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Prevention policies in the light of the changed distribution of dental caries.

Changes in the distribution of caries in economically developed nations over the last 15-20 years include 1) an overall decline in prevalence and severity in child populations; 2) an increasingly skewed distribution, with most disease now found in a small number of children; and 3) concentration of caries in pit and fissure lesions. Exposure to fluoride is usually seen as the principal reason for the caries decline, with little change in intraoral levels of cariogenic organisms or the annual consumption of sugars. Prevention activities are still most often conducted under policies that were established at a time when caries was a more widespread public health problem, so these policies should be critically examined in the light of modern conditions. While prevention should remain the prime activity of public health agencies, despite the reduced severity of caries, the relative economic efficiency of various procedures should be constantly evaluated. Despite the attractions of targeting, cost-effective prevention should be aimed first at the whole population, with more expensive activities targeted to all children in a chosen geographic area rather than to individually selected children. In the Scandinavian countries the prime population strategies are the regular use of fluoride toothpaste and public education that emphasizes oral hygiene. In selected areas where caries levels are still relatively high (that is, targeted geographic areas), fluoride rinse and tablet programs, provided for a whole classroom at a time, can enhance intraoral fluoride levels where necessary. Fluoride varnish and sealants, though effective, are expensive and need careful selection of locality and teeth to be efficient. Individual children with a persistent caries problem, now relatively small in number, can receive individualized preventive treatment in the clinics of the school dental service.

Cariostatic Agents↗

A passive flux denuder for evaluating emissions of ammonia at a dairy farm.

Passive samplers have been shown to be an inexpensive alternative to direct sampling. Diffusion denuders have been developed to measure the concentration of species such as ammonia (NH3), which is in equilibrium with particulate ammonium nitrate. Conventional denuder sampling has required active sampling that inherently requires air pumps and, therefore, electrical power. To estimate emissions of NH3 from a fugitive source would require an array of active samplers and meteorological measurements to estimate the flux. A recently developed fabric denuder was configured in an open tube to passively sample NH3 flux. Passive and active samplers were collocated at a dairy farm at the California State University, Fresno, Agricultural Research Facility. During this comparison study, NH3 flux measurements were made at the dairy farm lagoon before and after the lagoon underwent acidification. Comparisons were made of the flux measurements obtained directly from the passive flux denuder and those calculated from an active filter pack sampler and wind velocity. The results show significant correlation between the two methods, although a correction factor needed to be applied to directly compare the two techniques. This passive sampling approach significantly reduces the cost and complexity of sampling and has the potential to economically develop a larger inventory base for ambient NH3 emissions.

Air Pollutants↗

[NAFTA: a challenge and an opportunity for environmental health. The case of the maquila industry].

The three countries that have signed the North American Free Trade Agreement (NAFTA) have focused particular interest and concern on the potential impact that this agreement will have on the environmental health, based on the premise that economical development should not detriment neither the environment nor the human health. In this paper, the NAFTA is presented as an opportunity to improve environmental and occupational health in Mexico and assumes that the study of the potential impact of NAFTA could help to find the solutions of the former and actual environmental health problems. From this perspective, the north-border maquila industry is analyzed as a case study for the purpose of identifying and predicting the impact of NAFTA on environmental and the occupational health. Preventive as well as control measurements are suggested. The general characteristics of the U.S.-Mexico border and the maquila industry are presented. The lack of both social investment and urban planning along with population and economical growth are described. An explanation of the impact that these factors have had on the environmental and occupational problems is discussed. Special emphasis is given to the human health problems including that of water, air and soil contamination by industrial toxic residues. Also, some possible health impact of NAFTA are outlined. Finally a sustainable developmental intervention is suggested, based on NAFTA as an opportunity to take advantage of coming structural changes that will improve the environmental health conditions at the northern-border and in the entire country.

Adult↗

One-year outcome of unexplained fatigue syndromes in primary care: results from an international study.

BACKGROUND: Outcome studies of chronic fatigue, neurasthenia and other unexplained fatigue syndromes are few and have been carried out in developed Western countries. This paper aimed to study the outcome of unexplained fatigue syndromes in an international primary care sample and to identify risk factors for persistence. METHOD: We used data from the WHO collaborative study of psychological problems in general health care, in which 3201 primary care attenders from 14 countries were followed-up for 12 months. The assessment included a modified version of the Composite International Diagnostic Interview. RESULTS: Unexplained fatigue persisted in one-fifth to one-third of the subjects depending on the definition of fatigue. From the factors studied only severity of fatigue and psychiatric morbidity at baseline were associated with persistence 12 months later. Outcome did not differ between countries of different stages of economic development. CONCLUSIONS: The prognosis of fatigue syndromes in international primary care is relatively good. The study underlines the importance of psychological factors in influencing short-term prognosis.

Fatigue Syndrome, Chronic↗

Obesity and weight change related to parity and breast-feeding among parous women in Brazil.

OBJECTIVE: Studies on the independent role of parity in long-term body weight change in economically developing countries are scarce and inconclusive, and only a few studies have taken into account patterns of breast-feeding. This association was examined in a national cross-sectional survey representative of Brazilian parous women. DESIGN AND SETTING: The survey conducted in 1996 measured women's height and weight in the household and data on weight prior to the first pregnancy, parity and breast-feeding were recalled. SUBJECTS: A sample of 2338 parous women, 15 to 49 years of age, 29 months after last delivery on average, had current body mass index (BMI, in kg m(-2)) modelled through hierarchical multiple linear regression analysis. Explanatory variables included parity, days of predominant breast-feeding, BMI pre-pregnancy, socio-economic, geographic, demographic and other reproductive variables. RESULTS: Prevalences of overweight (BMI = 25.0-29.9 kg m(-2)) and obesity (BMI > or = 30.0 kg m(-2)) were 25.2% and 9.3%. The overall mean weight gain per year after the first pregnancy was 0.90 kg for an average time since first pregnancy of eight years. BMI pre-pregnancy modified the association between current BMI and parity. Therefore, weight change attributed to parity calculated for a woman of average height (1.56 m) was 0.60 kg greater for primiparous women with a BMI pre-pregnancy of 30 kg m(-2), compared with women with BMI pre-pregnancy of 25 kg m(-2). This greater weight retention among obese women was 1.21 kg for women with two children and 1.82 kg for women with three or more children. Parity reduced the effect of weight loss associated with lactation (1.75 kg for six months of lactation among primiparous women and 0.87 kg among women with three or more children). For the sub-sample of 793 primiparous women, a weight decrease of 300 g was associated with each month of predominant breast-feeding for all prior BMI levels. CONCLUSIONS: In this study, weight change associated to reproduction was highly dependent on BMI previous to pregnancy and the effects of parity and lactation were small.

Adolescent↗

Coral reefs of the Mascarenes, Western Indian Ocean.

The reefs of the Mascarenes differ in structure and stage of development. Mauritius is the oldest island, bound by a discontinuous fringing reef and small barrier reef, with large lagoon patch reefs. Rodrigues has nearly continuous fringing reefs bounding an extensive lagoon with deep channels and few patch reefs. Reunion, the youngest island, has short stretches of narrow fringing reefs along southwestern coasts. The islets of St Brandon are bound to the east by an extensive arc of fringing reef. Reef mapping of the Mascarenes using satellite imagery provides an estimate of 705 km2 of shallow reef habitats. These areas have been modified over geological time by changes in sea level, ocean-atmosphere disturbances and biological and chemical forcing. Further modification has resulted from historical changes in land-use patterns. Recent economic development has placed many of these reefs at risk from anthropogenic impact. The reefs of the Mascarenes have escaped mass mortality from bleaching to date, which increases their conservation significance within the wider Indian Ocean. The reefs are poorly protected. A case study shows how a geographic information system incorporating reef-habitat maps can help formulate and demonstrate Marine Protected Area boundaries.

Animals↗

Solar disinfection of infectious biomedical waste: a new approach for developing countries.

Poor developing countries cannot afford expensive technologies such as incineration for management of infectious biomedical waste. We assessed solar heating as an alternative technology. We immersed simulated infectious waste with added challenge bacteria in water in a box-type solar cooker, which was left in the sun for 6 h. In 24 sets of observations, the amount of viable bacteria was reduced by about 7 log. We also tested infectious medical waste with a heavy load of bacteria (10(8)-10(9)/g) from our hospital's burn unit for solar heat disinfection in 20 experiments. Our results showed a similar 7 log reduction in the amount of viable bacteria. Solar heating thus seems to be a cheap method to disinfect infectious medical waste in less economically developed countries.

Developing Countries↗

[Amur tiger: path to the third millennium (experience of development of the "Strategy of preservation of the Amur tiger in Russia")].

The development of a system of measures for conservation of the Amur tiger is summarized. In the middle of the 1990s, no marked reduction in the numbers of the Amur tiger took place in Russia; the animals were always present in most of the forest-covered area of the Primorskii and South Khababrovsk districts. However, new threats to the survival of the Amur tiger appeared. It is necessary to preserve the self-regulating population of the Amur tiger throughout its range. The key to solving this task is the identification of three functionally unequal zones in the southern Far East of Russia: a monolithic "tiger bastion" consisting of protected territories with different statuses, a zone of "stable compromise" (between the interests of tiger conservation and economic development of the territory), and a "tiger-free" zone, where the animals periodically migrate. The importance of Russian-Chinese cooperation in conservation of the Amur tiger has been stressed. A large international borderline reserve-cluster for this purpose has been proposed.

Animals↗

Toward an international case mix index for comparisons in OCED countries. Organization for Economic Cooperation and Development.

During the last 20 years, a number of studies have examined the effect of Diagnosis Related Group (DRG)-based health care prospective payment systems on the cost and quality of services. To examine these issues, it is necessary to control for variations in patient mix and the related resources needed by incorporating some form of a case mix index. As part of our ongoing research on comparative DRG-based health care payment systems, we develop a preliminary, international case mix index using the Organization for Economic Cooperation and Development (OECD) health care database. We illustrate the application of our case mix index and use it to devise a standardized cost per case and a standardized cost per day for several countries. We also provide some preliminary analysis of the data demonstrating the observable and predictable effects of DRG-based payments on case m ix index, length of stay,cost per day, and cost per case.

Benchmarking↗

Drug treatment of tropical parasitic infections: recent achievements and developments.

Drug development offers potential solutions to a number of tropical health diseases, although the expense of pharmaceutical research and lack of return on investment has limited the production of new agents. The greatest successes have been through the development of single dose therapy and mass treatment control programmes for a number of diseases. We review some of the current treatment regimens for malaria, intestinal helminth infection, onchocerciasis, filariasis and schistosomiasis, and their use in clinical practice. Geographical spread and emergence of drug resistant parasites have hindered the control of malaria, the most important global parasitic infection. Artemisinin compounds have proved effective antimalarial agents producing rapid reduction of parasite load and can be used in combination treatment regimens to combat multidrug resistance. Intestinal helminth infections are widespread, giving rise to nutritional deficiencies and impaired childhood cognitive development. Pregnant women in developing countries are at increased risk of morbidity. Treatment with a single dose benzimidazole such as albendazole or mebendazole has beneficial effects on morbidity and rates of transmission. Diethylcarbamazine has been used in the treatment of onchocerciasis and human filariasis. A complicated escalating dose regimen over several weeks is associated with systemic and allergic reactions and may require corticosteroid cover. Simplified regimens for mass population treatment with ivermectin have proved useful and been used in combination with single dose albendazole and diethylcarbamazine. The African Programme for Onchocerciasis Control in West and Central Africa has been one of the most successful mass control programmes virtually eliminating new infections by a combination of chemotherapy, education and vector control. Schistosomiasis is of increasing importance as a result of the creation of new snail habitats by agricultural and economic development. Praziquantel has become the most widely available and effective chemotherapy for schistosomiasis. There have been a number of reports of persistent schistosome egg shedding after treatment posing concerns about the emergence of drug resistance. Eflornithine has been successfully used in patients with human trypanosomiasis failing melarsoprol therapy however expense and availability have limited its potential. Mass control treatment programmes have targeted schoolchildren, adolescents and pregnant women. The integration of schistosomiasis, onchocerciasis, filariasis and helminth control programmes has been considered as a cost-effective method of delivering treatment. It is likely that future control will be based on this optimisation and integration of existing regimens, rather than the development of new agents.

Anthelmintics↗