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A patient diagnosed as having a myxoid liposarcoma of the broad ligament is presented. She was treated with surgical resection and radiation therapy and is free of disease 2 years after completing surgery.
Summary. We report the case of an 84-year-old patient presenting with a painless tumor between the thumb and the index finger. MRI showed a clearly defined tumor of the thenar eminence with a centrally localized more solid structure. There was a signal enhancement after intravenous administration of contrast medium. We performed a local resection of the tumor. Histologically, we found a lipoma with a centrally localized liposarcoma. We discuss the rare case of malignant transformation of a lipoma. In long-standing large lipomas we suggest regular controls by MR imaging.
In two cases of suspected myxoid liposarcoma, where chromosomal metaphase preparations were not available, fluorescence in situ hybridisation was performed on interphase nuclei of cytological preparations for the detection of the specific translocation, t(12;16), characteristic of this tumour and of trisomy 8, which is the most frequent secondary chromosome aberration. Probes directed against chromosomes 12 and 16 and against the centromeres of chromosomes 12 and 8 were hybridised on cell brushings and cytocentrifuge preparations. The finding of three painting domains of both chromosomes 12 and 16 and of only two signals with the centromeric probe directed against chromosome 12, suggested the presence of t(12;16) in both cases. In one case trisomy 8 was inferred from the occurrence of three centromere 8 signals. This approach can be used to detect specific chromosomal abnormalities when an urgent differential diagnosis is requested or when chromosome preparations are not available, or both.
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The radiographic appearance of fat in and around soft tissue sarcomas was evaluated to assess the diagnostic potential of this finding. Based on the distribution of fat and other components, these tumors are classified into three types.
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