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At least 1,135 records · Page 63Linked to original sources
PubMed1984

Parents' treatment expectations and attrition from a child psychiatric service.

In a large Child Psychiatric Service a structured questionnaire completed by parents (N = 80) prior to clinic contact tested the hypothesis that congruence between parent expectations and clinic actions as to the form, duration and process of treatment would be associated with greater acceptance of services. Empirical support was found for the importance of congruent expectations of treatment form and duration, but not of treatment process.

Child↗
PubMedDate not supplied

Improving ion mass ratio performance at low concentrations in methamphetamine GC-MS assay through internal standard selection.

In federally regulated drug testing, laboratories must identify and quantitate drugs and their breakdown products by gas chromatography-mass spectrometry (GC-MS) to a concentration that is at least 60% below the cutoff concentration for reconfirmation purposes. Use of methamphetamine-d5 as an internal standard in routine testing with derivatization by HFBA was found to contribute m/z 91 and 118 ions to the same ions from the nondeuterated methamphetamine in the specimen. This resulted in poor chromatography and occasionally caused the 91/254 and 118/254 ion mass ratios to exceed the +20% acceptance limit established in the calibration process at low concentrations. The analogues methamphetamine-d8 and -d11 were evaluated for contributions to the nondeuterated methamphetamine ion fragments. Methamphetamine-d8 produced m/z 91 and 118 ions, but in less abundance than methamphetamine-d5. Methamphetamine-d11 was found to produce little or no detectable m/z 91 or 118. Replacing methamphetamine-d5 with methamphetamine-d11 eliminates this problem and allows the assay to consistently produce ion mass ratios and acceptable chromatography sufficient for identifying and quantitating methamphetamine at 60% below the 500-ng/mL cutoff concentration.

Gas Chromatography-Mass Spectrometry↗
PubMed1990

Effect of acceptance or rejection on the author's evaluation of peer review of medical manuscripts.

To determine whether authors of rejected manuscripts would evaluate the editorial review process less favorably than would authors of manuscripts accepted for publication, a questionnaire was sent to solicit evaluations of the quality of the reviews that had led to the rejection or acceptance of manuscripts submitted to the Journal of Pediatrics. Similar evaluations of the editor's letter were also sought. Authors were more likely to respond to the questionnaire if their manuscripts had been accepted and were more likely to complete the questionnaire thoroughly. Authors of accepted manuscripts evaluated the editor's communication more favorably than did the authors of manuscripts not accepted for publication, but the evaluations of the reviews were not significantly different. Most authors utilized the reviews to modify their manuscripts before submitting them to another journal.

Authorship↗
PubMed2001

What is a good public participation process? Five perspectives from the public.

It is now widely accepted that members of the public should be involved in environmental decision-making. This has inspired many to search for principles that characterize good public participation processes. In this paper we report on a study that identifies discourses about what defines a good process. Our case study was a forest planning process in northern New England and New York. We employed Q methodology to learn how participants characterize a good process differently, by selecting, defining, and privileging different principles. Five discourses, or perspectives, about good process emerged from our study. One perspective emphasizes that a good process acquires and maintains popular legitimacy. A second sees a good process as one that facilitates an ideological discussion. A third focuses on the fairness of the process. A fourth perspective conceptualizes participatory processes as a power struggle--in this instance a power play between local land-owning interests and outsiders. A fifth perspective highlights the need for leadership and compromise. Dramatic differences among these views suggest an important challenge for those responsible for designing and carrying out public participation processes. Conflicts may emerge about process designs because people disagree about what is good in specific contexts.

Conflict of Interest↗
PubMed1996

Developing culturally sensitive HIV/AIDS and substance abuse prevention curricula for Native American youth.

In 1990, researchers and health care professionals joined with members of several southwestern Native American communities to form an HIV/AIDS and substance abuse prevention partnership. Culturally sensitive approaches to theory-based interventions were developed into highly replicable, structured, school-based and community-based intervention programs. Process evaluations indicated high levels of program acceptance and fidelity. Outcome evaluations demonstrated significant positive preventive intervention effects among participants. This article reports how NAPPASA school prevention curricula were developed and discusses three critical processes in developing these successful curricula: 1) selection of integrative theory to address the multi-dimensional antecedents of HIV/AIDS and substance abuse among Native Americans, 2) use of ethnographic methodology to obtain intensive input from target groups and community members to ensure cultural and developmental sensitivity in the curriculum, and 3) use of process and outcome evaluations of pilot and field trials to develop an optimal curriculum.

Adolescent↗
PubMed1988

Use of community analysis methods in community-wide intervention programs.

Successful implementation of large scale health intervention programs aimed at heart disease or cancer prevention require prior analysis and understanding of community structure, organization and influence networks. Systematic sociological analysis facilitates the health program entry process. Survey results are used to build acceptance, participation and to design educational programs. Specific methods used to assess the community's social configuration, organizational resources, and leadership patterns are described. Local leader identification process and participation in community advisory boards is presented. Approaches to the study of community are reviewed in the context of the Minnesota Heart Health Project, a ten year research and demonstration program to reduce risk of cardiovascular disease in three U.S.A. cities.

Cardiovascular Diseases↗
PubMed2005

Eilatin complexes of ruthenium and osmium. synthesis, electrochemical behavior, and near-IR luminescence.

The synthesis and characterization of new Ru(II) and Os(II) complexes of the ligand eilatin (1) are described. The new complexes [Ru(bpy)(eil)(2)](2+) (2), [Ru(eil)(3)](2+) (3), and [Os(eil)(3)](2+) (4) (bpy = 2,2'-bipyridine; eil = eilatin) were synthesized and characterized by NMR, fast atom bombardment mass spectrometry, and elemental analysis. In the series of complexes [Ru(bpy)(x)(eil)(y)()](2+) (x + y = 3), the effect of sequential substitution of eil for bpy on the electrochemical and photophysical properties was examined. The absorption spectra of the complexes exhibit several bpy- and eil-associated pi-pi and metal-to-ligand charge-transfer (MLCT) transitions in the visible region (400-600 nm), whose energy and relative intensity depend on the number of ligands bound to the metal center (x and y). On going from [Ru(bpy)(2)(eil)](2+) (5) to 2 to 3, the d(pi)(Ru) --> pi(eil) MLCT transition undergoes a red shift from 583 to 591 to 599 nm, respectively. Electrochemical measurements performed in dimethyl sulfoxide reveal several ligand-based reduction processes, where each eil ligand can accept up to two electrons at potentials that are significantly anodically shifted (by ca. 1 V) with respect to the bpy ligands. The complexes exhibit near-IR emission (900-1100 nm) of typical (3)MLCT character, both at room temperature and at 77 K. Along the series 5, 2, and 3, upon substitution of eil for bpy, the emission maxima undergo a blue shift and the quantum yields and lifetimes increase. The radiative and nonradiative processes that contribute to deactivation of the excited level are discussed in detail.

Journal Article↗
PubMed2000

Formulation of poly(D,L-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery.

An optimised water-in-oil-in-water double emulsion process for the microencapsulation of plasmid DNA in poly(D,L-lactic-co-glycolic acid) (PLGA) was used to prepare microparticles from a range of different PLGA formulations. This process has been developed using pharmaceutically accepted solvents and is potentially scaleable. Incorporation of plasmid DNA in the microparticles of up to 11 microg/mg was obtained and the retention of plasmid DNA integrity was considerably greater than previously reported. Microparticle structure was determined, by scanning electron microscopy, to be hollow and size distribution characteristics were found to be independent of polymer formulation. The ability to vary the plasmid DNA release profile by changing the PLGA formulation and polymer concentration used in the encapsulation process was also demonstrated. This ability to control the release profile of the microparticles was shown to be especially important as the physical integrity of the encapsulated plasmid DNA was found to deteriorate with extended release times in vitro.

DNA↗
PubMed2006

Characteristics of decision-making process during prescribing in general practice.

BACKGROUND/AIM: The process of precribing decision-making by general practitioners requires numerous consultations in order to obtain maximal effects, minimal risks, and cost-effectiveness with the full appreciation of a patient's right to choose. The aim of our study was to describe the process of decision-making by general practitioners who decide on the treatment for an individual patient, and to relate the scope and nature of this process to the quality of the outcome of the decision. METHODS: The study involved 53 general practitioners who worked in the Health Center, Kragujevac at the time of investigation (September-December 2002.). General practitioners made prescribing decisions, thinking aloud, for five patients with urinary tract infections (n = 2), or stomach complaints (n = 3). The resulting 265 transcripts were analyzed to determine the scope and nature of the decision-making processes. Differences in prescribing were related to the case or the practitioners' working experience, and to their educational background. RESULTS: Our results showed that the more years of practice the practitioners had the less treatments they prescribed, and the less additional aspects before prescribing they considered. The doctors with less experience, in most of the cases, considered the core aspects, while those with more experience more often considered the contextual and habitual aspects. Educational background of the general practitioners, and the type of a considered disease, had an influence on the decision-making process. The most optimal method for decision-making (marked as type F) was mostly used by the practitioners with the least experience, while the those with more experience mainly made their decisions in the ways considered the least acceptable. The optimal method for decision-making process does not necessarily provide the optimal therapy, so the least acceptable decision-making might not result in an inappropriate treatment. CONCLUSIONS: The observed prescribing decisions were mostly in disagreement with the Good Clinical Practice. Our study pointed out the need for the obligatory continuation of medical education of general practitioners in decision-making process during prescribing.

Adult↗
PubMed1977

Endometrial cancer: therapeutic decision and the staging process in "early" disease.

An all inclusive, widely accepted system for correlation of indices of pathophysiology in endometrial cancer with a spectrum of therapeutic management has yet to be developed. Improved understanding of tumor growth should lead to more logical, individualized treatment especially in terms of irradiation. To support these philosophies a brief review of past reports and studies, especially the Endometrial Adjuvant Study is provided. From an analysis of 574 patients in this study, it is apparent that prognostic factors could be separated as major, differentiation, and tumor penetration and minor, number of capsules of radium and depth of uterus. A pilot study under the Gynecologic Oncology Group suggests the correlation of the major factors with lymph node involvement. Since depth of penetration and lymph node involvement are most accurately determined by surgery and pathology, surgical staging is suggested as a guide for therapeutic decision.

Clinical Trials as Topic↗
PubMed2004

Configural/holistic processing or differential element versus compound similarity.

Before accepting a configural or holistic account of visual perception, one should be sure that an analytic (elemental) account does not provide an equal or better explanation of the results. I suggest that when one forms a compound of a color and a line orientation with one element previously trained as an S+ and the other as an S-, the resulting transfer found will depend on the relative salience of the two elements, and most important, the similarity of the compound to each of the training stimuli. Thus, if a line orientation is placed on a colored background (a separable compound), it will appear more like the colored field used in training, and color will control responding. However, if the line itself is colored (an integral compound), the compound will appear more like the line used in training, and line orientation will control responding. Not only does this account do a better job of explaining the data but it is simpler and it is testable.

Animals↗
PubMed2001

Server-based approach to web visualization of integrated 3-D medical image data.

Although computer processing power and network bandwidth are rapidly increasing, the average desktop is still not able to rapidly process large datasets such as 3-D medical image volumes. We have therefore developed a server side approach to this problem, in which a high performance graphics server accepts commands from web clients to load, process and render 3-D image volumes and models. The renderings are saved as 2-D snapshots on the server, where they are uploaded and displayed on the client. User interactions with the graphic interface on the client side are translated into additional commands to manipulate the 3-D scene, after which the server re-renders the scene and sends a new image to the client. Example forms-based and Java-based clients are described for a brain mapping application, but the techniques should be applicable to multiple domains where 3-D medical image visualization is of interest.

Anatomy, Cross-Sectional↗
PubMed2001

The style of processing scale: normative and reliability data.

Three student samples (ns=624, 653, and 566) yielded normative data for the Style of Processing scale. Analysis of subsamples found acceptable internal reliability (overall r=.78) and good test-retest reliability (overall r=.81, 6-mo. interval). The scale appears to have satisfactory reliability for assessing verbal-visual cognitive style, but further work is needed to test the scale's validity.

Attention↗
PubMed2006

[The reviewers' review].

Peer review is a process designed to ensure quality, integrity and novelty of scientific or medical studies, published in scientific journals. This process accompanies scientific publication since it began and is the cornerstone of scientific appreciation and acceptance. Since peer review is a non-transparent process and lacks standardized criteria for evaluation, it thereby attracts extensive criticism, as discussed in this article. Editors and reviewers of this journal have a special responsibility when discussing a submitted article, since this journal is the only scientific-medical platform in the Hebrew language.

Humans↗
PubMed2004

Funding free and universal access to Journal of Neuroinflammation.

Journal of Neuroinflammation is an Open Access, online journal published by BioMed Central. Open Access publishing provides instant and universal availability of published work to any potential reader, worldwide, completely free of subscriptions, passwords, and charges. Further, authors retain copyright for their work, facilitating its dissemination. Open Access publishing is made possible by article-processing charges assessed "on the front end" to authors, their institutions, or their funding agencies. Beginning November 1, 2004, the Journal of Neuroinflammation will introduce article-processing charges of around US$525 for accepted articles. This charge will be waived for authors from institutions that are BioMed Central members, and in additional cases for reasons of genuine financial hardship. These article-processing charges pay for an electronic submission process that facilitates efficient and thorough peer review, for publication costs involved in providing the article freely and universally accessible in various formats online, and for the processes required for the article's inclusion in PubMed and its archiving in PubMed Central, e-Depot, Potsdam and INIST. There is no remuneration of any kind provided to the Editors-in-Chief, to any members of the Editorial Board, or to peer reviewers; all of whose work is entirely voluntary. Our article-processing charge is less than charges frequently levied by traditional journals: the Journal of Neuroinflammation does not levy any additional page or color charges on top of this fee, and there are no reprint costs as publication-quality pdf files are provided, free, for distribution in lieu of reprints. Our article-processing charge will enable full, immediate, and continued Open Access for all work published in Journal of Neuroinflammation. The benefits from such Open Access will accrue to readers, through unrestricted access; to authors, through the widest possible dissemination of their work; and to science and society in general, through facilitation of information availability and scientific advancement.

Journal Article↗
PubMed1988

Decontamination: a microbiologist's perspective.

The primary objective of decontamination is to protect healthcare workers who handle medical devices from infectious diseases that may be present on those devices. Ideally, the decontamination process should provide both cleaning and biocidal activity. A wide range of equipment, from automatic washer/sterilizers to semi-automated washer/sanitizers are commercially available to satisfy this need. The primary difference between these pieces of equipment, from a microbiology perspective, is in the level of safety they provide. A summary comparison of the decontamination methods is shown in Table 1. Without a doubt, steam sterilization as a method of decontamination provides a greater safety level than may be required. However, the question is, "Do disinfection and sanitization provide an adequate safety level?" Although items do not necessarily need to be sterile to be safe to handle, sterilization processes provide the greatest margin of safety because of the significant microbial lethality and the ability to effectively monitor the process via biological indicators. Sterilization effectively eliminates the concern regarding the nearly unanswerable question of bioburden. Unfortunately, not all items are capable of being processed through a washer/sterilizer. Therefore, consideration must be given to the process compatibility of each device. Disinfection processes provide the next level of safety. Unfortunately, there is no recognized or accepted method for quantitatively describing or monitoring a thermal disinfection process. As is the case with sterilization consideration must be given to the process compatibility of each device. Sanitization provides the lowest level of safety for the decontamination process.(ABSTRACT TRUNCATED AT 250 WORDS)

Central Supply, Hospital↗
PubMedDate not supplied

[Ethics of care and new profiles of the woman].

INTRODUCTION: In health professions listening represents an essential condition for any cure relation. Learning to listen is thus neither easy nor granted. It requires the ability to put oneself in somebody else's place, maintaining self-possession of judgement and the ability of evaluating events. PROBLEM ANALYSIS: In health professions women have always occupied a privileged position for their sensitiveness and their ability of giving meaning even to everyday life. Empathy is the privileged way women have of getting to know, understand and take care of people. They follow a feminine style which accepts and welcomes other people even if they are not able to explain their intimate contradictions, their anxieties, their difficulties, their pain and weakness. Women know how to be near people, even if they understand they are not up to the situation, not expecting to solve pain: neither personal nor other people's. They act in a different way from men who instead are attached to a reductionism that assumes a theoretical scheme to understand the issue. Man's need to dominate the problem with knowledge makes him sacrifice the complexity of reality in which he lives. Men's simplicity, their tendency to generalize processes and easily find guidelines to proceed with no useless wastes, often sacrifices elements which find no place into the chosen standards. For women this way of behaving, apparently reassuring, is not possible because they are aware that such aspects while escaping their understanding express the personality of the people involved in this process, their uniqueness which does not accept generalisations. Behind interpretative schemes, behind apparently definitive diagnosis, women perceive vagueness and interpretative inadequacy. CONCLUSIONS: Female rationality is inclined to live with one's own and other's contradictions just because it is strongly attached to a reality which avoids simplification of understanding. It refuses interpretative schemes, theories which try to offer themselves as exhaustive models which can explain all events, lessening the value or even denying elements which do not fall within the interpretation model assumed. Women appear contradictory because they do not refuse confrontation with life contradictions and its perennial changes.

Attitude of Health Personnel↗
PubMed1990

Information systems and audit in antenatal care.

The obstetric record as initiated at the antenatal booking clinic essentially identifies the degree of risk engendered in that pregnancy so that consequent obstetric and paediatric management is tailored appropriately. Whether carried by the patient or based in the hospital with a summary carried by the patient (shared-care card), this record should be exhaustive, the emphasis being on quality, not quantity, of information recorded. To obviate human error in history-taking, patient management or record transcription, we believe on-line computerization of patient records with spin-off paperwork to be the only patient management system to fulfil the above criteria. User-friendly software can be designed with highly branching programmes which provide clinical action suggestions in high-risk cases. Various 'error traps' enhance the accuracy of information recorded. Such systems can be operated by medical and midwifery staff with minimal keyboard skills and are well accepted by patients and staff. Inexpensive and versatile microcomputer networks are excellent for such systems. The operational effects are discussed. Audit means different things to different people and one's view on the subject depends on which definition is selected. Obstetricians are quick to take credit for instituting audit in the form of local and national data collection exercises, such as statistics on perinatal mortality, birthweight, etc. While these exercises certainly constitute observational studies, they cannot be used to make conclusions about the quality of care. There is no sound inference that can be made from a review of information contained in amalgamated databases of hospital statistics. Audit, as properly defined, hinges on inference: the inference that the quality of care was or was not of a high standard. Descriptive statistics, therefore, can be used to generate hypotheses but should not be used as a form of audit, at least not in obstetrics. Auditing the quality of care involves a study of process. It therefore depends on the assumption that we know which practices maximize beneficial outcomes. This exercise is therefore only relevant when we have good evidence linking the process of care with these outcomes. In some cases the accepted standard against which the process of care can be compared is very obvious. In other cases, however, the accepted standard should itself be audited to ensure that it is based on sound evidence.

Confidentiality↗