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Results for “PULMONARY HEART DISEASE”

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At least 1,099 records · Page 61Linked to original sources
PubMed1977

Pharmacokinetics of digoxin.

The pharmacokinetics of digoxin, the most frequently used digitalis preparation, are reviewed. The dominate serum turnover time is about 34 hours, and is not affected by the route of administration. Excretion is largely as unchanged digoxin in the urine and this excretion is compromised in renal failure. Serum levels of digoxin (determined by radioimmunoassay) are generally available and are useful clinically in assessment of both toxicity and the state of underdigitalization, even though significant overlap exists. Special problems are presented in patients with myocardial infarction, pulmonary heart disease, and thyroid disease.

Acute Kidney Injury↗
PubMed1987

Concomitant lung cancer and surgical heart disease.

Concomitance of pulmonary carcinoma and heart disease poses problems of management. We encountered this disease combination in 6 of 2,139 patients operated on with extracorporeal circulation during a 5-year period. Our policy has been to correct the heart disease first. The tumour was subsequently operated on in five of the six patients, but the sixth was subjected only to excisional biopsy of malignant tumour nodules during the heart operation. There was no operative mortality. Three patients died in the follow-up period. A treatment strategy is suggested, based on our experience and on a review of the literature.

Female↗
PubMed1977

Fibrin thrombosis in monocrotaline pyrrole-induced cor pulmonale in rats.

Investigations were carried out to determine the lung lesions responsible for the development of pulmonary heart disease, cor pulmonale, in rats treated with monocrotaline pyrrole or monocrotaline. Animals with right ventricular hypertrophy showed microscopic lung alterations consisting of alveolar edema; fibrin thrombi with partial to complete occlusion of arteries, arterioles, capillaries, and veins; connective tissue proliferation of alveolar septae; cellular hyperplasia of septae; and medial hypertrophy of arterioles. Due to the high incidence of fibrin thrombi in animals with right ventricular hypertrophy, we believe that formation of fibrin thrombi plays a decisive role in the development of chemically induced cor pulmonale.

Animals↗
PubMed1998

Pulmonary arteriovenous malformations in and out of the setting of congenital heart disease.

BACKGROUND: Pulmonary arteriovenous malformations can occur in a variety of clinical situations, including liver disease, systemic disorders, or after palliation of congenital heart disease, with serious clinical consequences. METHODS: We reviewed the potential mechanisms of this condition, diagnostic tools, and clinical management. RESULTS: Contrast echocardiography is an important diagnostic modality, which has been shown to be more sensitive than pulmonary arteriography, especially when rapid contrast injection is used. The finding that pulmonary capillary vasodilation is observed in hepatopulmonary syndrome, in cirrhotic patients, and after congenital heart repair is strongly suggestive that an unidentified hepatic factor is involved in inhibiting the development of pulmonary arteriovenous malformations. CONCLUSIONS: Prompt detection and treatment of pulmonary arteriovenous malformations is of utmost importance, to prevent serious clinical consequences. It may very well be the case that the etiology of arteriovenous malformations is multifactorial. We are now investigating the role of alterations of gene expression in the vascular remodeling that results in formation of pulmonary arteriovenous malformations.

Arteriovenous Malformations↗
PubMed1990

Relation between mean ventricular phases in chronic cor pulmonale measured by radionuclide ventriculography.

ECG-gated equilibrium radionuclide ventriculography was performed in 17 patients with pulmonary heart disease (Cp) and in 11 healthy subjects (Nm). Fourier analysis was applied to the time activity curve in each pixel, and the phase and amplitude of the basic frequency were computed. From the pixel-by-pixel values, the mean phase of each ventricle was calculated. It was found that the difference between mean phase of right and left ventricle (psi(R-L)] was significantly greater in Cp (+13.8 degrees +/- 7.8 degrees) than in Nm (-0.3 degrees +/- 3.9 degrees). This difference was almost twice as great in Cp with RV failure (+15.9 degrees +/- 7.8 degrees) than in those without it (+8.8 degrees +/- 5.1 degrees). Abnormally increased psi(R-L) values were detected in about 70% of patients with Cp. Interventricular phase difference had a weak positive correlation with the amplitude of S wave in lead I of the ECG (r = 0.533). It is concluded that in most patients with Cp the phase of the RV contraction is delayed and that this delay may be connected with deterioration of RV performance.

Electrocardiography↗