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Results for “IMPOTENCE”

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At least 1,099 records · Page 61Linked to original sources
PubMed1997

Pharmacologically induced penile erections in the assessment and treatment of erectile impotence: a preliminary study of 100 patients.

OBJECTIVE: To assess and compare the immediate and subsequent response to pharmacologically induced penile erections, using intracavernosal injections of papaverine. DESIGN: Preliminary, prospective study. SETTING: Male sexual dysfunction clinic at the National Hospital of Sri Lanka. PATIENTS: 100 consecutive patients receiving 20 mg papaverine hydrochloride intracavernosally as the first dose. MAIN OUTCOME MEASURES: Assessment of the quality of the erection following the initial injection and determination of the optimum dose to achieve a normal erection; number who elected self-injection at home. RESULTS: Mean age of the 100 impotent men was 36.6 years and the mean duration of erectile dysfunction 43.9 months. Of men in the third decade 87.5% had a normal erection but only one-third of patients over 50 years showed a normal response. 16 patients had a reasonably well established organic problem. 42% of patients had normal nocturnal or early morning erections. The drop-out rate after the initial injection was 17%, 19% of men had a normal erection with 20 mg papaverine and 67% had a normal response to 20 to 80 mg papaverine. Seven patients continued on the self-injection program. Prolonged erections were experienced by 6% of men (1.9% of injections). CONCLUSIONS: Intracavernosal injection of papaverine hydrochloride is effective in a dose of 20 to 80 mg.

Adult↗
PubMed1997

[Neurobiology of postoperative impotence after rectal excision].

OBJECTIVE: The present study was conducted to determine the changes in the neuro-andrologic profile of patients with impotence following rectal ablative surgery. METHODS/RESULTS: The study comprised 18 patients who had undergone rectal surgery: abdominoperineal resection of the rectum (AP) in 12 cases (67%), anterior resection of the rectum (AR) in 6 cases (33%). The pharmacologic erection test was negative in 60% of the patients (56% of the AP cases and 67% of the RA cases; differences not significant). Sympathetic lesion was demonstrated in 67% of the patients (50% of the AP cases and 100% of the AR cases; significant difference). Parasympathetic lesion was demonstrated in 38% of the patients (56% of the AP and in none of the RA cases; tendency towards statistical significance). Pudendal lesion was demonstrated in 83% of the patients, although no significant differences concerning pudendal involvement were observed between both types of surgery (92% of the AP group and 67% of the RA group). The frequency of the pudendal lesion was significantly greater than the parasympathetic lesion and the sympathetic lesion tended to be significantly greater than the parasympathetic lesion in patients undergoing ablative rectal surgery. No significant differences were observed between the pudendal and the sympathetic lesion in these patients. No relationship was observed between the type of neurologic lesion and the results of the pharmacologic erection test. CONCLUSIONS: The type of neurological lesion appears to be related with the level of the rectal surgery. The sympathetic innervation would be more frequently compromised in anterior resection of the rectum. The parasympathetic innervation would be more frequently compromised in abdominoperineal resection. The pudendal innervation would be affected by both types of surgical techniques.

Aged↗
PubMed1997

[Impotence in diabetic patients: detection of prevalence and social-health implications].

OBJECTIVES: To classify information received from diabetics on erectile dysfunction (ED) and to find whether help is being sought or there is just passive resignation. DESIGN: Epidemiological, descriptive, crossover study. SETTING: Urban Health Centre. PATIENTS: 102 patients involved in the Diabetes Programme for over a year were studied. MEASUREMENTS AND MAIN RESULTS: A data collection sheet with the variables listed under objectives was designed. Average age was 63 +/- 12. Overall prevalence of ED was 56%, age being the most important related variable found (p < 0.01). 30% of patients with ED had requested medical care; only 18% had been treated. However, 54% of impotent diabetics accepted the theoretical possibility of treatment with intracavernous injections. CONCLUSIONS: A high prevalence of ED was detected in the diabetic patients studied. They considered the medical information on possible treatments scant (18%) and generally inadequate. Most preferred to be treated by the Primary Care doctor. Primary Care professionals must become more sensitive to ED and provide correct therapeutic information.

Adult↗
PubMedDate not supplied

Advances in the management of impotence.

With an estimated ten to twenty million men in the United States suffering from impotence, major advances have been made relative to the understanding of the pathophysiology of this disease. These advances have been translated into improved treatment options. Several exciting novel pharmacotherapeutic agents are in the final phase of their clinical trials. These should provide more favorable prospects for men with sexual dysfunction.

Clinical Trials as Topic↗
PubMed1998

Management of impotence in primary care.

A diversity of successful new therapies for men with impotence dysfunction offers renewed optimism about restoration for erectile dysfunction. A minimum of basic laboratory investigation, history, and physical is necessary before embarking on therapy.

Aged↗
PubMed1976

Impotence in diabetes mellitus.

Long-standing psychogenic factors underlying impotence in diabetic males may, in many cases, play a more significant role than does prematurely presumed organic disease. With an explicit sexual history, a committed couple, an explanation of the sexual responses, and specific exchange at home, the physician may comfortably and competently intervene to provide enlightened sex therapy.

Diabetes Complications↗
PubMed2001

Gene expression profiling of an arteriogenic impotence model.

Penile arterial insufficiency is one of the most common causes of ED. We have established a traumatic arteriogenic insufficiency rat model by the ligation of the pudendal arteries. To simulate both acute and chronic traumatic injuries, five ligation periods (6 h, 3 days, 7 days, 3 weeks, and 6 weeks) were chosen. By electrostimulation of the cavernous nerve, the intracavernous pressure was determined to be between 20 and 40-cm H(2)O for the ligated rats compared to around 100-cm H(2)O for the control rats. The erectile tissue in the corpus cavernosum of these rats was then subjected to microarray analysis, in which an array that contains cDNA fragments representing 1176 rat genes was used. The results demonstrated that normal rat corpus cavernosum expressed approximately 200 genes at detectable levels and that ligation produced differential expression of approximately 25 genes, depending on the duration of ligation. The most highly ligation-induced gene was apolipoprotein D (ApoD), with peak expression in the 3- and 7-day ligated rats. Three of the insulin-like growth factor binding proteins (IGFBP-1, 3, and 5) were upregulated in all ligated rats. IGFBP-6, which was one of the most highly expressed genes in the normal corpus cavernosum, was down-regulated in all ligated rats. Cysteine proteases of the cathepsin family were also differentially expressed between control and ligated rats, with cathepsin K being down-regulated most. A few genes were upregulated only in the 6-week ligated rats, including angiotensin-converting enzyme. Finally, VEGF, whose induction has been identified in many other ischemic tissues, was not induced in corpus cavernous tissue of ligated rats.

Animals↗
PubMed1995

Impotence.

Explore the source record for details and available documents.

Erectile Dysfunction↗
PubMed2001

Improving the accuracy of vascular testing in impotent men: correcting hemodynamic alterations using a vasoactive medication re-dosing schedule.

PURPOSE: Arteriogenic or venogenic vascular insufficiency is the most common pathophysiology of organic erectile dysfunction. While vascular insufficiency may be suspected on history and physical examination, the definitive diagnosis is made by vascular testing. Dynamic infusion cavernosometry is a recognized technique for evaluating the hemodynamics of erection. Assigning the correct vascular diagnosis during testing is important. Complete corporeal smooth muscle relaxation is essential for obtaining accurate data. Previously others have suggested that repeat dosing with vasoactive medication may improve the diagnostic accuracy of vascular testing. We investigated the hemodynamic effect of repeat doses of medication. MATERIALS AND METHODS: Data were prospectively obtained on men undergoing dynamic infusion cavernosometry. When veno-occlusive parameters were abnormal, the intracavernous vasoactive agent dose was repeated to a maximum of 3 doses. Standard dynamic infusion cavernosometry criteria were used for diagnosing arteriogenic and venogenic erectile dysfunction. We analyzed the proportion of men in whom the vascular diagnosis was altered using this regimen. RESULTS: Of 420 men undergoing dynamic infusion cavernosometry, 70% warranted re-dosing based on abnormal veno-occlusive parameters. Of these 294 men veno-occlusive values were corrected by repeat medication in 32% and, therefore, they would have been falsely diagnosed with venous leakage during vascular evaluation. Half of all corrections occurred with the second dose, while half of the patients required a third dose of medication. CONCLUSIONS: These data should encourage clinicians to consider re-dosing during the vascular evaluation of men in whom incomplete corporeal smooth muscle relaxation is suspected. In this way a false diagnosis of venous leakage may be avoided in a significant number of cases.

Adult↗