Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “CRIPPLES”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,117 records · Page 62Linked to original sources
PubMed2003

[Current conception of rheumatoid polyarthritis treatment: towards a therapeutic revolution?].

Rheumatoid arthritis (RA) is a frequent, heterogenous crippling disease. The diagnosis must be made as soon as possible in order to begin quickly the treatment. The improvement of our knowledge in the immunopathology of RA allowed the development of new biotherapies directed against harmful mediators such as TNF alpha and Interleukin 1. With anti-TNF alpha agents excellent clinical and biological results are observed in methotrexate refractory RA patients in 70% of cases. Moreover these drugs are able to stop the X ray evolution of the disease. They can be considered as a very important new step in the treatment of RA. Other targeted drugs such as anti-IL1, anti-IL6 agents, anti-B lymphocytes monoclonal antibody (Rituximab), CTL4 IgG are already used or under study. In this paper the modern treatment of RA is reviewed with a special emphasis on anti-TNF alpha and anti-IL1 biotherapies.

Abatacept↗
PubMedDate not supplied

Is fish consumption safe?

Louisiana's vital seafood industry provides nearly 40% of domestic seafood production. Unlike Louisianans, most Americans do not enjoy fresh seafood, yet manage to eat over 4 billion pounds of seafood annually, most of it foreign, frozen, and fried! America's commercial fisheries now face crippling economic and environmental pressures from seafood imports, over-fishing, urban and agricultural wastewater runoff, harmful algal blooms, and coastal wetlands loss. As a result of these ecosystem stresses, seafood-borne disease now causes 37% of all foodborne illness in the United States. Despite recent advisories on high mercury-containing finfish consumption, seafood provides more than a third of the world with essential dietary protein, rich in cardiovascular-protective omega-3 polyunsaturated fatty acids. Louisiana and other coastal-state physicians can effectively curtail the rising threat of local seafood-borne disease outbreaks by supporting responsible coastal restoration and regulation of commercial fishing, and by recommending careful inspection, selection, and preparation of seafood.

Botulism↗
PubMed2003

Intravenous immunoglobulin G is remarkably beneficial in chronic immune dysschwannian/dysneuronal polyneuropathy, diabetes-2 neuropathy, and potentially in severe acute respiratory syndrome.

Chronic Immune Dysschwannian/Dysneuronal Polyneuropathy is an autoimmune peripheral-nerve and/or nerve-root disorder known to usually respond to intravenous immunoglobulin-G treatment. Benefit can involve any combination of motor-nerve fibers and large and small sensory-nerve fibers responsible for a progressively crippling, unbalancing, discomforting or painful disorder. "Diabetic neuropathy" is commonly considered untreatable. However, 81% of my 48 recently-summarized type-2 diabetes patients with polyneuropathy, adequately-treated with intravenous immunoglobulin-G, off-label, were relieved, sometimes completely, of various motor and sensory symptoms, including pain, thereby resembling Chronic Immune Dysschwannian/Dysneuronal Polyneuropathy. Spinal fluid protein in them is often elevated, higher values seeming to auger a better intravenous immunoglobulin-G response. Continuing the improvement requires continuing the intravenous immunoglobulin-G treatment, indicating both intravenous immunoglobulin-G responsiveness and dependency. The intravenous immunoglobulin-G responsive type-2 diabetes polyneuropathy usually is dysschwannian, sometimes mainly dysneuronal intravenous immunoglobulin-G, the most beneficial and safest treatment, is costly, but if intravenous immunoglobulin-G-treatability of a dysimmune component of type-2 diabetes neuropathy is overlooked, dismissed or rejected, as commonly happens, other costs are high regarding the patient's worsening morbidity and disability, and resultant need for increased medical care. A novel intravenous immunoglobulin-G regimen effective for fragile patients is Two Non-Consecutive-Days Every Week, using 0.4 gm/kg body wt/day. Possible molecular mechanisms of intravenous immunoglobulin-G benefit are discussed. I propose that a) there is a higher incidence of Chronic Immune Dysschwannian/Dysneuronal Polyneuropathy-like neuropathy in type-2 diabetes patients and in patients with a strong family history of type-2 diabetes, and b) the intravenous immunoglobulin-G-treatable neuropathy in type-2 diabetes can be brought on by the genetico-diabetoid-2 state. The genetic-metabolic milieu (but not necessarily glucose dysmetabolism per se.) of type-2 diabetes putatively predisposes to the presumably-dysimmune intravenous immunoglobulin-G-responsive polyneuropathy. In some of our patients, especially ones having a strong type-2 diabetes genetic background, the intravenous immunoglobulin-G-responsive neuropathy preceded the diagnosis of type-2 diabetes by 5-10 years. Accordingly, Chronic Immune Dysschwannian/Dysneuronal Polyneuropathy patients having a strong type-2 diabetes genetic background are designated "genetico-diabetoid-2 neuropathy" prior to their manifesting type-2 diabetes. Intravenous immunoglobulin-G is herein suggested as a treatment for Severe Acute Respiratory Syndrome, a recent, and feared-repetitive, pandemic with many fatalities caused by a highly-contagious mutant coronavirus, for which there is no definitive treatment. Intravenous immunoglobulin-G might: a) combat a dysimmune component of Severe Acute Respiratory Syndrome, including the reactive cytokine-chemokine storm against respiratory tissues; b) contain some antibodies effective against the coronavirus non-specific components of Severe Acute Respiratory Syndrome; c) block host-cell receptors for the virus; and d) counteract secondary infections.

Chronic Disease↗
PubMed2004

Immune strategy.

AIDS is a disease of primary immune dysfunction caused by HIV. To date, all of the approved and proven strategies for treating HIV disease focus on crippling the virus' ability to infect and/or destroy these cells. There are no approved treatments directed toward the immune deficits and dysfunctions caused by HIV. The good news is that when HIV replication is slowed through the use of anti-HIV drugs, the immune system begins to repair itself and there is evidence of a degree of immune restoration when HIV is controlled over time.

CD4 Lymphocyte Count↗
PubMed2003

[Pott's disease and different clinical presentations Pott's disease and different clinical presentations].

Skeletal tuberculosis remains a potentially crippling disease in the developing world; particularly as it usually affects children and young adults. The spine is involved approximately 50% of bone and joint tuberculosis cases. The features of four spinal tuberculosis cases were looked over this article. Their ages were between 18 and 76 years. All of them were male and immunocompetent. Pain was the major complaint. There was no life-threatening neurological sign. Among them, a case who was admitted to the hospital with painful torticollis had upper cervical-lower thoracic spinal tuberculosis with psoas abscesses and peritoneal tuberculosis, but no pulmonary involvement. The other cases had thoracolumbal spinal tuberculosis with psoas abscesses and pulmonary tuberculosis of which miliary, chronic and new pulmonary tuberculosis. The whole diagnosis of spinal tuberculosis was made by radiographically-MRI and CT-. Specific antituberculous therapy with supportive care was begun and remarkable responses without surgical intervention were seen on them except miliary pulmonary tuberculosis case. The aim of this presentation was to emphasize the importance of early diagnosis so that adequate pharmacological treatment can be initiated to avoid serious complication.

Adolescent↗
PubMed1992

Modulan grip-aids for leprosy patients.

Made-to-measure Modulan grip-aids were fitted to 755 articles for 155 patients with hand deformities due to leprosy. The acceptance of the grip-aids was, in general, good. No instance of contact dermatitis or skin irritation was reported. These grip-aids facilitated a normal grip with crippled hands, and thus considerably improved the quality of the patient's personal and working life. They increased the patient's self-esteem and self-confidence because he/she could handle everyday objects or tools without the help of others and could do his/her job--an important step toward social and economic rehabilitation.

Epoxy Resins↗
PubMed2004

Characterization of the plastid-encoded carboxyltransferase subunit (accD) gene of potato.

The plastid accD gene encoding the carboxyltransferase b subunit of acetyl-coenzyme A carboxylase (ACCase) was cloned from potato. Potato accD (saccD) is 2487 bp in length with a 614 bp 5 cent upstream promoter region and an ORF of 1524 bp, corresponding to a polypeptide of 507 amino acids. The N-terminal region lacks recognizable motifs, while the C-terminal regions contains five motifs. Among these is motif II, PLIIVCASGGARMQE, the sole motif present in all available accD sequences of plants and animals, and of E. coli, suggesting that this motif may correspond to the catalytic site. saccD has the typical prokaryotic promoter signatures, TTGACA and TATCAA, which are -35 and -10-like sequences for plastid-encoded RNA polymerase (PEP), at positions -184 and -160, respectively. However, it seems to be transcribed by the nucleus-encoded RNA polymerase because it is expressed in tuber and root, and in the dark (under crippled PEP conditions) and its transcription initiation sites do not correspond to those of PEP. saccD is expressed in all potato tissues, i.e., leaf, stem, root, and tuber, and its transcript is produced at a similar rate in the light and dark, at different developmental stages, and during growth in the presence of different sugars and carbon sources. Taken together, our results suggest that potato accD is a housekeeping gene constitutively expressed in both chloroplast and amyloplast.

Acetyl-CoA Carboxylase↗
PubMed2004

Joint injury, repair, and remodeling: roles in post-traumatic osteoarthritis.

Joint injuries, especially intraarticular fractures, frequently lead to progressive joint degeneration that causes the clinical syndrome of posttraumatic osteoarthritis. Orthopaedists try to prevent this disease by attempting to restore joint congruity, alignment, and stability; however, many patients have crippling joint pain and dysfunction develop despite optimal current treatment. The pathophysiology of posttraumatic osteoarthritis has not been explained. It is not simply the magnitude and type of injury that determines whether an injured articular surface will repair and remodel or undergo progressive degeneration. For these reasons, clinically significant progress in preventing posttraumatic osteoarthritis depends on advances in understanding of the pathogenesis of this disease that will make it possible to decrease the risk of articular surface degeneration and facilitate articular surface repair and remodeling. We examine the relationships between joint injury, repair and remodeling, and joint degeneration; the factors that increase the risk of posttraumatic joint degeneration; and, the questions that need additional investigation to develop treatments of joint injuries that will decrease the risk or severity of posttraumatic osteoarthritis.

Bone Remodeling↗
PubMedDate not supplied

Bone sialoprotein promotes bone metastasis of a non-bone-seeking clone of human breast cancer cells.

Bone sialoprotein (BSP) is a major non-collagenous protein in mineralized tissues. BSP is also implied to be involved in tumor metastasis through its unique structure. Using the human breast cancer cell line MDA-231, we established both brain-seeking and bone-seeking cell clones. The brain-seeking cells (MDA4-231BR) showed no bone metastasis in an animal model. In this experiment, MDA-231BR cells were transfected with BSP cDNA and inoculated into the hearts of nude mice. All five nude mice which received BSP-transfected MDA-231BR cells developed bone metastases, while no bone lesions were observed in the control group. Histological examination revealed invasion of tumor cells into the endosteal space and erosion of the bone margin. Some animals were crippled due to large lesions. These results suggest that BSP may impart to breast cancer cells the capacity to metastasize and thus play an important role in bone metastasis of malignant tumors.

Animals↗
PubMedDate not supplied

Is shellfish consumption safe?

Louisiana provides nearly 40% of domestic seafood production. America's commercial fisheries, especially coastal shellfish fisheries, now face crippling economic and environmental pressures from seafood imports, over-fishing, urban and agricultural wastewater runoff, harmful algal blooms, and coastal wetlands loss. As a result of these ecosystem stresses, seafood-borne disease now causes 37% of all foodborne illness in the United States. Louisiana and other coastal-state physicians can effectively curtail the rising threat of local shellfish-borne disease outbreaks by supporting responsible coastal restoration and regulation of commercial shell-fishing, especially oyster fishing, and by recommending careful selection and preparation of all shellfish and crustaceans.

Arsenic Poisoning↗
PubMed1992

Idiopathic edema.

This article describes idiopathic edema, alias fluid retention syndrome, cyclical edema, or orthostatic edema. It occurs solely in women in the absence of any currently recognized cause and its symptoms are usually dismissed as premenstrual or "minor." In severe cases, it can be both crippling and limiting. This article describes the proposed pathophysiology and the resulting effects on the fluid and sodium excretion by the kidney. Two types of idiopathic edema are depicted: orthostatic sodium retention and orthostatic water retention. A case study is presented to better illustrate this syndrome.

Adult↗
PubMed2004

[A cross-sectional study on injuries in residents from the countryside of Huanghe Delta rural areas].

OBJECTIVE: To study the incidence of injuries among residents living in the countryside of Huanghe delta area. METHODS: A household questionnaire survey was conducted to 15 276 residents in 20 villages of Dongying municipality of Shandong province with a stratified-cluster sampling on their injuries from March 1, 2002 to February 28, 2003. Data were analyzed with Excel 2000 and SPSS 11.0 software. RESULTS: The crude incidence of injuries was 5.90% in total, and the standardized incidence was 5.93%. It was higher in men (7.79%) than in women (4.03%). There were 19 deaths with 20 cripples. The standardized death rate was 122.56 per 100 000 with leading causes of injuries was blunt or by sharp articles (24.61%), traffic accident (24.17%), falls (22.62%) and animal bites (13.08%). Peak incidence of age group was high in 25 - 54 age group and 0 - 4 age group (> 6.0%). 267 cases (29.60%) inpatients had had about 15.89 days hospitalization for each case. Rest of each case with injury had 19.20 days of rest. Direct economic loss for treatment would cost 904.85 RMB Yuan and 10.15 days with care takers and 221.88 RMB for other cost. The potential years of life lost was 24 years, the working years of life lost was 19.6 year, the valued years of life lost was 8.7 year, and the standardized period expected years of life lost was 31.73 year. CONCLUSION: Injury was common and frequently occurred among residents in the countryside of rural Huanghe delta areas, that seriously endangered the health care systems and burden on families.

Accidental Falls↗
PubMed1992

When the nurse encounters crying.

1. Crying has therapeutic value. For the patient and family, crying can facilitate working through grief, promote emotional healing, and release emotions that might otherwise lead to crippling emotional or physical illness. 2. Crying may be precipitated by a variety of emotions and may be related to a variety of situations. When patients cry, the behavior may express sadness and grief, release emotion, manipulate others, be a means to cope with unresolved stress, reduce distance, and may represent emotional lability related to organic brain impairment. 3. When the patient is crying, the nurse's action should be based on an assessment of the crying and the nursing strategies appropriate for the patient's unique situation. Generally, crying should be accepted nonjudgmentally and emotional support should be provided.

Adaptation, Psychological↗
PubMed2004

[The rise and fall of Zander-Institutes around 1900 in The Netherlands].

Around 1860 the Swedish physician dr. Jonas Gustav V. Zander (1835-1920) set himself to devise different sorts of contraptions. He believed that people who needed medical gymnastics could be treated better and more efficiently with the help of machines. His mechanistic approach can be understood in the context of the upcoming industrialisation that rapidly got a hold on Europe in this period. After a very successful presentation at the World Exhibitions in Philadelphia (1876) and in Paris (1878), the Zander-method soon caught on in the medical world and many so-called Zander-Institutes (which are very similar to the fitness-centres these days) emerged in teh bigger cities of various European countries. In the nineties of the nineteenth century Zander-therapy became very popular in The Netherlands as well. In 1894 the first Zander-Institute opened its doors in Groningen. WIthin four years another eight Zander-Institutes would follow in the major cities throughout the nation. In these institutes physical education teachers, who engaged themselves in medical gymnastics, and physicians worked closely together. This was considered to be a good development, since the domain of medical gymnastics was a heavily contested area in the field of labour in the last quarter of the nineteenth century. Afer a short flourishing period almost all of the Zander-Institutes had great difficulty to survive in the first decade of the twentieth century. Both rise and fall of teh Zander-Institutes can be ascribed to a combination of factors of a scientific (with regard to the method), social (viz. legislation concerning the care of the crippled) and professional (with regard to the different strategies of the involved professions) nature. In this article these factors and teh relations between them will be described.

Academies and Institutes↗
PubMed1992

Adult scoliosis: evaluation and nonsurgical treatment.

Adult spine deformities may result from idiopathic and degenerative etiologies. These two entities may have superimposed on them an iatrogenic component from diskectomies or laminectomies done to relieve localized stenosis or disk herniations. The cumulative effect on the spine may result in painful and even crippling spine deformities. These are common, and their incidence in the adult population ranges from 3% to 30%, depending on the age group. Spine deformities are commonly painful and can be disabling, but they are rarely fatal. It is incumbent on the surgeon to understand the pathology involved in painful spine disorders and to have a reasonable understanding of the prognosis before attempting invasive therapy. An understanding of the risk/benefit ratio to the patient is also necessary. The decision to proceed with surgical treatment is justified in many cases, but it must be based on a thorough understanding of the anticipated benefits from surgical treatment and the risk of serious complications leading to multiple surgeries and results that can be less desirable than the original condition.

Adolescent↗
PubMed2005

[Biomechanical test study of rat femurs growing under different stress environment].

By creating two kinds of stress environment in the same animal model, we performed a three-point bending test and a compressing test on the rat femurs growing under different stress conditions to characterize the effect of stress on bone mechanical properties. The right hindlimbs were subjected to sciatic nerve resection to become cripple and were used as unloading group; the left hindlimbs bore excess load and made up the overloading group; the normal rats were used as control group. The animals were encouraged to exercise for half an hour everyday in the morning, noon and evening. The experiment observation finished in four weeks. The biomechanical parameters of femur diaphyses were measured. The experiment results showed that stress environment may change several mechanical parameters of rat femurs. This study indicated that bone tissues can adapt to its stress environment by changing its mechanical properties. The experimental model in this article is practical and reliable.

Animals↗
PubMed1979

The implantable infusion pump: a new concept in drug delivery.

Several of our most useful drugs cannot be administered orally. This paper is a summary of our work with a new drug delivery system: a totally implantable, continuous infusion pump, with a self-contained inexhaustible power source. Currently, after bench tests and animal experimentation, we have initiated clinical series utilizing this device to treat individuals with refractory thromboembolic conditions by intravenous heparin, and patients with localized solid tumors by intra-arterial chemotherapy. The use of this device for the infusion of insulin in the management of diabetes mellitus is yet in the laboratory stage of development. In addition to improving dy-today diabetic control and obviating the need for daily insulin injections, this pump offers an ideal opportunity to test whether optimal blood glucose control can significantly prevent or delay the onset of the crippling vascular complications of diabetes. The potential uses of this device, in many fields, are myriad.

Adult↗