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At least 1,099 records · Page 61Linked to original sources
PubMed1996

Exposure to styrene and mortality from nonmalignant respiratory diseases.

A cohort of 34,560 men and 6128 women employed in 660 European factories manufacturing reinforced plastic products, followed up originally to assess the risk of cancer, was used to assess the risk of non-malignant respiratory diseases associated with exposure to styrene. Mortality from pneumonia was associated with intensity of exposure to styrene, but this may have been due to chance. Mortality from bronchitis, emphysema, and asthma was not associated with styrene exposure.

Cohort Studies↗
PubMed1986

Variations in respiratory disease morbidity among pulp and paper mill town residents.

This study investigated whether occupational exposure in pulp and paper mills or geographic proximity to mills was associated with an increase in risk for respiratory disease hospitalizations. Three years (1980 to 1982) of 100% age- and sex-adjusted hospital admission rates for selected respiratory diagnoses were calculated for 66 Maine towns located between 0 and 15 miles for seven Kraft mills and four groundwood pulp and paper mills. Additional data collected for each town included the number of production workers at each mill, mill proximity, insurance coverage, hospital distance, bed size, full-time equivalent physicians, unemployment and income rates. Regression results provide evidence that occupational exposure may be a significant factor in hospitalizations for respiratory infections, bronchitis and asthma, and respiratory signs and symptoms, although potential confounders (smoking, commercial health insurance) need to be examined.

Aged↗
PubMed1992

Changes in the bacterial flora of the upper and lower respiratory tracts and bronchoalveolar lavage differential cell counts in feedlot calves treated for respiratory diseases.

Serial nasopharyngeal swab and bronchoalveolar lavage cultures were used to estimate changes in the bacterial flora of the respiratory tracts of calves during the first month after arrival in the feedlot. Bronchoalveolar lavage (BAL) differential cell counts served to evaluate pulmonary inflammatory changes during this period. Two groups of calves were studied, one consisting of clinically normal controls (n = 60), the other, of cases (n = 59) which received treatment for respiratory disease (penicillin +/- trimethoprimsulfadoxine). A variety of organisms, including Pasteurella multocida, Pasteurella haemolytica, Haemophilus somnus, Mycoplasma bovis and Mycoplasma bovirhinis, were present in the upper and lower airways of both groups during the postarrival period. With the exception of M. bovis, an overall decline in the prevalence of these organisms was observed during the course of the study. In cases, there was a marked decrease in the number of Pasteurella spp. and H. somnus isolates immediately following treatment. For the Pasteurella spp., however, this effect was shortlived as they often appeared to recolonize the respiratory tract within eight days of terminating antimicrobial therapy. Treatment did not appear to affect the frequency of isolating M. bovis. Its prevalence, in both groups of calves, increased to levels approaching 100% during the course of the study. All Pasteurella spp. isolates were tested for susceptibility to several commonly used antimicrobials. Resistance was only evident among P. haemolytica isolated from cases and in every instance this was to a combination of penicillin, ampicillin and tetracycline. Significantly more isolates were resistant after treatment than before. There were BAL differential cell count abnormalities indicative of inflammation in both cases and controls.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1978

A study of acute respiratory disease in the community of Port Chalmers. II. Influenza A/Port Chalmers/1/73: intrafamilial spread and the effect of antibodies to the surface antigens.

During the first year of a study of respiratory disease in the semi-isolated community of Port Chalmers, New Zealand, an epidemic of clinical influenza occurred from which the variant influenza A/Port Chalmers/1/73 (H3N2) was isolated. Within a selected group of 26 families, 59 (46%) members had clinical or laboratory evidence of infection. During intrafamilial spread the infection frequency was highest for school-aged children (77%), followed by female adults (67%), infants (64%) and male adults (41%). The index infection in each family was a school-age child on 10 occasions, suggesting the role of this age group in the transmission of influenza A in this community. The secondary attack rate (SAR) of 58.3% was higher than expected. In sera taken before the 1973 epidemic, 59% of family members had detectable HI antibody and 25% NI antibody to A/England/42/72 while 38% had detectable HI antibody and 8% NI antibody to A/Port Chalmers/1/73. The relation between pre-existing antibody and infection frequency is discussed.

Adolescent↗
PubMed1981

The interrelations of some humoral factors of resistance with the prevalence of respiratory diseases in children. I. The differences among the protein levels in healthy and ill children.

The prevalence of respiratory diseases was followed in a group of 80 children (39 boys and 41 girls) of mean age 12.4 +/- 0.9 years during the part of school year (November - May incl.). The specimen of blood was taken from all studied children before the study started and the values of nine serum proteins were measured (IgG, IgA, IgM, IgE, alfa 1-antitrypsin = A 1-AT, transferrin = TRF, ceruloplasmin = CPL, alpha 2-macroglobulin = A 2M, lysozyme = LYS), as well as levels of two secretory proteins in saliva (sIgA and sLYS). The difference between the subgroup of boys, who fall into some respiratory illness during the observation time, and those who remain healthy, did not reach the level of significance. In contrast, the girls subgroup revealed significantly higher respiratory morbidity. With those girls, who remained healthy, the levels of serum IgE were highly increased and A 1-AT level weakly increased compared to ill girls. The level of TRF and CPL were significantly decreased with the healthy girls.

Blood Proteins↗
PubMedDate not supplied

Acute respiratory disease in Spain: seven years of experience.

The clinical and epidemiologic features of viral and nonviral pathogens involved in acute respiratory diseases are described in the context of cases of infection (especially atypical pneumonia and bronchiolitis) studied at the Centro Nacional de Microbiología, Virología e Immunología Sanitarias in Madrid during a 7-year period (1979-1986). These etiologies were demonstrated in 1,637 (36.2%) of 4,521 cases. Among viruses, respiratory syncytial virus most frequently infected children; influenza virus showed the same pattern of circulation as in other European countries. Of nonviral agents, Mycoplasma pneumoniae and C. burnetii were most often involved in lower respiratory tract infections, with a variable predominance in patients of different ages. A high proportion of cases of M. pneumoniae infection occurred in infants and children aged less than 1 year, and most of these cases occurred during spring and summer. The majority of Q fever cases, including those observed in two outbreaks, occurred in the northern region.

Acute Disease↗
PubMed1988

Cefodizime in acute purulent exacerbations of chronic respiratory disease.

Clinical, microbiological and pharmacokinetic studies were carried out after 1 or 2 g intramuscular injections bd of cefodizime (HR 221), a new aminothiazolyl cephalosporin, in 41 patients hospitalized for acute purulent exacerbations of chronic respiratory disease. Treatment was for 10 days. Serum Cmax values of 54.8 and 84.7 mg/l were recorded approximately 2 hours after the injections, the corresponding sputum values averaging 1.01 and 2.58 mg/l. Penetration from blood to sputum was 2 to 3.6%. The elimination phase half-life in serum was approximately 4.5 h. Clinical, microbiological and pharmacokinetic studies were carried out after 1 or 2 g intramuscular injections bd of cefodizime (HR 221), a new aminothiazolyl cephalosporin, in 41 patients hospitalized for acute purulent exacerbations of chronic respirators disease. Treatment was for 10 days. Serum Cmax values of 54.8 and 84.7 mg/l were recorded approximately 2 hours after the injections, the corresponding sputum values averaging 1.01 and 2.58 mg/l. Penetration from blood to sputum was 2 to 3.6%. The elimination phase half-life in serum was approximately 4.5 h.

Adult↗
PubMedDate not supplied

[Nonspecific methods of prophylaxis of influenza and other acute respiratory diseases with dibasole and ascorbic acid].

A marked prophylactic effect of dibasole and ascorbic acid in influenza and other acute respiratory diseases (ARD) is described. The analysis was based on comparison with a control group observed for the same period and being at the same risk of contracting infection with influenza or other ARD. The control group was given glucose according to the same procedure.

Acute Disease↗
PubMed1976

Chronic nonspecific respiratory disease in Berlin, New Hampshire, 1967 to 1973. A further follow-up study.

The 1967 sample of Berlin, New Hampshire was resurveyed in 1973 by means of a standard questionnaire on respiratory symptoms and by simple tests of pulmonary function. Measurements of the levels of air pollution showed a decrease in the number of suspended particulates and an increase in the concentration of sulfation. These values were close to the Federal Primary Standard. No differences in respiratory symptoms, prevalences of chronic, nonspecific respiratory disease, or pulmonary function were detected. Within the limitations of this study, we concluded that the Federal Primary Standards for sulfur dioxide and total suspended particulates are probably adequate to protect the public.

Adult↗
PubMed2000

Deficiency of lamellar bodies in alveolar type II cells associated with fatal respiratory disease in a full-term infant.

We report a case of a full-term female infant who presented with severe respiratory distress shortly after birth and died at 23 d of age with unremitting respiratory failure. Infectious and other known causes of respiratory disease in this clinical setting were excluded. Examination of a lung biopsy showed abnormal lung parenchyma with features reminiscent of desquamative interstitial pneumonitis. Ultrastructural studies revealed that alveolar type II cells lacked cytoplasmic lamellar bodies, while other organelles appeared normal. Histochemical and immunohistochemical investigations indicated normal alveolar type II cell marker expression including surfactant proteins (SP-A, SP-B, pro-SP-B, and pro-SP-C). Mutations in the coding sequences of the SP-B gene were excluded as a cause of disease. This case appears to be a novel congenital defect affecting the pulmonary surfactant system. The cellular abnormality may involve the assembly of cytoplasmic lamellar bodies in alveolar type II cells-the principal storage site of pulmonary surfactant.

Biopsy↗
PubMed2001

[Smoking in adolescents, saliva cotinine concentrations and respiratory disease].

OBJECTIVE: To assess cotinine levels in the saliva of adolescents and the relationship between these levels, smoking habits and respiratory disease. PATIENTS AND METHODS: We studied 420 adolescents (54.7% boys and 45.3% girls) aged between 14 and 21 years (mean age, 16.4 +/- 1.32), from state and private schools in Tenerife. An individualized survey, based on the American Thoracic Society's model, was carried out and saliva cotinine concentrations were determined by radioimmunoassay. RESULTS: Distribution according to smoking habits was as follows: 26.5% were regular smokers, 11% were sporadic smokers, 3.6% were former smokers, 45.6% were passive smokers, and 13.4% were not exposed to smoking. Mean cotinine levels were 225.4 ng/ml in regular smokers, 19.5 ng/ml in sporadic smokers, 17.4 ng/ml in former smokers, 4.2 ng/ml in passive smokers and 2.2 ng/ml in individuals not exposed to tobacco smoke, which demonstrated the correlation between saliva cotinine concentrations and smoking habits (p=0.0001). The cotinine level in smokers of <10 cigarettes/day was 142,7 ng/ml and in smokers of >10 cigarettes/day it was 341,1 ng/ml (p=0.0001). A significant correlation was also found between cotinine concentrations and the number of cigarettes smoked regularly and in the last 24 hours before sample collection (p=0.0001). Lower respiratory tract infection (p=0.0001), chronic cough (p=0.0001) and bronchospasm on physical exercise (p=0.0001) were more frequent in adolescents with higher cotinine concentrations. CONCLUSIONS: Higher saliva cotinine concentrations were correlated with greater tobacco consumption and exposure to tobacco smoke. Adolescents with lower respiratory tract infections, chronic cough and bronchospasm on physical exercise had higher saliva cotinine concentrations.

Adolescent↗
PubMed2005

The blocking effect of essential controller medications during aspirin challenges in patients with aspirin-exacerbated respiratory disease.

BACKGROUND: The blocking effect of controller medications for asthma could have an effect on the outcome of aspirin challenges in patients suspected of having aspirin-exacerbated respiratory disease (AERD). OBJECTIVE: To evaluate whether there was any blocking effect of long-acting beta2-agonists, systemic corticosteroids, and/or inhaled corticosteroids alone or as co-therapy with leukotriene modifier drugs (LTMDs). METHODS: Between 1981 and 2004, 678 patients with suspected AERD were admitted for aspirin challenge and desensitization. All patients had asthma, chronic sinusitis, nasal polyposis, and at least 1 historical reaction to a nonsteroidal anti-inflammatory drug. Asthma controller medications taken during aspirin challenge were recorded and analyzed with respect to their potential effects on 4 possible outcomes of aspirin challenge, namely, naso-ocular reaction, lower airway reaction, classic upper and lower airway reaction, or a negative challenge result. RESULTS: When compared with AERD patients who received no controller medications, the combined use of LTMDs, inhaled corticosteroids, and long-acting beta2-agonists led to a statistically significant change in aspirin challenge outcomes (P = .009), mainly shifting the reaction from a classic upper and lower respiratory tract reaction to naso-ocular reactions only. LTMDs appeared to have the strongest effect (P < .001) in blocking lower respiratory tract reactions. Systemic corticosteroids did not have the same effects. Blocking of both upper and lower respiratory tract reactions to aspirin as a result of taking controller medications did not occur. CONCLUSION: Controller medications are frequently needed to stabilize airways of patients with AERD. LTMDs alone or in combination with other controllers blocked lower respiratory tract reactions during aspirin challenge in some patients with AERD but did not change the overall rate of positive aspirin challenge results and did not lead to false-negative challenges.

Administration, Oral↗
PubMed1994

The clinical recovery of fattening pigs from respiratory disease after treatment with two injectable oxytetracycline formulations.

A double blind randomized clinical trial was performed with pigs suffering from clinical respiratory disease. The goal of the trial was to test the null hypothesis that the clinical recovery after treatment with two oxytetracycline injectables with different pharmacokinetic profiles (high peak concentration and low persistence versus low peak concentrations and long persistence) was similar. Fattening pigs (n = 529) were treated intramuscularly with either product A or product B at a dose of 20 mg OTC per kg b.w. when they showed signs of acute pneumonia, i.e., coughing, tachypnoea or dyspnoea combined with a rectal temperature of 40 degrees C or higher. When necessary, treatment was given again after 3 and/or 6 days. Both treatments resulted in a rapid fall in mean temperature and an improved clinical condition. In this trial no significant differences were found in clinical recovery between the two therapies as measured by group mean temperature, number of pigs requiring retreatment, and time to recovery. The conclusion that there was no important difference in clinical recovery between the treatment groups was made with a power of at least 90%.

Animals↗
PubMed1993

Human respiratory disease: environmental carcinogens and lung cancer risk.

Inhalatory intake of environmental agents may have adverse effects on health, the lung being the first target. Therefore, an increased risk of lung cancer and respiratory disease is in general considered as an indication of environmental health problems related to exposure to industrial emissions, traffic exhaust and smog. Classical epidemiological studies of the association between exposure to ambient air pollutants and respiratory dysfunctions and studies with laboratory animals have failed to demonstrate the distinct proof of risk for the general population that would be needed to form a basis for high impact environmental policy measures. Here, as an example, we describe the uncertainty in assessing risks of lung cancer associated with environmental exposure to polycyclic aromatic hydrocarbons. The recently introduced methodology of molecular cancer epidemiology is considered to yield more information on the relationship between exposure to environmental carcinogens and tumour development. Recent advances in the study of carcinogen (polycyclic aromatic hydrocarbon) dosimetry at the DNA level in combination with proto-oncogenic activation in humans are described.

Animals↗
PubMedDate not supplied

Risk of acute respiratory disease among pregnant women during influenza A epidemics.

The medical literature contains little information on the occurrence of excess morbidity among pregnant women during recent influenza epidemics. Rates of medical visits for acute respiratory disease (ARD) among pregnant and nonpregnant members of a large prepaid practice population were examined. Use of medical services for ARD was ascertained for approximately 1,000 pregnant women and 3,000 nonpregnant women during each of four epidemic periods (1975, 1976, 1978, 1979) and a nonepidemic period (1977). Comparing the combined epidemic periods with the nonepidemic period, there were significant excesses of 23.7 (standard error (SE) = 8.1) ARD contacts per 1,000 attributable to epidemic influenza for pregnant women and 10.2 (SE = 3.4) for nonpregnant women. ARD hospitalization rates among pregnant women were low (2 per 1,000), and there were no maternal deaths. The significant ARD excess among pregnant women was concentrated in the 1978 period with reappearance of the A/Russia H1N1 subtype in the community and was confined to those under age 25 who would not have ben previously exposed to this subtype (94.4 (SE = 28.5]. These findings indicate that recent influenza epidemics caused only modest excess ARD morbidity among pregnant women, and significant excess occurred only in association with antigenic shift. These findings support current national policy recommendations with respect to influenza vaccination of pregnant women.

Adult↗
PubMed2001

A field comparison of the efficacy and tolerance of marbofloxacin in the treatment of bovine respiratory disease.

A multicentre, controlled, randomized and blinded trial was carried out in 180 ruminating calves with pyrexia and respiratory sign(s) on nine Belgian, British and French farms. All animals were sampled for pathogenic bacteria before treatment and at failure/relapse. Calves were injected with either marbofloxacin (M) solution [Marbocyl (Laboratoire Vétoquinol, Lure, France) 10%] at 2 mg/kg/24 h for 4 days intravenously on the first day then subcutaneously, or tilmicosin (T) solution (Micotil, Elanco Products Ltd, Basingstoke, Hants, UK) at 10 mg/kg as a single subcutaneous (s.c.) injection. The animals were examined clinically eight times up to day 28. The bacterial pathogens were found to be sensitive to marbofloxacin: for Pasteurella haemolytica the minimum inhibitory concentration (MIC)90 was 0.08 microg/mL and for P. multocida the MIC90 was 0.04 microg/mL. Cure rates at day 4 for group M and group T were 84 vs. 82%, respectively (P > or = 0.05). However, overall clinical score was significantly lower after 1 day in group M (P < 0.05). There was no difference in either relapse rate or average daily weight gain between groups. Marbofloxacin was found to be better tolerated than tilmicosin at the s.c. injection site (77.5 vs. 42.2% calves without local swelling, P=0.001) and was well tolerated when injected intravenously. Marbofloxacin was shown to have comparable but faster efficacy and better local tolerance than tilmicosin in the treatment of bovine respiratory disease (BRD).

Analysis of Variance↗
PubMedDate not supplied

Large, persistent epidemic of adenovirus type 4-associated acute respiratory disease in U.S. army trainees.

In May 1997, a large, persistent epidemic of adenovirus type 4-associated acute respiratory disease began at Fort Jackson, South Carolina, the largest army basic training center. The epidemic lasted until December and declined when vaccine administration resumed. More than 1,000 male and female trainees were hospitalized; 66.1% of those hospitalized had an adenovirus type 4 isolate.

Acute Disease↗