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Results for “Intestinal Neoplasms”

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At least 1,117 records · Page 62Linked to original sources
PubMed1996

Gastric tumorigenicity of 1,2-dimethylhydrazine on the background of gastric intestinal metaplasia induced by X-irradiation in CD (SD) rats.

Five-week-old male CD (SD) rats were X-irradiated with a total of 20 Gy in 2 equal fractions with a 3-day interval. After the second irradiation, rats were fed normal diet supplemented with 1% sodium chloride, which is known to increase intestinal metaplasia. 1,2-Dimethylhydrazine (DMH) solution was injected i.m. into the back musculature at a dose of 20 mg/kg body weight weekly for 10 weeks, beginning 20 weeks after the final irradiation. Twelve months after the initial carcinogen treatment, gastric tumors in the glandular stomach were observed in 2 (3 lesions) of 30 animals in the X-irradiated and DMH-treated group fed diet supplemented with 1% sodium chloride. No gastric tumors were observed in the group which excluded X-irradiation from the experimental protocol.

1,2-Dimethylhydrazine↗
PubMed2003

Detection of sulfated glycoproteins in intestinal metaplasia: a comparison of traditional mucin staining with immunohistochemistry for the sulfo-Lewis(a) carbohydrate epitope.

BACKGROUND: Premalignant Barrett's oesophagus (BO) and gastric intestinal metaplasia (IM) show phenotypic variability. Incompletely differentiated sulfomucin rich gastric IM (type III) may have increased malignant potential. The types of sulfated oligosaccharide structures present in IM, BO, and colon have not been fully characterised. AIMS: To compare sulfo-Lewis(a) epitope tissue distribution with high iron diamine (HID) positive sulfomucin in metaplastic, dysplastic, and neoplastic tissues from oesophagus and stomach. METHODS: Sections containing gastric IM or BO (some associated with dysplasia or adenocarcinoma) were stained by the HID/alcian blue (AB) method and immunohistochemically (antibody 91.9H) to detect sulfo-Lewis(a). Based on HID/AB staining, IM was subtyped into type I (complete) or types II and III (incomplete). RESULTS: In total, 125 sections from 38 subjects were studied. Normal squamous oesophagus, normal gastric epithelium, and type I IM were negative for sulfomucin and sulfo-Lewis(a). In type II IM, occasional goblet cells were HID and sulfo-Lewis(a) positive, but sialomucin secreting (AB positive) columnar cells were sulfo-Lewis(a) negative. Type III IM was always sulfo-Lewis(a) positive. Sulfomucin staining in dysplasia and cancer was variable, but HID positive areas were always sulfo-Lewis(a) positive. CONCLUSIONS: Sulfo-Le(a), which is expressed on colonic mucin, is invariably present on sulfomucins in gastric IM and BO. Its presence in incomplete variants of IM and its absence from type I IM emphasises the phenotypic differences between complete and incomplete forms of metaplasia. 91.9H immunostaining is useful in IM subtyping. Characterising the molecular basis of sulfo-Lewis(a) expression may help understand the process of aberrant differentiation.

Adenocarcinoma↗
PubMed2006

Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice.

Cancers of breast and bowel are increasingly frequent in humans. Chronic inflammation is known to be a risk factor for these malignancies, yet cellular and molecular mechanisms linking inflammation and carcinogenesis remain poorly understood. Here, we apply a widely used T-cell transfer paradigm, involving adoptive transfer of proinflammatory CD4+ CD45RB(hi) (T(E)) cells to induce inflammatory bowel disease (IBD) in mice, to investigate roles of inflammation on carcinogenesis in the Apc(Min/+) mouse model of intestinal polyposis. We find that transfer of T(E) cells significantly increases adenoma multiplicity and features of malignancy in recipient Apc(Min/+) mice. Surprisingly, we find that female Apc(Min/+) recipients of T(E) cells also rapidly develop mammary tumors. Both intestinal polyposis and mammary adenocarcinoma are abolished by cotransfer of anti-inflammatory CD4+ CD45RB(lo) regulatory lymphocytes or by neutralization of key proinflammatory cytokine tumor necrosis factor-alpha. Lastly, down-regulation of cyclooxygenase-2 and c-Myc expression is observed coincident with tumor regression. These findings define a novel mouse model of inflammation-driven mammary carcinoma and suggest that epithelial carcinogenesis can be mitigated by anti-inflammatory cells and cytokines known to regulate IBD in humans and mice.

Adenocarcinoma↗
PubMed1976

Long-term study of large-bowel cancer.

A personal series of 2,314 patients with large bowel cancer has been reviewed. This series has been treated over a 25-year period and all patients have been followed up. Although patients appear to be presenting earlier, there has been only a marginal improvement in the 5-year survivals. The recognized precancerous conditions of the large bowel account for a very small percentage of carcinomas.

Colitis, Ulcerative↗
PubMed1999

Inhibitory effect of intestinal bacteria on spontaneous multiple polyps in the small intestine of gnotobiotic BALB/c mice.

The incidence of multiple polyps and number of polyps per mouse were significantly lower in conventionalized (CVz), and chloroform-resistant bacteria (CRB)- or fusiform bacteria (FB)-associated mice than in germfree (GF) BALB/c mice. The concentration of fecal fatty acids was also higher in mice associated with either CRB or FB than in GF mice. The incidence of multiple polyps and number of polyps per mouse were significantly correlated with the concentration of fatty acids in the feces of CVz and CRB-GB mice. This study demonstrated that inhibition of multiple polyps in the small intestine of BALB/c mice was affected by the production of intestinal fatty acids.

Animals↗
PubMed1992

[An exceptional complication of bladder cancer: intestinal metastases with obstruction of the small intestine].

Intestinal metastases from bladder cancers are extremely rare and all of the cases reported in the international literature have concerned patients in whom the tumour was resected by open surgery. The authors report a unique case of obstructive intestinal metastases from a bladder cancer resected via the transurethral route and regularly followed by endoscopy and systematic biopsies.

Carcinoma, Transitional Cell↗
PubMedDate not supplied

[Mesenteric lymphangiomas of the small intestine in children].

The authors have made an analysis of 15 cases with lymphangiomas of the small intestine mesentery in children aged from 3 days up to 12 years. Attention is called to problems in diagnosing this pathology. The optimum variant of examination is presented which allow the correct diagnosis to be made. All the children were operated upon. The method was chosen depending on localization of the cyst and on the patient's age. Good results of treatment were obtained.

Child↗
PubMed1992

[Distant metastasis of malignant melanoma in the small intestine, 2 case reports].

The authors present the case history of two patients with metastases of a malignant skin melanoma into the gastrointestinal tract. One case detected on operation, with concurrent affection of the adrenal gland, the second one with the symptomatology of occult haemorrhage. The paper is supplemented by a review of the literature covering the last five years. The authors recommend in the described cases an active surgical approach.

Humans↗
PubMed1992

[Distant metastasis of malignant melanoma in the small intestine].

The authors describe the case-histories of two patients with rarely encountered secondaries of a malignant skin melanoma into the gastrointestinal tract. One case was revealed before operation, the second one due to symptoms of occult haemorrhage. The paper is supplemented by a review of the world literature of the past five years.

Humans↗