Ethanol withdrawal: altered ambient temperature selection in rats.
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Amphetamine↗
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Urocortin in the lateral septal area modulates feeding induced by orexin A in the lateral hypothalamus.
The intermediate portion of the lateral septum (LSi) contains high levels of urocortin (UCN) peptide and type 2 corticotropin-releasing hormone (CRH) receptor (CRHR2) and has anatomic and functional connections with the lateral hypothalamus (LH). We tested the effect of UCN in the LSi on feeding. Injection of 10 or 30 pmol UCN into LSi significantly decreased feeding in food-deprived rats for 24 h without producing conditioned taste aversion (CTA). Pretreatment with a CRH receptor antagonist, alpha-helical CRH (alpha-hCRH), blocked the inhibitory effect of UCN on deprivation-induced feeding at 1 and 2 h postinjection. Furthermore, UCN in the LSi significantly decreased feeding induced by LH-injected orexin A at 2 and 4 h postinjection, and addition of alpha-hCRH blocked the inhibitory effect of UCN on orexin A-induced feeding. In conclusion, UCN significantly inhibits feeding induced by deprivation and LH-injected orexin A without producing a CTA, an effect that is mediated by CRHR2. These data define the LSi as an important site for UCN-induced anorexia and indicate that LSi UCN may influence orexin A feeding signals in the LH.
Animals↗
Influence of spatial information on responses of tonically active neurons in the monkey striatum.
Previous studies have demonstrated that tonically active neurons (TANs) in the primate striatum play an important role in the detection of rewarding events. However, the influence of the spatial features of stimuli or actions required to obtain reward remains unclear. Here, we examined the activity of TANs in the striatum of monkeys trained to make spatially directed movements elicited by visual stimuli presented ipsilaterally or contralaterally to the moving arm. Among 181 neurons responding to the trigger stimulus, 127 (70%) were nonselective for stimulus location and 54 (30%) responded to only one location of the stimulus. Most of the selective responses (63%) occurred when the stimulus was presented contralaterally to the moving arm. To examine whether TAN responses are related to the location of the stimulus or to the direction of the movement, we tested a subset of the trigger-responsive neurons (n = 44) in a condition that elicited reaching toward or away from the stimulus. By comparing TAN activity between the two conditions, we found that half of the responses can be interpreted as being related to the location of the stimulus, one quarter to the direction of movement, and one quarter to the context in which stimulus-movement combination occurs. These results demonstrate that TANs are not limited to motivational processing, but may play a role in the processing of spatial attributes of stimulus and/or movement as well. These response properties suggest that TANs are involved in the flexible shifting of motor responses during spatially directed behavior.
Action Potentials↗
Neurons in the rostral cingulate motor area monitor multiple phases of visuomotor behavior with modest parametric selectivity.
We examined the cellular activity in the rostral cingulate motor area (CMAr) with respect to multiple behavioral factors that ranged from the retrieval and processing of associative visual signals to the planning and execution of instructed actions. We analyzed the neuronal activity in monkeys while they performed a behavioral task in which 2 visual instruction cues were given successively with an intervening delay. One cue instructed the location of the target to be reached; the other cue instructed which arm was to be used. After a second delay, the monkey received a motor-set cue to be prepared to initiate the motor task in accordance with instructions. Finally, after a GO signal, the monkey reached for the instructed target with the instructed arm. We found that the activity of neurons in the CMAr changed profoundly throughout the behavioral task, which suggested that the CMAr participated in each of the behavioral processing steps. However, the neuronal activity was only modestly selective for the spatial location of the visual signal. We also found that selectivity for the instructional information delivered with the signals (target location and arm use) was modest. Furthermore, during the motor-set and movement periods, few CMAr neurons exhibited selectivity for such motor parameters as the location of the target or the arm to be used. The abundance and robustness of the neuronal activity within the CMAr that reflected each step of the behavioral task and the modest selectivity of the same cells for sensorimotor parameters are strikingly different from the preponderance of selectivity that we have observed in other frontal areas. Based on these results, we propose that the CMAr participates in monitoring individual behavioral events to keep track of the progress of required behavioral tasks. On the other hand, CMAr activity during motor planning may reflect the emergence of a general intention for action.
Action Potentials↗
Korean adolescents' experiences of smoking cessation: a prelude to research with the human becoming perspective.
Smoking cessation has been identified as an important factor for health and quality of life in Korean society. This article explicates Korean adolescents' experiences of smoking cessation from the perspective of Parse's human becoming theory, as a prelude to conducting research. A nurse was truly present with individual students as they shared their experiences of trying to stop smoking. Interpreted through the principles and concepts of Parse's theory, the experience of quitting smoking is elucidated as a struggle of choosing one's value priorities amid the opportunities and limitations inherent in this decision, while moving with unique patterns of relating. Staying with the commitment to stop smoking is changing one's health and quality of life. The authors briefly discuss the implications of this perspective for nursing practice, and identify struggling to change as a phenomenon for future research.
Adolescent↗
The impact of low levels of carbon dioxide on rats.
The widespread use of individually ventilated cage (IVC) systems today has made the impact of CO(2) on rodents a highly important matter. Leaving cages from these systems without ventilation increases CO(2) concentrations inside the cages, as CO(2) generated from the animals is no longer removed actively. In modern IVC systems the CO(2) levels may reach 3-5% within a very short time, as the cages are very tightly sealed. The aim of the present study was to investigate the effects of 1%, 3%, and 5% CO(2) by studying the preferences of the animals as well as changes in the heart rate and systolic blood pressure as measured by telemetry. The rats avoided the cages, which contained 3% CO(2). In the telemetric study an anaesthetic effect on the rats were seen at 3% as a drop in the heart rate, and at 5% CO(2) a drop in the systolic blood pressure was also seen. The results from the present study could indicate that CO(2) levels of up to 3% do not affect the animals, or at least only to a minor extent, but that if the animals are exposed to CO(2) levels of higher than 3% they are affected directly as seen by changes in physiological parameters and preferences.
Animal Husbandry↗
Procedural misconceptions and informed consent: insights from empirical research on the clinical trials industry.
This paper provides a simultaneously reflexive and analytical framework to think about obstacles to truly informed consent in social science and biomedical research. To do so, it argues that informed consent often goes awry due to procedural misconceptions built into the research context. The concept of procedural misconception is introduced to describe how individuals respond to what is familiar in research settings and overlook what is different. In the context of biomedical research, procedural misconceptions can be seen to function as root causes of therapeutic misconceptions.
Behavioral Research↗
Postpubertal sex differentiation of forebrain structures and functions depend on transforming growth factor-alpha.
Sex- and age-associated deficits in brain structure and behavior are reported in a number of neuropsychiatric disorders. Although genetic and environmental factors are thought to contribute to the pathogenesis, there are only few examples in clinical or experimental systems that have identified specific causes. Here, we report that transforming growth factor-alpha (TGFalpha) may regulate sex- and age-dependent development of forebrain structures and associated neural functions after puberty. Waved-1 (Wa-1) mice inherit an autosomal recessive, spontaneous mutation that results in a postnatal reduction in TGFalpha gene expression. The assessment of forebrain structures using a three-dimensional magnetic resonance microscopy indicated ventricular enlargement and striatal reduction in both male and female Wa-1 adult mice, with Wa-1 males exhibiting a more severe phenotype. In contrast, the hippocampal volume was reduced only in adult Wa-1 males. Similarly, behavioral analyses showed impaired auditory and contextual fear learning in adult Wa-1 males only, whereas abnormal stress response was expressed by both male and female adult Wa-1 mice. Interestingly, all behavioral deficits were absent before full sexual maturation, despite some slight forebrain structural abnormalities. These results suggest that TGFalpha may regulate postpubertal, sex differentiation in ventricular and periventricular anatomy and associated behavior, affecting predominantly males. In particular, the adult male-specific reduction in hippocampal volume may reflect an age- and sex-specific regulation of stress homeostasis and fear learning. Furthermore, a lack of a behavioral phenotype, despite anatomical alterations in peripubertal Wa-1 mice, suggests that analysis of certain neuroanatomical features at puberty may predict neurobehavioral deficits in adulthood.
Acoustic Stimulation↗
Chemically mediated competition between microbes and animals: microbes as consumers in food webs.
Microbes are known to affect ecosystems and communities as decomposers, pathogens, and mutualists. However, they also may function as classic consumers and competitors with animals if they chemically deter larger consumers from using rich food-falls such as carrion, fruits, and seeds that can represent critical windfalls to both microbes and animals. Microbes often use chemicals (i.e., antibiotics) to compete against other microbes. Thus using chemicals against larger competitors might be expected and could redirect significant energy subsidies from upper trophic levels to the detrital pathway. When we baited traps in a coastal marine ecosystem with fresh vs. microbe-laden fish carrion, fresh carrion attracted 2.6 times as many animals per trap as microbe-laden carrion. This resulted from fresh carrion being found more frequently and from attracting more animals when found. Microbe-laden carrion was four times more likely to be uncolonized by large consumers than was fresh carrion. In the lab, the most common animal found in our traps (the stone crab Menippe mercenaria) ate fresh carrion 2.4 times more frequently than microbe-laden carrion. Bacteria-removal experiments and feeding bioassays using organic extracts of microbe-laden carrion showed that bacteria produced noxious chemicals that deterred animal consumers. Thus bacteria compete with large animal scavengers by rendering carcasses chemically repugnant. Because food-fall resources such as carrion are major food subsidies in many ecosystems, chemically mediated competition between microbes and animals could be an important, common, but underappreciated interaction within many communities.
Animals↗
Brief hierarchical assessment of potential treatment components with children in an outpatient clinic.
Seven patients conducted assessments in an outpatient clinic using a prescribed hierarchy of antecedent and consequence treatment components for their children's problem behavior. Brief assessment of potential treatment components was conducted to identify variables that controlled the children's appropriate behavior. Experimental control via a brief reversal was achieved for 6 of the 7 children, (1 child continued to behave appropriately following initial improvement in behavior). For these 6 children, improved behavior occurred with changes in treatment components. Our results extend previous studies of direct assessment procedures conducted in outpatient clinic settings.
Ambulatory Care↗
Evaluation of client preference for function-based treatment packages.
Functional communication training (FCT) and noncontingent reinforcement (NCR) are commonly prescribed treatments that are based on the results of a functional analysis. Both treatments involve delivery of the reinforcer that is responsible for the maintenance of destructive behavior. One major difference between the two treatment procedures is that client responding determines reinforcement delivery with FCT (e.g., reinforcement of communication is delivered on a fixed-ratio 1 schedule) but not with NCR (e.g., reinforcement is delivered on a fixed-time 30-s schedule). In the current investigation, FCT and NCR were equally effective in reducing 2 participants' destructive behavior that was sensitive to attention as reinforcement. After the treatment analysis, the participants' relative preference for each treatment was evaluated using a modified concurrent-chains procedure. Both participants demonstrated a preference for the FCT procedure. The results are discussed in terms of treatment efficacy and preference for control over when reinforcement is delivered. In addition, a method is demonstrated in which clients with developmental disabilities can participate in selecting treatments that are designed to reduce their destructive behavior.
Aggression↗
The effect of reinforcer preference on functional analysis outcomes.
We combined functional analyses and concurrent-schedule assessments to identify reinforcer preference during situations in which problem behavior may have been multiply controlled. Participants were 3 children with developmental delays who engaged in problem behavior during toy play with another child and one adult present, suggesting that problem behavior may have been maintained by adult attention or access to tangible reinforcement. Thus, conditions were designed to test attention and access-to-toys hypotheses. Initial functional analyses suggested multiple control. Subsequent concurrent-schedule assessments identified preference between the reinforcers, and treatments were based on these findings. Findings are discussed regarding the assessment of potentially multiply controlled problem behavior.
Adult↗
Evaluation of a brief multiple-stimulus preference assessment in a naturalistic context.
We evaluated a brief multiple-stimulus preference assessment within the context of an early intervention program for 3 children who had been diagnosed with autism. Subsequent curriculum-based reinforcer evaluations confirmed the predictions of the preference assessments. In addition, eight additional preference assessments that were conducted over a period of 1 month indicated generally stable preferences for 2 of the 3 participants.
Autistic Disorder↗
Training staff to conduct a paired-stimulus preference assessment.
Three staff members were trained to conduct stimulus preference assessments using a paired-stimulus format with 8 children with autism. Staff were trained to mastery level using brief instruction, a video model, and rehearsal with verbal feedback. Training took about 80 min per staff member. Results demonstrated that staff rapidly learned to correctly perform paired-stimulus preference assessments with children.
Adult↗
Progressing from programmatic to discovery research: a case example with the overjustification effect.
Scientific research progresses along planned (programmatic research) and unplanned (discovery research) paths. In the current investigation, we attempted to conduct a single-case evaluation of the overjustification effect (i.e., programmatic research). Results of the initial analysis were contrary to the overjustification hypothesis in that removal of the reward contingency produced an increase in responding. Based on this unexpected finding, we conducted subsequent analyses to further evaluate the mechanisms underlying these results (i.e., discovery research). Results of the additional analyses suggested that the reward contingency functioned as punishment (because the participant preferred the task to the rewards) and that withdrawal of the contingency produced punishment contrast.
Activities of Daily Living↗
On the effectiveness of and preference for punishment and extinction components of function-based interventions.
The current study describes an assessment sequence that may be used to identify individualized, effective, and preferred interventions for severe problem behavior in lieu of relying on a restricted set of treatment options that are assumed to be in the best interest of consumers. The relative effectiveness of functional communication training (FCT) with and without a punishment component was evaluated with 2 children for whom functional analyses demonstrated behavioral maintenance via social positive reinforcement. The results showed that FCT plus punishment was more effective than FCT in reducing problem behavior. Subsequently, participants' relative preference for each treatment was evaluated in a concurrent-chains arrangement, and both participants demonstrated a dear preference for FCT with punishment. These findings suggest that the treatment-selection process may be guided by person-centered and evidence-based values.
Attention Deficit and Disruptive Behavior Disorder↗
Brief functional analysis and treatment of tantrums associated with transitions in preschool children.
A brief functional analysis was used to examine the influence of termination of prechange activities and initiation of postchange activitieson tantrums exhibited by 2 preschool children. For 1 participant, tantrums were maintained by access to certain (pretransition) activities. For a 2nd participant, tantrums were maintained by avoidance of certain task initiations. Although advance notice of an upcoming transition was ineffective, differential reinforcement of other behavior plus extinction reduced tantrums for both participants.
Child Behavior Disorders↗
Discriminability and sensitivity to reinforcer magnitude in a detection task.
Three pigeons discriminated between two sample stimuli (intensities of red light). The difficulty of the discrimination was varied over four levels. At each level, the relative reinforcer magnitude for the two correct responses was varied across conditions, and the reinforcer rates were equal. Within levels, discriminability between the sample stimuli did not change systematically as reinforcer magnitude varied. Across levels, the sensitivity of behavior to changes in the reinforcer-magnitude ratio decreased as the discriminability between the sample stimuli increased. Subsequent analysis showed that this relation was limited to performance following only one of the sample stimuli, the dim red light that remained constant across all conditions. Extant behavioral models of signal detection cannot easily accommodate these results.
Animals↗