Variations in skin surface lipid composition with different sampling techniques. I.
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Skin surface lipid composition was measured in thirty-one patients with rosacea and their age-matched controls. Patients with rosacea had normal lipid composition, and there was no correlation between the lipid composition and the severity of the disease. Tetracycline therapy produced no measurable change in lipid composition.
Epidermal lipid biosynthesis was normal in patients with mild ichthyosis due to Hodgkin's disease, but greatly reduced in one patient with severe ichthyosis. Dermal (sebaceous) lipid synthesis was decreased in all patients with Hodgkin's disease, whether or not they had ichthyosis, and was greatly reduced in the patient with severe ichthyosis. Neither the mechanism nor the possible relationship between the dermal and epidermal changes is understood.
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