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[Early detection of chronic obstructive pulmonary disease by following individual annual changes in lung function].

The possibility of early detection of chronic obstructive pulmonary disease (COPD) was investigated among subjects whose lung function could be followed for more than ten years. Ten subjects aged 60 or more were selected from among about 1500 cases using the following diagnostic criteria; (1) subjects had complained of exertional dyspnea (2) chest X-ray abnormalities were suggestive of COPD (3) FEV1.0% was under 55%. Data on FVC/height, FEV1.0/height and FEV1.0% of these subjects were available for the previous ten years. Individual linear regression equations were estimated. Average annual changes of cases of obstruction were compared with those of normal cases, and individual deviations from the normal standard range were observed. Declines of the regression lines were as follows; FEV1.0/height: normal case--0.016 +/- 0.017, obstruction cases--0.038 +/- 0.018 (L/m/yr), FEV1.0%: normal cases 0.164 +/- 0.627, obstruction cases--1.522 +/- 0.638 (%/yr). Significant differences were observed between the normal and the obstruction cases (p < 0.01). FEV1.0% of all obstruction cases was under--2 SD of that of normal subjects. All individual FEV1.0% regression lines of the obstruction cases were outside +/- 2 RSD of the normal standard range more than 5 years before the onset of symptoms. Following individual annual changes in lung function was considered to be useful for the early detection of COPD.

Adult↗

[Association of borderline glucose tolerance to dietary intakes and life style-cross sectional study of urban male workers examined at the annual health examination].

In this study, the association of borderline glucose tolerance to dietary intakes and life style was examined. Subjects were 2215 male workers aged 23 through 69, who visited a medical examination center in Tokyo between January 1987 through February 1989 for an annual health examination. Based on results of a 75 gram glucose tolerance test, subject were divided into three groups: 1. diabetes mellitus,2. borderline glucose tolerance, and 3.normal. Nearly one half of the subjects were found to have borderline glucose tolerance. Clinical results and ages of the borderline glucose tolerance group were between those of the normal and the diabetes mellitus groups. Differences between the borderline glucose tolerance group and the normal group with respect to dietary intake and life style were analyzed by a logistic model. Because associations were found to differ by obesity level (calculated by Katsura method) in the primary analysis, second stage analysis was performed with obesity level. For subjects who were less than 10% overweight, borderline glucose tolerance was more frequent with the following characteristics: age over 40; administrative or sales position; eating and drinking after 9:00 pm; consumption of more than three caps of coffee with sugar per day; having a sweet taste; eating rapidly; positive for Type A personality score. For the subjects who were more than 10% overweight, borderline glucose tolerance was more frequent with the following: age less than 40; consumption of more than three caps of coffee with sugar per day; preferring fatty foods; and positive for Type A personality score. These results indicate the importance of dietary education especially in workers who are less than 10% overweight.

Adult↗

Multiphasic health testing. Benefit-cost analysis of high-volume and low-volume testing programs.

Cost analysis of a low-volume multiphasic health testing program (30 patients/week) has demonstrated that unit costs are similar to those reported by high-volume automated programs (500 patients/week). This comparability in unit costs appears to result from the savings in personnel and space requirements of the smaller program as compared with the larger ones. Cost effectiveness studies (costs per positive findings) of comparable test groups have yielded similar results. This fact leads the authors to suggest that physicians should consider establishing multiphasic health testing programs in occupational and small group medical settings.

Cost-Benefit Analysis↗

9 Health Fair.

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Colorado↗

Checkup interval and cancers in automated multiphasic health testing and services.

The purpose of this study was to disclose which types of cancer and how many persons with cancer were detected among the AMHTS examinees of our AMHTS center by using the hospital information retrieval system, and to study the relationship between cancer and the number of examinees, checkup intervals, and frequency in AMHTS. The examinees who had checkups more than twice were divided into three groups based on their checkup intervals: within one year, one to two years, and over two years. The relationship between cancer ratios and checkup intervals was evaluated in each group of examinees. In those having checkups within one year and from one to two years the cancer rate was 2.9 patients per 1,000 persons. However, in those having checkups after a two-year period or longer, the cancer rate was 4.3, clearly greater than the rate of the other two groups.

Adult↗

Economic evaluation of a Ninngen-dokku (medical checkup).

An economic evaluation of a medical checkup center (Ninngen-dokku, "human dry dock") was conducted from two perspectives: the cost for cancer checkup, and the cost for medical treatment after a diagnosis was obtained. We studied the cost of diagnosing cancer, compared with the cost required when cancer of an individual organ was detected through mass health testing, and studied the economics of a Ninngen-dokku according to Kawai's method of medical judgment. Assuming that the cost of death is more than the cost of saving the lives of persons who undergo the Ninngen-dokku, the Ninngen-dokku will be affordable. In the group undergoing the Ninngen-dokku compared with the group which did not, the estimated cost of medical treatment was reduced. The Ninngen-dokku carries advantages that cannot be quantified in financial terms; therefore, a multi-layered economic analysis of the Ninngen-dokku was required.

Cost-Benefit Analysis↗

Athletes as health testing examinees.

Health-testing examination data of 91 male and 54 female athletes were studied, together with age-matched controls, on serum biochemistry, ECG findings, hematology, and some data on gynecological physiology. Analysis of serum biochemical values revealed statistically significant differences in 14 of 18 routine test items as compared with the age-matched controls. In ECG findings, the combination of bradycardia and left ventricular hypertrophy was most frequently found in male athletes, whereas that of bradycardia and sinus arrhythmia was observed predominantly in female athletes. The incidence of anemia and menstrual dysfunction was higher in female athletes than in controls, especially in the basketball team. In the same team, a high rate of deviant ECG records and a different distribution of the age at menarche were also observed.

Adult↗

Defining normality--art or science?

The problem of defining normality, and in particular the establishment of reference ranges, is discussed. A so-called "objective" method of determining such ranges is described. It is suggested, however, that all currently used methods for defining "normal" ranges rely ultimately on a subjective choice. We propose the use of "How Often That Happens" (HOTH) graphs as an alternative to the conventional reference range. Such graphs show the frequency of results at least as extreme as any observed value. We have used such graphs, along with computer simulation models, in an attempt to describe how the frequency distribution of a given parameter changes as a population ages. Finally, an analogy is drawn between the states of "health", "illness" and "death", and the attractors which arise in non-linear dynamic systems. We conclude that the definition of normality is in fact more of an art than a science.

Adult↗

HEALTH WATCH: health promotion and disease prevention in primary care.

HEALTH WATCH, a longitudinal prospective study of healthy aging, was designed to characterize a healthy population of 2,200 men and women, ages 20-80 years in 1970. Biochemical, hematological, and physiological tests are performed annually over three weekly visits, combined with a self-administered HEALTH WATCH questionnaire to measure health status and behaviors in seven areas (with over 1,330 variables). In 1988, the HEALTH WATCH study was modified to assess characteristics of an oldest old "productive aging" cohort in Kauai, Hawaii. Nutrition, physical activity, extended family, and spirituality were found to be major health determinants. During 1989 to 1991 a controlled intervention study (ten local primary care physicians and their patients, aged 65-89 years) was completed in the Sun Cities, Arizona. These studies provide evidence that primary care physicians can promote positive health outcomes in patients of any chronological age and baseline health status through active healthy aging interventions.

Aged↗

Physiological age-related changes: cross-sectional and longitudinal studies.

Physiological age-related changes were investigated by cross-sectional and longitudinal studies. The data of the study were derived from volunteers admitted to the Gerontology Center in Budapest. In the follow-up study 864 subjects took part, and in the cross-sectional study 2,281 individuals. The 20-year longitudinal study and the cross-sectional examination showed that from a clinical standpoint the most important observation is that several biochemical data do not change with age. No changes were found in the values in erythrocyte sedimentation, hemoglobin, hematocrit, serum total protein, albumin, liver function, glucose, creatinine, triglyceride, and HDL-cholesterol levels. Changes were observed in the levels of HDL-cholesterol, immunoglobulins, rheumatoid factors, antinuclear factors, morphology of lymphocytes, serum TSH and T3 concentration, and systolic blood pressures.

Aged↗

Health-risk appraisal applied to ordinary AMHTS.

The main purpose of an automatic health testing system (AMHTS) has changed from early detection to primary prevention. Health-risk appraisal is now widely available as a tool of health education aiming at the modification of unhealthy lifestyles. However, the opportunity to offer appropriate health education was less frequent for those who had no particular findings during AMHTS. The results of an AMHTS should be evaluated from the viewpoint of health-risk appraisal, because the system is expected to supply useful information regarding one's lifestyle. Our system consists of two health-risk appraisal subsystems. One subsystem estimates the degree of improvement in medical indicators after a patient's lifestyle has been modified. The other subsystem predicts the occurrence of abnormal findings in medical indicators. These health-risk appraisal subsystems provide patients with information about their health-risks, based on their AMHTS results. Our health-risk appraisal subsystems should play an important role in future health education through the application of ordinary AMHTS.

Health Education↗

[Synchronous bilateral renal cell carcinoma in mass examination: a case report].

A 65-year-old female with bilateral renal cell carcinoma which was incidentally found by general check-up developed left hemiplegia following left nephrectomy. Marked metastasis of cervical spine was demonstrated by computerized tomography scanning, which was not evident before the operation by X-ray examinations. The patient died of respiratory paralysis one month after the operation. This case was difficult to treat, because the disease advanced so rapidly.

Aged↗

[Relationship of hypertension prevalence in companies to business type and scale--from an analysis of health examination results in Fukui prefecture].

The results of health examinations of 89,299 examines from companies in Fukui Prefecture conducted pursuant to the Occupational Safety and Health Act were analyzed to study the relationship between the prevalence in these companies of hypertension, and company size business type. The Mantel-Haenszel method was utilized to adjust for age structure of the examinees according to gender and the type of business of their companies to compare prevalence of hypertension. The results of the analysis indicated that the prevalence of hypertension was significantly higher in small-scale companies for the female examinees working in pulp/paper processing and motor freight transport business than in large-scale companies, but no significant difference was seen for scale of business when the female examinees were grouped without regard to the business type of their companies. In the case of the male examinees, the analysis results revealed that the prevalence of hypertension was significantly higher in small-scale companies for those working in ceramic/earth/rock, motor passenger transport and hotel/restaurant business than in large-scale industry while the prevalence of hypertension was significantly higher in large-scale companies for those working in non-ferrous metal industry, financial and other types of business. Moreover, the analysis results for the male examinees grouped without regard to the type of business of their companies indicated that the prevalence of hypertension remained significantly higher in small-scale companies. The above also suggests the need for measures for health care of workers that considers business type and scale for the purpose of primary prevention of hypertension.

Adult↗