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PubMed2004

Phasic alterations in dopamine and serotonin release in striatum and prefrontal cortex in response to cocaine predictive cues in behaving rhesus macaques.

The ability of environmental cues associated with cocaine availability to cause relapse may result from conditioned activation of dopamine (DA) release. We examined this hypothesis in macaque monkeys by conducting microdialysis studies in animals during exposure to a cocaine predictive compound cue. In addition to studying DA release in mesolimbic and sensorimotor striatum, both DA and serotonin levels were determined in the prefrontal cortex (medial orbitofrontal and anterior cingulate). The compound cue employed visual, auditory, and olfactory components, and was salient to the animals as demonstrated by anticipatory lever pressing in the absence of cocaine. During a 10-min period of exposure prior to cocaine availability, there was no significant increase in striatal or cortical DA. The addition of a DA uptake inhibitor to the striatal perfusate to reduce the potential interference of neuronal uptake did not alter the results. In contrast to the lack of any change in striatal DA, a significant decrease in extracellular serotonin in the prefrontal cortex during the 10 min of cue exposure was observed.

Animals↗
PubMed2005

The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat.

This study examines, for the first time, the effects of acamprosate and the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist neramexane on ethanol-seeking induced by alcohol-related environmental stimuli in an animal model of relapse. Wistar rats were trained to operantly self-administer ethanol (10% w/v) or water on a fixed-ratio 1 schedule in a 30-min daily session. Ethanol availability was signaled by an olfactory discriminative stimulus of orange extract (S+). In addition, each lever press was accompanied by a 5-s illumination of the operant chamber's house light (CS+). Water availability was signaled by anise odor (S-) and 5-s white noise stimulus (CS-). After completion of the conditioning phase, indicated by stable levels of responding, operant behaviors were extinguished. Prior to reinstatement tests, animals were divided into groups according to either treatment with acamprosate (100, 200 mg/kg given twice), neramexane (1.0, 2.0, 4.0 mg/kg), or vehicle. In vehicle-treated rats, re-exposure to the S+/CS+ in the absence of further ethanol availability elicited strong recovery of responding. No effect was observed following presentation of water-paired cues (S-/CS-). Acamprosate dose-dependently attenuated recovery of responding elicited by ethanol-paired cues (S+/CS+), whereas responding under S-/CS- was not modified by drug administration. Treatment with 1.0 and 2.0 mg/kg of neramexane did not significantly modify responding under both S+/CS+ and S-/CS- conditions. However, a slight reduction of cue-induced reinstatement of alcohol seeking was observed. At the dose of 4.0 mg/kg, neramexane elicited a marked inhibition of responding following presentation of both ethanol- and water-paired cues. In conclusion, acamprosate significantly and selectively reduced alcohol-seeking elicited by environmental stimuli predictive of alcohol availability. Treatment with neramexane that shares part of the pharmacological effects of acamprosate on NMDA receptors, however, resulted in a nonselective reduction of lever responding.

Acamprosate↗
PubMed2003

Not letting the left leg know what the right leg is doing: limb-specific locomotor adaptation to sensory-cue conflict.

We investigated the phenomenon of limb-specific locomotor adaptation in order to adjudicate between sensory-cue-conflict theory and motor-adaptation theory. The results were consistent with cue-conflict theory in demonstrating that two different leg-specific hopping aftereffects are modulated by the presence of conflicting estimates of self-motion from visual and nonvisual sources. Experiment 1 shows that leg-specific increases in forward drift during attempts to hop in place on one leg while blindfolded vary according to the relationship between visual information and motor activity during an adaptation to outdoor forward hopping. Experiment 2 shows that leg-specific changes in performance on a blindfolded hopping-to-target task are similarly modulated by the presence of cue conflict during adaptation to hopping on a treadmill. Experiment 3 shows that leg-specific aftereffects from hopping additionally produce inadvertent turning during running in place while blindfolded. The results of these experiments suggest that these leg-specific locomotor aftereffects are produced by sensory-cue conflict rather than simple motor adaptation.

Adaptation, Physiological↗
PubMed1999

Cue exposure treatment for smoking relapse prevention: a controlled clinical trial.

AIMS: In an additive design, test the efficacy of cue exposure treatment for smoking relapse prevention as an adjunct to current standard cognitive behavioral and pharmacological treatments. DESIGN: Randomized, controlled clinical trial. SETTING: Outpatient behavioral medicine clinic. PARTICIPANTS: One hundred and twenty-nine cigarette smokers recruited through newspaper advertisements. INTERVENTION: After receiving an initial counseling session for cessation and setting a quit day, 129 smokers were randomly assigned to one of four relapse prevention treatment conditions: (1) brief cognitive behavioral; (2) cognitive behavioral and nicorette gum; (3) cognitive behavioral and cue exposure; and (4) cognitive behavioral and cue exposure with nicorette gum. All smokers met individually with their counselor for six RP sessions. MEASURES: Seven-day, point-prevalence abstinence rates (CO verified) taken at 1, 3, 6 and 12-months post-treatment and time to first slip. FINDINGS: All manipulation checks and process measures suggested that the treatments were delivered as intended. There were no significant differences between conditions in point-prevalence abstinence rates or in time to first slip. CONCLUSIONS: These results call into question the utility of cue exposure treatment for smoking relapse prevention.

Adult↗
PubMed2000

Cue-dose training with monetary reinforcement: pilot study of an antiretroviral adherence intervention.

OBJECTIVE: To assess the feasibility and efficacy of two interventions for improving adherence to antiretroviral therapy regimens in HIV-infected subjects compared with a control intervention. DESIGN: Randomized, controlled, pilot study. SETTING: Department of Veterans Affairs HIV clinic and community-based HIV clinical trials site. PARTICIPANTS: Fifty-five HIV-infected subjects on stable antiretroviral therapy regimens. Subjects were predominantly male (89%) and African American (69%), and had histories of heroin or cocaine use (80%). INTERVENTIONS: Four weekly sessions of either nondirective inquiries about adherence (control group, C), cue-dose training, which consisted of the use of personalized cues for remembering particular dose times, and feedback about medication taking using Medication Event Monitoring System (MEMS) pill bottle caps, which record time of bottle opening (CD group), or cue-dose training combined with cash reinforcement for correctly timed bottle opening (CD+CR). MEASUREMENTS: Opening of the pill bottle within 2 hours before or after a predetermined time was measured by MEMS. RESULTS: Adherence to the medication as documented by MEMS was significantly enhanced during the 4-week training period in the CD+CR group, but not in the CD group, compared with the control group. Improvement was also seen in adherence to antiretroviral drugs that were not the object of training and reinforcement. Eight weeks after training and reinforcement were discontinued, adherence in the cash-reinforced group returned to near-baseline levels. CONCLUSIONS: Cue-dose training with cash reinforcement led to transient improvement in adherence to antiretroviral therapy in a population including mostly African Americans and subjects with histories of drug abuse. However, we were not able to detect any sustained improvement beyond the active training period, and questions concerning the timing and duration of such an intervention require further study. Randomized, controlled clinical studies with objective measures of adherence can be conducted in HIV-infected subjects and should be employed for further evaluation of this and other adherence interventions.

Anti-HIV Agents↗
PubMed2003

[Sound localization cues of binaural hearing].

The ability to localize sound sources in space is of considerable importance to the human safety- and survival-system. Consequently the current scientific interest in improving the safety-standard i. e. in air-traffic control has provided a new momentum for investigating spatial hearing. This review deals with the nature and the relative salience of the localization cues. Localization refers to judgements of the direction and distance of a sound source but here we will deal with direction only. We begin with a short introduction into the so-called Duplex theory which dates back to John William Strutt (later Lord Rayleigh). The idea is that sound localization is based on interaural time differences (ITD) at low frequencies and interaural level differences (ILD) at high frequencies. If the head remains stationary neither a given ITD nor an ILD can sufficiently define the position of a sound source in space. On such a theoretical basis cones of confusion which open outward from each ear can be predicted ambiguously projecting any source on the surface of such a cone onto an interaural axis. Our restricted ability at localizing sound sources in the vertical median plane is another example of possible ambiguity. At the end of the 19th century scientists already realized that occlusion of the pinnae cavities decreases localization competence. As a result of later achievements in physics and signal-theory it became more obvious that the pinnae may provide an additional cue for spatial hearing and that the outer ear together with the head and the upper torso form a sophisticated direction-dependent filter. The action of such a filter is mathematically described by the so-called Anatomical Transfer Function (ATF). The spectral patterning of the sound produced by the pinnae and the head is most effective when the source has spectral energy over a wide range and contains frequencies above 6 kHz, that is it contains wavelengths short enough to interact with the anatomical characteristics of the outer ears. Scientific findings further suggest that spectral patterns like peaks and notches may also be exploited monaurally, albeit an a priori-knowledge at the central-auditive level concerning the corresponding transfer functions and relevant real-world sounds is required. Binaural spectral cues are more likely to play a major role in localization. They are derived from another transfer function, the so-called Interaural Transfer Function (ITF), being the ratio of the ATFs at the two ears. The contributions of all these cues may sometimes not be enough to prevent the listener from opting for the wrong direction. But things can be eased by allowing head-movements: More than 60 years ago science reasoned that small head movements could provide the information necessary to resolve most of the ambiguities. Recent studies have proved that these findings have been accurate all along.

Cues↗
PubMed1992

Spectral content as a cue to perceived auditory distance.

Changes in the spectral content of wide-band auditory stimuli have been repeatedly implicated as a possible cue to the distance of a sound source. Few of the previous studies of this factor, however, have considered whether the cue provided by spectral content serves as an absolute or a relative cue. That is, can differences in spectral content indicate systematic differences in distance even on their first presentation to a listener, or must the listener be able to compare sounds with one another in order to perceive some change in their distances? An attempt to answer this question and simultaneously to evaluate the possibly confounding influence of changes in the sound level and/or the loudness of the stimuli are described in this paper. The results indicate that a decrease in high-frequency content (as might physically be produced by passage through a greater amount of air) can lead to increases in perceived auditory distance, but only when compared with similar sounds having a somewhat different high-frequency content, ie spectral information can serve as a relative cue for auditory distance, independent of changes in overall sound level.

Acoustic Stimulation↗
PubMed1999

Stored representations of three-dimensional objects in the absence of two-dimensional cues.

Object recognition was studied in human subjects to determine whether the storage of the visual objects was in a two-dimensional or a three-dimensional representation. Novel motion-based and disparity-based stimuli were generated in which three-dimensional and two-dimensional form cues could be manipulated independently. Subjects were required to generate internal representations from motion stimuli that lacked explicit two-dimensional cues. These stored internal representations were then matched against internal three-dimensional representations constructed from disparity stimuli. These new stimuli were used to confirm prior studies that indicated the primacy of two-dimensional cues for view-based object storage. However, under tightly controlled conditions for which only three-dimensional cues were available, human subjects were also able to match an internal representation derived from motion of that of disparity. This last finding suggests that there is an internal storage of an object's representations in three dimensions, a tenet that has been rejected by view-based theories. Thus, any complete theory of object recognition that is based on primate vision must incorporate three-dimensional stored representations.

Analysis of Variance↗
PubMed2001

Visuospatial attention: the role of target contrast and task difficulty when assessing the effects of cues.

Cueing paradigms have become popular in assessing the processes of attention. In two experiments we manipulated (i) the contrast of the target, and (ii) the similarity between the targets discriminated. We used a cue that would isolate the exogenous component of attention. Both a reduction in target contrast and an increase in target similarity raised overall reaction times by a similar amount; however, the target contrast manipulation produced a much greater cueing effect compared with the target similarity manipulation. The results suggest that manipulation of target contrast changes the attention cueing effect at a stage of attracting attention to a location of the target (the 'move' stage), rather than at a later processing stage.

Adolescent↗
PubMed2004

DNA targeting of rhinal cortex D2 receptor protein reversibly blocks learning of cues that predict reward.

When schedules of several operant trials must be successfully completed to obtain a reward, monkeys quickly learn to adjust their behavioral performance by using visual cues that signal how many trials have been completed and how many remain in the current schedule. Bilateral rhinal (perirhinal and entorhinal) cortex ablations irreversibly prevent this learning. Here, we apply a recombinant DNA technique to investigate the role of dopamine D2 receptor in rhinal cortex for this type of learning. Rhinal cortex was injected with a DNA construct that significantly decreased D2 receptor ligand binding and temporarily produced the same profound learning deficit seen after ablation. However, unlike after ablation, the D2 receptor-targeted, DNA-treated monkeys recovered cue-related learning after 11-19 weeks. Injecting a DNA construct that decreased N-methyl-d-aspartate but not D2 receptor ligand binding did not interfere with learning associations between the cues and the schedules. A second D2 receptor-targeted DNA treatment administered after either recovery from a first D2 receptor-targeted DNA treatment (one monkey), after N-methyl-d-aspartate receptor-targeted DNA treatment (two monkeys), or after a vector control treatment (one monkey) also induced a learning deficit of similar duration. These results suggest that the D2 receptor in primate rhinal cortex is essential for learning to relate the visual cues to the schedules. The specificity of the receptor manipulation reported here suggests that this approach could be generalized in this or other brain pathways to relate molecular mechanisms to cognitive functions.

Animals↗
PubMed2003

Implicit learning in memory rehabilitation: a meta-analysis on errorless learning and vanishing cues methods.

The objective of this study was to present a quantitative review on the treatment effects of memory rehabilitation techniques based on intact implicit learning capacity in amnesic patients, that is, errorless learning and the method of vanishing cues. English-language journal articles focusing on these rehabilitation techniques were examined using MedLine (1966-2002) or PsychInfo (1887-2002), as well as additional papers listed in the references of these articles. Studies had to meet the following inclusion criteria: (1) original data were reported, (2) memory rehabilitation was studied in memory-impaired patients, (3) a control intervention was included, (4) exact scores were listed for both intervention conditions, or the exact statistics were presented. Studies were classified on the basis of the to-be-learned material and the method of intervention (errorless learning, vanishing cues, control intervention), patient characteristics were determined, and the tasks that were used were taken into account. Effect sizes and variances were computed for each individual study compared to control treatment using within-group statistics. A "large" and statistically significant ES was found for errorless learning treatment, but no significant ES was demonstrated for the vanishing cues method. The results of the present study show that the errorless learning technique is effective in amnesic patients. The effects on the vanishing cues method are only small (and nonsignificant).

Adult↗
PubMed2000

Effects of a target movement direction cue on head-tracking performance.

A review of the literature has shown that most investigations of head-tracking performance have used symmetrically shaped targets. This paper identifies a problem in using circular targets to represent the movement of complex targets (i.e. targets giving directional cues). Two experiments investigated the effects of a target direction cue on head-tracking performance. In the first experiment, practice did not improve performance when tracking either with or without a 'look-ahead trace' showing all target positions 160 ms into the future. A second experiment utilized a 'look-ahead trace' showing target positions with eight different lead-times (0-560 ms). With lead-times of 160 ms or more, significant improvements in tracking performance and subjective difficulty ratings were obtained. Tracking responses were also significantly affected. The results suggest caution when performance data obtained with a symmetrical target are generalized to predict tracking performance with a real target giving cues to the direction of movement. The look-ahead trace offers a systematic means of bridging the gap between a symmetrical target and a real target having direction of movement cues.

Audiovisual Aids↗
PubMed1983

The effect of distance and location cues on linear arm positioning by children.

Forty-five boys in each of three age groups learned a 40 cm linear arm movement, without the aid of vision. Fifteen in each age group attempted to reproduce the movement using either distance, location, or distance plus location cues. Analysis of absolute error scores showed a significant effect of movement cue with inferiority in recall using distance cues compared with the other cue conditions. The interaction effect was also significant. The results are discussed in terms of the development of coding systems for movements in short-term memory.

Adolescent↗
PubMed2001

Speech-reading of synthetic and natural faces: effects of contextual cueing and mode of presentation.

A natural and a synthetic face were compared with regard to speech-reading performance, with a visual and an audio-visual condition, and with three levels of contextual cueing in an experiment with 90 normal-hearing subjects. Auditory presentation (speech in noise) served as a control condition. The results showed main effects for type of face, presentation mode and contextual cueing, and also an interaction between presentation mode and type of face, such that performance was superior for the natural compared with the synthetic face, and especially in the audio-visual mode. Audio-visual speech-reading was more accurate than visual and auditory presentation and contextual cueing improved performance overall. It is suggested that a synthetic face can be a valuable and useful support if proper cueing and an auditory signal are provided, but it is outperformed by a natural face with regard to complementarity to an underspecified auditory speech signal.

Adult↗
PubMed2004

Environmental context-dependent recognition memory effects: an examination of ICE model and cue-overload hypotheses.

The ICE model account (e.g., Murnane & Phelps, 1993; Murnane, Phelps, & Malmberg, 1999) of environmental context (EC)-dependent recognition memory is described, and new predictions concerning the effect of multiple presentation ECs are derived. Experiment 1 tested the ICE model predictions in relation to predictions derived from the cue-overload hypothesis (e.g., Watkins, 1979). In addition, the sensitivity of recognition reaction time (RT) as a measure of EC-dependent memory effects was examined. Minimal support was obtained for the ICE model, but greater support was provided for the cue-overload hypothesis. In Experiment 2, further manipulations were employed to test ICE model predictions and the cue-overload hypothesis, with relevance to the mental reinstatement and outshining hypotheses. Again support for the cue-overload hypothesis was obtained, and an EC reinstatement effect with RTs was detected. The ICE model is considered in respect of these findings.

Cues↗
PubMed2005

Enhanced self-localization by auditory cues in blind humans.

PURPOSE: Investigate the involvement of auditory spatial compensation, which is observed in blind humans, in self-localization processes. METHOD: Sighted and early-blind subjects had to indicate, on a two-dimensional view of the experimental room, the position where they previously sat and had passively listened to auditory spatial cues. Two different environments were distinguished. In a first session, auditory cues (i.e., white broadband sounds) were displayed successively in a dark anechoic room. This condition was defined as a simple acoustic environment. In a second session, four different auditory cues were displayed simultaneously at regular intervals in an experimental room, where echo cues were salient. This condition, which is more reminiscent of the natural situation, was described as a complex acoustic environment. RESULTS: Self-localization capacities were significantly better in early-blind individuals than in sighted subjects, whatever the type of acoustic environment. CONCLUSIONS: Auditory compensation leads to improved self-localization capacities in early-blind humans and indicates that prior visual experience is not essential for the development of spatial competence.

Adolescent↗
PubMed2001

Prospective remembering in younger and older adults: role of the prospective cue.

In these studies, adult age differences in event-based prospective memory were examined using an adapted version of G.O. Einstein and M.A. McDaniel's (1990) task. In Experiments 1-3, we varied prospective cue specificity by assigning a specific target word or an unspecified word drawn from a given taxonomic category. In Experiment 3, we manipulated cue typicality by presenting low or high typicality target words. Results yielded positive effects of cue specificity on prospective performance. Age effects occurred when high typicality target words served as prospective cues (Exps. 1 and 3), but younger and older adults performed comparably with moderate and low typicality words (Exps. 2 and 3). Hierarchical regression analyses indicated that age accounted for a small but significant amount of variance in prospective memory, although the contribution of age was substantially reduced after statistically controlling for recognition memory. Implications of these data for current views on prospective remembering are discussed.

Adolescent↗
PubMed2005

The effects of cue modality on the quality of personal memories retrieved.

We investigated the effect of cue modality on the specificity, speed, vividness, and age of autobiographical memory retrieval. Cues were presented as either an odour, a visual image, or a word label. Odour-cued memories were older, more likely to be categoric, and were slower to be retrieved. Few gender differences were found although females reported more vivid memories than males. We suggest that cue modality directly affects retrieval processes; odour cues are more likely to initiate a perceptual search strategy, in contrast to memories cued by visual images and words, which are usually conceptually/verbally mediated.

Adult↗