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PubMed1978

Human bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbons.

Cultured human bronchial explants activated benzo[alpha]pyrene (BzaP) into electrophilic metabolites that bind to DNA in bronchial epithelial cells. Promutagenic and mutagenic metabolites of BzaP were also released into the culture medium. An increase in mutation frequency for ouabain resistance was found in Chinese hamster V-79 cells when they were cocultivated with bronchial explants in the presence of BzaP. The proximate carcinogenic form of BzaP, the 7,8-diol [(+/-)-r7,t8-dihyroxy-7,8-dihydrobenzo[a]pyrene], was 5-fold more potent as a promutagen than the parent compound. Neither BzaP nor the 7,8-diol increased the mutation frequency in V-79 cells when they were cultured without bronchial explants. The mutation frequency was directly related to the binding levels of BzaP to bronchial DNA and the concentratin of either BzaP or the 7,8-diol in the medium.

Adenosine Triphosphatases↗
PubMedDate not supplied

Mucoepidermoid carcinoma of the bronchus.

Bronchoscopy in a 4.5-year-old girl with recurrent pneumonia showed an exophytic endobronchial mass. Biopsy disclosed microscopic and ultrastructural features of a low-grade mucoepidermoid carcinoma. Complete cure was accomplished by surgical removal of the tumor and right lower lobe.

Adolescent↗
PubMedDate not supplied

Early appearance of TNF-alpha and other cytokines in bronchus associated lymphoid tissues (BALT) from growing Wistar rats. what is the role of TNF-alpha?

Several different cytokines trigger the development of determined cell subsets in BALT of growing Wistar rats. Early appearance (4 days post partum) of gammadeltaT cells in BALT has been shown, as well as its role in up-regulating TNF-alpha production. In the present report, we studied in the BALT: (1) the profile of the cytokines, TNF-alpha, INF-alpha and IL-10 and (2) in TCR gammadelta+ cells, the existence of a colocalization with TNF-alpha as well as with INF-gamma. All the cytokines studied were observed at an early stage of BALT development by immunohistochemistry and in bronchoalveolar cells (BAL cells) by flow cytometry and western blot. (1) The principal cytokine found at 4 days of age in BALT cells was TNF-alpha that increases along BALT development. The same behavior was found for cells containing IL-10 and INF-gamma. (2) TCR gammadelta+ cells colocalize mainly with TNF-alpha as it has been shown by immunohistochemistry in BALT and by flow cytometry when we studied BAL. The early appearance of TNF-alpha concomitant with TCR gammadelta+ cell suggests an important role for this cytokine along BALT development. Moreover, mutual regulation between them exists taking part in the immune surveillance and repair of damaged epithelia.

Animals↗