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PubMed1993

Acute amniotic fluid loss and changes in the amniotic fluid index. Correlation and effect on umbilical artery velocimetry.

This study was undertaken to determine whether changes in the amniotic fluid index accurately reflected measured amniotic fluid loss after artificial rupture of membranes and whether this acute loss of fluid volume affected umbilical artery resistance as measured by Doppler velocimetry. Twenty-five uncomplicated term pregnancies underwent umbilical artery velocimetry and amniotic fluid index determination in the active phase of labor before and after amniotomy. Amniotic fluid loss was measured by direct collection of fluid during and immediately following rupture of the membranes. The preamniotomy and postamniotomy data were compared using the paired t test, and the relationship between amniotic fluid index change and actual fluid loss was tested by linear regression. The change in the amniotic fluid index after amniotomy was significant (paired t test, P < .0001), and a significant relationship was found by linear regression between the actual amniotic fluid loss and the change in the amniotic fluid index (P < .01, r2 = .28). Despite significant changes in the amniotic fluid index, however, no significant change in the umbilical artery systolic/diastolic ratio could be demonstrated. Our data suggest that amniotomy in the active phase of labor in uncomplicated pregnancies does not affect umbilical artery resistance and that the amniotic fluid index is a limited, semiquantitative method of assessing acute changes in amniotic fluid volume.

Adolescent↗

PubMed2003

Allergenicity evaluation of p-chloro-m-cresol and p-chloro-m-xylenol by non-radioactive murine local lymph-node assay and multiple-dose guinea pig maximization test.

p-Chloro-m-cresol (PCMC) and p-chloro-m-xylenol (PCMX) are known to cause allergic contact dermatitis. For risk assessment of skin sensitizers, information on dose-response profiles in the induction and elicitation phases and cross-reactivity with analogous chemicals are important. In the non-radioactive local lymph-node assay (LLNA) using 5-bromo-2'-deoxyuridine instead of 3H-methyl thymidine, significant effect on lymph node cell proliferation was detected at 10% PCMC and 25% PCMX, while in the multiple-dose guinea pig maximization test (GPMT) at least one animal tested in the group was sensitized at a 5 ppm induction dose of either chemical. When mean skin reaction score in an animal group maximally sensitized with each allergen with the GPMT was plotted against log challenge concentration, linear regression lines with high correlations were obtained in both cases. The calculated elicitation threshold was lower for PCMC than PCMX. The area under the linear regression line between the threshold point and 1% of the elicitation concentration, another index of relative elicitation potency, was also greater for PCMC. Bidirectional cross-reactivity between PCMX and PCMC was detected in the GPMT. PCMC was thus identified in both LLNA and GPMT as a stronger sensitizer than PCMX in both the induction and elicitation phases. These results suggest that the non-radioactive LLNA is a simple and useful method for evaluating allergenicity in the induction phase, while the GPMT using a maximally sensitized animal group is more suitable for assessing the dose-response profile and cross-reactivity in the elicitation phase.

Allergens↗

PubMed1996

Coupling electrical and mechanical outputs of human jaw muscles undertaking multidirectional bite-force tasks.

Previous studies have identified both linear and curvilinear relations between increasing bite-force magnitude and the integrated electromyogram (EMG) of jaw-closing muscles. In an attempt to explain the discrepancy, bite forces of incrementally increasing magnitude were produced on the right-hand side in five specified directions by eight humans. Linear regression lines were fitted to normalized EMG activities of the left and right masseter and temporalis muscles against increasing bite-force magnitude in each direction. The grand mean of linear correlation coefficients was 0.79 (+/- 0.11 SD), suggesting an overall linear relation. Each set of individual data was fitted with polynomial lines up to the third order. The best fit was selected by statistical significance of coefficients and the least-square analysis of the sum of residues for each fitted line; 62% of individual data-sets were best fitted with linear regression lines, 31% with quadratic lines and the remaining 7% with cubic lines. Repeated analysis of residue variance of the pooled data showed that either a linear or quadratic line fitted every data set except one, for which a cubic line had the best fit. Working-side muscles had significantly larger linear correlation coefficients than corresponding balancing-side muscles for most bite-force directions. Analysis of variance of linear correlation coefficients revealed that the degree of linearity often depended upon the roles played by a muscle in producing forces in different directions. It appears that linearity or non-linearity of the EMG force relation is a determinant, among other variables, of the direction of the resultant force.

Adult↗

PubMed2002

Validation of a radiographic method to establish new fetal growth standards: radio-anatomical correlation.

In forensic medicine, specialists might face difficulties when estimating age at death from fetal remains. Depending on the state of preservation, this age assessment is essentially based on the diaphyseal size of long bones. In a previous work, for the measurement of fetal femoral ossified shafts, we already established a simple and reliable method using a radiographic protocol. Since we previously stated that radiographic measurement values were closer to real anatomical size than ultrasonographic ones, in the present study we decided to check the importance of the difference between radiographic and anatomical measurements. Therefore, we dissected 30 pairs of fetal femurs and compared the difference between the two kinds of measurements (in percentages). This difference seemed to be slight (4.027%), but it was large enough to entail significant differences (p < 0.001). In order to provide a correction factor for radiographic measurements, we established a linear regression formula, which was tested on another sample of 30 pairs of dissected femurs. As a consequence of the good results, we improved the linear regression using a powerful statistical tool: the bootstrap. Finally, we obtained a simple equation that allowed us to figure out the real anatomical size with an R2 of 99% and a mean relative difference of 0.153% (with a standard error of 0.252 mm, and therefore a 95% confidence interval with limits of -0.35 and 0.657 mm). This difference did not entail any significant differences (p = 0.498), and therefore, we concluded that with the proposed correction, radiographic measurements can easily be used by forensic specialists in their daily tasks or to establish new growth standards in order to best fit their population of interest.

Age Determination by Skeleton↗

PubMed1986

Influence of lignin on digestibility of forage cell wall material.

One-hundred-ninety-four grass samples, representing eight species, were used to determine the relationships of in vitro forage dry matter, cell wall, hemicellulose and cellulose digestibilities with lignin concentration. Linear regressions indicated that dry matter digestion was inhibited to a lesser degree (P less than .05) by lignin concentration than was cell wall digestion. Results for linear regressions of hemicellulose and cellulose digestibilities as functions of lignin concentration showed a greater (P less than .05) effect of lignin on cellulose digestion. Smooth bromegrass and switchgrass were collected at both Clay Center and Mead, NE; for all digestibility measures, the Clay Center samples gave stronger (P less than .05) negative correlations with lignin. A comparison of linear and curvilinear models indicated that, for all digestion measurements, the curvilinear model was a better (P less than .05) description of relationships with lignin concentration. For all digestibility measures, lignin's inhibiting effect declined at higher lignin concentrations. The curvilinear models did not show significant differences among the digestibility measures for effect of lignin. The demonstration that the forage digestibility response to lignin's inhibitory effect is curvilinear in nature suggests that the mechanism of lignin's inhibition is complex.

Animal Feed↗

PubMed2004

IGF-I and testosterone levels as predictors of bone mineral density in healthy, community-dwelling men.

OBJECTIVE: Age-related decline in IGF-I and gonadal hormones have been postulated to play an important role in the pathogenesis of age-related bone loss in men. In this cross-sectional study, the relation between serum IGF-I and gonadal hormones with bone mineral density (BMD) was examined in community-dwelling men. DESIGN AND SUBJECTS: Serum IGF-I, testosterone and BMD were examined in 61 community-dwelling men over the age of 27, who were randomly selected from the Calgary cohort of 1000 subjects in the Canadian Multicentre Osteoporosis Study. In the present study, IGF-I, serum testosterone, SHBG, free androgen index (FAI), parathyroid hormone (PTH), 25-hydroxy-vitamin D [25(OH)D] and other markers of bone turnover were measured. BMD was measured at the spine and hip (HOLOGIC 4500). Simple linear regression was used to assess the linear relation between IGF-I, testosterone, BMD and other biochemical markers of bone metabolism and potential confounding variables and subsequent multivariate regression models were constructed separately for each BMD measurement to assess the importance of IGF-I and testosterone in the presence of potential confounding variables. RESULTS: Serum IGF-I, FAI and SHBG significantly decreased as a function of age, whereas serum levels of PTH increased. Only 25(OH)D, total testosterone and FAI were positively associated with serum IGF-I after adjusting for age and BMI. Multiple linear regression models revealed that IGF-I was a significant predictor of BMD at the total hip, femoral neck and femoral trochanter neck (P < or = 0.001). In contrast, the FAI was a significant predictor of BMD at the lumbar spine and wards area (P < or = 0.011), and SHBG was a significant predictor at the total hip and femoral trochanter (P < or = 0.045). CONCLUSION: These data support the hypothesis that the age-related decline in bone mass in men is associated with declining levels of IGF-I and testosterone.

25-Hydroxyvitamin D 2↗

PubMed2005

Impact of body mass index values on sperm quantity and quality.

Body mass index (BMI) has been demonstrated to affect female fertility; however, little information is available on the impact of BMI on male fertility or semen parameters. Therefore, the study objective was to determine the relationship between BMI and semen parameters, including sperm chromatin integrity. We analyzed data on semen samples from 520 men who were grouped based upon calculated BMI values (normal, 20-24 kg/m(2); overweight, 25-30 kg/m(2); obese, >30 kg/m(2)). The data collected included patient height and weight, semen volume, sperm concentration, percent sperm motility, percent sperm morphology (normal forms), and sperm chromatin integrity (DNA fragmentation index [DFI]). Data were analyzed by regression analysis and analysis of variance (ANOVA) with Tukey's test for multiple pairwise comparisons. The overall BMI mean (+/-SEM) was 27.5 (+/-0.49) kg/m(2). Linear regression revealed a significant (P < .05) and negative relationship between BMI and the total number of normal-motile sperm cells. ANOVA revealed a significant difference (P < .05) in the total number of normal-motile sperm cells among the different BMI groups. The number of normal-motile sperm cells per BMI group was as follows: normal, 18.6 x 10(6); overweight, 3.6 x 10(6); and obese, (0.7) x 10(6). All multiple pairwise comparisons were found to be significantly (P < .05) different. The overall DFI mean (+/-SEM) was 24.7 (+/-2.57). Linear regression revealed a significant (P < .05) and positive relation between BMI and DFI. Men presenting with a BMI greater than 25 kg/m(2) have fewer chromatin-intact normal-motile sperm cells per ejaculate. Therefore, to ensure maximum fertility potential, patients may be advised to reduce body weight.

Adult↗

PubMed2003

Analysis of natural gas: the necessity of multiple standards for calibration.

The importance of natural gas as an international trading commodity and the cost to consumers has made the accuracy of determinations for the components of natural gas very important. Pricing of natural gas is based on the heating value of the gas determined from either calorimetry measurements or calculations based on individual component concentrations determined by gas chromatography (GC). Due to the expense of accurate calibration standards, many analysts and laboratories will use a single calibration standard to perform natural gas determinations. Therefore, the purpose of this study was to determine whether an analyst could accurately measure the components of natural gas, in particular methane, using a single standard, or whether a suite of standards is necessary to calibrate the analytical instrument. A suite of eight gravimetric primary standards was prepared covering a concentration range for methane of 64-94 mol%, with uncertainties of +/-0.05% relative (95% confidence interval). These natural gas primary standards also contained nitrogen, carbon dioxide, ethane, propane, iso-butane, n-butane, iso-pentane, n-pentane, and n-hexane with varying concentrations from 0.02 to 14%. A single analytical method was used in which only the amount of sample injected onto the column was altered. The results show that when injecting a 0.5 ml sample volume a second-order regression through the standards is necessary for the determination of methane. The results for nitrogen, ethane and propane also show the same trend. Only those individual standards whose methane concentration is within 1% of the test mixture predicted a concentration within 0.05% of the regression value. Those individual primary standards whose methane concentration is different by more than +/-1% of the test mixture predicted values differing by +/-0.5 to +/-2.0% from the regression value. These differences lie well outside the predicted concentration uncertainty interval of +/-0.20%. A smaller sample volume, 0.1 ml, resulted in a set of data that could be fit using linear regression. Each of the eight primary standards individually predicted the methane in the test mixture to be within +/-0.11% of the predicted value from linear regression. The data confirm that it is imperative to fully characterize the analytical system before proceeding with an analysis.

Calibration↗

PubMed2004

Changes in public order after the opening of a medically supervised safer injecting facility for illicit injection drug users.

BACKGROUND: North America's first medically supervised safer injecting facility for illicit injection drug users was opened in Vancouver on Sept. 22, 2003. Although similar facilities exist in a number of European cities and in Sydney, Australia, no standardized evaluations of their impact have been presented in the scientific literature. METHODS: Using a standardized prospective data collection protocol, we measured injection-related public order problems during the 6 weeks before and the 12 weeks after the opening of the safer injecting facility in Vancouver. We measured changes in the number of drug users injecting in public, publicly discarded syringes and injection-related litter. We used Poisson log-linear regression models to evaluate changes in these public order indicators while considering potential confounding variables such as police presence and rainfall. RESULTS: In stratified linear regression models, the 12-week period after the facility's opening was independently associated with reductions in the number of drug users injecting in public (p < 0.001), publicly discarded syringes (p < 0.001) and injection-related litter (p < 0.001). The predicted mean daily number of drug users injecting in public was 4.3 (95% confidence interval [CI] 3.5-5.4) during the period before the facility's opening and 2.4 (95% CI 1.9-3.0) after the opening; the corresponding predicted mean daily numbers of publicly discarded syringes were 11.5 (95% CI 10.0-13.2) and 5.4 (95% CI 4.7-6.2). Externally compiled statistics from the city of Vancouver on the number of syringes discarded in outdoor safe disposal boxes were consistent with our findings. INTERPRETATION: The opening of the safer injecting facility was independently associated with improvements in several measures of public order, including reduced public injection drug use and public syringe disposal.

British Columbia↗

PubMed2006

Exploring predictive and reproducible modeling with the single-subject FIAC dataset.

Predictive modeling of functional magnetic resonance imaging (fMRI) has the potential to expand the amount of information extracted and to enhance our understanding of brain systems by predicting brain states, rather than emphasizing the standard spatial mapping. Based on the block datasets of Functional Imaging Analysis Contest (FIAC) Subject 3, we demonstrate the potential and pitfalls of predictive modeling in fMRI analysis by investigating the performance of five models (linear discriminant analysis, logistic regression, linear support vector machine, Gaussian naive Bayes, and a variant) as a function of preprocessing steps and feature selection methods. We found that: (1) independent of the model, temporal detrending and feature selection assisted in building a more accurate predictive model; (2) the linear support vector machine and logistic regression often performed better than either of the Gaussian naive Bayes models in terms of the optimal prediction accuracy; and (3) the optimal prediction accuracy obtained in a feature space using principal components was typically lower than that obtained in a voxel space, given the same model and same preprocessing. We show that due to the existence of artifacts from different sources, high prediction accuracy alone does not guarantee that a classifier is learning a pattern of brain activity that might be usefully visualized, although cross-validation methods do provide fairly unbiased estimates of true prediction accuracy. The trade-off between the prediction accuracy and the reproducibility of the spatial pattern should be carefully considered in predictive modeling of fMRI. We suggest that unless the experimental goal is brain-state classification of new scans on well-defined spatial features, prediction alone should not be used as an optimization procedure in fMRI data analysis.

Artifacts↗

PubMed1999

On the use of image-derived input functions in oncological fluorine-18 fluorodeoxyglucose positron emission tomography studies.

There is growing interest in monitoring response to therapy in oncology patients using positron emission tomography and fluorine-18 fluorodeoxyglucose (FDG). Quantification is required, and various methods have been described. Arterial sampling, which provides the most accurate input function, often is not feasible in patients undergoing chemotherapy. In the thorax an image-derived input function can be obtained from the large vascular structures. In many studies the left ventricle (LV) is used, but the obtained data are rarely validated. In this study a simple quality control procedure for the image-derived input function was developed and compared with a standard LV curve. Twenty dynamic FDG scans were obtained in nine patients with non-small cell lung cancer stage IIIA-N2. Three venous blood samples were taken as a quality control for the image-derived input function. Regions of interest (ROIs) were defined for aorta, LV and left atrium. Input curves were generated according the the standard use of the LV curve and by applying the quality control method to all vascular ROIs. Tumour ROIs were defined and both input functions were used to calculate tumour glucose metabolism (MRglu), using both standard non-linear regression and Patlak analyses. Mean differences in MRglu using "standard" LV and "quality control approved" input functions were 16.2% and 17.5% for non-linear regression and Patlak analyses, respectively, indicating that the use of "standard" LV curve might lead to significant errors. It is concluded that care should be taken in using image derived input functions without appropriate quality control. The proposed procedure is simple and results in significantly more accurate MRglu data.

Carcinoma, Non-Small-Cell Lung↗

PubMed1994

Relationship between the excretion of protostrongylid larvae in sheep in north-west Spain and climatic conditions.

The relationship between different climatic factors (temperature, relative humidity and rainfall) and the pattern of lungworm larval excretion was studied in sheep under a continuous grazing pattern in North-west Spain, where the climate is intermediate between sub-humid Mediterranean with an Atlantic tendency and European Atlantic. Over a period of one year, 44 animals were sampled once a month at random from a flock of 80 Galician breed sheep, all over 4 years old. Faeces were taken directly from the rectum and the number of first stage larvae per gram of faeces was determined for each animal, and the species of Protostrongylidae (Nematoda) identified. Larval excretion was irregular during the study. The prevalence and intensity of infection were greater in the colder months (40.9%; x = 12.3 +/- 40.4) and less in the warmer months (21.9%; mean = 0.7 +/- 2.7). The species of Protostrongylidae identified and prevalences (%) were Neostrongylus linearis (71.5), Muellerius capillaris (18.8) and Cystocaulus ocreatus (9.7). Between November and March, with low temperatures, the prevalence and intensity of parasitism with N. linearis and M. capillaris were greater than in the months with high temperatures (May to September). Multiple linear regression analysis showed statistical correlation between temperature, relative humidity and rainfall considered together and the number of N. linearis larvae per gram of faeces. Linear regression showed a correlation between the temperature and the percentage of sheep that passed M. capillaris. In general, the prevalence and intensity of infection of the sheep with N. linearis, M. capillaris and C. ocreatus larvae decrease when the temperature increases and increase when the relative humidity and rainfall increases.

Animals↗

PubMed1998

Postpartum maternal blood helper T (CD3+CD4+) and cytotoxic T (CD3+CD8+) cells: correlations with iron status, parity, supplement use, and lactation status.

Iron deficiency reduces T cell counts; however, iron sufficiency is difficult to maintain during pregnancy and to reestablish in the early postpartum period. This cross-sectional study examined relations among postpartum maternal iron status, parity, lactation, supplement use, and maternal blood T cell populations. Sixty lactating and 41 nonlactating postpartum (NLPP) women at 1-2 wk and 1, 2, 4, or 8 mo postpartum and 13 nulliparous women were studied. Among multiparous women, multiple linear regression showed that relative percentages and absolute numbers of CD3+CD8+ cells were correlated positively with maternal serum transferrin saturation. In a separate multiple linear regression model, multiparous NLPP women who did not use multivitamin and mineral supplements had lower CD3+CD4+ cell percentages in the first month postpartum than did nulliparous control women. Lactating women who used supplements, however, had reduced CD3+CD4+ percentages 4-8 mo postpartum compared with control women. CD3+CD4+ percentages did not differ among control women, NLPP women who used supplements, or lactating women who did not use them. These results suggest that nutritional factors such as maternal iron status and use of dietary supplements play a role in a mother's postpartum immune status.

Adult↗

PubMed2005

Relation between intraocular pressure and systemic health parameters in Taiwan.

OBJECTIVE: The aim of the study was to evaluate the association between intraocular pressure (IOP) and several systemic health parameters in Taiwan. METHODS: We retrospectively reviewed the medical records from all participants who had been examined in China Medical University Hospital. A total of 1,271 subjects (mean age, 50.0 +/- 12.0 years; age range, 21 to 85) who had not undergone any medical treatment for ocular hypertension or glaucoma were included in this study. Systemic factors (age, sex, blood pressure, total cholesterol, triglycerides, fasting glucose, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, body mass index, waist circumference) were measured. One-way analysis of variance, Pearson correlation coefficients, and multivariate linear regression were used. RESULTS: There were 674 (53.0%) males and 597 (47.0%) females in this study. After controlling for the other covariates, the multivariate linear regression analysis showed that in males and females, systolic blood pressure was positively associated with IOP. That is, a change in systolic blood pressure by 1 mm Hg would alter the measured IOP by 0.024 mm Hg in males (95% CI, 0.002, 0.046; P = 0.031) and 0.030 mm Hg in females (95% CI, 0.006, 0.053; P = 0.014). In males, age was inversely associated with IOP. That is, a change in age by 1 year would alter the measured IOP by -0.039 mm Hg (95% CI, -0.059, -0.020; P = 0.0001). CONCLUSIONS: IOP was found to have a strong positive association with systolic blood pressure in males and females. IOP was inversely associated with age in males. This study may provide basic information for further studies on IOP in Taiwan.

Adult↗

PubMed1995

Alcohol consumption and physical fitness among young adults.

The relationship between alcohol consumption and physical fitness was analyzed using data from the baseline examination of the Coronary Artery Disease Risk Development In Young Adults study (CARDIA), a longitudinal study of the evolution of risk factors for cardiovascular disease in Black and White men and women aged 18-30 years. Two parameters of submaximal exercise treadmill testing were evaluated: time to heart rate 130 and duration of the treadmill test. In men and women qualified for treadmill testing, time to reach heart rate 130 was positively associated with ethanol intake. The relationship between fitness and ethanol intake persisted in sex-specific analysis after adjustment for age, ethnicity, systolic blood pressure, sum of subscapular and triceps skinfolds, and physical activity level. The magnitude and strength of the relationship were greater in women than in men. A negative interaction between ethanol intake and smoking status was evident. Linear regression coefficients in men were 0.29 sec to heart rate 130/ml ethanol/day in nonsmokers and -0.06 sec to heart rate 130/ml ethanol/day in smokers. Linear regression coefficients in women were 1.07 sec to heart rate 130/ml ethanol/day in nonsmokers and 0.23 sec to heart rate 130/ml ethanol/day in smokers. Men and women who smoked showed 31 sec longer time to heart rate 130, regardless of ethanol intake. Mean daily ethanol intake was positively associated with duration of treadmill testing in women, but weakly associated with duration in men. These results show increased physical fitness as ethanol intake increased in women and nonsmoking men and mildly decreased physical fitness as ethanol consumption increases among men who smoke.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed2025

Epigenome-Wide Analysis Identifies Pollution-Sensitive Loci in Fibrotic Interstitial Lung Disease.

Rationale: Particulate matter ⩽2.5 μm (PM2.5) adversely impacts patients with fibrotic interstitial lung disease (fILD). Objectives: We sought to determine whether PM2.5-associated epigenetic alterations contribute to the environmental pathogenesis of fILD. Methods: A retrospective two-cohort study applied satellite-derived PM2.5 and constituent exposure matching to the residential location of patients with fILD. Robust linear regressions were used to evaluate cohort-specific, epigenome-wide differential blood DNA methylation with increasing pollutant exposures (Illumina MethylationEPIC BeadChip). Cox and linear regressions were used to evaluate associations of cytosine-phosphate-guanine (CpG) loci with transplant-free survival and lung function. A Wilcoxon test was used to evaluate cartilage-associated protein (CRTAP) levels in fILD and control lungs. Measurements and Main Results: The University of Pittsburgh cohort (n = 306) had 5-year median PM2.5 exposures of 12.1 μg/m3 compared with 5.1 μg/m3 in the University of British Columbia cohort (n = 170). Higher pollutant exposures in the University of Pittsburgh cohort were associated with lower methylation at cg25354716, annotated to CRTAP, a critical extracellular matrix remodeling enzyme. Higher exposures in the University of British Columbia cohort were associated with higher methylation at cg01019301, annotated to TLN2 (talin-2), a cytoskeletal protein involved in fibroblast migration. A 10% increase in cg25354716 methylation was associated with a hazard ratio of 0.81 for death or lung transplantation in the meta-analyzed cohorts (95% confidence interval = 0.69-0.96; P = 0.01), whereas the same change in cg01019301 was associated with a hazard ratio of 1.36 (95% confidence interval = 1.07-1.74; P = 0.01). CRTAP protein was more abundant in lungs from patients with fILD compared with those from donor controls (P < 0.001). Conclusions: PM2.5 is associated with altered blood DNA methylation in fILD. This work identifies novel pollution-sensitive targets that hold potential for therapeutic modulation in fILD.

Humans↗

PubMed1976

[Utilisation of Olivetti P 652 calculator system for RIA evaluation (author's transl)].

The AA. take into consideration the utilisation of the Olivetti calculator system including the following hardware: P 652 basic unit microcomputer; paper tape reader LN 20; Editor 4 ST typewriter, for RIA evaluation. For this purpose they have compiled a series of generalized programmes that utilise for the calculation of the standard curve, the logit transform fitted by using a linear regression or a cubic regression and the sigmoidal linear logarithmic curve calculated by cubic regression. Other two programmes are described also for automatic data reduction in the detection of hepatitis associated antibody (anti-Australia antigen) and of normalized serum thyroxine.

Antibodies↗

PubMedDate not supplied

Quantifying scatter in Shack-Hartmann images to evaluate nuclear cataract.

PURPOSE: Quantify and localize lenticular forward scatter using Shack-Hartmann wavefront sensing (SHWS) as single-valued metrics and a scatter map, and to examine the relationships between forward scatter and backscatter metrics and visual acuity. METHODS: We obtained SHWS images from 148 patients in the Texas Investigation of Cataract Optics study. Patient age was 22 to 84 years, with Lens Opacities Classification System III (LOCS III) nuclear opalescence (NO) scores ranging from 0.8 to 5.6. Visual acuities were measured at photopic (280 cd/m2) high (VA(PHC)) and low contrast (VA(PLC)) and mesopic (0.75 cd/m2) high (VA(MHC)) and low contrast (VA(MLC)). Scattering was described in a scatter map and by five single-valued metrics characterizing SHWS lenslet point spread functions. The relationships between scatter and visual acuity were tested using linear regression. RESULTS: Visual acuities decreased proportional to both LOCS III NO (R2=up to 39%) and scatter metrics (R2=up to 21%). Stepwise multiple linear regression improved visual acuity prediction by including a backscatter and a forward scatter metric (R2 up to 51.2%). For the subjects over age 60 years (N=46, 68.8+/-6.12 years), the forward scatter metrics explain as much variance in visual acuities (R2=up to 29%) as LOCS III NO (R2=up to 26%). Combined they accounted for up to 48.8% of visual acuity variance. CONCLUSION: Forward light scatter can be quantified using SHWS and the resulting metrics explain significant variance in visual acuity, especially in the aging eye. Together with a backscatter metric they explain approximately 50% of the variance in VA.

Adult↗