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At least 1,099 records · Page 61Linked to original sources
PubMed1980

The activity against Trypanosoma cruzi and cutaneous leishmaniasis, and toxicity, of moxipraquine (349C59).

A novel 8-aminoquinolone compound, 8(6-4' 3-hydroxybutyl)piperazin-1'-ylhexylamino)-6-methoxyquinoline di(hydrogen maleate), moxipraquine, 349C59, was shown to be active against experimental infections with Trypanosoma cruzi. It was effective in suppressing parasitaemia but did not eradicate the infection from mice or guinea-pigs. Other clinically tested drugs, including nifurtimox, were likewise incapable of eradicating the parasite from infected mice. Moxipraquine was less potent against mouse infections with strain Peru than it was against other strains of T. cruzi. In limited tests, moxipraquine was effective on experimental infections of Leishmania major, L. mexicana mexicana and L. brasiliensis panamensis but not L.b. brasiliensis. Significant foetal toxicity, observed experimentally in rats and rabbits, resulted in the termination of clinical trials.

Aminoquinolines↗
PubMed1980

The treatment of giardiasis.

Very effective treatment for giardiasis is available. There is little to choose in efficacy between the major drugs I have mentioned, used at optimum dosage, but mepacrine probably has a higher frequency of unwanted effects than many of the newer drugs, and the required duration of treatment is longer. Tinidazole is a very promising drug, being effective in single dosage with infrequent side effects.

Furazolidone↗
PubMed1981

A study of drug resistance among Salmonella typhi and Salmonella paratyphi A in an endemic area, 1977-79.

Tests for antibiotic resistance were carried out on 198 strains of Salmonella typhi and S. paratyphi A isolated from cases of enteric fevers. Their minimal inhibitory concentrations for streptomycin, chloramphenicol, ampicillin, furazolidine and co-trimoxazole were estimated by plate dilution technique. Four strains of S. typhi and one strain of S. paratyphi A were found to show multiple resistance with a set pattern of resistance to chloramphenicol, streptomycin, sulphonamide, tetracycline and spectinomycin. All the five strains carried R-factors. Three of the resistant S. typhi belonged to Phage type 'O' and one was in Phage type 'A'. The single resistant S. paratyphi A belonged to Phage type '2'.

Ampicillin↗
PubMed1986

Epidemiological differences between cholera due to multiple antibiotic resistant and multiple antibiotic sensitive Vibrio cholerae infection.

The appearance of cholera caused by multiply antibiotic resistant Vibrio cholerae in Bangladesh provided an opportunity to compare epidemiological features of infection caused by resistant and by sensitive V. cholerae. A prospective study was carried out using 46 families of hospital in-patient cholera cases due to resistant V. cholerae and 11 families of hospital cases due to sensitive V. cholerae and nine cases of cholera due to resistant and six cases due to sensitive V. cholerae detected in the neighbourhoods of hospital patients. All families were visited daily during ten days for cultures of rectal swabs, samples of domestic water and for history of diarrhoea. The results showed no significant difference in secondary infection and case rates in contacts of hospital cholera cases due to resistant and sensitive V. cholerae. However, the secondary infection rate (57%) in contacts of cases due to resistant V. cholerae detected from the neighbourhoods of hospital cases was significantly higher (p less than 0.05), than in the neighbourhood case-contacts (29%) of cases due to sensitive V. cholerae. The mean duration of diarrhoea in untreated resistant V. cholerae cases who were contacts of hospital cases (3.3 days) was significantly longer (p less than 0.05) than that of untreated sensitive V. cholerae (2.2 days). Higher isolation rates of V. cholerae were obtained from water sources used by cholera cases due to resistant V. cholerae, than from sources used by cases due to sensitive V. cholerae, but the differences were not statistically significant (p greater than 0.05). The study suggests that resistant V. cholerae poses an additional threat through a higher secondary infection rate and by causing illnesses of longer duration.

Anti-Bacterial Agents↗
PubMed1991

Mechanism of allergic cross-reactions--I. Multispecific binding of ligands to a mouse monoclonal anti-DNP IgE antibody.

A recently developed solid-phase binding assay was used to investigate the specificity of ligand binding to a mouse monoclonal anti-dinitrophenyl IgE [IgE(aDNP)]. All DNP-amino acids, that were tested, inhibited the binding of radio-labeled IgE(aDNP) to DNP covalently attached to polystyrene microtiter plates; however, the concentration for 50% inhibition varied within four orders of magnitude, DNP-L-serine being the most, DNP-proline the least potent inhibitor. In addition to DNP analogues a large number (2074) of drugs and other compounds were tested for their ability to compete with DNP for the binding site of IgE(aDNP). At the concentrations used for screening 59% of the compounds had no significant inhibition; 19% inhibited the binding of IgE(aDNP) more than 50%. Several families of compounds (tetracyclines, polymyxines, phenotiazines, salicylates and quinones) of effective competitors were found. Within these families change in the functional groups attached to the "family stem" had major effects on the affinity of ligand binding. The occurrence frequencies of interactions of ligands with IgE(aDNP) is in good agreement with a semi-empirical model for multispecific antibody-ligand interactions.

Amino Acids↗
PubMed1985

The role of mutagenicity testing in the ecotoxicological evaluation of industrial discharges into the aquatic environment.

An important task of ecotoxicology is to provide data for use by governments as a scientific basis for regulating the discharge of potentially hazardous substances into the environment. The criteria on which such regulations are based include biological and chemical degradability, bioavailability (accumulation) and toxicity, the latter manifesting itself in a reduced ability of organisms to survive and reproduce. There are also arguments for including the mutagenicity of chemicals in these criteria. In the past decade many studies have revealed the contamination of water and the atmosphere by mutagens originating in human activities and having observable effects on organisms in these environments. The extent to which this mutagenic stress can alter ecosystems as a whole is not yet known, but if mutagens are shown to cause major changes, mutagenicity is clearly an important ecotoxicological criterion. In the meantime its use must be based on the actual damage caused to organisms by mutagens and on the rising concern over a novel ecological phenomenon that might be named 'increased mutagenic stress'. A detailed report on the ecotoxicological case history of the discharge from a nitrofuran factory demonstrates the role of mutagenicity tests in the evaluation of effluents. As well as being toxic to algae, the discharge was found to be mutagenic in the Ames test. Toxicity and mutagenicity were used as criteria in studies of the biodegradability of the offending substances in a chemostat, as well as in studies to monitor the success of detoxification attempts. In the chemostat the mutagens did not appear to be very degradable but the algal toxicity decreased by 90%. Detoxification was reasonably successful for the mutagens in contrast to the algal toxicants.

Biodegradation, Environmental↗
PubMed1987

Hymenolepis diminuta: one of three enteric pathogens isolated from a child.

This article describes a case of enteritis in a 3.5-yr-old child with persistent diarrhea and the isolation of three gastrointestinal pathogens, including a rare human pathogen Hymenolepis diminuta (rat tapeworm). This is the first reported case in the northeastern United States in 20 yr and demonstrates that persons living in homes infested with rodents and arthropods are at risk of acquiring this infection.

Campylobacter Infections↗
PubMed1984

Animal models of drug-induced cardiomyopathy.

Animal models of drug-induced cardiomyopathy relevant to clinical medicine have been difficult to produce. Animal species commonly used to study cardiomyopathies include the rabbit, rat, and mouse of which none are completely satisfactory. Recently, the turkey poult has been proposed as an attractive animal model for investigation of drug-induced cardiomyopathy.

Animals↗