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At least 1,135 records · Page 63Linked to original sources
PubMed1995

Protein binding of acetylsalicylic acid and salicylic acid in porcine and human serum.

As part of a pilot project establishing a porcine model for aspirin overdose, the percentage protein binding of acetylsalicylate (ASA) and salicylate (SA) in porcine and human sera was evaluated in vitro over a range of concentrations. Serum from 2 pigs and 4 humans were spiked with ASA concentrations of 0.5-100 mg/dL and SA concentrations of 1-120 mg/dL. Protein binding for each concentration of ASA and SA was determined using radiolabeled drug and ultrafiltration with the Centrifree micropartition system. The percentage protein binding for ASA in pig and human sera were similarly low (< 50%) for all concentrations evaluated. Percentage protein binding for SA for pig and human sera were high (approximately 90% and 80%) at low therapeutic concentrations, but then declined to approximately 30% at higher toxic concentrations (120 mg/dL). The protein binding of ASA and SA over a range of concentrations was similar for porcine and human sera.

Animals↗
PubMed1982

Influence of acetylsalicylic acid on glucose turnover in normal man.

This study was designed to evaluate the influence of intravenous infusion (72 mg min-1) of lysine acetylsalicylate (LAS), an inhibitor of endogenous prostaglandin synthesis, on glucose homeostasis in normal man. LAS infusion produced a transient decrease of both hepatic glucose production (Ra, p less than 0.01) and peripheral glucose uptake (Rd, p less than 0.01). Since Ra fell more than Rd, a slight but significant decrease of plasma glucose concentration occurred. Glucose metabolic clearance rate also showed a rapid, although transient, decrease after the start of LAS infusion. Plasma insulin rose twofold in response to LAS, while plasma glucagon remained unchanged. The failure of the glucose clearance to increase as a consequence of the augmented insulin levels suggests that salicylate compounds may cause a state of insulin resistance.

Adult↗
PubMed1977

Dissociation of acetylsalicylic acid in blood and joint fluid.

Assay method in blood of 30 patients, who had ingested 0.6 g buffered aspirin, showed earlier appearance of acetylsalicylate (ASA) than of de-acetylated salicylate (SA); the values for ASA averaged 7.7 min, and for SA, 10.9 min. Similarly in joint fluid, ASA appeared earlier than SA; the values of ASA averaged 19.4 min, and those for SA, 21.9 min. Transport times did not differ significantly between ASA and SA in most types of synovitis. Close to maximum concentrations in blood averaged 18.9 mg/l for total salicylates (TSA), 3.3 mg/l for ASA, and 23.3 mg/l for SA, whereas maximum concentrations in joint fluid averaged 15.7 mg/l for TSA, 2.5 mg/l for ASA, and 14.5 mg/l for SA. ASA in blood initially consituted 65% of TSA and decreased to less than measurable amounts 75 min after intake. Joint fluid initially contained a somewhat smaller maximal proportion of ASA, but de-acetylation progressed more slowly than in blood; ASA decreased to undetectable levels within 140-145 min after intake.

Adult↗