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PubMed2000

Neuropsychological outcome following unilateral stereotactic pallidotomy in intractable Parkinson's disease.

Neuropsychological functioning was examined at baseline and 2- to 3-month follow-up in 40 subjects with advanced Parkinson's disease (PD) who underwent unilateral posteroventral pallidotomy. Most subjects demonstrated improved verbal learning, visual memory, confrontation naming, and figural fluency at follow-up. Right pallidotomy was associated with decreased cognitive flexibility and increased verbal fluency, whereas Left pallidotomy uniquely resulted in a decline in verbal fluency. Significant motor improvement was demonstrated in both groups. Pallidotomy appears to be an effective treatment for advanced PD, providing a significant improvement in motor functioning, while resulting in few deleterious neurocognitive changes in most cases.

Aged↗
PubMed2005

Cognitive consequences of cannabis use: comparison with abuse of stimulants and heroin with regard to attention, memory and executive functions.

This review aims to compare cognitive consequence between cannabis, and stimulants and heroin with regards to attention, memory and executive functions. The available studies using brain imaging techniques and neuropsychological tests show that acutely, all drugs create a disharmony in the neuropsychological network, causing a decrease of activity in areas responsible for short-term memory and attention, with the possible exception of heroin. Cannabis induces loss of internal control and cognitive impairment, especially of attention and memory, for the duration of intoxication. Heavy cannabis use is associated with reduced function of the attentional/executive system, as exhibited by decreased mental flexibility, increased perserveration, and reduced learning, to shift and/or sustain attention. Recent investigations on amphetamine/methamphetamine have documented deficits in learning, delayed recall, processing speed, and working memory. MDMA users exhibit difficulties in coding information into long-term memory, display impaired verbal learning, are more easily distracted, and are less efficient at focusing attention on complex tasks. The degree of executive impairment increases with the severity of use, and the impairments are relatively lasting over time. Chronic cocaine users display impaired attention, learning, memory, reaction time and cognitive flexibility. Heroin addiction may have a negative effect on impulse control, and selective processing.

Amphetamine-Related Disorders↗
PubMed1992

Factor analysis of the Wechsler Memory Scale and the Warrington Recognition Memory Test.

Subjects were 156 individuals referred, for psychological and neuropsychological evaluation. The Wechsler Memory Scale (WMS) including the 12h delayed condition of Russell's revision and Warrington's Recognition Memory Test (RMT) were administered as part of each evaluation. Using scores from the RMT subtests: (1) Memory for Words and (2) Memory for Faces, and scores from the WMS subtests: (3) Logical Memory, (4) Digit Span, (5) Visual Reproduction, and (6) Associate Learning flow associate pairs only), a principal components factor analysis was carried out with an orthogonal varimax rotation yielding four factors: (1) verbal learning and memory, (2) Figurai memory, (3) Recognition memory, and (4) Attention-Concentration. Results are discussed with respect to the independent, but complementary information provided by the WMS and RMT for measurement of memory functions.

Journal Article↗
PubMed1991

Maze learning in Alzheimer's disease.

Alzheimer's disease (AD) patients and normal elderly controls performed a block of 10 trials on a finger maze, followed by a 45-min period during which verbal learning measures were administered. Subjects then performed an additional 10 trials on the original maze, followed by 10 trials on a new maze. The AD patients and a subset of control subjects decreased mean completion time across Blocks 1 and 2, suggesting skill acquisition. Mean time on Block 3 was significantly less than mean time on Block 1, suggesting skill generalization. A subset of controls did not show the above pattern. The results of this study suggest that AD patients are able to acquire and generalize a cognitively mediated perceptual-motor skill.

Aged↗
PubMed1999

Serial malingering on verbal and nonverbal fluency and memory measures: an analog investigation.

Analysis of response consistency on neuropsychological test performance, both within and across testing sessions, can be an important method of detecting malingering. Little systematic research, however, has examined how suspected malingerers perform across repeat evaluations, a common forensic occurrence. To address this issue, we examined performance across a 3-week interval in an analogue malingering design on the California Verbal Learning Test (CVLT), the Rey Complex Figure, the Controlled Oral Word Association Test, and the Ruff Figural Fluency Test. Malingering simulators (n = 21) performed more poorly on all measures than the controls (n = 21) and demonstrated practice effects on the nonverbal, but not the verbal, tests. Controls demonstrated practice effects on all measures across time. Contrary to hypotheses, malingering simulators demonstrated high and similar levels of between and within time consistency as controls when assessed via a series of correlations. Despite this consistency, when qualitative performance patterns were assessed on the CVLT, simulators were less likely to consistently recall the same word across successive learning trials. The following issues are discussed: (a) the differential pattern of practice effects on verbal and nonverbal tasks, (b) qualitative and quantitative differences in assessment of consistency, and (c) how future research should study consistency/inconsistency.

Journal Article↗
PubMed1998

Awareness of remembering achieved through automatic and conscious processes in multiple sclerosis.

Fifty multiple sclerosis (MS) and forty-one matched control subjects were administered a word stem completion task and the California Verbal Learning. Test (CVLT). As predicted, priming in a conventional "implicit" task did not differ for MS and control groups, and under "explicit" instructions verbal list recall was significantly lower in the MS group with recognition intact. Application of the process dissociation procedure (Jacoby, Toth, & Yonelinas, 1993) to the word stem task demonstrated that conscious and unconscious processes both contribute to remembering in MS. Exploratory analyses found no group differences in words remembered under inclusion nor exclusion conditions, though preliminary estimates for MS automatic processing exceeded those for controls. As predicted, prospective metamemory judgments reflected subsequent performance for both groups in the inclusion but not the exclusion condition. By contrast, retrospective monitoring for both groups reflected memory performance in both conditions. However post hoc analyses demonstrated that those MS subjects who employed more automatic processing were less aware retrospectively of their successful remembering under exclusion than MS subjects who used less automatic processing.

Adult↗
PubMed1993

Analysis of verbal memory and learning by means of selective reminding procedure in Alzheimer and multi-infarct dementias.

Several studies aimed at defining the characteristics of memory impairment resulting from different etiologic forms of dementia have been inconclusive. These unsatisfactory results might be due to the enrollment of various groups of demented patients not matched for disease severity, as well as the use of different psychometric procedures. The object of the present study was to verify the existence of a different pattern of verbal memory impairment that might be useful in clinical practice in two groups of AD and MID patients who were matched for degree of cognitive deterioration. Thirty-seven AD and 41 MID patients were assessed for memory and learning by means of the Supraspan Verbal Learning test (Selective Reminding by Buschke-Fuld), which provides a simultaneous analysis of storage, retention and retrieval abilities. Twenty-four normal subjects were studied as a control group. No differences in storage and retrieval mean scores were found between the two groups. AD patients showed a higher mean score in random retrieval; the mean score in selective retrieval at the end of learning was significantly higher in MID patients, suggesting a more impaired retrieval from long-term storage in AD than in MID patients. Intrusions, defined as inappropriate recurrences from preceding tests, were observed more frequently in AD patients. The presence of intrusions and the delayed retrieval score showed a good level of sensitivity and specificity in the differential diagnosis between the two groups.

Aged↗
PubMed2000

Neuropsychological profile of a large kindred with familial Alzheimer's disease caused by the E280A single presenilin-1 mutation.

It was hypothesized that subjective memory complaints represent the earliest sign of dementia in carriers of the presenilin-1 (PS1) mutation. A total of 122 subjects (44 males, 78 females) were included in this study. Forty of them were positive for the mutation in the PS1 gene (mutation positive, MP) whereas 82 showed negative results (mutation negative, MN). Subjects were active, functionally normal, even though some of them complained of memory difficulties. Two groups of neuropsychological instruments were administered: (a) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological test battery (Morris et al., 1989), and (b) some additional neuropsychological tests (Raven Test, Wechsler Memory Scale, Rey-Osterrieth Complex Figure, Boston Naming Test, Naming of Categories, Boston Diagnostic Aphasia Examination, Memory of Three Phrases, Knopman Test, Digit Symbol, and Visual "A" Cancellation Test). Performance in both groups was quite similar. In a secondary analysis, the MP group was subdivided into two subgroups: without and with memory complaints. When comparing both subgroups, a better performance in the first subgroup was found throughout the different subtests. Statistically significant differences were observed in the following test scores: Mini-Mental State Examination, Naming Test (Low Frequency), Memory of Words Test, Recall of Drawings, Wechsler Memory Scale (Logical Memory, Associative Learning, and Total Score), Rey-Osterrieth Complex Figure (Immediate Recall Condition), Boston Diagnostic Aphasia Examination (Complex Ideational Material Subtest), Memory of Three Phrases Test, Serial Verbal Learning (maximum score and Delayed Recall), Knopman Test (First Trial, Second Trial, and Recall after 5 Minutes), Digit Symbol, and Visual "A" Cancellation Test (Additions). Results supported the hypothesis that memory complaints represent the earliest symptom of familial Alzheimer's disease. In addition to the memory difficulties, other minor cognitive impairments were also found, particularly, mild anomia, concentration difficulties and defects in the understanding of complex verbal material.

Journal Article↗
PubMedDate not supplied

Why is learning and memory dysfunction in Type 2 diabetes limited to older adults?

Review of the literature on the cognitive correlates and consequences of Type 2 diabetes reveals two very intriguing findings. Not only are verbal learning and memory skills most likely to be disrupted as compared to other cognitive skills (e.g. attention, executive function; psychomotor efficiency), but these mnestic deficits appear to be restricted to individuals with diabetes who are older than 60-65 years of age. Middle-aged adults with either Type 2 or Type 1 diabetes are apparently protected insofar as researchers have only infrequently reported learning and memory impairments in that age group. Why do older adults have such an increased risk of diabetes-associated memory dysfunction? In our view, this phenomenon is a consequence of a synergistic interaction between diabetes-related metabolic derangements and the structural and functional changes occurring in the central nervous system (CNS) that are part of the normal ageing process. To critically evaluate that possibility, we summarise what is known about learning and memory dysfunction in the adult with diabetes, examine the extent to which chronic hyperglycaemia may adversely affect the integrity of the CNS, and selectively review the literature on age-associated changes in brain morphology and cognitive function, paying special attention to the threshold theory of cognitive impairment.

Adult↗
PubMed2000

An exploration of the construct validity of the Heaton memory tests.

The Heaton techniques for assessing memory differ from most other memory measures by employing the combination of learning trials, repeated exposure to test stimuli, and 4-hour recall measures. The present study was designed to explore the relationship between the Heaton Story and Figure memory procedures, the California Verbal Learning Test (CVLT), and measures of attention, word fluency, and spatial perception. Data from 126 individuals were analyzed. Three separate factor analyses were performed that examined measures of attention, learning, and recall. Each revealed a three-factor solution accounting for 71, 70, and 72% of the variance, respectively. Regression analyses supported the visual components of Figure Memory and the verbal components of Story Memory obtained in the factor analyses. Overall, the findings supported the independence of the Heaton Memory procedures and the role of spatial factors in performance of Figure Memory. Additionally, both Figure and Story Memory shared variance with the CVLT, supporting the validity of both procedures as memory measures.

Journal Article↗
PubMed1997

Degree of left hippocampal atrophy correlates with severity of neuropsychological deficits.

The relationship between the degree and distribution of hippocampal atrophy measured by volumetric magnetic resonance imaging and severity of memory deficits in 25 patients with temporal lobe epilepsy secondary to mesial temporal sclerosis was assessed. Hippocampal volumes were expressed as a ratio of smaller to larger, normal ratio greater than 0.95. Neuropsychology tests included: subtests of the WAIS-R, Rey Auditory Verbal Learning Task, Rey Figure and the Austin Maze. Degree of left hippocampal atrophy in patients with left temporal lobe epilepsy was associated with severity of verbal memory deficits as measured by RAVLT total recall (P < 0.05), delayed recall (P < 0.001), story recognition (P < 0.001), list recognition (P < 0.001) and final delayed recall (P < 0.001) and recall of the Rey Figure (P < 0.01). There was no association between degree of right hippocampal atrophy and any of the memory tests. Diffuse left hippocampal atrophy was associated with more severe verbal memory deficits than anterior atrophy. We conclude, the association between degree of left hippocampal atrophy and verbal memory provides further evidence of the predominant involvement of the left hippocampus in verbal memory. The finding of a relationship between degree of left hippocampal atrophy and measures of non-verbal function suggests these tests are dependent on verbal memory, or that mesial temporal sclerosis is a bilateral but asymmetrical condition.

Adolescent↗
PubMedDate not supplied

Decline in learning ability best predicts future dementia type: the Freedom House Study.

The authors studied longitudinal change in learning efficiency as a predictor of future dementia type among healthy, well-educated, noninstitutionalized elderly retirees. Serial assessments of memory were obtained using the California Verbal Learning Test (CVLT). Latent growth (LG) models were developed from the slopes of the subjects' performance over the first five CVLT learning trials at each of three serial administrations (e.g., cohort inception [i.e., baseline] [CVLT1], 18 months [CVLT2] and 36 months [CVLT3]). The resulting growth curves were incorporated into a higher order LG model representing the dynamic change in learning efficiency over time (DeltaCVLT). DeltaCVLT was used to predict each subject's "dementia type" (i.e., clinical state) at 36 months (e.g., no dementia, Type 1 [Alzheimer type] dementia or Type 2 [non-Alzheimer type] dementia), after adjusting for CVLT1, baseline age, and baseline dementia type. Nonlinear (logarithmic) LG models of CVLT1-CVLT3 and DeltaCVLT best fit the data. There was significant variability about both CVLT1 and DeltaCVLT, suggesting subgroups in the sample with significantly different baseline memory function, and different rates of deterioration in learning efficiency. Age, baseline dementia type, and DeltaCVLT made significant independent contributions to final dementia type. CVLT1 did not predict final dementia type independently of the other covariates. These data suggest that baseline memory performance in noninstitutionalized elderly retirees does not predict future dementia type independently of the dynamic rate of change in memory measures. Serial administrations of memory tests may help identify nondemented persons at greater or lesser risk for conversion to frank dementia in the near-term.

Aged↗
PubMed2006

Standardized assessment of cognitive functioning during development and aging using an automated touchscreen battery.

This study examined the effects of age, gender and education on subjects spanning nine decades on a new cognitive battery of 12 tests. One thousand and seven participants between 6 and 82 completed the battery under standardized conditions using an automated, computerized touchscreen. Sensitive indicators of change were obtained on measures of attention and working memory, learning and memory retrieval, and language, visuospatial function, sensori-motor and executive function. Improvement tended to occur through to the third and fourth decade of life, followed by gradual decrement and/or stabilized performance thereafter. Gender differences were obtained on measures of sustained attention, verbal learning and memory, visuospatial processing and dexterity. Years of education in adults was reflected in performance on measures of verbal function. Overall, the test battery provided sensitive indicators on a range of cognitive functions suitable for the assessment of abnormal cognition, the evaluation of treatment effects and for longitudinal case management.

Adolescent↗
PubMed2001

Developmental patterns of verbal and visuospatial spans.

This study presents developmental data for verbal and spatial memory tasks: Corsi's block-tapping test and Luria's verbal learning test. Norms have been collected from 275 primary and early secondary school children aged from 5 years, 4 months to 13 years, 6 months. Our results confirm a slow and constant improvement in performances over time, and the advantage of about 1.5 items of the verbal span over the spatial span supports the existence of developmental differences between separate memory systems. No significant sex difference was found even if a slight trend in verbal span favouring female subjects is present.

Adolescent↗
PubMed1996

Bilateral medial temporal lobe damage without amnesic syndrome: a case report.

After the case report H.M. [42], unilateral neurosurgical interventions in the mediotemporal area have no longer been performed, if damage to the contralateral mediotemporal region was present, because of running the risk of provoking a postoperative amnesic syndrome. We present a patient with bilateral mediotemporal cysts and medically refractory complex partial seizures originating in the left mediotemporal region. Although our patient had additional right mediotemporal damage and poor non-verbal learning and memory, the left amygdaloid body and the left hippocampal formation were resected because the patient passed a selective anterior temporal lobe Amobarbital test. Postoperatively, our patient's non-verbal memory recovered to normal, but his verbal memory declined. Nevertheless, he was non-amnesic and seizure-free.

Age of Onset↗
PubMed2005

Infant motor development and adult cognitive functions in schizophrenia.

BACKGROUND: Childhood neuromotor dysfunction is a risk factor for schizophrenia, a disorder in which cognitive deficits are prominent. The relationship between early neurodevelopment and adult cognition in schizophrenia remains unclear. METHODS: We examined the associations between infant motor development and adult cognitive functions in schizophrenia (n = 61) and the general population (n = 104) in a sample drawn from the The Northern Finland 1966 Birth Cohort. Data on ages of learning to stand and walk with or without support were obtained at age 12 months by health visitor assessment. Neurocognitive measures at age 33-35 included executive function, verbal and visual episodic memory, and visuo-spatial working memory. RESULTS: The schizophrenia group achieved neuromotor milestones later and performed significantly worse than the control group on all measures of cognition. In pooled analyses there were associations between infant motor development and adult cognition in the domains of executive function, verbal learning and visuospatial working memory, but not in visual object learning. The pattern of associations between development and cognition was similar in schizophrenia and the general population. CONCLUSIONS: These findings are consistent with the hypothesis that in schizophrenia mild infant motor developmental delay and adult cognitive deficits (at least in some domains) are age dependent manifestations of the same underlying neural process. Thus, they may be better considered as part of a single longitudinal syndrome.

Adult↗
PubMed2005

The relationship between executive functioning and verbal and visual learning and memory.

Executive functions, which include an individual's ability to develop a response set, inhibit behaviors, plan, and reason, likely impact other areas of cognitive functioning, such as learning and memory. The present study examined the relationship between executive functioning and a wide array of standardized, clinical verbal and visual learning and memory measures in 212 patients referred for a neuropsychological evaluation. IQ was also included in the analyses. Results of the canonical correlation analyses indicated that the two cognitive domains shared 55-60% of variance, and two canonical variates were present. Although causality cannot be inferred, a clear and robust relationship between executive functioning and memory is evident, and clinicians should consider this overlap when interpreting poor performance among these two domains.

Adolescent↗