[Estriol levels in cystic fluid from women with cystic disease of breast].
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This paper reported the determination of urine E3 in 326 normal pregnancies from 28 to 41 gestational weeks, and 80 abnormal pregnancies by E3-125I-RIA. The results showed that E3 levels in normal pregnancies increased with advance of gestational weeks with their peaks at the 38th week and decreased gradually after the 40th week. There was a positive correlation between urine E3 and the 12 hour urine E/C ratio (r = 0.798, P less than 0.001). In monitoring the high-risk pregnancies, we found 92.3% with E3 less than or equal to 10 mg/L in severe PIH, 23.5% in mild and moderate PIH, 37.9% in post-term pregnancy and 78.9% in intrauterine growth retardation (IUGR). It indicated that measurement of urine E3 using E3 125I-RIA is a better index for detecting and screening placenta 1 function.
This multidisciplinary research has been subdivided into two parts. The first examines prognosis of the foetus and its weight development in relation to changes in the hormonal curves of HPL and E3 carried out in a batch of 339 3rd term pregnancies. A very high incidence of small-for-date newborns (30-64%) was noted in mothers with low hormonal values and generally a more frequent onset of hypoxia in pregnancy and in labour. The second part assesses the neurological profile of children born to the same mothers examined in the first part up to the 4th year of life. A neurological deficiency of a different extent was evidenced in 33.3% of the children born to mothers with low hormonal values in pregnancy, especially among those born underweight. The neurological deficiency in the control sample was 7.84%.
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