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Results for “MANDELIC ACID”

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At least 1,099 records · Page 61Linked to original sources
PubMed1986

Dicyclomine, benzhexol and oxybutynine distinguish between subclasses of muscarinic binding sites.

The interactions of various unlabelled antimuscarinic drugs with the muscarinic receptors in the cerebral cortex, heart and urinary bladder were studied by a receptor binding technique, using (-)[3H]QNB as radioligand. In contrast to the other drugs examined, dicyclomine, benzhexol, oxybutynine and pirenzepine were bound with a significantly higher affinity in the cortex than in the heart and bladder. Furthermore, not only pirenzepine, but also dicyclomine and benzhexol were capable of distinguishing between two populations of muscarinic binding sites in the cortex. The low affinity sites for these drugs in the cortex were characterised by dissociation constants which were similar to those determined in the heart and the bladder, respectively. It was concluded that dicyclomine and benzhexol, like pirenzepine, are selective antagonists at the putative M1-receptor. Oxybutynine exhibited the same affinity profile but the tissue selectivity of this drug was less pronounced.

Animals↗
PubMed1981

A sensitive radioenzymatic assay for dihydroxymandelic acid, dihydroxypenylglycol and dihydroxyphenylacetic acid .

A sensitive radioenzymatic procedure for the simultaneous determination of dihydroxymandelic acid, dihydroxyphenylglycol, and dihydroxyphenylacetic acid has been developed. The catechols were methylated by catechol-O-methyltransferase using S-adenosyl[methyl-3H]methionine as methyl donor. The assay involved extraction into organic solvent, thin-layer chromatography and periodate oxidation. The applicability of the procedure was tested by measuring the amounts of deaminated metabolites of noradrenaline, adrenaline and dopamine in heart perfusion samples and plasma of rabbits.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1987

Liquid chromatographic method for the determination of 3,4-dihydroxyphenylethylene glycol and 3,4-dihydroxymandelic acid in plasma.

A method is described for the simultaneous determination of the deaminated catecholamine metabolites 3,4-dihydroxyphenylethylene glycol (DOPEG) and 3,4-dihydroxymandelic acid (DOMA) in plasma by liquid chromatography with amperometric detection. The compounds are extracted from plasma by adsorption on alumina, then separated on a reversed-phase column coated with tributyl phosphate as the stationary liquid phase. It is a simple and selective method that permits the determination of basal levels of DOPEG and DOMA in plasma with a relative standard deviation of 3%.

Chromatography, Liquid↗