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At least 1,117 records · Page 62Linked to original sources
PubMed2006

Kinetics of insulin adsorption at the oil-water interface and diffusion properties of adsorbed layers monitored using fluorescence correlation spectroscopy.

The adsorption of insulin at an oil-water interface was studied with fluorescence correlation spectroscopy (FCS). FCS is able to measure diffusion properties of insulin at nanomolar concentrations, making it possible to detect the very early steps in the adsorption process. Below 20 nM bulk insulin concentration, the insulin molecules adsorbed to the surface diffuse freely at all times during the experiment (a few hours). At higher concentrations, a surprisingly abrupt transition to a slow diffusion phase is observed. Based on the information about both diffusion times and molecular brightness derived from the FCS experiments, we suggest that the transition represents the formation of a fractal network. FCS may be a valuable tool in pharmaceutical formulation science, because it provides information about concentration buildup and phase changes at interfaces formed in drug delivery systems.

Adsorption↗
PubMed2002

Chaplains and science.

The decision between science and religion is eroding. The changing relationship is associated with the discovery of similarities between science and religion. Chaplains must become more comfortable with science and let it inform our ministry.

Chaplaincy Service, Hospital↗
PubMedDate not supplied

The impact of biomedical literature published in the province of Vojvodina on researchers in the world and in Yugoslavia.

This study uses bibliometric analysis to evaluate scientific biomedical literature published on the territory of Vojvodina and its impact on researchers in Yugoslavia and in the world. The study sample comprised 6.979 publications from the territory of Vojvodina published in the period 1986-1997. The following parameters were determined: productivity of authors and institutions where they were employed and some other bibliometric parameters. The impact of these publications on other researches was analyzed for the same period, by citation analysis of papers published in 3 most eminent medical journals in Yugoslavia (3.440 articles, 58.484 references) and in Science Citation Index. Results of the study revealed that production of biomedical literature on the territory of Vojvodina was at high level. Medical research presented in journals of Vojvodina, which are the carriers of current information and accomplishments in science, technique, and practice in biomedicine, was satisfactory. Biomedical articles published in Vojvodina showed a tendency towards increase in number of authors, whereas the greater number of publications were written by a small number of extremely productive authors and institutions. Biomedical researches in Yugoslavia usually cite only foreign literature, while domestic references are mostly self-citations or citations of older literature. The impact of publications published in Vojvodina on other researchers in Yugoslavia is evident, but it is greatest on the territory where they are published. In regard to biomedical journals from Vojvodina "Medical review" is the most cited journal in Yugoslavia and in SCI. Most of the cited references belong to a small number of authors. Thus, according to bibliometric criteria the impact of medical science and professional practice in Vojvodina on international scientific streems is negligible, as well as the impact of papers published in Vojvodina on researchers in the world. Only 0.4 works published in Vojvodina, 0.87% papers from journals published in Vojvodina and written by 0.59% authors were cited in SCI.

Bibliometrics↗
PubMed2003

'Science is really needed--that's all I know': informed consent and the non-verbal practices of collecting blood for genetic research in northern Sweden.

In Vasterbotten County in northern Sweden a start-up biotech company has recently gained all commercial rights to one of the worlds largest population based research biobanks. The biobank and the company have publicly emphasized that all donors have given their informed consent to participate, but within the academy it has become debated whether people have been adequately informed. Based on anthropological fieldwork it is shown that many people do not read the information provided. The data do not, however, suggest that donors themselves perceive a lack of information. This article endeavours to make meaningful the apparent lack of interest among donors in the information they are offered. It is argued that the donation of blood should be analysed in its social and historical context rather than as a response to rational assessment of information of research purposes. It implies a conceptualisation of agency more aware of the intersubjective nature of moral negotiation than usually implied in studies of informed consent.

Biological Specimen Banks↗
PubMed1999

Importance of philosophy of science to the history of medical thinking.

Popular approach to the history of medicine rests on naive assumptions that: 1) only the present state of medical knowledge can be counted as scientific and only those elements of the former knowledge and practice which fitted the body of contemporary science should be regarded by the historians of medicine (presentism); 2) medical sciences, like the other natural sciences, portray natural phenomena as they really are (naturalism); 3) progress in sciences consists of cumulative growth of information and explanation. The twentieth century philosophical critique of science revealed that none of these assumptions were true. Empirical facts, which are taken as a basis for any true knowledge, are dependent on the presumed theories; theories are intertwined into a broader socio-cultural context; theory-changing processes are caused by social factors rather than by the theoretical content. Therefore, it is a common task of historians of medicine and philosophers of science to reveal all theoretical and cultural premises on which our comprehension of the contemporary medicine is founded.

Bioethics↗
PubMed1986

Determining the core competencies of the ideal health sciences communicator.

The Education Committee of HeSCA conducted a Delphi study to generate agreement among a panel of experts regarding the core competencies of an ideal health sciences communicator. Seventy-five present and future competencies were identified and classified in terms of relative importance. Competencies concerning general communications techniques were determined to be most important, followed by abilities specifically related to the health sciences communications field. Management competencies were third in order of importance, and competencies that dealt with having a knowledge of the health sciences ranked fourth. The information reported helps to describe the knowledge and skill basis of the profession, as perceived by leaders in the field. The results can serve as guidelines for planning continuing education programs and professional development activities for health sciences communicators.

Communication↗
PubMed2004

The call to life: revitalizing a healthy Hawaiian identity.

The meaning of health is typically defined as the absence of disease. This definition, while highlighting our ability to measure the physiological attributes of health through morbidity and mortality statistics in turn obscures alternative meanings of health. In this paper, I ask three questions about the meaning of health. First, is health simply the body without disease? Second, are there alternative meanings of health that are not solely informed by Enlightenment views of science and biomedicine? Third, in what ways does health give meaning to and inform social orders and our place within them? Drawing on interviews with Native Hawaiians conducted on the islands of Maui and Hawaii, this paper examines what it means to be a "healthy Hawaiian", and in doing so, problematizes meanings of health. For those I interviewed, definitions of health were embedded in understandings of what it means to be a Native Hawaiian and presented an opportunity to talk about the cultural and material dispossession of Native Hawaiians. These definitions also remind the present generation of the vitality of their ancestors. In remembering the life, health and subsequent dispossession of Hawaiian ancestors, contemporary Hawaiians are provided with an alternative definition of what it means to be a "healthy Hawaiian", thus raising serious questions about "health" as defined by biomedicine and how best to achieve it. This case illustrates how a focus on concepts of health elucidates the relationship between health and inequality as well as Native Hawaiian's agency in charting a positive direction for health that has meaning in the everyday life of Hawaiians.

Adult↗
PubMed1991

Issues in information malpractice.

In today's information explosion environment, the health sciences librarian is increasingly placed in the role of interpreting, translating, and evaluating information for clientele. With this emerging role and the burgeoning of fee for service programs, the question of information malpractice liability becomes an increasingly important issue. This paper explores the basis for legal actions against librarians and offers some precautionary measures to help protect against such legal action.

Humans↗