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Psychological and social barriers to women in science.

Commitment and creativity in science are not merely a function of an individual's competence or excellence, but are a product of the social environment as well. Acceptance and recognition from significant other people (one's peers and other professionals), and opportunities for stimulating and challenging interaction are essential for developing a strong occupational or professional identiy, and for creating the inner sense of role competence which can lead to greater commitment and productivity in professional work. Unfortunately women, especially those who have experienced interrupted or discontinuous careers, find such opportunities and acceptance difficult to obtain.

Female↗

The social construction of the human brain.

OBJECTIVE: The purpose of this article is to review the development of concepts about the contribution of nature and nurture to brain structure and mental function, and to derive the implications of these changing concepts for clinical practice. METHOD: The literature of the past five decades, as refracted by the author's personal experience in academic psychiatry during that interval, is reviewed. RESULTS: Psychiatric theory has swung through mighty arcs in recent years but has begun to re-equilibrate. Fifty years ago, psychoanalysis dominated the academic scene; for the past two decades, reductionist biological determinism has held the fort. Neither position is tenable. To subscribe to either is possible only by ignoring conflicting evidence. Worse, it means short-changing patients, whose disorders do not come neatly packaged into "organic" and "functional" compartments. Development is neither predestined in the genome nor completely malleable to shaping by the environment. Children inherit, along with their parents' genes, their parents, their peers, and the communities they inhabit. CONCLUSIONS: Contemporary psychiatric research conclusively demonstrates that mind/brain responds to biological and social vectors and is jointly constructed by both. Major brain pathways are specified in the genome; detailed connections are fashioned by, and consequently reflect, socially mediated experience in the world. Just at the time when integration at the level of theory is coming into sight, comprehensive patient care is endangered by for-profit corporate managed care, which is transforming medical visits into commodities on a production line. Physicians and patients must join in a coalition to protect quality, ensure access, and build continuity into all of medical care.

Animals↗

Nonrandom divergence of gene expression following gene and genome duplications in the flowering plant Arabidopsis thaliana.

BACKGROUND: Genome analyses have revealed that gene duplication in plants is rampant. Furthermore, many of the duplicated genes seem to have been created through ancient genome-wide duplication events. Recently, we have shown that gene loss is strikingly different for large- and small-scale duplication events and highly biased towards the functional class to which a gene belongs. Here, we study the expression divergence of genes that were created during large- and small-scale gene duplication events by means of microarray data and investigate both the influence of the origin (mode of duplication) and the function of the duplicated genes on expression divergence. RESULTS: Duplicates that have been created by large-scale duplication events and that can still be found in duplicated segments have expression patterns that are more correlated than those that were created by small-scale duplications or those that no longer lie in duplicated segments. Moreover, the former tend to have highly redundant or overlapping expression patterns and are mostly expressed in the same tissues, while the latter show asymmetric divergence. In addition, a strong bias in divergence of gene expression was observed towards gene function and the biological process genes are involved in. CONCLUSION: By using microarray expression data for Arabidopsis thaliana, we show that the mode of duplication, the function of the genes involved, and the time since duplication play important roles in the divergence of gene expression and, therefore, in the functional divergence of genes after duplication.

Amino Acid Substitution↗

Risk perception: unrealistic optimism or realistic expectancy.

The current study investigated risk perception and Unrealistic Optimism as a function of involvement in risk. 74 undergraduate students were asked to rate how likely they were to encounter various negative consequences relative to various comparison targets (child, peer, and parent) and specified their actual involvement in risk-taking. Over-all, 37 High and 37 Low Risk-takers rated harmful events similarly, adding support for disputing the hypothesis that risk-takers consider themselves to be invulnerable. When these older adolescents compared themselves with children, they rated their personal risk of engaging in the health threatening behaviors as higher. Adolescents can realistically appraise the differences between themselves and children and view themselves as more likely to encounter the negative outcomes of risk-taking behaviors. Implications are discussed.

Adult↗

Hydrogen peroxide upregulates TNF-related apoptosis-inducing ligand (TRAIL) expression in human astroglial cells, and augments apoptosis of T cells.

The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL- mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions.

Allergy and Immunology↗

Observations as to male fertility in the Flemish environment and health studies.

We report the observations made on 101 healthy non-smoking men aged 21-40 (50 from two industrial suburbs of the big city of Antwerp and 51 from Peer, a predominantly rural municipality with 14,622 inhabitants, 70 km east of Antwerp, chosen as the "control" area in spite of its intensive agriculture). Persons with known occupational exposures, persons working in a region with characteristics clearly different from the area of residence, and people commuting over long distances were excluded from the study. Sperm morphology was significantly worse in Peer than in Antwerp. Serum testosterone levels were significantly lower in Peer than in Antwerp. The proportions of men with very low and low serum testosterone levels, of men with very low and low spermatozoa concentrations and of men with very low and low percentages of spermatozoa with normal morphology, were all higher in Peer than in Antwerp. We speculate that both the lower testosterone concentrations and the poorer sperm quality are due to disturbance of the hypothalamic-pituitary-testicular function by hormone disrupters. Our data suggest that exposure to levels of environmental pollution which are widespread in developed nations, can have unfavourable effects on endocrine equilibrium and may disturb male fertiline disrupters.

Adult↗

Peer relationships and social and recreational activities among adolescents and adults with autism.

In this study, we investigate peer relationships and participation in social and recreational activities among 235 adolescents and adults with autism who live at home. The prevalence of having friendships, peer relationships, and participating in social and recreational activities were all low and comparable to previous research. Both individual and environmental factors were investigated as predictors of having peer relationships and participation in social and recreational activities. Having peer relationships was predicted by individual characteristics (younger age, and less impairment in social interaction skills), but not by characteristics of the environment. Greater participation in social and recreational activities was predicted by characteristics of the individual with autism (greater functional independence, less impairment in social interaction skills, higher levels of internalizing behaviors) and characteristics of the environment (greater maternal participation in social and recreational activities, greater number of services received, and inclusion in integrated settings while in school).

Adolescent↗

Variability in trauma center outcomes for patients with moderate intracranial injury.

BACKGROUND: The variability of outcome between Trauma Centers has not been extensively studied as a possible avenue for performance improvement. Trauma Center variability in severity-adjusted survival for patients with moderate intracranial injury (MII) was studied in order to determine the association of MII-related process of care variables with outcomes. The analytic results were supplemented with peer review of MII patients with unexpected outcomes and identified potential process of care variables. METHODS: A retrospective cohort study was undertaken based on data submitted to a statewide trauma center database from July '95 through June '98. MII patients had one or more selected ICD-9-CM codes with an AIS-90 severity score of 3 or 4 but no higher. Severity adjustment was done using case matching and a logistic function based New Model that appropriately accounts for patients intubated on Emergency Department arrival. MII-related process of care variables derived from the database were identified and their relationship with outcome were evaluated individually and using multivariate methods. Trauma center personnel conducted standardized peer reviews. RESULTS: The study included data from 6765 patients treated at 26 trauma centers. Two centers (2PZW) had significantly more survivors than expected by both severity adjustment methods. Three had significantly fewer survivors than expected (3NZW). By several measures, patients treated in the 2PZW centers were more seriously injured and older than those in the 3NZW centers. CT of the head performed in the treating hospital was the only process of care variable associated with outcome in multivariate evaluations. Peer review also found little association between process of care variables and patient outcomes. However, peer review reported that 23.7% of unexpected deaths identified by case matching or the New Model were preventable or potentially preventable. Peer review also identified as medically unnecessary significant percentages of patients with unexpectedly long stays in hospital (26.4%) or in ICU (17.3%) identified by case matching. Nearly 45% of unexpected complications were judged preventable or potentially preventable. CONCLUSIONS: Two severity adjustment methods identified significant variability in trauma center outcomes for patients with MII. The difference in outcomes between the centers with better than expected (2PZW) and poorer than expected outcomes (3NZW) was substantial. Peer review identified significant opportunities for reducing unexpected deaths, stays in hospital and in ICU, and the occurrence of complications. Trauma registry data and peer reviews found little relationship between available process of care variables and patient outcomes. This study should stimulate discussions to understand reasons for outcome variability and ways to reduce it.

Adult↗

Aging and immune response to exercise.

Human immune function undergoes adverse changes with aging. The T cells, which have a central role in cellular immunity, show the largest age-related differences in distribution and function, with thymus involution as the apparent underlying cause. The immune responses to acute exercise and training have not been studied extensively in the elderly. The natural killer (NK) cell response to a single exercise challenge is normal in older individuals, but immediately after exercise the elderly subjects manifest less suppression of phytohemagglutinin (PHA)-induced lymphocyte proliferation than younger individuals. In contrast, a strenuous exercise seems to induce a more sustained postexercise suppression of cellular immunity in older individuals than in their young peers. A few cross-sectional comparisons of immune status between physically fit elderly individuals and young sedentary controls suggest that habitual physical activity may enhance NK cell activity, checking certain aspects of the age-related decline in T cell function, such as reduced mitogenesis in response to plant lectins and decreases in the production of certain types of cytokine. The clinical implications, however, remain to be clarified by future study.

Adult↗

Similarities and differences in correlates of alcohol consumption and problem behaviors among male and female adolescents.

This study examined similarities and differences in correlates of alcohol consumption and problem behaviors among a random household sample of male and female adolescents between the ages of 12 and 17. Several similarities emerged between the two gender groups which were consistent with previous research, including a pattern of convergence among the variables of alcohol consumption, times drunk in the last year, and delinquent behavior; the salience of the peer context in alcohol-related behavior; and high associations between reasons, or motives, for drinking and alcohol consumption and problem behaviors. With respect to reasons for drinking, excitement-seeking, or pleasurable, reasons were highly related to outcome variables. Gender differences were reported for relationships between two indices of affective functioning, namely distress symptoms and escapist, tension-reducing reasons for drinking, and outcome variables related to delinquent behavior, school functioning, and aspects of self-concept. These differences are discussed with respect to possible differential socialization experiences among males and females.

Adolescent↗

Factors determining post selection: a literature review.

Most endodontically treated teeth require a post-and-core build-up for restoring the teeth to optimum health and function. Selection of an appropriate post-and-core system from the wide variety of those available may be a clinical dilemma. Therefore, the purpose of this article is to review the literature to identify the various factors that influence the selection of the post-and-core assembly. English-language peer-reviewed articles between 1961 and 2002 were identified using MEDLINE, as well as a hand search. The following key words were used: post, design, retention, fracture resistance, survivability, and esthetics. Selection of a post and core system should satisfy many interrelated biologic, mechanical, and esthetic factors to optimally restore the endodontically treated tooth to adequate form and function. This review may serve as a guide to aid the clinician in the selection of a post-and-core system.

Dental Prosthesis Design↗

Childhood social predictors of adolescent antisocial behavior: gender differences in predictive accuracy and efficacy.

This study examined the ability of several childhood, school-based, social variables to correctly classify antisocial adolescents. Children (N = 314; 163 boys, 151 girls) in the 3rd-5th grade were assessed on academic and social variables (i.e., peer rejection, aggression, withdrawal, and low prosocial behavior) and followed forward for 6-7 years until the 9th and 10th grade. Adolescent antisocial outcomes included a consensus measure formed from diagnostic interviews, contact with juvenile authorities, adolescent self-report, and mother's report. The gender-differential predictive accuracy and efficacy of the early predictor domains to a consensus measure of antisocial behavior were compared with the same estimates found for adolescent self-report of antisocial behavior. Both gender and criterion-method differences were found. For girls, regardless of the measure of antisocial behavior, early academic problems were the strongest predictors of future problems. For boys' self-reported antisocial outcomes, peer rejection was the strongest independent predictor. For consensus-reported antisocial outcomes, both early fighting-anger and withdrawn behavior displayed equally strong predictive relations. For boys, the combination of early fighting-anger and disruptive and withdrawn behavior was the strongest set of predictors for the consensus measure of antisocial functioning. Predictive accuracy and efficacy estimates are discussed in terms of predictive strength as well as the cost-benefit of misidentification.

Adolescent↗

Case management for people with severe mental disorders.

BACKGROUND: Since the 1960s, in many parts of the world, large psychiatric were closed down and people were treated in outpatient clinics, day centres or community mental health centres. Rising readmission rates suggested that this type of community care may be less effective than anticipated. In the 1970s case management arose as a means of co-ordinating the care of severely mentally ill people in the community. OBJECTIVES: To determine the effects of case management as an approach to caring for severely mentally ill people in the community. Case management was compared against standard care on four main indices: (i) numbers remaining in contact with the psychiatric services; (ii) extent of psychiatric hospital admissions; (iii) clinical and social outcome; and (iv) costs. SEARCH STRATEGY: Electronic searches of CINAHL (1997), the Cochrane Schizophrenia Group's Register of trials (1997), EMBASE (1980-1995), MEDLINE (1966-1995), PsycLIT (1974-1995) and SCISEARCH (1997) were undertaken. References of all identified studies were searched for further trial citations. SELECTION CRITERIA: The inclusion criteria were that studies should be randomised controlled trials that (i) had compared case management to standard community care; and (ii) had involved people with severe mental disorder mainly between the ages of 18-65. Studies of case management were defined as those in which the investigators described the intervention as 'case' or 'care' management rather than 'Assertive Community Treatment' or 'ACT'. DATA COLLECTION AND ANALYSIS: A study was carried out to test the reliability of the inclusion criteria. Categorical data were extracted twice and then cross-checked, any disagreements being resolved by discussion. Odds ratios and the number needed to treat were estimated. Continuous data collected by a measuring instrument was only included if the instrument (i) had been described in a peer-reviewed journal; (ii) was a self-report or had been completed by an independent rater; and (iii) provided a summary score for a broad area of functioning. Normally distributed continuous data were included if means and standard deviations were available. Non-normal data were included if analysed either after transformation or using non-parametric methods. Tests for heterogeneity were conducted. MAIN RESULTS: Case management increased the numbers remaining in contact with services (for case management odds ratio = 0.70; 99%CI 0.50-0. 98; n=1210). Case management approximately doubled the numbers admitted to psychiatric hospital (OR 1.84; 99% CI 1.33-2.57; n=1300). Except for a positive finding on compliance, from one study, case management showed no significant advantages over standard care on any psychiatric or social variable. Cost data did not favour case management but insufficient information was available to permit definitive conclusions. REVIEWER'S CONCLUSIONS: Case management ensures that more people remain in contact with psychiatric services (one extra person remains in contact for every 15 people who receive case management), but it also increases hospital admission rates. Present evidence suggests that case management also increases duration of hospital admissions, but this is not certain. Whilst there is some evidence that case management improves compliance, it does not produce clinically significant improvement in mental state, social functioning, or quality of life. There is no evidence that case management improves outcome on any other clinical or social variables. Present evidence suggests that case management increases health care costs, perhaps substantially, although this is not certain. In summary, therefore, case management is an intervention of questionable value, to the extent that it is doubtful whether it should be offered by community psychiatric services. It is hard to see how policy makers who subscribe to an evidence-based approach can justify retaining case management as 'the cornerstone' of community mental hea

Case Management↗

Association of being overweight with greater asthma symptoms in inner city black and Hispanic children.

OBJECTIVE: To determine whether the weight status of inner city black and Hispanic children with asthma differs from that of their peers and to assess whether overweight asthmatic children experience greater asthma symptoms. STUDY DESIGN: A cross-sectional study in an ambulatory chest clinic of an inner city medical center. METHODS: We studied black and Hispanic children aged 2 to 18 years (n = 209) with the single diagnosis of asthma. The peer control subjects consisted of a sample of black and Hispanic children aged 6 to 13 years (n = 1017), enrolled in the New York City schools. Asthma symptoms, the number of asthma medications prescribed, and peak expiratory flow rate (PEFR) measurements were used to classify asthma severity and relate to body mass index (BMI). Bivariate categorical analysis and chi 2 tests were performed to examine the relationship between high BMI and the individual measures of asthma severity. RESULTS: The prevalence of overweight was significantly higher in children with moderate to severe asthma than in their peers. The risk of overweight based on a BMI in the 85th percentile or greater was significantly associated with the following measures of asthma severity: (1) the number of school days missed per year; (2) a PEFR less than or equal to 60% of the predicted PEFR; and (3) the number of asthma medications prescribed. CONCLUSIONS: The prevalence of overweight was significantly higher in children with moderate to severe asthma than in their peers, and being overweight was associated with significantly more severe asthma symptoms. Further studies in overweight asthmatic children are needed, including the effect of weight loss on lung function and other markers of asthma severity.

Adolescent↗

Age-related changes in preschool children's systematic use of private speech in a natural setting.

This study set out to explore the contexts in which preschool children use private speech, or self-talk, in the naturalistic setting of the preschool classroom, and age-related changes in the contexts in which preschoolers talk to themselves. A total of 2752 naturalistic observations of fourteen three-year-old and fourteen four-year-old children were conducted using a time-sampling procedure in two preschool classrooms over the course of one semester. Results from logistic regression analyses revealed that both age groups were (a) more likely to use private speech during the self-selected activity classroom context as opposed to both large group and outside free play classroom contexts, and (b) most likely to talk to themselves when alone, next likely in the presence of peers, and least likely when in the presence of a teacher. Although the probability of private speech among three-year-old children did not vary as a function of the child's immediate activity, four-year-old children's private speech was more likely to occur during sustained and focused goal-directed activity as opposed to rapidly-changing and non goal-directed activity. The findings suggest that private speech appears systematically in young children and that, in several ways, four-year-old children use private speech more selectively than three-year-olds.

Adult↗

Depression and heavy alcohol use among adolescents: concurrent and prospective relations.

This study of over 1,000 adolescents focused on common and distinctive correlates of four subgroups--no problem, depressed only, heavy drinking only, and mixed (depressed and heavy drinking). Correlates were evaluated from the domains of personal dispositions (e.g., temperament), interpersonal relations (e.g., parent and peer), stressful life events, and other problem behaviors (e.g., delinquency, substance use). The no-problem subgroup differed from the other three subgroups in the direction of healthier functioning on almost all measures. The mixed subgroup reported the most pervasive, low levels of functioning, with the highest levels of childhood externalizing problems and stressful life events, the lowest levels of family social support, and high levels of delinquency and substance use. The depressed-only subgroup reported a more internalized pattern characterized by childhood avoidance problems, a difficult temperament (e.g., inflexibility, withdrawal, low task orientation), interpersonal stressors, and poor coping strategies. The heavy-drinking-only subgroup was characterized by higher drinking levels by primary caregivers and lower levels of family cohesion as reported by primary caregivers. The 1-year prospective findings were generally consistent with the concurrent findings in that variables that were associated with transitions toward and away from depression and heavy drinking were associated with specific transitions (e.g., childhood externalizing problems were associated with the transition from no problem to heavy drinking).

Adaptation, Psychological↗

Immigrant parents and their emigrant adolescents: the tension of inner and outer worlds.

This article examines different experiences of immigrant parents and their children in transit between the parents' ethnic world and American culture through three clinical cases: a 16-year-old male, whose mother is Persian and father East Indian and who presents with depression and lack of focus; an 18-year-old girl, whose mother is Nigerian and father African American and who was reporting depressive symptoms and confusion about sexual identity; and an 18-year-old depressed male from an Assyrian Iraqi background whose parents both are from Northern Iraq, but have lived in the United States for 20 years. Adolescents of immigrant families have much more complicated tasks during this phase of their development to establish a future sense of self-identity. A well-consolidated sense of self-identity is more complicated for these types of multiethnic immigrant families. The adolescents must rely on parental ego functions and their coherent sense of identity to weather this stage of their turbulent experience. In their strong fantasy framework, these adolescents strive to belong to their new peer groups, in which parents do not belong, particularly when the immigrant parents present a variety of different social and cultural values discordant to the contemporary culture. The cases suggest that both positive and negative aspects of ethnic identification become diluted during adolescence, when identification with parental mores occurs.

Adolescent↗