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[Mechanism of impairment of energy metabolism in respiratory muscles in experimental botulism].

Phase alterations in content of adenylic nucleotides were observed in muscular and nervous tissues in dynamics of botulinic intoxication in rats. Experiments with administration of 4-aminopyridine and alpha-tocopherol showed that a decreased rate of mediator liberation in cholinergic synapses and activation of lipid peroxidation were apparently responsible for impairments in energy metabolism.

Adenine Nucleotides↗
PubMed1985

[Botulism--1983].

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Adolescent↗
PubMed1977

[Botulism after eating country smoked ham (author's transl)].

14 persons ate from a country smoked ham in which botulin was found. From this group, two had complaints which suggested a nonspecific food poisoning; two persons died. Of the dead, clinical symptoms of a botulinus intoxication could be ascertained from other people. In one case, botulinus toxin could be demonstrated in the blood, in the other the botulinus toxin was identified on forensic examination in suspensions of the preserved organ and body fluids, in spite of advanced putrefaction. Histological examination of the brain and of the cerebral and peripheral nerves provided no clear indication of the primary disease.

Adult↗