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PubMed1992

[Malignant lymphoma developing from the wall of chronic empyema following artificial pneumothorax].

A 60-year-old man who had had chronic empyema following an artificial pneumothorax for pulmonary tuberculosis when he was 26 years old developed malignant lymphoma of the chest wall. The patient was admitted because of right pyothorax as a result of pseudomonas aeruginosa infection and underwent right thoracotomy. During lavage of the right thoracic cavity a tumor was found arising from the empyematic wall. Pathologic examination revealed that it was malignant lymphoma (diffuse large, immunoblastic, B cell type). Treatment with VEAP-Bleomycin elicited a good response. Seven months after chemotherapy, the patient underwent thoracoplasty in addition to packing the cavity with the latissimus dorsi and the greater omentum. Following this, the patient received chemotherapy once a month for one and a half years, after which he was kept under close observation without treatment. Complete remission has now lasted for 49 months since the initial treatment. This is the first reported lymphoma case with closure of the empyematic wall and is remarkable since this patient has remained in complete remission for the last two years without any treatment.

Empyema, Pleural↗
PubMed1992

Bronchopleural fistulas associated with lung cancer operations. Univariate and multivariate analysis of risk factors, management, and outcome.

During a 28-year period, 52 bronchopleural fistulas developed after pulmonary resection of 49 primary and three recurrent lung cancers at the National Cancer Center Hospital, Tokyo. During the same period there were 2359 pulmonary resections for primary lung cancer; the prevalence of bronchopleural fistula was 2.1%. Multivariate analysis on 15 variables in the most recent 1360 resections revealed significant risk factors for bronchopleural fistula: wider resection such as pneumonectomy, residual carcinomatous tissue at the bronchial stump, preoperative irradiation, and diabetes. Univariate analysis further recognized a risk in preoperative bronchial arterial infusion and the postsurgical stage of lung cancer. Six patients were not treated. Apart from chest tube drainage in seven patients, surgical repair was attempted in 39, direct resuture of the stump in 16, wrapping in 25, thoracoplasty in 31, completion pneumonectomy in 6, and other treatments. Despite various treatments, 37 patients (71.2% mortality) died from fistula-related complications (such as regurgitation of infected pleural fluid through the fistula and airway/intrathoracic bleeding). Even for patients whose fistulas were cured and who were discharged, the average hospital stay was 189 days. Further investigation is necessary to answer whether prevention by flap coverage is of any benefit.

Adult↗
PubMed2003

[Treatment of acute pyopneumothorax during the tuberculosis epidemic].

Pathogenetical mechanisms of pyopneumothorax formation that cause hypoxia--hypoxemia, decreased cardiovascular function and intoxication have been described. The existing approach leads to the progression of disease, and the majority of patients die within the next 1.5-2 years. The immediate surgery (step-by-step thoracoplasty with modelling of parietal pleura on the terms of pneumoperitoneum) were suggested. Positive statistical data are provided.

Disease Outbreaks↗
PubMed2004

Congenital scoliosis.

The management of congenital scoliosis requires a systematic approach with careful attention to detail. Any fortuitous diagnosis of vertebral anomalies in infancy, even if there is no significant scoliosis at that time on x-ray, requires frequent clinical and radiographic follow-up to detect progression. The presence of associated anomalies of the spinal cord, the kidneys and the heart should be evaluated by MRI, renal ultrasound or IVP, with cardiology evaluation as indicated. Curve progression or severe vertebral anomalies known to cause curve progression require immediate treatment to prevent deformity. Significant thoracic deformity, especially in a patient with thoracic insufficiency syndrome, is best treated with expansion thoracoplasty. The patient with congenital scoliosis requires a long term commitment to care with frequent orthopaedic follow-up throughout the growing years along with routine pulmonary function assessment once the patient is able to cooperate with testing.

Child↗
PubMedDate not supplied

Presentation and management of empyema thoracis at Lady Reading Hospital Peshawar.

BACKGROUND: Empyema thoracis remains a common thoracic problem with challenging management strategies. We undertook the present study to outline key aspects of the presentation and management of this condition at our tertiary care hospital. METHODS: We analyzed 105 consecutive patients treated for empyema thoracis over a one-year period at Thoracic Surgical unit, Lady Reading Hospital Peshawar Pakistan. The study included patients aged 10-60 years of either sex. Patients were subjected to detailed diagnostic and management protocols with a view to define successful diagnostic and management strategies. RESULTS: The majority of patients (68%) were male, with a mean age of 28.5 +/- 14.2 years, a majority (42%) being in the 10-20 years age group. Common presentation was with fever (73%), cough (65%) and chest pain (60%). The mean duration of symptoms was 6.1 weeks. Common aetiologies of empyema were pneumonia (46.7%), iatrogenic (21.9%), traumatic (16.2%) and malignancies (11.4%). Forty patients (38%) underwent an unsuccessful therapeutic procedure prior to admission to the Thoracic unit. In the unit, 58 patients received closed intercostal drainage (31 of which required further intervention), five patients were treated with repeated thoracentesis and 8 patients were subjected to fibrinolytic therapy. The majority of patients underwent a surgical procedure like rib resection (7), decortication (23), thoracoplasty (3) and other procedures in the first instance with only 4 patients requiring further surgery. Majority of patients (97/105, 92.4%) were cured of their disease. The hospital mortality was 7.6%. CONCLUSION: Multiple therapeutic options exist for the treatment of thoracic empyema. Optimal therapy requires selection of the most appropriate first procedure for each patient with post procedure imaging to avoid inordinate delays between interventions. Early referral of all empyema patients to thoracic units for definitive therapy is recommended.

Adolescent↗
PubMed2004

[Surgical treatment for postoperative recurrent pulmonary tuberculosis].

The long-term results of 1311 primary resections for pulmonary tuberculosis and 203 repeated interventions for postoperative recurrences were studied. During a 10-year follow-up, the cumulative rate of postoperative recurrences was 18.4%, the minimum (5.7%) being in the operated on for tuberculosis, the maximum in cavernous tuberculosis (27.9%) and caseous pneumonia (40%). 58% of recurrent tuberculosis occur within the first 3 years after surgery, the efficiency of their medical treatment does not exceed 30%, indications for resurgery are established at the same rate. Repeated lung resections, final pneumonectomies were performed in 72.8% of the patients with the immediate efficiency of 87.5-86.2% and mortality rates of 6.2-12.1%. Caverno- and thoracoplasties were made in 27.2% of the patients. The efficiency of these deliberately nonradical operations was 83.3-55.5%.

Humans↗
PubMed2002

Idiopathic scoliosis. Segmental fusion with transpedicular screws.

The purpose of this study is to evaluate whether the surgical correction of the scoliotic curve with the use of segmental pedicle screw fixation system is effective. We studied 20 patients (19 girls, 1 boy) with a mean age of 14,6 years (range from 13 to 22). The spinal deformities were evaluated by Cobb method with anteroposterior and lateral bending radiographs. There were 13 right thoracic curves and 7 left thoracolumbar curves. The width of the pedicles was estimated in all patients by computerized tomography of the thoracic and lumbar spine. Posterior instrumentation (Moss-Miami transpedicular system) was used and additional thoracoplasty was performed in 2 patients. The transpedicular screws were placed between T2 and L5. Intraoperatively the image intensification was indispensable and the wake-up test was always conducted. All the patients were assessed both clinically and radiographically at 3,6,9,12 months and annually until now. The average follow-up was two years. There was an average correction of 73% of the primary curve (pre-op standing average 59 degrees (range from 42 degrees to 87 degrees), lateral bending average 33 degrees (range from 10 degrees to 75 degrees), post-op average 13 degrees (range from 6 to 30 degrees), at last examination average 14 degrees (range from 6 degrees to 33 degrees). Infection and neurological complications were not noted. No major complications were observed. Exact evaluation of the pedicles by CT scan is an essential prerequisite for transpedicular screw insertion. The correction of idiopathic curves with the use of segmental pedicle screw fixation system is a very effective method(correction > 70%) It seems that control of the three columns of the spine by the transpedicular screws offers sufficient apical translation and coronal realignment.

Adolescent↗
PubMed2004

[Three cases of angiosarcoma complicated with chronic pleuritis].

We report three cases of angiosarcoma complicated with chronic pleuritis associated with tuberculosis. Patient 1 was a 55-year-old man who had received artificial pneumothorax therapy 30 years before. Patient 2 was a 85-year-old man who had suffered from pleuritis for 10 years; and patient 3 was a 72-year-old man who had received plombage thoracoplasty with plastic balls 40 years before. All cases had began with sudden-onset chest pain and bloody sputa. A surgical procedure was indicated in patient 1 only. Conservative therapy was indicated for the other cases because of aging, performance status and systemic metastasis. Prognoses from the onset were 83, 9 and 1 months, respectively. We concluded that angiosarcoma is a disease of equal importance as a malignant tumor to lymphomas appearing in the course of chronic inflammatory diseases such as chronic empyema, and that only aggressive resection, when it is possible, is effective in offering prolonged survival.

Aged↗
PubMed1992

Artificial pneumothorax in the treatment of lung tuberculosis.

Artificial pneumothorax (APT) was the first positive treatment of tuberculosis to cause improvement. As a basic of therapy after 1910 it was replaced by chemotherapy 30 years later. Its development followed an early 19th century observation that spontaneous pneumothorax improved a tuberculosis patient. In 1822 James Carson originated the concept and principles of inducing a collapse after discovering the elasticity of the lungs in animal experiments. He also defined the limits of animal tolerance in induction by open chest incision, but failed in his only clinical attempt at an APT. Fornalini in 1984 independently revived the concept of APT using the closed method of needle induction, as later accepted. The principles of APT promoted thoracic surgery with the concept of permanent collapse in thoracoplasty; the experience of the management of postoperative shock in turn benefited the development of lung resection.

Europe↗
PubMed2004

[Pathogenesis and treatment of chronic empyema].

In chronic empyema (CE), thickened pleura, collapsed chest wall, and the accumulation of purulent fluid in the thoracic cavity are typical findings. Patients complaints of symptoms with bronchopleural fistula (BPF). On the other hand, there is another type of CE in which the pleural space expands progressively to shift the neighboring lungs, mediastinum, and diaphragm. This type of CE is considered to be chronic expanding hematoma (Reid et al.) occurring in the thoracic cavity. In the empyemic cavity, mycobacterial infection is found approximately in 20-30% of cases, pyogenic bacillus or fungus in about 40%, but the cavity is aseptic in other 30-40%. Although the fundamental treatment procedures include decortication and pleuropneumonectomy, the method of muscle or omental plombage to manage dead space or BPF are far superior functionally in intractable CE. Recently, the methods of plastic and reconstructive surgery have been used to utilize the muscle or omentum more effectively. The classic thoracoplasty procedure should not be undertaken unnecessarily to avoid additional deterioration of respiratory function. Additionally, it should be remembered that malignant lymphoma occurs frequently in the empyemic chest wall.

Chronic Disease↗
PubMed2005

[Chest wall distraction in thoracogenic scoliosis].

INTRODUCTION: Combined congenital scoliosis and rib fusion associated with other chest deformities during infancy can lead to a progressive hypoplastic thorax that could be unable to support normal lung growth and respiratory function. Campbell introduced an expansion thoracoplasty technique in which fused ribs are separated and a vertical expandable prosthetic titanium rib is used as a chest wall distraction device to enlarge the affected hemithorax. This technique benefits the underlying lung by improving the thoracic volume and the respiratory function. PATIENTS AND METHODS: Four patients (3 boys and 1 girl) with severe unilateral thoracic deformity with combined scoliosis and rib fusion plus a restrictive respiratory insufficiency are presented herein; 1 of them needed continuous CPAP preoperatively. All had progressive scoliosis and failure to thrive. Preoperative evaluation included three-dimensional CT reconstruction. A thoracic expansion placing an intercostal vertical expandable prosthetic titanium device as a chest wall distractor was performed. Afterwards, distraction control was made every four months. RESULTS: Our 4 patients had a satisfactory outcome. Scoliosis was corrected and there were improvements of volume and function of the thorax. CONCLUSIONS: The placement of an intercostal distractor device improves the thoracic insufficiency syndrome, lengthening and expanding the thoracic cage at the same time. These effects benefit respiratory function and correct scoliosis, allowing an adecuate lung function.

Child↗
PubMed2004

[Surgical treatment of chronical pulmonary abscesses--contemporary treatment].

Between Jan 1991 and Dec 2000 a total of 67 patients were operated on for chronic primary pulmonary abscesses. They were 57 men and 10 women with mean age of 46.2 (range, 12 to 72) years. The indications for surgery was mainly "delayed closure" following medical therapy and percutaneous tube drainage (3), as well as a massive hemoptysis in 4 cases. CT scanning and brochoscopy were performed in all patients. The majority of them had multiple isolates (51/67) of both aerobic and anaerobic (predominantly Bacteroides sp., Fusobacterium sp., and Peptococci) organisms. The following operations were carried out: lobectomy (52) including 8 decortications, bilobectomy (5), pneumonectomy (4) including two pleuro pneumonectomy, polysegmentectomy (4) and segmental resection (2). The 30-day hospital mortality rate was 1.49% (1 patient died following rethoracotomy for bronchial stump fistula with empyema and polyorganic insufficiency). Major postoperative complications were 6 (8.9%) and included 3 pleural empyema (additional drainage), two rethoracotomy for intrapleural bleeding and one residual pleural cavity, treated by thoracoplasty. Minor postoperative complications (atelectasis, wound infection and prolonged air-leakage) were observed in 9 patients (13.4%). The long-term results (following-up ranged from 6 to 112 weeks) are considered very good. In conclusion, surgery is indicated for patients with significant hemoptysis, suspected malignancy and those with "late healing" abscesses with acceptable postoperative results, although the rate of major postoperative complications remains relatively high.

Adolescent↗
PubMed2005

[Long-term results of treatment in patients with pulmonary tuberculosis, by using main bronchial occlusion, impact of pulmonary hemodynamics].

The outcomes of treatment were analyzed in 108 patients with disseminated and complicated pulmonary tuberculosis. The patient's mean age was 38.3 +/- 4.2 years. Transsternal occlusion of the main bronchus was performed. Concurrently, the following draining interventions were made: thoracostomy, cavernotomy, cavernostomy, or stepwise thoracoplasty. Nine (8.3%) patients intraoperatively died; 20 (18.5%) patients developed recanalization of the main bronchus. Twenty-four (22.2%) patients had a progressive tuberculous process in the contralateral lung. The operation was effective and ensured recovery or stabilization of the tuberculous process in 55 (50.9%) patients. After surgery, dilatation of the pulmonary trunk was 2.8 cm; stroke volume in the pulmonary trunk was 42.4 ml and its distribution along the branches was 83% on the side of the least affection and 17% on that of the greatest affection. At diastole, there was a retrograde blood flow in the branch of the pulmonary artery of the collapsed lung in the volume of 61% of the systolic stroke volume. The calculated pulmonary pressure was 52 mm Hg. Transsternal occlusion of the main bronchus, involving stepwise draining interventions, should be considered the method of choice in treating these patients.

Adult↗
PubMedDate not supplied

[Acute postoperative mononeuropathy in a patient with type II diabetes mellitus].

Diabetes mellitus is an endocrinologic illness that affects multiple systems. One of then is the nervous system. It has been attempted to establish a relationship between metabolic abnormalities associated with diabetes and the degree of nervous system affectation. We present a case of mononeuritis involving the left peroneal nerve which occurred suddenly during the postoperative phase of a thoracoplasty in a patient with type II diabetes mellitus. The clinical picture was associated with a hyperglycemic nonketotic decompensation. We analyze the precipitating factors and their possible prevention.

Diabetes Mellitus, Type 2↗
PubMedDate not supplied

[Excretion of pyridinoline with urine in children with Ehlers-Danlos syndrome and Marfan's syndrome and the effect of beta blocker and complex vitamin therapy on it].

Excretion of pyridinoline and polypeptide-bound hydroxyproline with urine was studied in 27 children with hereditary impairment of connective tissue. At the same time, effects of beta-adrenoblocking agents and vitamin complex, prescribed during preoperation period before thoracoplasty in hereditary chest deformation, were investigated. Clinical efficiency of the treatment depended distinctly on the initial value of ratios pyridinoline/creatinine and polypeptide-bound hydroxyproline/creatinine. Total positive effect of the therapeutic course, considering also echocardiographic examination and postoperational complications, was observed in 44% of patients with Ehlers-Dunlop syndrome and in 75% of patients with Marfan syndrome.

Adolescent↗
PubMed2006

[Clinical analysis of patients with sequelae of pulmonary tuberculosis undergoing home oxygen therapy].

PURPOSE: To clarify the clinical characteristics of patients with sequelae of pulmonary tuberculosis undergoing home oxygen therapy. OBJECTS AND METHODS: We conducted a cross-sectional survey of those with newly-introduced home oxygen therapy for the sequelae of pulmonary tuberculosis from 1998 through 2001, using national hospital network of respiratory diseases. RESULTS: The study subjects were 402 in total (271 men and 131 women), who started the home oxygen therapy at the age ranging between 33 and 100 years (72.2 +/- 8.1 years, mean +/- S.D.). They suffered from pulmonary tuberculosis at the mean age of 37.7 +/- 19.4 years, and the interval leading to oxygen therapy averaged 33.1 +/- 19.1 years. Sixty-eight percent of these patients demonstrated body mass index (BMI) less than 20. Pulmonary function studies revealed the markedly-decreased vital capacity (46.2 +/- 15.0%) as well as reduced FEV1/FVC (68.5 +/- 18.8%). Arterial blood gases measured when home oxygen therapy was introduced showed hypoxemia (Pa(O2), 60.4 +/- 10.7 Torr) with hypercapnea (Pa(CO2), 50.5 +/- 9.4 Torr). The average flow rate of oxygen was 0.94 +/- 0.64 L/min at rest and 1.51 +/- 0.70 L/min on exertion. The patients were divided into two groups; those with surgical intervention including thoracoplasty or lung resection (126 cases, group 1) and those without surgery (148 cases, group 2). The mean age of the patients in the group 1 when home oxygen therapy was started was 72.3 +/- 6.4 years and 71.6 +/- 9.1 years in the group 2, respectively. Subjects in group 1 were more likely suffered from TB in younger age than those in group 2 (28.2 +/- 9.7 vs. 45.4 +/- 21.5 years, p < 0.01), and had the longer duration to initiate domiciliary oxygen therapy (43.0 +/- 10.9 vs. 25.3 +/- 20.3years, p<0.01). The former was also more likely to have lower % VC (p < 0.01), more elevated Pa(CO2) (p<0.05), and lower inspired flow rate of oxygen (p<0.01). There was no significant difference between the two groups with respect to BMI, FEV1/FVC, or CONCLUSION: Our investigation demonstrated that patients with sequelae of pulmonary tuberculosis under oxygen therapy revealed the different clinical course and characteristics regarding the presence or absence of previous surgical intervention.

Adult↗
PubMed2006

[Pulmonary edema due to upper airway obstruction after extubation].

We report a patient who developed pulmonary edema due to airway obstruction after extubation. A 22-year-old man underwent removal of the nails for thoracoplasty under general anesthesia combined with epidural anesthesia. Upper airway obstruction occurred after extubation. SpO2 decreased to 70%. Insertion of an oral airway relieved the airway obstruction. However, inspiratory wheezing was heard over both lung fields. Chest X-ray taken 90 minutes after the event revealed pulmonary edema. Pulmonary edema gradually resolved after intravenous furosemide and oxygen inhalation by mask.

Adult↗
PubMed2006

Adolescent scar contracture scoliosis caused by back scalding during the infantile period.

To investigate the pathogenesis, clinical manifestation and treatment of the adolescent scar contracture scoliosis caused by back scalding during infancy. From August 1997 to May 2005, about 1300 patients with scoliosis received surgery in our department. Only four of them were diagnosed with adolescent scar contracture scoliosis. One patient was first treated with skin expansion, back scar excision, and skin flap transfer, followed with anterior correction with TSRH instrumentation. Two patients were first treated with back scar excision and anterior spinal release, then treated with posterior correction with TSRH instrumentation; thoracoplasty was performed after 50 days in halo-wheelchair traction. The other patient was treated with posterior correction with TSRH instrumentation. No management of scalding was performed on the fourth patient. Anterior release and posterior correction were performed at intervals of 3 weeks. The deformities of four patients were well corrected. The trunk balance was restored and the pelvis leveled. The skin incision wounds healed well. Minor loss of correction was recorded during the last follow-up.

Adolescent↗