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PubMed1991

Antineutrophil cytoplasmic autoantibody-associated diseases: a pathologist's perspective.

Antineutrophil cytoplasmic autoantibodies (ANCA) are a useful diagnostic serologic marker for the most common forms of necrotizing vasculitis, provide a means of categorizing vasculitides so that diagnostically useful shared pathologic and clinical characteristics can be recognized, and offer insight into the pathogenesis of previously idiopathic diseases. ANCA-associated vasculitides can be categorized into a number of distinctive clinicopathologic categories, eg, Wegener's granulomatosis, Churg-Strauss syndrome, pulmonary renal syndrome, microscopic polyarteritis nodosa, leukocytoclastic angiitis, and necrotizing and crescentic glomerulonephritis. At least the latter four syndromes can also be caused by other ANCA-negative immunopathogenic mechanisms, eg, immune complex deposition. Therefore, thorough diagnostic classification requires both an assessment of clinicopathologic category, as well as an assessment of immunopathologic category. Although different ANCA-associated vasculitic syndromes have distinctive clinical and pathologic features, all ANCA-associated vasculitides share a number of common pathologic features, ie, focal distribution, necrosis, and neutrophil infiltration. ANCA assays have very good sensitivity and specificity for ANCA-associated diseases, but the prevalence of these diseases in the patient population being analyzed must be taken into consideration when determining the predictive value of a test result. As with all serologic tests, ANCA results must be integrated with other clinical and pathologic data in order to reach the most accurate diagnostic conclusion.

Antibodies, Antineutrophil Cytoplasmic↗
PubMed1984

A pathologist's approach to the treatment of ameloblastoma.

There are three clinical types of ameloblastoma: the solid or multicystic type; the unicystic type; and the rare peripheral type. Important considerations in planning treatment include the clinical type as well as the anatomic location of the tumor and the availability of the patient for follow-up examinations. The various histologic patterns exhibited by this tumor have no bearing on its biologic behavior. In this article the treatment of the three types of ameloblastoma is discussed, with emphasis on their biologic behavior and anatomic considerations.

Ameloblastoma↗