTS: The two main determinants of death were shock (hazard ratio [HR] = 14.5, 95% confidence level [CL] 4.7, 44.5; p < 0.001) and visceral ischemia (HR = 10.9, 95% CL 3.9, 30.3; p < 0.001). Arch involvement, rupture, stroke, previous sternotomy, and coronary or lung disease roughly doubled the hazard. Female sex was also a significant but weaker independent predictor of death. Actuarial survival estimates for all patients were 71%, 60%, 35%, and 17% at 1, 5, 10, and 15 years, respectively, and were similar for the medical and surgical patients. The Marfan syndrome predicted reoperation and late aortic complications or late death. In a separate analysis of the 142 patients in quintiles I and II, survival, freedom from reoperation, as well as freedom from late aortic complications or death were almost identical in the medical and surgical subsets. CONCLUSIONS: The poor long-term prognosis of patients with acute type B aortic dissection is determined primarily by dissection-related and patient-specific risk factors, which are not readily modifiable. Whether the outlook in the future will be improved using stent-grafts remains to be determined.

Acute Disease↗
PubMed2006

Stent-supported angioplasty of a residual coronary artery dissection following replacement of the ascending aorta for acute type A aortic dissection. A report of a successful case.

A 54-year-old-man suddenly experienced severe back pain while eating. On admission to our hospital, contrast-enhanced computed tomography revealed an acute type A aortic dissection, and emergency surgical repair was performed the same day. Through median sternotomy, graft replacement of the ascending aorta, including removal of the site of the intimal tear, was carried out under deep hypothermia and retrograde cerebral perfusion. Although the postoperative course was satisfactory, the patient suddenly complained of sever chest pain on postoperative day 23; the ECG trace showed anomalous alterations. Emergency coronary angiography revealed the presence of a wide coronary artery dissection from the entry of the left anterior descending aorta (LAD) to the re-entry of the left circumflex artery (LCX). Multiple stents were implanted in the LAD and LCX. After stenting, the chest symptoms remitted and the ECG trace was normal. The patient was discharged from our hospital on postoperative day 42.

Aortic Dissection↗
PubMedDate not supplied

Steady state evaluation of aortic dissections: A feasibility study.

PURPOSE: One the main reasons for the limited use of MRI in the evaluation of aortic dissection in emergency conditions is its long execution time. The authors report their experience regarding a new MRI sequence that reduces execution time and avoids the use of contrast medium. MATERIALS AND METHODS: Eighteen haemodynamically stable patients with suspected (16 cases, 3 with confirmed diagnosis of aneurysm) or known aortic dissection (2 cases) underwent in emergency conditions 1.5T MRI with Steady-State sequence (Fast Imaging Employing Steady-State Acquisition: GRE 2D; TR 3.5, TE 1.6; Flip Angle 45, bandwidth 125, matrix 224x224, NEX 1, acquisition time per slice 7 s, thickness 6-8 mm, FOV 38; 2D-GE breath-hold sequence requiring cardiac triggering). The results obtained were compared in terms of diagnostic accuracy and execution time with those of classical MRI examination (black blood T1, FSE T2 and 3D MR-angiography) or multislice CT. RESULTS: The diagnostic accuracy of MRI, both with Steady-State sequence and the ''classical'' technique, and multislice CT in the diagnosis of dissection or aneurysm is equal (100%), whereas execution time is 6, 25 and 6 minutes, respectively. Multislice CT proved to be more accurate than Steady-State MRI in evaluating the renal parenchyma and the extension of the dissection to the renal arteries. CONCLUSIONS: The Steady-State MRI sequence provides a diagnosis of aortic dissection or aneurysmal dilatation in a short time and may represent a valuable alternative to CT in emergency settings, especially in patients with reported contraindications to iodinated contrast media.

Acute Disease↗
PubMed2004

[Chronic circumferential aortic dissection with intimo-intimal intussusception].

A circumferential aortic dissection with so-called intimo-intimal intussusception is a very rare complication of a dissecting aneurysm, in which the sock-like intimal flap is upended in the true lumen by the blood stream. The few cases reported thus far are based on radiological or intraoperative findings in acute dissections. The present postmortem study documents the very rare case of long-term survival of a chronic circumferential dissection with intimo-intimal intussusception.

Aortic Dissection↗
PubMed2002

Percutaneous placement of a low-profile stent-graft device for aortic dissections.

PURPOSE: The use of stent-grafts has proved to be safe and effective treatment for complicated aortic dissections but usually requires surgical cutdown to accommodate large-profile devices. Preliminary results of the use of a low-profile design that allows percutaneous access are presented. MATERIALS AND METHODS: Fifteen patients with aortic dissection were treated with use of a low-profile stent-graft. Dissection types included Stanford type A (n = 6) and type B (n = 9). The procedures were performed with use of Perclose devices to achieve hemostasis. The stent-graft device was composed of Gianturco stents connected with longitudinal wire struts covered with radially expanded polytetrafluoroethylene. The delivery sheath sizes were 14-20 F. RESULTS: In 87% of patients (13 of 15), the entry tear was excluded completely. Successful femoral closures were achieved in 93% of patients (14 of 15) with use of the suture-mediated devices. In 7% of patients (one of 15), surgical closure of the femoral arteries was required. The rate of pseudoaneurysm occurrence was 7% (one of 15). Hospitalization ranged from 1 to 30 days with a mean duration of 6.5 days. The 30-day mortality rate was 27% (four of 15). In the remaining 11 patients, entry tear sites were excluded and, on follow-up CT examinations, there was thrombosis and retraction of the false lumen and enlargement of the true lumen. CONCLUSION: Preliminary results of the use of a low-profile stent-graft device to treat aortic dissections show that, in most patients, it can be used with a suture-mediated device without surgical exposure of the common femoral artery.

Adult↗
PubMed1995

[Hiatal hernia incarceration during cardiopulmonary bypass in patient with acute aortic dissection--a case report].

A 67-year-old woman was admitted to our hospital under diagnosis of Stanford type A acute aortic dissection. Chest CT showed aortic dissection from the ascending to descending aorta, and large hiatal hernia. Operation was undergone under cardiopulmonary bypass and circulatory arrest with retrograde cerebral perfusion. A graft replacement was carried out from the ascending to transverse arch aorta. After the release of the cross-clamping of aorta, the heart was gradually oppressed anteriorly by extrapericardial mass, so that the patient could not be weaned from the cardiopulmonary bypass. The mass was revealed incarcerated hiatal hernia by ultrasonography. After laparotomy, diaphragm and hiatus were incised, the incarceration was relieved and the diaphgragm was repaired with a Goretex sheet. Then the patient could be weaned from cardiopulmonary bypass. Her postoperative course was uneventful except for acute renal failure, and she was discharged 60 days after the operation. The incarceration of hiatal hernia was thought to be caused by tissue edema and small bleeding during cardiopulmonary bypass. This is the first reported case with the incarceration of hiatal hernia which occurred during cardiopulmonary bypass.

Acute Disease↗
PubMedDate not supplied

Treatment of aortic dissections with a percutaneous intravascular endoprosthesis: comparison of covered and bare stents.

PURPOSE: The authors developed a percutaneous endoprosthesis for treatment of aortic dissections. The device is a Gianturco stent wrapped with Dacron or nylon mesh. Effectiveness of the covered stent versus a bare stent was compared in the treatment of acute aortic dissection. MATERIALS AND METHODS: Experimental aortic dissections were created in 10 mongrel dogs. Occlusion of intimal tears was attempted with covered stents in five dogs (group 1) and with bare stents in the remaining five dogs (group 2). RESULTS: In group 1, entry tears were obliterated within 1 day (n = 3) or 1 week (n = 2) after stent placement and false lumina were thrombosed within 1 week (n = 3) or 1 month (n = 2). In group 2, entry tears and false lumina remained patent. Histologic specimens showed that the covered stents were entirely covered with smooth neointima. CONCLUSIONS: This endoprosthesis offers an alternative to surgical treatment for dissections of the descending aorta.

Acute Disease↗
PubMed1998

Transesophageal echocardiography for ascending aortic dissection: is it enough for surgical intervention?

BACKGROUND: Acute ascending aortic dissection is a surgical emergency that requires expeditious diagnosis and prompt surgical intervention. In many centers, transesophageal echocardiography (TEE) is the test of choice on which surgical decisions are based. Echocardiographic false-positive diagnoses are rare but can occur with potentially severe consequences. CASE REPORT: Two clinical cases where ascending aortic dissections were falsely diagnosed by TEE are presented. DISCUSSION: Recent literature comparing the diagnostic accuracy of TEE and other imaging techniques are reviewed. Anatomical limitations of TEE and potential causes of false-positive results are discussed. Multiplane probe reduces, but does not eliminate, the occurrence of false-positive findings. To improve diagnostic specificity without undue delays in the course of clinical decision making, we recommend dividing positive TEE findings into "definite" and "probable" categories. Such subclassification is helpful in identifying cases where additional confirmatory tests are desirable in situations of uncertain diagnosis.

Adult↗
PubMed1990

[Clinical assessment of rotational digital angiography for the diagnosis of aortic dissection].

Rotational digital angiography was performed in five patients with aortic dissection. Intimal tears, intimal flap and involvement of major branches were clearly demonstrated in two patients with opacified false lumen. Ulcer-like projections were also identified in three patients with thrombosed false lumen. The device has, therefore, been found to be of great value in diagnosing aortic dissection particularly for the detection of intimal tear sites and ulcer-like projections.

Aortic Dissection↗
PubMed2002

[The use of a circulatory assistance device during replacement of descending aorta to treat chronic aortic dissection; report of a case].

A 70-year-old woman with Marfan syndrome had undergone Y-graft replacement for abdominal aortic aneurysm at the age of 61. She recently underwent axillo-bifemoral bypass to treat ischemia of the lower extremities caused by acute aortic dissection. The patient was admitted for surgical treatment to treat a remaining dissecting descending aortic aneurysm. Aortography revealed that the entry was present at the takeoff of the left subclavian artery, and that the false lumen extended up the proximal anastomosis of the Y-graft to where the true lumen ended. All the abdominal vessels originated from this false lumen, with the lower extremities being supplied via an axillo-bifemoral bypass. No re-entry was detected. Replacement of the descending aorta was carried out using a 28 mm woven Dacron graft. First, double-barreled distal anastomosis under single clamping was performed; then, proximal anastomosis was carried out under antegrade perfusion from the graft to shorten the ischemic time of the abdominal organs. The patient suffered no postoperative complications.

Aged↗
PubMed2004

The coexistence of acute aortic dissection with autosomal dominant polycystic kidney disease--description of two hypertensive patients.

BACKGROUND: Acute aortic dissection is a rare but potentially lethal disease characterized by high early mortality when left untreated. However, survival may be significantly improved by the timely institution of appropriate medical and/or surgical therapy. Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary disorders, accounting for 8-10% of the cases of end-stage renal disease. Hypertension occurs frequently and is an early manifestation of ADPKD in approximately 50-70% of non-azotemic patients. ADPKD, often caused by mutations in the PKD1 gene, is associated with life-threatening vascular abnormalities that are commonly attributed to the frequent occurrence of hypertension. METHODS: We present two cases of hypertensive patients with acute aortic dissection (type A Stanford) coexisting with ADPKD. RESULTS: A 54-year-old male hypertensive patient and a 47-year-old male hypertensive patient, both with known ADPKD were diagnosed and operated with acute dissection of ascending aorta. Both patients were characterized by severe hypertension; therefore, in both cases, degree of hypertension is likely to be causative for this vascular complication. However, since ADPKD is associated with the vascular complications mentioned above, abnormality of the structure of the arterial wall of the thoracic aorta cannot be ruled out. CONCLUSION: Aortic dissection is a rare but potentially disastrous complication, and clinicians should always consider this when dealing with patients with ADPKD who present with chest pain or collapse.

Aortic Dissection↗
PubMed1997

Follow-up of aortic dissection: contribution of MR angiography for evaluation of the abdominal aorta and its branches.

Spin-echo MR is an established method to evaluate thoracic aortic dissections, but is not well suited to study the abdominal aorta. In this study we evaluated whether MR angiography could provide a complete examination of the abdominal aorta. In 28 patients (40 MR studies) with suspected (n = 6) or known (n = 34) aortic dissection, MR studies were performed. Thoracic aorta was evaluated with spin-echo and gradient-recalled-echo MR imaging. Axial two-dimensional time-of-flight MR angiography with thin overlapping slices was used to study the abdominal aorta. Intermediate and high signal intensity on MR angiography was interpreted as patent flow, and low signal was interpreted as thrombus. The presence of an intima flap and the re-entry site could be depicted in all MR studies. Thrombus in the false channel was seen in 8 studies. The origin of the abdominal visceral branches and their relation to the false-true channel could be depicted, except in 4 of 80 renal arteries studied. Extension of the dissection into the coeliac trunk was seen in 2 and in the superior mesenteric artery in 10 studies. Dilatation of the suprarenal abdominal aorta was seen in 20 studies, and of the infrarenal aorta in 9 studies. MR angiography provides valuable information about the abdominal aorta and its branches in patients with aortic dissection. This makes MR imaging appealing as the preferred imaging modality for the diagnosis and follow-up of aortic dissection.

Aortic Dissection↗