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Results for “Carrying Capacity”

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PubMed2006

Training of healthcare personnel to improve performance of community-based antenatal care program.

BACKGROUND: The present study was performed to evaluate the effectiveness of a training course designed to improve the knowledge, skills, and attitudes of healthcare personnel to allow them to provide a comprehensive community-based antenatal care (ANC) program in rural Paraguay. METHODS: Sixty-eight of 110 healthcare personnel in the Caazapa Region of Paraguay participated in a nine-day training course between November 1997 and March 1998. The knowledge of the participants related to maternal healthcare services was assessed both before and after the training course, and enrollment rates of pregnant women in ANC before and after the training were compared as a measure of patient satisfaction. The participants were also asked to evaluate the appropriateness of each individual method used in the training course. RESULTS: The average scores of the participants' knowledge increased significantly from 41.0 before to 60.1 after training (p<0.001). The enrollment rates of pregnant women in ANC increased from 2.2 times per pregnancy in 1996 to 3.4 times in 1998 (p<0.001). The participants reported that role-playing, demonstrations using visual information, and hands-on practice at a hospital were useful training methods. CONCLUSIONS: Continuous training for healthcare personnel in rural Paraguay contributes to an increase in their capacity to carry out community-based ANC program. The participants reported that learning through peer-educators, interactive communications, role-playing, and supervision provided in actual community services were beneficial. Continuous supervision should be provided to enable healthcare personnel to maintain the knowledge and skills acquired in the training.

Clinical Competence↗
PubMed2006

Functional status in the elderly with insomnia.

BACKGROUND: Insomnia causes psychological distress in the elderly. Besides primary insomnia (PI), illness, medications and psychosocial factors contribute to development of sleep disorders. Although elderly insomniacs usually complain of poorer daytime functioning, it is unknown whether the disorder affects capacity to carry out activities. OBJECTIVE: To assess the relationship in the elderly between PI, level of physical functioning, depression and anxiety symptoms, state of psychological well-being and consumption of psychopharmaceuticals. DESIGN: Cross-sectional, observational study. SETTING: Populational. SUBJECTS: About 424 non-institutionalized elderly patients. METHODS: Subjects were interviewed at public Health Centres or at home. They were considered to have PI if DSM-IV criteria were met. The remaining variables measured were: depression and anxiety symptoms (The Goldberg's Depression and Anxiety Scale), cognitive state (Short Portable Mental Status Questionnaire), physical functioning (The Katz Index and the Instrumental Activities of Daily Living Scale), life satisfaction (The Philadelphia Geriatric Center Morale Scale), health problems, consumption of pharmaceuticals and sociodemographic variables. RESULTS: About 34.2% of the elderly admitted to having problems with sleep, but only 20.3% (CI: 95%: 16.5-24.1) fulfilled the criteria for PI. The existence of an anxiety disorder, a score below the 50th percentile on The Philadelphia Geriatric Center Morale Scale (lower life satisfaction) and consumption of psychopharmaceuticals were variables associated with insomnia. Amongst the most common illnesses reported, only diabetes appeared with significantly higher frequency in the elderly with insomnia (24.4% vs. 14.7%) (p < 0.05). No statistically significant association was found between insomnia and level of dependence in carrying out basic or instrumental activities. CONCLUSIONS: Approximately one fifth of the non-institutionalized elderly meet the criteria for PI. Those affected present a poorer state of psychological and social well-being, although level of autonomy for conducting basic and instrumental activities does not appear to be modified by the disorder. The existence of an anxiety disorder, low life satisfaction and consumption of psychopharmaceuticals constitute variables associated with PI in the population we studied.

Aged↗
PubMed2026

The TyrRS cascade: circadian gating of neuronal DNA repair and its collapse in aging.

Age-related neurodegenerative diseases are characterized by progressive DNA damage in post-mitotic neurons against a backdrop of deteriorating circadian rhythms, yet the molecular link between these conjoined features of brain aging remains unclear. We propose the TyrRS cascade as that link: a signaling architecture in which the noncanonical nuclear functions of tyrosyl-tRNA synthetase (TyrRS/YARS1) schedule neuronal genome maintenance across the day through three coregulated streams, PARP1-mediated damage sensing, TRIM28/NuRD heterochromatin maintenance, and LIN9/DREAM control of a 67-gene repair archive. The model's central commitment is that the operative variable is oscillation amplitude rather than mean activity. We argue that as serum tyrosine rises with age and circadian amplitude flattens, these insults compound into a double-hit collapse that traps the cascade in a frozen-intermediate state, which bulk-tissue assays misread as elevated mean activity when the oscillation has merely lost its excursion. Placed in dialogue with oscillatory-clearance models of sleep, the cascade and the glymphatic system emerge as complementary, compartment-separated arms of a single sleep-dependent maintenance program that fail together through amplitude collapse, yielding a signature of preserved phase architecture with reduced dynamic range. Reframing neurodegeneration as a scheduling failure rather than a capacity failure carries three translational consequences: Pulsatile, phase-aligned dosing should outperform sustained-release pharmacology, which is predicted to flatten the rhythm it aims to restore; demonstrating target engagement will require phase-resolved rather than single-timepoint measurement; and because both arms fail together, combined restoration of intracellular repair and extracellular clearance should outperform single-arm intervention.

Alzheimer&#x2019;s disease↗
PubMed1977

The effect of calcium on the respiratory responses of mung bean mitochondria.

Purified mung bean hypocotyl mitochondria were examined for their capacity to carry out respiration-dependent accumulation of calcium. The addition of 0.1-1.0 mM calcium to mung bean mitochondria supplemented with succinate gave no stimulation of state 4 respiration even in the presence of inorganic phosphate and the ionophoretic antibiotic A-23187. Even at high calcium concentrations, no transient changes in the respiratory activity occurred and subsequent addition of ADP initiated a further state 3 response. Although the additions of calcium resulted in a rapid H+ ejection, it was insensitive to lanthanum and uncoupling agents. Similarly, additions of calcium failed to initiate any transient changes in the oxidation-reduction states of either pyridine nucleotides or cytochrome b. Direct spectrophotometric recordings of absorbance changes of murexide revealed no respiration-linked calcium transport. It is proposed that although mung bean mitochondria possess a respiration-linked electrochemical potential gradient it would appear that this potential cannot be expressed as calcium transport even at high ion concentrations, probably due to a low calcium membrane permeability.

Anaerobiosis↗
PubMed1989

Fertility decline in Mauritius: the role of Malthusian population pressure.

Mauritius provides 1 of the outstanding cases of modern fertility reduction in the Third World, yet there has been little analysis and virtually no comparative assessment of this important demographic progression. It is argued that fertility decline in Mauritius has been hindered by cultural composition, assisted only modestly by ongoing development, but aided significantly by family planning program intervention and by a remarkable wide recognition at government and individual levels of the diseconomies associated with population growth in a congested society; comparisons are made with other densely peopled, small islands. Spatial variations in fertility and in family planning activity are slight, but Western economic theories of fertility are found to be helpful in interpreting significant temporal fluctuations.

Africa↗
PubMed1988

Gerbil adrenal 11 beta- and 19-hydroxylating activities respond similarly to inhibitory or stimulatory agents: two activities of a single enzyme.

A high level of steroid 19-hydroxylation is exhibited by adrenal mitochondria of the gerbil, Meriones, unguiculatus, that accounts for the ability of that species to produce nearly equal amounts of corticosterone and 19-hydroxycorticosterone (Proc. Soc. exp. Biol. Med. 165 (1980) 69-74). Inhibitors of steroidogenesis and a polyclonal antibody against bovine cytochrome P-450(11 beta) were used to determine if the agents would effect differential or parallel suppression of 19- vs 11 beta-hydroxylation by gerbil adrenal mitochondria in vitro. The inhibitors (0.1-60 microM) tested (listed in order of decreasing effectiveness) were imazalil, metyrapone, miconazole and 4-hydroxyandrostenedione. With each inhibitor the degree of suppression of 11 beta-hydroxylation was accompanied by a parallel decline in 19-hydroxylation. The addition of the polyclonal antibody preparation also produced equivalent declines in the rates of the two hydroxylation reactions. The addition of ACTH 1 microM to primary cultures of gerbil adrenal cells brought about nearly equal increases in the secretion of 11 beta- and 19-hydroxylated steroids into the culture media. These results support the hypothesis that the 11 beta-hydroxylase of gerbil adrenal mitochondria has the capacity to carry out 11 beta- and 19-hydroxylations with nearly equal facility.

Adrenal Cortex↗
PubMed1984

Food and water hygiene and diarrhoea in young Gambian children: a limited case control study.

During the annual rainy season epidemic of diarrhoea in The Gambia, two groups of urban children were identified, one of which remained completely free of diarrhoea and another in which diarrhoeal prevalence exceed 30% over a period of three months. Microbiological studies on the food and water consumed by these children during one day showed widely varying degrees of contamination in both groups. No difference was observed in levels of contamination, faecal or otherwise, between the two groups. The real problem seemed to lie in accounting for the freedom from diarrhoea of some children rather than explaining possible causes of morbidity in others.

Child, Preschool↗
PubMed1983

Libido and scrotal circumference of rams as affected by season of the year and altered photoperiod.

Two trials were conducted to evaluate the influence of season of the year and altered photoperiod on libido and scrotal circumference (SC). A 30-minute serving-capacity test was used to measure ram libido. the measures of libido were reaction time (RT), time from entry into the pen to first mount and/or service, total mounts (M), and total services (S). The serving-capacity test was conducted by placing a ram with four estrus-induced ewes and measuring RT and counting M and S. Prior to each serving-capacity test, SC was measured for each ram. Rams were tested every two weeks. In Trial I, eleven two-year-old Rambouillet rams from each of three selection lines -a high line (four rams; selected on the basis of high prolificacy), a low line (three rams; selected on the basis of low prolificacy) and a random bred control line (four rams) - were used in a one-year study. Rams were exposed to ambient conditions throughout the year. Rams were more active during the short days of fall and winter, i.e. normal breeding season, as evidenced by a greater number of total mounts and services plus a shorter reaction time. Selection line affected reproductive parameters measured, with the high line having more M and S and a shorter RT than the low line. However, SC was larger in the low line. In Trial II twelve rams were divided into two groups of six. The control group was exposed to ambient conditions from April 18 through July 24. The treated group was exposed to eight hours of light and 16 hours of darkness (8L:16D) from April 18 through July 24, simulating short days of fall and winter. Total services (S) in the 30-minute test interval were higher for rams subjected to the 8L:16D treatment (P<0.01; 2.7+/-0.2 vs 1.6+/-0.2 for 8L:16D and control, respectively). SC was 31.7+/-0.2 vs 30.2+/-0.2 for 8L:16D and control, respectively (P<0.01). Total mounts in 30 minutes were not affected by treatment (6.9+/-0.8 vs 5.7+/-0.8 for 8L:16D and control, respectively; P>0.10). No significant differences in any of the reproductive parameters between treatment groups were observed during the first 28 days. However, there were significant differences (P<0.05) observed between 8L:16D rams and control rams for SC during 42 to 84 days and S between days 42 to 70, respectively. Serving-capacity tests carried out about one month following the end of altered photoperiod trial showed no significant differences between treated and control rams, thus indicating that treatment had no carry-over effect.

Journal Article↗