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PubMed2002

Quantitative investigation of acoustic streaming in blood.

Acoustic streaming may have practical utility in diagnostic medical ultrasound in distinguishing between stagnant blood and tissue as well as clotted and unclotted blood. This distinction can be difficult with conventional ultrasound but have high value in managing trauma patients with internal hemorrhage. Ultrasound energy applies a force to blood by momentum transfer, resulting in bulk streaming that is a function of the acoustic attenuation, sound speed, acoustic intensity, blood viscosity, and the boundary conditions posed by the geometry around the hematoma. A simple tubular model was studied analytically, by finite element simulation, and experimentally by in vitro measurement. The simulation agreed closely with measurements while the analytic solutions were found to be valid only for beam diameters approximating the diameter of the tubular channel. Experimentally, the acoustic streaming in blood decreased as the blood began to clot and the streaming flow was not detected in clotted blood. In contrast, the echogenicity of the same blood samples did not change appreciably from the unclotted to the clotted state for the stagnant blood studied. Streaming detection appears to offer a potential tool for improving hemorrhage diagnosis.

Acoustics↗
PubMed2002

Toward a model for lexical access based on acoustic landmarks and distinctive features.

This article describes a model in which the acoustic speech signal is processed to yield a discrete representation of the speech stream in terms of a sequence of segments, each of which is described by a set (or bundle) of binary distinctive features. These distinctive features specify the phonemic contrasts that are used in the language, such that a change in the value of a feature can potentially generate a new word. This model is a part of a more general model that derives a word sequence from this feature representation, the words being represented in a lexicon by sequences of feature bundles. The processing of the signal proceeds in three steps: (1) Detection of peaks, valleys, and discontinuities in particular frequency ranges of the signal leads to identification of acoustic landmarks. The type of landmark provides evidence for a subset of distinctive features called articulator-free features (e.g., [vowel], [consonant], [continuant]). (2) Acoustic parameters are derived from the signal near the landmarks to provide evidence for the actions of particular articulators, and acoustic cues are extracted by sampling selected attributes of these parameters in these regions. The selection of cues that are extracted depends on the type of landmark and on the environment in which it occurs. (3) The cues obtained in step (2) are combined, taking context into account, to provide estimates of "articulator-bound" features associated with each landmark (e.g., [lips], [high], [nasal]). These articulator-bound features, combined with the articulator-free features in (1), constitute the sequence of feature bundles that forms the output of the model. Examples of cues that are used, and justification for this selection, are given, as well as examples of the process of inferring the underlying features for a segment when there is variability in the signal due to enhancement gestures (recruited by a speaker to make a contrast more salient) or due to overlap of gestures from neighboring segments.

Attention↗
PubMed2002

Range-dependent seabed characterization by inversion of acoustic data from a towed receiver array.

The MAPEX2000 experiments were conducted in the Mediterranean Sea in March, 2000 to determine seabed properties using a towed acoustic source and receiver array. Towed systems are advantageous because they are easy to deploy from a ship and the moving platform offers the possibility for estimating spatially variable (range-dependent) seabed properties. In this paper, seabed parameters are determined using a matched-field geoacoustic inversion approach with measured, towed array data. Previous research has successfully applied matched-field geoacoustic inversion techniques to measured acoustic data. However, in nearly all cases the inverted data were collected on moored, vertical receiver arrays. Results here show that seabed parameters can also be extracted by inverting acoustic measurements from a towed array of receivers, and these agree with those inverted using data received simultaneously on a vertical array. These findings imply that a practical technique could be developed to map range-dependent seabed parameters over large areas using a towed acoustic system. An example of such a range-dependent inversion is given using measurements from the MAPEX2000 experiments.

Acoustics↗
PubMed2002

Sweet spot size of virtual acoustic imaging systems at asymmetric listener locations.

Virtual acoustic imaging systems are effective when the listener's head location is close to the head location assumed when the system was designed. The "sweet spot" refers to the spatial bubble of head location in which the system is still effective. Some of the previous work investigating the "stereo dipole" acoustic imaging system shows that for the traditional on-axis listener location the "sweet spot" is about +/-5 cm for lateral head translations. Larger head movements than this require an update of the virtual acoustic imaging filters. The interest here is the "sweet spot" size at off-axis asymmetric listener locations or an understanding of how often one needs to update the filters to ensure the listener perceives a stable virtual image as they move. The examination of the off-axis "sweet spot" size comprises a theoretical acoustic analysis, computer simulations, and a subjective study. The simulations and subjective evaluation both demonstrate that the width of tolerable lateral head translations is comparable for the symmetric on-axis listener location and asymmetric listener locations that are as far as 25 cm off-axis.

Acoustics↗
PubMed2003

Using links between speech perception and speech production to evaluate different acoustic metrics: a preliminary report.

This paper examines whether correlations between speech perception and speech production exist, and, if so, whether they might provide a way of evaluating different acoustic metrics. The cues listeners use for many phonemic distinctions are not known, often because many different acoustic cues are highly correlated with one another, making it difficult to distinguish among them. Perception-production correlations may provide a new means of doing so. In the present paper, correlations were examined between acoustic measures taken on listeners' perceptual prototypes for a given speech category and on their average production of members of that category. Significant correlations were found for VOT among stop consonants, and for spectral peaks (but not centroids or skewness) for voiceless fricatives. These results suggest that correlations between speech perception and production may provide a methodology for evaluating different proposed acoustic metrics.

Female↗
PubMed2004

Quantification of optison bubble size and lifetime during sonication dominant role of secondary cavitation bubbles causing acoustic bioeffects.

Acoustic cavitation has been shown to deliver molecules into viable cells, which is of interest for drug and gene delivery applications. To address mechanisms of these acoustic bioeffects, this work measured the lifetime of albumin-stabilized cavitation bubbles (Optison) and correlated it with desirable (intracellular uptake of molecules) and undesirable (loss of cell viability) bioeffects. Optison was exposed to 500 kHz ultrasound (acoustic pressures of 0.6-3.0 MPa and energy exposures of 0.2-200 J/cm2) either with or without the presence of DU145 prostate cancer cells (10(6) cells/ml) bathed in calcein, a cell-impermeant tracer molecule. Bubble lifetime was determined using a Coulter counter and flow cytometer, while bioeffects were evaluated by flow cytometry. The lifetime of Optison cavitation nuclei was found to decrease and bioeffects (molecular uptake and loss of cell viability) were found to increase with increasing acoustic energy exposure. These bioeffects correlated well with the disappearance of bubbles, suggesting that contrast agent destruction either directly or indirectly affected cells, probably involving unstabilized cavitation nuclei created upon the destruction of Optison. Because Optison solutions presonicated to destroy all detectable bubbles also caused significant bioeffects, the indirect mechanism involving secondary cavitation bubbles is more likely.

Acoustics↗
PubMed2003

A short latency vestibular evoked potential (VsEP) produced by bone-conducted acoustic stimulation.

In this paper data are presented from an experiment which provides evidence for the existence of a short latency, acoustically evoked potential of probable vestibular origin. The experiment was conducted in two phases using bone-conducted acoustic stimulation. In the first phase subjects were stimulated with 6-ms, 500-Hz tone bursts in order to obtain the threshold V(T) for vestibular evoked myogenic potentials (VEMP). It was confirmed that the difference between bone-conducted auditory and acoustic vestibular thresholds was slightly over 30 dB. The estimated threshold was then used as a reference value in the second part of the experiment to stimulate subjects over a range of intensities from -6 to +18 dB (re: V(T)). Averaged EEG recordings were made with eight Ag/AgCl electrodes placed on the scalp at Fpz, F3, F4, F7, F8, Cz, T3, and T4 according to the 10-20 system. Below V(T) auditory midlatency responses (MLRs) were observed. Above V(T) two additional potentials appeared: a positivity at about 10 ms (P10) which was maximal at Cz, and a negativity at about 15 ms (N15) which was maximal at Fpz. Extrapolation of the growth functions for the P10 and N15 indicated a threshold close to V(T), consistent with a vestibular origin of these potentials. Given the low threshold of vestibular acoustic sensitivity it is possible that this mode may make a contribution to the detection of and affective responses to loud low frequency sounds. The evoked potentials may also have application as a noninvasive and nontraumatic test of vestibular projections to the cortex.

Acoustic Stimulation↗
PubMed2004

A neural network model of the articulatory-acoustic forward mapping trained on recordings of articulatory parameters.

Three neural network models were trained on the forward mapping from articulatory positions to acoustic outputs for a single speaker of the Edinburgh multi-channel articulatory speech database. The model parameters (i.e., connection weights) were learned via the backpropagation of error signals generated by the difference between acoustic outputs of the models, and their acoustic targets. Efficacy of the trained models was assessed by subjecting the models' acoustic outputs to speech intelligibility tests. The results of these tests showed that enough phonetic information was captured by the models to support rates of word identification as high as 84%, approaching an identification rate of 92% for the actual target stimuli. These forward models could serve as one component of a data-driven articulatory synthesizer. The models also provide the first step toward building a model of spoken word acquisition and phonological development trained on real speech.

Adult↗
PubMed2004

On the acoustic vaporization of micrometer-sized droplets.

This paper examines the vaporization of individual dodecafluoropentane droplets by the application of single ultrasonic tone bursts. High speed video microscopy was used to monitor droplets in a flow tube, while a focused, single element transducer operating at 3, 4, or 10 MHz was aimed at the intersection of the acoustical and optical beams. A highly dilute droplet emulsion was injected, and individual droplets were positioned in the two foci. Phase transitions of droplets were produced by rarefactional pressures as low as 4 MPa at 3 MHz using single, 3.25 micros tone bursts. During acoustic irradiation, droplets showed dipole-type oscillations along the acoustic axis (average amplitude 1.3 microm, independent of droplet diameter which ranged from 5 to 27 microm). The onset of vaporization was monitored as either spot-like, within the droplet, or homogeneous, throughout the droplet's imaged cross section. Spot-like centers of nucleation were observed solely along the axis lying parallel to the direction of oscillation and centered on the droplet. Smaller droplets required more acoustic intensity for vaporization than larger droplets, which is consistent with other experiments on emulsions.

Acoustics↗
PubMed2004

Tracking sperm whale (Physeter macrocephalus) dive profiles using a towed passive acoustic array.

A passive acoustic method is presented for tracking sperm whale dive profiles, using two or three hydrophones deployed as either a vertical or large-aperture towed array. The relative arrival times between the direct and surface-reflected acoustic paths are used to obtain the ranges and depths of animals with respect to the array, provided that the hydrophone depths are independently measured. Besides reducing the number of hydrophones required, exploiting surface reflections simplifies automation of the data processing. Experimental results are shown from 2002 and 2003 cruises in the Gulf of Mexico for two different towed array deployments. The 2002 deployment consisted of two short-aperture towed arrays separated by 170 m, while the 2003 deployment placed an autonomous acoustic recorder in tandem with a short-aperture towed array, and used ship noise to time-align the acoustic data. The resulting dive profiles were independently checked using single-hydrophone localizations, whenever multipath reflections from the ocean bottom could be exploited to effectively create a large-aperture vertical array. This technique may have applications for basic research and for real-time mitigation for seismic airgun surveys.

Acoustics↗
PubMed2004

The control of aerodynamics, acoustics, and perceptual characteristics during speech production.

One of the most important areas of study in speech motor control is the identification of control variables, the variables controlled by the nervous system during motor tasks. The current study examined two hypotheses regarding control variables in speech production: (1) pressure and resistance in the vocal tract are controlled, and (2) perceptual and acoustic accuracy are controlled. Aerodynamic and acoustic data were collected on 20 subjects in three conditions, normally (NT), with an open air pressure bleed tube in place (TWB), and with a closed bleed tube in place (TNB). The voice recordings collected from the speakers in the production study were used in the perceptual study. Results showed that oral pressure (Po) was significantly lower in the TWB condition than in the NT and TNB conditions. The Po in the TWB condition seemed to be related to maintenance of subglottal pressure (Ps). Examination of the perceptual and acoustic data indicated that perceptual accuracy for [a] was achieved by maintaining Ps to preserve a steady sound pressure level, fundamental frequency, and voicing. Overall, it appeared speakers controlled pressure in compensating, but for the ultimate goal of maintaining acoustic and perceptual accuracy.

Adult↗
PubMed2005

Application of acoustic reflection tomography to sonar imaging.

Computer-aided tomography is a technique for providing a two-dimensional cross-sectional view of a three-dimensional object through the digital processing of many one-dimensional views (or projections) taken at different look directions. In acoustic reflection tomography, insonifying the object and then recording the backscattered signal provides the projection information for a given look direction (or aspect angle). Processing the projection information for all possible aspect angles enables an image to be reconstructed that represents the two-dimensional spatial distribution of the object's acoustic reflectivity function when projected on the imaging plane. The shape of an idealized object, which is an elliptical cylinder, is reconstructed by applying standard backprojection, Radon transform inversion (using both convolution and filtered backprojections), and direct Fourier inversion to simulated projection data. The relative merits of the various reconstruction algorithms are assessed and the resulting shape estimates compared. For bandpass sonar data, however, the wave number components of the acoustic reflectivity function that are outside the passband are absent. This leads to the consideration of image reconstruction for bandpass data. Tomographic image reconstruction is applied to real data collected with an ultra-wideband sonar transducer to form high-resolution acoustic images of various underwater objects when the sonar and object are widely separated.

Acoustics↗
PubMed2005

Optimal nonlocal boundary control of the wide-angle parabolic equation for inversion of a waveguide acoustic field.

This paper applies the concept of optimal boundary control for solving inverse problems in shallow water acoustics. To treat the controllability problem, a continuous analytic adjoint model is derived for the Claerbout wide-angle parabolic equation (PE) using a generalized nonlocal impedance boundary condition at the water-bottom interface. While the potential of adjoint methodology has been recently demonstrated for ocean acoustic tomography, this approach combines the advantages of exact transparent boundary conditions for the wide-angle PE with the concept of adjoint-based optimal control. In contrast to meta-heuristic approaches the inversion procedure itself is directly controlled by the waveguide physics and, in a numerical implementation based on conjugate gradient optimization, many fewer iterations are required for assessment of an environment that is supported by the underlying subbottom model. Furthermore, since regularization schemes are particularly important to enhance the performance of full-field acoustic inversion, special attention is devoted to the application of penalization methods to the adjoint optimization formalism. Regularization incorporates additional information about the desired solution in order to stabilize ill-posed inverse problems and identify useful solutions, a feature that is of particular importance for inversion of field data sampled on a vertical receiver array in the presence of measurement noise and modeling uncertainty. Results with test data show that the acoustic field and the bottom properties embedded in the control parameters can be efficiently retrieved.

Acoustics↗
PubMed2005

A modeling investigation of articulatory variability and acoustic stability during American English /r/ production.

This paper investigates the functional relationship between articulatory variability and stability of acoustic cues during American English /r/ production. The analysis of articulatory movement data on seven subjects shows that the extent of intrasubject articulatory variability along any given articulatory direction is strongly and inversely related to a measure of acoustic stability (the extent of acoustic variation that displacing the articulators in this direction would produce). The presence and direction of this relationship is consistent with a speech motor control mechanism that uses a third formant frequency (F3) target; i.e., the final articulatory variability is lower for those articulatory directions most relevant to determining the F3 value. In contrast, no consistent relationship across speakers and phonetic contexts was found between hypothesized vocal-tract target variables and articulatory variability. Furthermore, simulations of two speakers' productions using the DIVA model of speech production, in conjunction with a novel speaker-specific vocal-tract model derived from magnetic resonance imaging data, mimic the observed range of articulatory gestures for each subject, while exhibiting the same articulatory/acoustic relations as those observed experimentally. Overall these results provide evidence for a common control scheme that utilizes an acoustic, rather than articulatory, target specification for American English /r/.

Cues↗
PubMed2005

Contextual variation in the acoustic and perceptual similarity of North German and American English vowels.

Strange et al. [J. Acoust. Soc. Am. 115, 1791-1807 (2004)] reported that North German (NG) front-rounded vowels in hVp syllables were acoustically intermediate between front and back American English (AE) vowels. However, AE listeners perceptually assimilated them as poor exemplars of back AE vowels. In this study, speaker- and context-independent cross-language discriminant analyses of NG and AE vowels produced in CVC syllables (C=labial, alveolar, velar stops) in sentences showed that NG front-rounded vowels fell within AE back-vowel distributions, due to the "fronting" of AE back vowels in alveolar/velar contexts. NG [I, e, epsilon, inverted c] were located relatively "higher" in acoustic vowel space than their AE counterparts and varied in cross-language similarity across consonantal contexts. In a perceptual assimilation task, naive listeners classified NG vowels in terms of native AE categories and rated their goodness on a 7-point scale (very foreign to very English sounding). Both front- and back-rounded NG vowels were perceptually assimilated overwhelmingly to back AE categories and judged equally good exemplars. Perceptual assimilation patterns did not vary with context, and were not always predictable from acoustic similarity. These findings suggest that listeners adopt a context-independent strategy when judging the cross-language similarity of vowels produced and presented in continuous speech contexts.

Female↗
PubMed2005

Three-dimensional passive acoustic tracking of sperm whales (Physeter macrocephalus) in ray-refracting environments.

A wide-aperture towed passive acoustic array is used to obtain ranges and depths of acoustically active sperm whales in the Gulf of Mexico in June 2004, by extending a technique previously reported [Thode, J. Acoust. Soc. Am. 116, 245-253 (2004)] to explicitly account for ray-refraction effects arising from a depth-dependent sound speed profile. Under this expanded approach, three quantities are measured from an impulsive sound: the time difference between direct-path arrivals on a forward and rear subarray, the time difference between the direct and surface-reflected paths on the rear subarray, and the acoustic bearing measured on the rear subarray. These quantities, combined with independent measurements of hydrophone depths and cable inclination, are converted into range-depth position fixes by implementing an efficient numerical procedure that uses a ray-tracing code to account for ray-refraction effects caused by depth-dependent sound speed profiles. Analytic expressions that assume a constant waterborne sound speed are also derived. Foraging depths of various sperm whales over 10 days in June, 2004 are estimated using the numerical technique.

Acoustics↗
PubMed2006

Acoustic features of objects matched by an echolocating bottlenose dolphin.

The focus of this study was to investigate how dolphins use acoustic features in returning echolocation signals to discriminate among objects. An echolocating dolphin performed a match-to-sample task with objects that varied in size, shape, material, and texture. After the task was completed, the features of the object echoes were measured (e.g., target strength, peak frequency). The dolphin's error patterns were examined in conjunction with the between-object variation in acoustic features to identify the acoustic features that the dolphin used to discriminate among the objects. The present study explored two hypotheses regarding the way dolphins use acoustic information in echoes: (1) use of a single feature, or (2) use of a linear combination of multiple features. The results suggested that dolphins do not use a single feature across all object sets or a linear combination of six echo features. Five features appeared to be important to the dolphin on four or more sets: the echo spectrum shape, the pattern of changes in target strength and number of highlights as a function of object orientation, and peak and center frequency. These data suggest that dolphins use multiple features and integrate information across echoes from a range of object orientations.

Acoustics↗
PubMed2006

Quantitative measurements of acoustic emissions from cavitation at the surface of a stone in response to a lithotripter shock wave.

Measurements are presented of acoustic emissions from cavitation collapses on the surface of a synthetic kidney stone in response to shock waves (SWs) from an electrohydraulic lithotripter. A fiber optic probe hydrophone was used for pressure measurements, and passive cavitation detection was used to identify acoustic emissions from bubble collapse. At a lithotripter charging voltage of 20 kV, the focused SW incident on the stone surface resulted in a peak pressure of 43 +/- 6 MPa compared to 23 +/- 4 MPa in the free field. The focused SW incident upon the stone appeared to be enhanced due to the acoustic emissions from the forced cavitation collapse of the preexisting bubbles. The peak pressure of the acoustic emission from a bubble collapse was 34 +/- 15 MPa, that is, the same magnitude as the SWs incident on the stone. These data indicate that stresses induced by focused SWs and cavitation collapses are similar in magnitude thus likely play a similar role in stone fragmentation.

Acoustics↗