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Pre-treatment with an optimum dose of diuretic administered in appropriate time relation to the injection of contrast medium can improve urographic quality by increasing urinary iodine concentration as well as diuresis. The doses of contrast medium can probably be reduced.
In a urographic experimental study in six rabbits conventional film-screen images were compared with digitized images. Two digitized images were examined, one simulating the conventional film-screen combination, and one frequency modified. The nephrographic and excretory phases of four different doses of contrast medium (iohexol, 350 mg I/ml) were investigated in each rabbit (4, 2, 1, and 0.5 ml/kg body weight). No differences were found between the different doses of contrast medium for the two imaging systems. With digitized images the exposure (radiation dose) could be decreased to 12.5 per cent of the conventional film-screen combination without any loss of information.
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