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At least 1,099 records · Page 61Linked to original sources
PubMed1985

Amniotic membrane is an effective burn dressing material.

Human amniotic membrane is a readily available biological dressing material used to treat burns. It not only prevents oozing of plasma from burn wounds but also relieves pain and controls sepsis. We used human amniotic membrane to treat fifteen burn patients, and this material was effective. The application of this cost-free dressing material warrants further study as it can be made use of in areas where expensive and specialized equipment is not available.

Adolescent↗
PubMed2005

Enhancing dermal matrix regeneration and biomechanical properties of 2nd degree-burn wounds by EGF-impregnated collagen sponge dressing.

To better define the relationship between dermal regeneration and wound contraction and scar formation, the effects of epidermal growth factor (EGF) loaded in collagen sponge matrix on the fibroblast cell proliferation rate and the dermal mechanical strength were investigated. Collagen sponges with acid-soluble fraction of pig skin were prepared and incorporated with EGF at 0, 4, and 8 microg/1.7 cm2. Dermal fibroblasts were cultured to 80% confluence using DMEM, treated with the samples submerged, and the cell viability was estimated using MTT assay. A deep, 2nd degree- burn of diameter 1cm was prepared on the rabbit ear and the tested dressings were applied twice during the 15-day, post burn period. The processes of re-epithelialization and dermal regeneration were investigated until the complete wound closure day and histological analysis was performed with H-E staining. EGF increased the fibroblast cell proliferation rate. The histology showed well developed, weave-like collagen bundles and fibroblasts in EGF-treated wounds while open wounds showed irregular collagen bundles and impaired fibroblast growth. The breaking strength (944.1 +/- 35.6 vs. 411.5 +/- 57.0 Fmax, gmm(-2)) and skin resilience (11.3 +/- 1.4 vs. 6.5 +/- 0.6 mJ/mm2) were significantly increased with EGF-treated wounds as compared with open wounds, suggesting that EGF enhanced the dermal matrix formation and improved the wound mechanical strength. In conclusion, EGF-improved dermal matrix formation is related with a lower wound contraction rate. The impaired dermal regeneration observed in the open wounds could contribute to the formation of wound contraction and scar tissue development. An extraneous supply of EGF in the collagen dressing on deep, 2nd degree-burns enhanced the dermal matrix formation.

Animals↗
PubMed1984

Clinical experience with a new hydrogel wound dressing.

A new dressing is described which appears to improve wound healing after partial-thickness skin loss. The period between dressing changes is increased and patient discomfort decreased. It has been particularly useful in the treatment of scalds in children. There is no evidence of an increased infection rate. Alternative methods of sterilization may reduce the small number of minor hypersensitivity reactions.

Burns↗
PubMed1994

Use of glutaraldehyde-gentamicin-treated bovine pericardium as a wound dressing.

Glutaraldehyde (GA)-pretreated gentamicin post-fixed bovine pericardium has been evaluated as a wound dressing in this study. Two excisions approximately 7 x 4 cm, each of full thickness skin, from the upper and lower parts down to, but not including, the panniculus carnosus were made from the back of the guinea pig. The skin excised from the upper part was placed on the wound bed of the lower part as an autograft, whereas the upper wound was closed using 5% sodium chloride-trypsin-0.1% GA-0.048% gentamicin-treated bovine pericardium and sutured for comparative study. The wounds were inspected every 3-6 d for infection and exudation. Histopathological studies were performed at weekly intervals in the post-operative period. At the fifth week, a very thin linear scar on the epidermal aspect without remarkable contracture was observed and histopathology showed the completion of epithelization across the wounds in all cases. This study demonstrates that GA-pretreated, gentamicin-post-fixed bovine pericardium may be used as an alternative biological dressing in the case of large wounds.

Animals↗
PubMed1993

Fingertip injuries management with semi-occlusive dressing.

We have developed a simple, cheap and efficient method of management of fingertip injury using a semi-occlusive dressing ("Opsite"--Smith and Nephew). The fingertip is covered with the "Opsite" once a week only. The dressing provides a temporary "skin", making the finger painless. This semi-occlusive "skin" allows the healing environment to reach an optimal milieu (e.g. pH, oxygen, tension, immunoagents) actively promoting granulation tissue formation and epithelialization. The result of 200 fingertip injuries treated with this method proves the development of a near normal pulp shape and useful epithelium within an average of 20 days.

Amputation, Traumatic↗
PubMed1987

The use of semipermeable dressings in fingertip injuries.

A randomised prospective trial was carried out to compare the use of semipermeable and petroleum gauze dressings in fingertip injuries. The results demonstrate advantages in the use of semipermeable dressings.

Clinical Trials as Topic↗
PubMed1984

Clinical experience with Biobrane biosynthetic dressing in the treatment of partial thickness burns.

Biobrane, a synthetic, bicomposite wound dressing, has been used to treat 17 patients with partial thickness burn wounds covering 0.5-12.5 per cent of the total body surface area (mean 4.4 per cent). In 16 patients we found complete healing of the wound after removal of the dressing, 6-15 days after the injury. In one patient, the wounds were determined on the third day post-injury to be deeper than initially suspected, and she was taken to the operating room for surgical debridement and grafting. Biobrane is an effective wound covering for clean, superficial partial thickness burns of limited extent; the simultaneous use of topical antimicrobial agents for such wounds is not necessary.

Adult↗
PubMed1985

The role of sampling in the detection of microbial contamination on cadaveric allograft skin used as a biological wound dressing.

The availability of cryopreservation and low temperature storage techniques for cadaveric allograft skin allows it to be preserved while microbial assessments are made before its use as a temporary biological dressing on burn wounds. In a 300-donor, 5-year prospective study, we tested ten skin samples from defined areas on each donor for microbiological contamination. Although the skin from 52.3 per cent of the donors possessed some detectable residual microbial contamination after surgical body preparation and skin removal, such contamination was limited to an average of 1.4 areas per body, leaving 86 per cent of all skin obtained free from detectable contamination and suitable for use as biological wound dressings. The number of skin samples tested per donor body determined the accuracy of detection of the presence of contamination. Testing one skin sample per donor body yielded a correct skin assessment 92 per cent of the time, while testing five skin samples increased the accuracy to 96 per cent, and testing ten skin samples yielded a 99.9 per cent accuracy in detection of skin contamination. Thus, it is within the ability of a skin bank to set the limits of microbiological risk to patients receiving processed cadaveric allograft skin.

Bacteria↗
PubMed1989

Amniotic membrane as a biological dressing in the management of burns.

This report details observations in 90 patients with dermal depth burns treated using amniotic membrane. The patients were divided into three subgroups: superficial dermal, intermediate dermal and deep dermal burns diagnosed clinically. All patients were dressed with amniotic membrane which was changed daily. The amniotic membrane relieved the discomfort of dressing changes, postoperative pain and oozing and allowed rapid epithelialization and early healing in superficial and intermediate depth dermal burns. In deep dermal burns the membrane was dissolved because of slough in the burn wound. After removal of the slough the amniotic membrane helped in rapid regeneration of epithelium and early healing.

Bandages↗
PubMed1989

Comparison of E-Z Derm and Jelonet dressings for partial skin thickness burns.

A prospective, randomized trial of 32 patients with partial skin thickness burns is reported comparing E-Z Derm with Jelonet as a burn dressing. The bacterial colonization rate, need for surgical treatment, time for spontaneous healing, analgesic requirements and frequency of dressing changes were assessed in each group. No statistically significant differences were found between the two groups, for any of these factors.

Adolescent↗
PubMed1990

Clinical application of collagen sheet, YCWM, as a burn wound dressing.

In the Linkou Burn Unit, a recently developed new wound dressing derived from porcine skin was evaluated. This newly designed porcine dressing, called young collagenous wettable membrane (YCWM), was developed by the staff of the Department of Cellular and Molecular Biology of Chang Gung Memorial Hospital. Many specific characteristics, such as negligible antigenicity, semitransparency, sterilizability, good pain relief and low costs, have been associated with it. The results of a clinical trial on 59 wounds on 50 burn patients proved encouraging. Some disadvantages such as maceration and delayed eschar separation were noted. We conclude that YCWM is suitable for the treatment of the clean, dry donor sites and superficial partial skin loss burn wounds of non-infected, non-immunocompromised patients.

Biological Dressings↗
PubMedDate not supplied

"Xenograft" dressing in the treatment of burns.

Biologic dressings (xenografts and allografts) are an integral part of modern burns care. They provide; reduction of pain and adherence without need for additional fixation; antibacterial action that is a function of its adherence; protection against physical trauma; appropriate heat and moisture retention. Allografts are more effective but supply may be severely restricted. Porcine skin is our standard dressing for partial-thickness burns; it also has a role in providing temporary coverage of full-thickness defects and for debriding burns/ulcers.

Animals↗
PubMed2005

Preparation of porcine small intestinal submucosa sponge and their application as a wound dressing in full-thickness skin defect of rat.

Small intestinal submucosa (SIS) sponge was prepared by crosslinking with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). The prepared SIS sponges exhibited elastic and soft property on touch and were ease to handle. The SIS sponges have the pore diameter of 100-200 microm and an interconnective porous structure. The SIS sponges exhibited high water absorption ability over 8000%. The water uptake of SIS sponges decreased as SIS concentration used to manufacture SIS sponge increased. In wound healing test, SIS sponge attained uniform adherence to the wound surface. The SIS sponges absorbed higher extent of exudation for wound than that covered with Tegaderm as control. Wound area contracted above 80% at the 21st postoperative day. The SIS sponge treated wound was almost completely covered with a thin layer of epidermis at 4 weeks. In addition, the dermal collagen in the wound regenerated at only SIS sponges treated wounds. The progress of granulous tissue formation was faster in SIS sponges as wound dressing than in Tegaderm. In conclusion, we found that the SIS sponges might be a potential material as a wound dressing.

Absorption↗
PubMed2005

A comparison of negative-pressure dressings versus Bolster and splinting of the radial forearm donor site.

OBJECTIVE: Negative-pressure dressings (NPDs) have been reported to improve split-thickness skin graft survival in some settings; we assessed whether NPDs could improve skin graft results in radial forearm donor sites. METHODS: Between October 2003 and November 2004, 45 radial forearm donor sites underwent split-thickness skin graft immobilization either with conventional bolster dressing and splint or with an NPD. Split-thickness skin graft take was recorded at 1 and 4 weeks postoperatively. RESULTS: Overall split-thickness skin graft healing was improved in the NPD group (92%) compared with the case of conventional splinting (81%) at 4 weeks (P = .10). The rate of major graft loss was less in NPDs (10%) compared with the case of conventional management (28%) after 4 weeks (P = .06). CONCLUSIONS: Split-thickness skin graft survival was significantly improved by the use of NPDs. Because the use of NPDs is expensive, we consider their use only in patients with potential wound-healing problems, when there is a need to monitor the hand, or when immediate postoperative hand immobilization might impede the patient's recovery.

Drainage↗
PubMed2001

Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing.

A novel asymmetric chitosan membrane has been prepared by immersion-precipitation phase-inversion method and evaluated as wound covering. This new type of chitosan wound dressing which consists of skin surface on top-layer supported by a macroporous sponge-like sublayer was designed. The thickness of the dense skin surface and porosity of sponge-like sublayer could be controlled by the modification of phase-separation process using per-evaporation method. The asymmetric chitosan membrane showed controlled evaporative water loss, excellent oxygen permeability and promoted fluid drainage ability but could inhibit exogenous microorganisms invasion due to the dense skin layer and inherent antimicrobial property of chitosan. Wound covered with the asymmetric chitosan membrane was hemostatic and healed quickly. Histological examination confirmed that epithelialization rate was increased and the deposition of collagen in the dermis was well organized by covering the wound with this asymmetric chitosan membrane. The results in this study indicate that the asymmetric chitosan membrane thus prepared could be adequately employed in the future as a wound dressing.

3T3 Cells↗
PubMed1994

Histologic evaluation of chronic human wounds treated with hydrocolloid and nonhydrocolloid dressings.

BACKGROUND: Studies of acute surgical wounds in pigs have shown granulomatous tissue reactions induced by hydrocolloid dressings. OBJECTIVE: We examined biopsy specimens from chronic wounds in humans treated with hydrocolloid or nonhydrocolloid dressings to determine whether such reactions occurred. METHODS: A blinded retrospective analysis of 22 chronic ulcer biopsy specimens from 22 patients was performed by two dermatopathologists independently. RESULTS: No differences were seen between hydrocolloid-treated and non-hydrocolloid-treated wounds. Granulation tissue was seen in all specimens. No cavities, eosinophilic inclusions, polarizable material, or multinucleated giant cells were identified. CONCLUSION: There are no significant histologic differences between hydrocolloid-treated and non-hydrocolloid-treated wounds in humans.

Biopsy↗
PubMed2002

Allogenic skin: transplant or dressing?

The use of biological dressings is an established aspect of contemporary burns care. The type and source of these biological materials can give rise to both legal and ethical issues. This paper looks at these issues in relation to allogenic skin. It is argued, from a medical perspective, that non-viable allogenic skin, cannot be transplanted and so should therefore be classified both medically and legally as a dressing.

Animals↗
PubMed1998

Clinical experience of postage stamp autograft with porcine skin onlay dressing in extensive burns.

Fifteen patients with extensive burns (deep second-degree burn > 50%, or third-degree burn > 30% of total body surface area) were treated with postage stamp autograft and meshed porcine skin onlay dressing from 1992 to 1996. All patients received the procedure within 10 days of sustaining the burn, with an average of 6.3 days. The areas chosen for postage stamp autograft were the anterior chest, abdomen, back, buttocks and the proximal part of the extremities. The scalp was the donor site of choice when available. The harvested skin was cut into 0.5-1.0 cm postage-stamp-like squares and applied to the recipient sites separated by a distance of 0.5-2.0 cm. The expansion ratio was from 1:4 to 1:9. Meshed porcine skin was then used for onlay dressing. The average graft area was 26% of the total body surface area. The success rate of the skin grafts was nearly 100% in 14 patients. One patient had a 40% loss due to contamination from adjacent wounds. In conclusion, the postage stamp autograft with porcine skin overlay is an effective way to treat extensive burn wounds in the early stages.

Adolescent↗