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Results for “GOLGI APPARATUS”

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PubMed1981

Adrenal depletion during hypoglycemia without participation of the Golgi apparatus.

Adrenal depletion in rats due to hypoglycemia was effected by prolonged administration of adrenaline, without artificial increase in insulin levels. In spite of significantly enhanced catecholamine turnover in this stadium Golgi complexes - which are usually reported to develop hypertrophy during adrenal depletion using insulin induced hypoglycaemia - could never be observed. This leads to the conclusions, that firstly the presence of hypertrophic Golgi complexes is not necessarily linked with increased catecholamine turnover and secondly that permanent adrenalin application suppresses and insulin application promotes the formation of Golgi systems. Moreover, our electromicrographs do strongly suggest, that catecholamine turnover is linked with the rough endoplasmatic reticulum.

Adrenal Medulla↗
PubMedDate not supplied

Changes of the Golgi apparatus induced by diethylmaleate in rat hepatocytes.

Ultrastructural studies of the liver of rats given diethylmaleate (DEM) (0.7 ml per kg body, i.p.) weight revealed marked alterations of the configuration of the Golgi complex in all hepatocytes. This consisted in dilatation of the cisternae leading to the formation of large cysts. The alteration was more prominent 15 min after administration of the drug, coincident with a 2-fold increase of bile flow and a decrease of hepatic glutathione to 15% of controls. The morphology returned to normal at 45 min after DEM administration together with a return of bile flow to control values whereas hepatic glutathione level remained markedly depressed for 2 hr, rising slowly afterwards. No other signs of altered hepatic morphology developed up to 5 hr. The morphological changes correlated with altered bile flow induced by DEM, suggesting involvement of the Golgi complex in biliary excretion of osmotically active glutathione conjugates of DEM.

Animals↗
PubMed2006

[Evolutionary approach to the understanding of structural and functional organization of Golgi apparatus].

This article analyzes the literature data related to the discussion of the main models of intracellular protein transport, including vesicular and cistern maturation-progression models. The existence of an important Golgi complex (GC) component--continuous tubular structures--is emphasized and their possible participation in the intracellular transport is discussed. A brief review is presented, describing the peculiarities of intracellular traffic in eukaryotic species belonging to different stages along the evolutionary process. The evidence suggests that in higher eukaryotes, the dynamic membranous GC system was formed on the basis of tubular networks that performs protein sorting and selective protein transport.

Animals↗