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At least 1,099 records · Page 61Linked to original sources
PubMed1979

Phenothiazine analgesia--fact or fantasy?

Double-blind clinical trials involving the use of phenothiazines as analgesics or potentiators of analgesics (aspirin, meperidine, morphine sulfate) and adverse effects of phenothiazines are reviewed and evaluated. Promethazine, promazine and propiomazine were not found to possess analgesic or potentiating properties. One chlorpromazine study contained important design and reporting deficiencies which precluded a recommendation for use of chlorpromazine in the treatment of pain. Methotrimeprazine was determined by numerous authors to have analgesic properties; however, most of the studies also were deficient in design or data presented, or both. Adverse reactions to phenothiazines, including hypotension, sedation, drowsiness, extrapyramidal symptoms, tardive dyskinesia, cardiac toxicity and agranulocytosis, are often more common and severe than those attributed to narcotic analgesics. Because of the lack of data supportive of analgesic activity and the adverse reactions associated with phenothiazines, use of these agents in the management of pain should be discouraged. The prophylactic use of phenothiazine for narcotic analgesic-induced emesis also is, in most cases, a questionable practice.

Analgesics↗
PubMed1985

Anaemia in primary hyperparathyroidism--fantasy or reality.

Controversy exists as to whether primary hyperparathyroidism is associated with an anaemia. Records corresponding to 215 patients operated on at the Karolinska Hospital between 1972 and 1981 were reviewed. An incidence of 7.4% of anaemia was found, but in only 3% of these cases the anaemia could not be explained by any other known cause. The anaemic group was characteristic in presenting a normochromic and normocytic picture, with iron and serum transferrin values below the normal range. No renal or osseous pathology was observed. In these patients, the anaemia disappeared after the parathyroidectomy, and iron values remained below the normal range. In conclusion, a mild normochromic and normocytic anaemia that disappeared after parathyroid surgery was observed in six patients with PHPT (3%). Its mechanisms are obscure, but data available suggest that parathyroid disease could be of aetiological importance.

Anemia↗
PubMed1979

Headaches--fact or fantasy?

Headaches are among the commonest symptoms encountered in active general practice. Much appears in the medical literature on this subject, most of it not applicable to everyday practice. A simple classification, a pattern of easy recognition, and a treatment plan for these chronic headaches are presented.

Chronic Disease↗