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Aortic occlusion by a balloon catheter: a method to induce hind limb rigidity in rats.

Post-ischaemic spinal extensor or flexor rigidity can be induced in different species by clamping or ligature of the descending aorta after thoracotomy or laparotomy. A similar motor deficit can also be induced by an intraluminal aortic occlusion produced by inflation of a balloon attached to the tip of a catheter inserted via the femoral artery. This method is easy to perform and avoids all the possible complications of thoracotomy or laparotomy. In rats the occlusion time for obtaining the maximum percentage of animals exhibiting a permanent hind limb extensor (62.5%) or flexor (12.5%) rigidity was 15-16 minutes. A marked depression of hind limb sensory perception accompanied this rigidity but there were no urinary, bowel or skin disturbances. The unilateral femoral ligation following the catheterization did not induce a difference in muscle tone between both hind limbs. The present procedure which is simpler than other published procedures might thus serve as a useful animal model for spastic paraplegia.

Animals↗

Severe muscular rigidity at birth: malignant hyperthermia syndrome?

A case of severe muscular rigidity in a premature male infant born by Caesarean Section under general anaesthesia is described. A probable diagnosis of malignant hyperthermia was supported by the clinical symptoms of muscular rigidity and cyanosis, a creatinine phosphokinase of 24,630 I.U. (Normal 0--100) and a urinary myoglobin of 248 mg/l (normal 6--35). The muscle tone and laboratory values slowly returned to normal over a period of days. Anaesthetic management for a ventriculoperitoneal shunt performed at seven weeks of age included pre and postoperative treatment with dantrolene. No crisis occurred at this time. The parents, who have normal CPK and a negative family history, were advised to treat the child as if he had malignant hyperthermia until such time as a definitive diagnosis can be made.

Anesthesia, General↗

Acoustic changes related to laryngeal examination with a rigid telescope.

The influence on voice quality of the insertion of endoscopic equipment with tongue anchoring and head position requirements during endoscopic evaluation has not been fully investigated. The present study attempted to examine the influence of: (1) the presence of a rigid endoscope and tongue anchoring, and (2) the angle of position technique (70-degree and 90-degree) on participants' vocal output during sustained production of the vowel /i/. Five acoustic measurements including fundamental frequency (F0) values, percent jitter values, relative average perturbation of F0 shimmer, and noise-to-harmonic ratios were used to represent participants' voice quality. Results indicated that F0 values were significantly influenced by the angle of sitting position, while percent jitter values, relative average perturbation of F0, shimmer, and noise- to-harmonic ratios were affected by the presence of a rigid endoscope and tongue anchoring.

Adult↗

[Unilateral abolition of parkinsonian rigidity after subthalamic nucleus hemorrhage].

A 63-year-old man with parkinsonism suddenly developed a right hemiballism, and the CT showed a hematoma of the left subthalamic nucleus. After the ballistic movement had disappeared, muscular rigidity improved on the right. This case suggests that excessive output from the subthalamic nucleus to the internal segment of globus pallidus plays a critical role in the pathophysiology of parkinsonian rigidity.

Cerebral Hemorrhage↗

The hemodynamic influence of the ischiocavernosus muscles on erectile function.

PURPOSE: Special attention has been focused on the contribution of the ischiocavernosus muscles to intracorporeal pressure during erection. MATERIALS AND METHODS: Length of the ischiocavernosus muscles and corpora cavernosa was studied in 30 cadavers. RESULTS: A biomechanical model for calculating interference of the ischiocavernosus muscles in rigidity during the initial phase of penile erection is proposed. CONCLUSIONS: We found that, among other things, intracorporeal pressure can be influenced by the ischiocavernosus muscles during erection.

Cadaver↗