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At least 1,117 records · Page 62Linked to original sources
PubMed1991

Peripheral odontogenic fibroma: a clinicopathologic study.

The clinicopathologic features of 30 cases of peripheral odontogenic fibroma are reviewed. The age distribution is wide (11 to 76 years), and there is a slight predilection for males. The majority of the lesions (93%) occurred in blacks on the attached gingiva, and with equal frequency in the maxilla and mandible. Size varied between 1 and 3 cm in diameter. One case recurred after 14 months. Histologically, the lesions are nonencapsulated and poorly delineated. The amount of odontogenic epithelium varies considerably and consists usually of small islands or strands, although larger follicles are sometimes present. In one case the epithelial cells had a clear cytoplasm, whereas in another it was granular and eosinophilic. Origin from the surface oral mucosa can sometimes be seen. The connective tissue component is usually cellular, but collagenous, myxomatous, and mixed forms occur. Calcifications were present in 22 cases and consisted of tissue interpreted as either dentinoid, cementum, bone, or dystrophic calcific material.

Adolescent↗
PubMed1994

Peripheral odontogenic fibroma.

The peripheral odontogenic fibroma is characterized by a fibrous or fibromyxomatous proliferation that contains varying amounts of odontogenic or presumed odontogenic epithelium. It has been considered a rare gingival neoplasm that, because of a lack of follow-up information in most reported cases, has had an unknown biologic behavior. Clinical data from this study indicate that the lesion is more common than previously reported and that it has a significant recurrence rate. Light and electron microscopic data reveal a relatively broad spectrum of epithelial and mesenchymal components, including a rare granular cell type. Because the presence of both epithelial and mesenchymal elements are required for its diagnosis, the lesion is logically classified as a mixed epithelial/mesenchymal odontogenic tumor, rather than a purely mesenchymal tumor.

Adolescent↗
PubMed1989

Chondromyxoid fibroma of bone: thirty-six cases with clinicopathologic correlation.

A series of 36 cases of chondromyxoid fibroma (CMF) of bone, a rare benign tumor that may be confused with chondrosarcoma, is presented to aid in correctly identifying and diagnosing these neoplasms. In this series, CMFs were found in patients of all age groups, with no predominance between sexes. Long bone tumors were more common in young patients, while small and flat bone lesions were more common in older patients. Radiographically, long, flat, and small bone lesions were well-defined and benign-appearing. Tumors in the vertebrae had a more aggressive appearance, with marked bone destruction. The histologic picture was of a pseudolobulated tumor with myxoid and chondroid regions. Tumor cells were at times bizarre, pleomorphic, and binucleate, but rarely contained mitoses. Curettage with or without bone grafting and en bloc resection were the most common modes of treatment. The majority of recurrences were seen in patients treated by curettage alone. Radiation therapy was associated with the development of sarcoma in one case. No cases of malignant transformation were found in this series, but unusually aggressive recurrences were noted in CMFs involving a phalanx, the cervical vertebra, and the sacrum.

Adolescent↗
PubMed1993

A recurrent chondromyxoid fibroma with chromosome aberrations ins(5;2)(q13;p21p25) and 2p deletion: a case report.

We report a patient with a recurrent chondromyxoid fibroma, a rare benign tumor of the bone with clonal aberrations in chromosomes 2 and 5. Karyotyping, chromosome painting, interphase cytogenetics by in situ hybridization, and DNA flow cytometry were used. The karyotype was interpreted as 46,XX,der(2)ins(5;2)(q13;p21p25),der(2)ins(5;2)(q13;p21p25), der(5)ins(5;2) (q13;p21p25).

Adult↗
PubMedDate not supplied

Histochemical characterization of collagen fibers in fibrous overgrowth (irritation fibroma) of the oral mucosa: effect of age and duration of lesion.

In a study of 43 specimens of oral mucosa irritation fibroma, polarization colours of collagen thin (0.8 microm) and thick (1.6-2.4 microm) fibers were recorded in formalin-fixed and paraffin-embedded sections stained with Picrosirius red. Examination of polarization colours of both the 'thin' and 'thick' collagen fibers revealed an increase of yellowish-orange and orange fibers as a function of age in patients over 30 years old (P < 0.05 only in thick fibers). When the polarization colours of thin and thick collagen fibers were recorded as a function of duration of the lesion, there was an increase in the number of yellowish-orange and orange fibers and a decrease in blue-green and green fibers in both thin (P < 0.1) and thick (P < 0.05) populations as the lesion matured. These findings show that increments in both the patient's age and the duration of the lesions increase the amount of collagen fibers which exhibit yellowish-orange and orange polarization colours indicating tighter packing and better alignment of the microfibrils, similar to normal mature collagen. These differences may have an effect on the timing of the surgical excision.

Journal Article↗
PubMedDate not supplied

Endoscopic removal of chondromyxoid fibroma of the ethmoid sinus.

The first case of the endoscopic intranasal excision of chondromyxoid fibroma as an outgrowth of the ethmoid bone is reported. This case appears to represent the second reported type of recurrence of CMF in the head and neck area and the second type of CMF originating in the ethmoid.

Adult↗
PubMed1988

Chondromyxoid fibroma of the maxilla.

A case of chondromyxoid fibroma of the anterior maxilla arising in a 38-year-old Japanese woman is presented. Review of the literature reveals 16 cases of CMF of the jaws, of which only 3 were in the maxilla. Curettage and subsequent 5 year followup showed no evidence of recurrence.

Adult↗
PubMed1991

Central odontogenic fibroma: clinicopathologic features of 19 cases and review of the literature.

The odontogenic fibroma is a benign neoplasm infrequently reported in the literature (20 cases). Nineteen additional examples are reported. This lesion occurs most frequently in the maxilla anterior to the molars and displays a striking female predilection. On occasion, it may be associated with an unerupted mandibular third molar. Histomorphologically, it is not encapsulated. A spectrum of fibrous connective tissue stroma is present: from myxoid to densely hyalinized and from relatively acellular to cellular. Calcification may or may not be present. It is distinguished by the presence of sparse cords and islands of inactive odontogenic epithelium. Enucleation or surgical curettage is appropriate therapy and recurrence is low. As there appears to be no correlation of histologic pattern with clinical behavior, it seems unnecessary to try to separate the tumor into two variants.

Adolescent↗
PubMed1996

Treatment of fibromas.

This study defines the current modes of treatment of patients with uterine fibromas with a review of the literature. Progesterone treatments appear to be principally used in cases of minor functional symptomatology and we discuss recent studies of mifepristone. GnRH agonists are particularly effective in preoperative treatment for conservative surgery. The indications and results of hysteroscopic resection and laparoscopic myomectomy are compared to those of classic myomectomy and hysterectomy. The indications for myolysis are discussed.

Female↗
PubMed2004

Ameloblastic fibroma of the maxillary sinus.

Ameloblastic fibroma is a rare true mixed tumor of odontogenic origin with both mesenchymal and ectodermal components. It usually arises from the mandibular dentition and presents in the second decade of life. It is a benign slow growing tumor that is less infiltrative than an ameloblastoma but tends to expand bone. It infrequently involves the maxilla and hence the management of these tumors in that region is controversial. The goal of therapy is to avoid cosmetic deformity without compromising on tumor eradication. We present the tenth reported case of this type of tumor in the maxilla, and the second one in an infant.

Humans↗
PubMed2004

Calcifying odontogenic cyst with ameloblastic fibroma: report of three cases.

Although it is a rare event, odontogenic tumors such as ameloblastoma, ameloblastic fibroma (AF), ameloblastic fibro-odontoma, and odontoma have been reported associated with calcifying odontogenic cyst (COC). There are only four cases of COC with AF cited in the English literature. However, three of these four cases were either included in a review of a series of cases or reported as an abstract, and limited clinical and histological information was provided. We present three additional cases of COC with AF and discuss the management for this combined lesion. Because COC is known for its histologic diversity and variable clinical behavior, and the clinical significance of an association of COC with AF is still unknown, we think it is valuable to report COC with AF with detailed clinical and pathological documentation.

Adolescent↗
PubMed2003

Chondromyxoid fibroma of the sternum.

Primary chondromyxoid fibroma (CMF) of the sternum is quite rare with only four cases documented in the literature. We present a new case of CMF arising from the sternum of a 47-year-old man and compare it with the previous cases.

Biopsy, Needle↗
PubMed1978

Ameloblastic fibroma: report of two cases.

Two cases of ameloblastic fibroma are described. One case was a seven-year-old girl, the other a 13-year-old boy. In both cases the tumour was located in the posterior part of the maxilla. Both neoplasms were associated with failure of tooth eruption, in one case a primary molar, in the other case a permanent molar. Local excision was performed in both cases, with a recurrence observed in one case ten months after surgery.

Adolescent↗
PubMed1998

Chondromyxoid fibroma of bone: a clinicopathologic review of 278 cases.

In a study of the clinical, radiographic, and pathological features of chondromyxoid fibroma, the tumor was slightly more common in men, usually in the second decade of life. Almost half of the tumors involved the long bones, although the ilium and the small bones were also common sites. Roentgenograms showed a sharply marginated, lobulated, lucent defect in the metaphysis. The tumor involved the medullary bone in an eccentric fashion, and the cortex was thinned and expanded. Periosteal reaction and soft tissue extension were uncommon. Mineralization was identified in 13% of the lesions. Histologically, the tumors were almost always arranged in lobules, which were prominent (macrolobular) or somewhat indistinct (microlobular). The tumor cells were spindle-shaped or stellate and arranged in a myxoid matrix. Calcification was seen in more than one third of the cases but was rarely prominent. Hyaline cartilage and chondroblastoma-like areas were not uncommon. Approximately 18% of tumors showed bizarre nuclei. Permeation of bony trabeculae was uncommon. Treatment was conservative surgical removal; approximately one fourth of the patients had recurrence.

Adolescent↗
PubMed1978

Chondromyxoid fibroma of the mandible. Case report.

Chondromyxoid fibroma in the jaws is an extremely rare, benign tumor. The lesion is relatively more common in the long bones and mainly occurs in adolescents and young adults. The treatment of choice is local resection of the tumor. Recurrences are not uncommon, especially when curettage was the method of treatment. Differentiation from chondrosarcoma is mandatory as treatment and prognosis are dissimilar.

Adolescent↗
PubMed1978

Transformation of ameloblastic fibroma to fibrosarcoma.

The direct transformation of an ameloblastic fibroma into a fibrosarcoma in a 16-year-old Caucasian male is reported. Although no ameloblastic epithelium was found in the recurrent tumor, the odontogenic origin of the fibrosarcoma was evident. The ameloblastic fibrosarcoma and the fibrosarcoma of identical odontogenic origin represent an entity which should be distinguished from conventional fibrosarcoma as these tumors demonstrate different clinical behaviors.

Adolescent↗
PubMed1979

Ameloblastic fibroma.

Four cases of ameloblastic fibroma appearing in the posterior maxilla and the cupsid area of the mandibula are presented. One of the lesions appeared in the wall of a cyst and another was found in connection with a cyst. The treatment is conservative but the tumor needs close follow up for possible recurrence.

Adolescent↗
PubMed1981

Cementifying fibroma of the maxilla. Report of a case.

A case of cementifying fibroma growing into the right maxillary sinus is reported. Clinical and histopathological findings are presented. The differentiation from central fibro-osseous lesions in jaw bones is discussed.

Humans↗