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Vitamin deficiencies and neural tube defects.

Serum folate, red cell folate, white blood cell vitamin C, riboflavin saturation index, and serum vitamin A were determined during the first trimester of pregnancy in over 900 cases. For each of these there was a social classes I + II showed the highest levels which differed significantly from other classes, except for serum folate. In 6 mothers who gave birth to infants with neural tube defects, first trimester serum folate, red cell folate, white blood cell vitamin C, and riboflavin values were lower than in controls. In spite of small numbers the differences were significant for red cell folate (P less than 0-001) and white blood cell vitamin C (P less than 0-05). These findings are compatible with the hypothesis that nutritional deficiencies are significant in the causation of congenital defects of the neural tube in man.

Adult↗

Vitamins and sport.

In a double blind test on 40 men and women high performance fencers the influence of a multivitamin-electrolyte-preparation on reaction time, hit-frequency and neuromuscular irritability was determined. Evidence of B1, B2 and B6-deficiencies up to 70% were found. After application of the preparation an increase of performance of 3% could be observed. The tests were carried out by means of coenzymatic activation of the respective vitamins in the haemolysate of erythrocytes. The results are explained by the role of the vitamins in the human organism and by the special conditions under which endurance athletes have to perform: high turn-over rate of the energy metabolism, an increase of the body core temperature and thus increased sweat loss, factors leading to deficiencies of the water soluble B-vitamins.

Adolescent↗