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At least 1,117 records · Page 62Linked to original sources
PubMed1990

[Clinico-pathogenetic observations on the subject of "superficial vasculitis"].

A clinical, histopathologic, laboratory and therapeutic study in 44 subjects with "superficial vasculitis", consecutively observed during the last two years, has been carried out. The findings showed that 1. the anamnesis was sometimes not relevant; 2. the clinical pictures were not in a regular manner correlated with histologic reports (a polymorphonuclear infiltrate with leukocytoclasis or a lymphomononuclear + one); and 3. a non-correlation between clinical, histologic and etiologic data. Infectious agents were responsible, mostly pyogenic bacteria, Mycobacterium tuberculosis, and hepatitis B virus; Chlamydiae were rarely responsible, whereas the etiologic role of Toxoplasma was uncertain. In this respect, drugs were not relevant. All these agents seem to act on the immunological response of the patient with previous microvascular changes (diabetes, chronic venous insufficiency). The latter condition seems to play a predominant role: the recovery of the lesions and/or their relapse shows the same behaviour both in case of etiological and symptomatic therapy.

Adolescent↗
PubMed1987

Density of Langerhans' cells in ATPase stained epidermal sheet preparations from stasis dermatitis skin of the lower leg.

The density of Langerhans' cells (LC) stained with ATPase was determined in epidermal sheet preparations in skin specimens from patients with stasis dermatitis of the lower leg. Their density was highest in areas adjacent to manifest stasis dermatitis areas. Clinically diseased skin contained less LC than the adjacent areas, but still more than skin from control patients without venous insufficiency. The increased number of ATPase positive cells within and around stasis dermatitis skin might contribute to the high number of contact allergies observed in this patient group because of the antigen presenting capacity of these cells.

Adenosine Triphosphatases↗
PubMed1988

Hyperkeratosis lenticularis perstans (Flegel's disease). In situ characterization of T cell subsets and Langerhans' cells.

We report a patient with hyperkeratosis lenticularis perstans (HLP) manifesting as multiple reddish-brown hyperkeratotic papules on the lower extremities. Typical histologic features of HLP include hyperkeratosis, thinning or absence of the granular layer and a band-like infiltrate in the upper dermis underlying an atrophic epidermis. In order to determine the cellular composition of the infiltrate, skin biopsy specimens were studied immunohistochemically using a series of commercially available monoclonal antibodies. The dermal infiltrate consists predominantly of helper/inducer T cells (Leu-4+, Leu-3a+). Suppressor/cytotoxic T cells (Leu-2a+) were fewer at the periphery of the infiltrate. The majority of T cells were activated as they expressed HLA-DR-antigen. Large numbers of Leu-6+ Langerhans' cells were observed at the dermo-epidermal interface. Few natural killer cells (Leu-11b+) were noted within the dermal infiltrate. These findings support the hypothesis than an active cellular immune reaction involving the epidermis is of pathogenic importance for HLP.

Antibodies, Monoclonal↗
PubMedDate not supplied

[Comparison of blood gas analysis and skin oximetry in phlebopathic dermatitis of the lower limbs].

A cutaneous oximetry and blood gas analysis study was performed on the return system from the dorsal aspect of the foot and the vein at the third median of the leg in 65 phlebopathic patients, using the cubital vein as a control site. The series (25 men and 40 women) comprised 32 cases of non-ulcerative lesions. The statistical analysis of results from the dorsal aspect of the foot in patients with ulcers showed an inverse correlation between transcutaneous O2 diffusion and the blood levels of O2, which was probably associated to AVA hyperstomy. In the vein at the third median of the leg, in both groups, the same inverse correlation was linked to chronic venous hypertension. Lastly, no correlation was observed between the two parameters of the dorsal aspect of the foot in non-ulcerative patients, probably because of the diverse influence of pathogenetic co-factors.

Adult↗
PubMed1989

[Multinodular keratoacanthoma].

Multinodular Keratoacanthoma is a variant of keratoacanthoma presenting with large annular plaques localized on the photo-exposed surfaces of the aged people. It is characterized by progressive growth of new nodules of keratoacanthoma at the periphery, while partial or complete spontaneous central healing occurs with scar formation. There is no tendency toward spontaneous regression. Multinodular Keratoacanthoma is quite rare. In our opinion only ten cases can be complied from the literature. We report an additional case in a diabetic 87 year old woman. She was previously affected by a vulvar squamous cell carcinoma. No recurrence was observed four months after the surgical excision.

Aged↗
PubMedDate not supplied

[Gianotti-Crosti acrodermatitis. Description of a case of rare etiology].

Originally described in 1955, papular acrodermatitis is considered a rare disease whose manifestations are mainly cutaneous. The disease is characteristically associated to a non icteric hepatitis with B serologic tests positive. We recently observed a case whose etiology is unusual and, therefore, in our opinion worth of a brief description.

Acrodermatitis↗
PubMed1989

Primary cutaneous actinomycosis of the extremities: a report from Japan.

A 30-year-old man with cerebral palsy showed cutaneous actinomycosis of the extremities. The diagnosis was confirmed by the histopathologic finding of "sulfur granules." Actinomyces israelii was not cultured as is often the case with actinomycosis. The disease was successfully treated with piperacillin and then with minocycline. This is, to the author's knowledge, the first report in English on actinomycosis from Japan, and the rarity of its occurrence in the extremities is documented.

Actinomycosis↗
PubMed1989

[Immunopathogenetic, endocrinologic and therapeutic problems of EMO syndrome. Observations based on a case report].

The EMO-syndrome (thyroid acropachy) consists of the triad of exophthalmus, circumscribed pretibial myxedema and hypertrophic osteoarthropathy. The clinical picture is seen in thyroid disorders, as a rule occurring in hyperthyroidism, rarely in hypothyroid or euthyroid states. Our 47 year old female patient showed a hyperthyroidism in the beginning. The thyrostatic treatment resulted in a euthyroid stage. Serum antibodies against microsomal thyroid gland antigen with high titers were detected. The immunosuppressive treatment resulted in a titer reduction, but not in an improvement of the disease. The pathogenetical importance of the thyroid stimulating immunoglobulins and the role of aggressive and destructive antibodies against thyroid gland for the development of EMO-syndrome are discussed.

Autoantibodies↗