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A septic hip complicated by a ruptured appendix in an intravenous drug user.

This paper reports on a case of hip joint sepsis complicated by a ruptured appendix in an intravenous drug user. A 41-year-old woman underwent open irrigation and débridement of her right hip joint for a methicillin-sensitive Staphylococcus aureus infection. Five days later the patient developed an intraperitoneal mass, requiring laparotomy and débridement of a periappendiceal abscess. The organisms infecting the abscess were different from those infecting the patient's hip. The patient recovered satisfactorily after 6 weeks of intravenous antibiotic therapy.

Abdominal Abscess↗

The grumbling appendix in urban Zimbabwe--what are we treating?

The concept of chronic appendicitis has not been accepted by pathologists. However, quite a number of patients with chronic Right Iliac Fosa (RIF) pain are subjected to appendicectomy. Most of them are found to have fibrosed appendices indicating previous inflammation. A number are found normal. A number of urban people with Right Iliac Fosa (RIF) pain have established parasitic conditions which can be found if they are thoroughly investigated. Some of these may be responsible for the grumbling appendix syndrome.

Abdominal Pain↗

[Adenocarcinoma of the cecal appendix].

The authors report one rare case of primary adenocarcinoma of the vermiform appendix. The patient, an 83 year old female, presented with a non-pathognomonic symptomatology; diagnosis was made postoperatively. Surgery consisted of appendicectomy. The patient, due to her poor general condition, died three days after surgery for cardiocirculatory complications. In the light of the very rare case published in the literature, some diagnostic, anatomic-clinical, therapeutic and prognostic aspects of this rare tumor are discussed.

Adenocarcinoma↗

Novel immunohistochemical localization of 28,000 molecular-weight (Mr) calcium binding protein (calbindin-D28k) in enterochromaffin cells of the human appendix and neuroendocrine tumors (carcinoids and small-cell carcinomas) of the midgut and foregut.

Calbindin-D28k is a highly conserved 28,000 (dalton) molecular-weight (Mr) calcium binding protein with broad tissue distribution, yet cell-type-specific expression predominantly in subpopulations of central and peripheral nervous system neurons, distal tubular cells of the kidney, and enteric neuroendocrine cells. A polyclonal antiserum against rat renal calbindin-D28k and a monoclonal antibody to calbindin-D28k purified from chicken intestine (clone CL-300) were used for immunohistochemical evaluation of formalin-fixed, paraffin-embedded tissues from multiple areas of the human small and large intestines and 93 primary neoplasms of the gastrointestinal tract (foregut, midgut, and hindgut derivatives) and the lung (foregut derivative). Calbindin-D28k immunostaining was obtained in a minority of enterochromaffin (neuroendocrine) cells, predominantly of the appendix and small intestine, as well as in autonomic neurons of the neural plexuses. Focal cytoplasmic Golgi-type staining was obtained with monoclonal antibody CL-300 in the appendiceal surface epithelium and dendritic macrophages confined to the appendiceal lymphoid follicles. Epithelial progenitor cells in enteric crypts and absorptive, goblet, and Paneth cells were calbindin-D28k negative, while no immunoreactivity was demonstrated in the mucosae of the colon and rectum. Calbindin-D28k staining was consistently detected in subpopulations of neuroendocrine phenotypes in midgut (appendiceal/ileal) and foregut (bronchial) carcinoids and small-cell carcinomas, but was absent in adenocarcinomas, squamous cell carcinomas, leiomyomas/leiomyosarcomas, schwannomas, and lymphomas. Our observations suggest that calbindin-D28k is a novel adjuvant neuroendocrine marker that is potentially useful in diagnostic tumor immunohistochemistry.

Adult↗

The long-term outcome after negative appendix operation.

We evaluated the long-term outcome of "negative appendix" (NA) by analysing the follow-up results of 76 patients identified from a group of 670 appendectomized patients. Randomly selected and histologically proven cases of true acute appendicitis (TA) matched for age and sex were identified to construct case control pairs. Special interest was focused on gender and age, by analysing the results separately in men and women in two age groups (15-39 years and > or = 40 years). The results showed that NA was most common in women aged 15-39 years (21% of appendectomized cases in this age group). At follow-up examination after a mean follow-up of 2.9 years two-thirds of patients were symptomfree. Women aged 15-39 years had significantly more complaints (P < 0.05) and findings (P < 0.05) than patients with TA. In women aged > or = 40 years no significant differences were detected, nor in either age groups in men. Lactose intolerance was the most common finding in symptomatic patients. In conclusion, patients with NA were mostly young women. At long-term follow-up the great majority of patients were symptomfree and appeared not to have developed any serious disease. Routine follow-up for patients with NA does not thus seem necessary.

Adolescent↗

[Carcinoma of the appendix--rare but important].

Villous adenoma of the vermiform appendix is very rare; the treatment of choice is appendectomy. We report a 72-year-old woman with a villous adenoma and a single focus of invasive, colonic adenocarcinoma. This finding required changes in diagnostic procedures and treatment, and altered the prognosis. The purpose of this report is to increase awareness of this phenomenon and to indicate correct management.

Adenocarcinoma↗

Ectopic kidney presenting as appendix mass or abscess.

Renal ectopia is very rare and its associated pyelonephritis can simulate an appendix mass/ abscess or colonic tumour which may result in needless surgical exploration, as illustrated by our experience with 3 cases reported in this article. Careful ultrasonography and urinalysis can obviate this confusion and save unnecessary operation.

Female↗

Unusual tumors of the appendix and pseudomyxoma peritonei.

This report covers hyperplastic and neoplastic lesions of the human vermiform appendix that, although unusual, are likely to be encountered by general surgical pathologists. Topics include epithelial neoplasms, hyperplastic polyps, diffuse epithelial hyperplasia, pseudomyxoma peritonei, goblet cell and tubular carcinoid tumors, neuroma, and neurogenous hyperplasia. We discuss recent advances in the prognosis and management of appendiceal carcinoma, current controversies regarding the relationship between ovarian and appendiceal epithelial neoplasms, the concept of the mucinous tumor of uncertain malignant potential (UMP), and practical aspects of reporting pseudomyxoma peritonei. Classical carcinoid tumors are beyond the scope of this article, and primary neoplasms that are so rare they occur in the literature only as isolated case reports are not covered.

Adenocarcinoma↗

[Hemoperitoneum caused by lesions to the appendix epiploica. An unusual complication of colonoscopy].

A rare case of hemoperitoneum in a young man who performed a diagnostic colonoscopy is reported. The rupture of an epiploic appendix among rectum and colon sigma caused massive bleeding into the peritoneum cavity followed by haemorrhagic shock. Diagnostic and therapeutic colonoscopy has a low rate of morbility; perforation and bleeding are the most common events; hemoperitoneum following colonscopy is usually due to spleen rupture. Among other complications, ileal and cecal volvolus, incarceration of hernias and subcutaneous emphysema are reported.

Adult↗

[Mucinous cystadenocarcinoma of the appendix. A rare case].

The authors report case of mucinous cysto-adenocarcinoma of the vermiform appendix which was not diagnosed during appendectomy but by routine histological tests. The patients was reoperated and underwent right hemicolectomy with lymphadenectomy, ending with the creation of an ileo-transverse stomy. At the follow-up after 1, 6 and 12 months, the patient showed no signs of recurrence of the disease. The authors examine this rare pathology which, owing to the difficulty of preoperative diagnosis, often results in the patient undergoing a second operation, and given the early diffusion of the disease frequently presents a severe prognosis.

Adult↗

Schistosomiasis of the appendix in the UK.

Schistosomiasis is endemic in many parts of the world but is rare in the UK. It usually affects the bladder or intestine, resulting in bleeding and fibrosis. However, schistosomal eggs are frequently found in the appendix and these can be symptomatic. The present case describes appendiceal infestation accompanied by acute appendicitis.

Adult↗

[Laparoscopic appendectomy as routine operation for treatment of inflammatory diseases of the appendix. Analysis of 733 laparoscopic appendectomies 6/1992 to 8/1997 in the Reichenbach district hospital].

All laparoscopic appendectomies were analysed retrospectively during 6/1992 and 8/1997 in our hospital. Operation time was 33.6 +/- 12.9 min. In 9 patients the operation had to be converted. Complications occurred in 1.77% (13 patients). 7 complications could be treated laparoscopically and 6 required a laparotomy. The hospital time was 6.4 +/- 2.2 days. The patients needed 1.3 +/- 1.7 days oral analgetics. We believe the laparoscopic appendectomy a reliable operation to treat all inflammatory diseases of the appendix.

Adolescent↗