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PubMed1999

New refractive surgery procedures in ophthalmology and the influence on Pilot's fitness for flying.

During the last years more and more procedures came up to render people with refractive errors possible to see without contact lenses or glasses. The different procedures for hyperopia, myopia and astigmatism are performed in increasing numbers in hospitals, laser-centres and in private practise. Modern radial keratotomy was introduced in the late 70 by the Russian Fjodorov. Because of the many complications this procedure was replaced by other procedures. Photorefractive keratectomy (PRK) was introduced in 1985, using an excimer laser to vaporize corneal tissue. Because of the side effects as pain and glare and the limited indication area Laser in situ keratomileusis (LASIK) was developed. In this procedure a corneal lamella is cut in, flapped back and the excimer laser vaporize the corneal tissue. These two procedures are mostly applied nowadays. But there are also new techniques that are still in an experimental state. One of that is the implementation of an intrastromal corneal ring that can reduce myopia up to 4 diopters. During the laser thermo keratoplasty 8 to 16 laser applications are performed in the periphery of the cornea to reduce hyperopia up to + 5 diopters. Another refractive surgery procedure is the phakic intraocular lens implantation for high myopia and +3 to +10 diopters hyperopia and the clear lens extraction with intraocular lens implantation for high hyperopia. The Joint Aviation Authority Requirements allow a hyperopia and myopia for commercial pilots of 3 diopters. Some pilot candidates with higher refractive errors undergo refractive surgery. But there are also pilots who are customers of the refractive operating ophthalmologists to get rid of the crutch glasses. This paper gives an overview about the refractive procedures that are performed nowadays on pilots and pilot candidates and gives information about the relevant indications and complications of refractive procedures in the aviation environment.

Adult↗
PubMed2005

Pattern of eye diseases in children of 5-15 years at Bazzertaline Area (South Karachi) Pakistan.

OBJECTIVE: To assess the prevalence and pattern of eye diseases in children aged 5-15 years. DESIGN: Population based cross-sectional survey. PLACE AND DURATION OF STUDY: Bazzertaline area of Karachi (South) from July to August, 2003. PATIENTS AND METHODS: A community-based survey was carried out at the Bazzertaline Area, South Karachi, Pakistan on 5110 children 5-15 years of age. The socioeconomic status of the area was low, with many living below the poverty line. The survey used the WHO definitions of visual impairment as criteria for classification. Standard Snell's literate and illiterate charts were used for assessing the visual acuity. An anterior segment examination with a torch light and loupe was carried out and the posterior segment examined with a direct ophthalmoscope, initially without pupil dilation. Suspected cases of amblyopia, albinism, traumatic cataract and squint, etc. were examined with pupil dilatation. RESULTS: Refractive error of 2% was found to be the primary ocular morbidity, followed by conjunctivitis 1.2%, and squint was found as third ocular morbidity with the prevalence of 0.6%. Those diseases that were less than 0.5% included unilateral amblyopia, corneal ulcer/opacity, cataract, aphakia, trauma, blepharitis, albinism, stye, chalazion and unilateral/bilateral blindness. Bilateral blindness was present in 2.7/1000 children, the major causes being cataract and corneal diseases. Low vision was found in 2.2%, the leading cause being uncorrected refractive error. Visual acuity according to 2.42%. Gender showed higher visual impairment in girls as compared to boys 1.72%. Only one case of vitamin-A deficiency was seen. CONCLUSION: Provision of spectacles would address the most commonly found problem of uncorrected refractive error. Lack of trained personnel and facilities for low vision services in addition to lack of advocacy and awareness in the community contribute to the pattern of eye disease in the area.

Adolescent↗
PubMed2006

[The use of accommodative lenses for surgical correction of the presbyopia using the Prelex method].

The authors refer about their experience with the surgical correction of the presbyopia by means of the Prelex (presbyopic lens exchange) method. Patients, who underwent this type of refractive surgery procedure to decrease their dependency on glasses correction for far as well as for near vision (12 patients, 23 eyes) and 1 young female patient (2 eyes) with juvenile cataract and high hyperopia, were included in the study. The average age at the time of the surgery was 51.0 +/- 5.5 years (range, 19-77 years). The average follow up period of the whole group of patients is 9.8 months (range, 1-13 months). Depending on the type of the lens implanted, the group was divided into subgroup A with the accommodative lens 1 CU produced by Human Optics Company implanted, and subgroup B with the accommodative lens Kellan TetraFlex KH 3500 produced by LensTec Company implanted. The subgroup A consists of 8 patients (15 eyes) with the average preoperative refractive error +2.35 +/- 3.45 diopters. The average uncorrected visual acuity of this group was 0.24 +/- 0.18, and the average best-corrected visual acuity was 0.77 +/- 0.22 at the time before the surgery. The average glasses correction for near was +4.1 dioptres, and the uncorrected vision for near was Jaeger's table Nr. (J) 13. The B subgroup consists of 5 patients (10 eyes). The average preoperative refractive error was +2.23 +/- 0.93 diopters. The average value of the uncorrected visual acuity before the surgery was 0.43 +/- 0.28, and the average corrected visual acuity was 0.82 +/- 0.25. The average value of the glasses correction for near was +5.25 and uncorrected vision for near J 13. The final average postoperative error at the time of the last visit was in the A subgroup +0.06 +/- 1.17 dioptres. The average uncorrected visual acuity was 0.69 +/- 0.24, and the average best-corrected visual acuity 0.96 +/- 0.12. The average vision of the patients of this subgroup for near was J 3. In the B subgroup we found at the last visit the average final value of the postoperative refractive error -0.2 +/- 0.72 dioptres. The average uncorrected visual acuity 0.57 +/- 0.22 and the average corrected visual acuity 0.95 +/- 0.12. Average uncorrected vision for near was J 5. We did not notice any serious per- or postoperative complication of this procedure.

Accommodation, Ocular↗
PubMed1993

Prevalence and causes of visual impairment and blindness in the south western region of Saudi Arabia.

A population-based survey of the prevalence of major causes of blindness and visual impairment was conducted in Bisha region, Saudi Arabia. Overall, 2882 people were examined. The prevalence of blindness (visual acuity of < 3/60 in the better eye with best available correction) was 0.7% and the prevalence of visual impairment (visual acuity < 6/12 but > or = 3/60 in the better eye with best available correction) was 10.9%. Cataracts were responsible for 52.6% of blindness and 20.6% of visual impairment. Refractive errors accounted for 67.9% of visual impairment. Proper management of cataracts and correction of refractive errors will cure 73.6% of blind subjects and 88.5% of visually handicap people in this part of the world.

Adolescent↗
PubMed2003

Comparative evaluation of Teller and Cardiff acuity tests in normals and unilateral amblyopes in under-two-year-olds.

PURPOSE: To compare and evaluate Teller Acuity Cards (TAC) and Cardiff Acuity Cards (CAC) to assess vision in children below the age of two. METHODS: The study evaluated TAC and CAC to assess visual acuity in 90 normal children divided into three age groups, 0-6 months (group I), 6-12 months (group II) and 12-24 months (group III). 30 cases of unilateral amblyopiogenic conditions, 10 cases each of unilateral refractive error, unilateral esotropia, and unilateral cataract, were also examined. Trained optometrists carried out binocular testing followed by monocular testing, and recorded the test time in each case. RESULTS: The mean visual acuity (in Snellen units) and standard deviation (in octaves) in the three age groups of normal children, I, II, III respectively were 6/44 +/- 0.54, 6/21 +/- 0.37 and 6/21 +/- 0.41 (binocularly by TAC) and 6/46 +/- 0.80, 6/21 +/- 0.59 and 6/14.5 +/- 0.84 (binocularly by CAC). Although the time taken for testing with CAC was less, its coefficient of variance was greater for all age groups as compared to TAC. Diminution of visual acuity could be assessed correctly by both the tests in cases of strabismus and cataract, but not in some cases of refractive error. CONCLUSION: CAC is a useful and child-friendly test. It can be used clinically but may miss some cases of visually significant refractive errors. TAC is a more dependable test to assess amblyopiogenic conditions despite the use of gratings.

Amblyopia↗
PubMed2001

Values of electroretinogram responses according to axial length.

Accurate interpretation of electroretinograms (ERGs) requires knowledge of effects of axial myopia on ERG responses. Our purpose was to derive expected changes of ERG responses according to axial length, to stimulus conditions that conform to the International Society for Clinical Electrophysiology of Vision (ISCEV) Standard for Electroretinography. ERGs from 60 subjects were recorded. The subjects were assigned to one of three groups according to the level of myopia. Thirty-three subjects had high myopia (-6.00 D to -14.50 D; mean age, 31 years), eight had mild myopia (-3.00 D to -5.00; mean age, 28 years), and 19 had a small refractive error (+0.75 D to -2.75 D; mean age, 27 years). No subjects had myopic retinopathy. Stimulus-response curves were fitted to dark-adapted b-wave amplitudes and maximum amplitude and semi-saturation constants derived. Axial lengths, measured with A scan ultrasound, ranged from 22.2 mm to 30.0 mm. Analysis of variance and post hoc t-tests revealed significant difference between subjects with high myopia and subjects with small refractive error for ERG amplitude data. There were no significant differences between the three groups for implicit times, the ratio of b- to a-wave and semi-saturation constant. There is linear reduction in the logarithmic transform of ERG amplitude with increasing axial length, related more to axial length than refractive error. We provide relative slope and intercept values, allowing labs to derive expected ERG amplitudes according to axial length. These derivations are valid for persons with no retinopathy.

Adolescent↗
PubMed2004

[Changes in axial length/corneal radius ratio (AL/CR) according to refractive state of the eye. Relationship with ocular components].

PURPOSE: Determination of the role of the axial length/corneal radius ratio (AL/CR) in the refractive state and investigation of its relationship with the ocular optical components: AL, CR, anterior chamber depth (ACD), crystalline lens thickness (CT) and vitreous chamber depth (VCD). METHODS: The RE (right eye) of 193 University students 22.27 (SD 3.24) years, with different refractive errors (spherical equivalent range: +3.00 D to -11.00 D), being divided into: emmetropes, hyperopes and myopes (low, moderate and high). The ACE, the CT, the VCD and the AL were measured by ultrasonography (unidimensional echography); and the mean CR by videokeratoscopy. RESULTS: The value of AL/CR obtained was 2.98 (SD 0.69) for emmetropes, 2.89 (SD 0.87) for hyperopes, 3.01 (SD 0.07) in low myopias, 3.10 (SD 0.11) in moderate myopias and 3.23 (SD 0.12) in high myopias. The AL/CR ratio showed a higher correlation with the refractive error. Besides, all the refractive groups were observed to have lower CE values as the AL/CR increased. This tendency is statistically significant in hyperopes, emmetropes and low myopes; and is not in moderate and high myopias. All the study groups could be observed to have a positive and statistically significant correlation between AL/CR and ACD. CONCLUSION: The ratio AL/CR is the most important parameter and the best predictor of the refractive state of the human eye. It provides important information on how best to determine the degree of emmetropization given by the crystalline, decreasing its power and the ACD in concordance with the LA. A value for the ratio AL/CR above 3.00 could be considered as a risk factor for the development of myopia in emmetropic eyes.

Adult↗
PubMedDate not supplied

Accommodative lag under habitual seeing conditions: comparison between myopic and emmetropic children.

PURPOSE: To determine whether or not myopic children have a larger lag of accommodation than emmetropic children under natural seeing conditions. METHODS: In 61 myopic children (age, 9.5 +/- 1.3 years; spherical equivalent refractive error, -6.50 to -1.00 D), accommodative response was objectively measured while they were binocularly viewing a target at 50.5, 32.5, 20.9, or 16.0 cm (1.98-6.25 D) through fully correcting glasses. In the 33 children who habitually wore spectacles, the accommodative responses were also measured while they wore their own spectacles. As controls, 18 emmetropic children were recruited. Accommodative response gradients and lags were compared between the groups after calibration for residual refractive errors and the vertex distance of the glasses. RESULTS: With fully correcting glasses, the myopic children showed a larger mean lag of accommodation than the emmetropic children, as well as wide intersubject variation. However, when the children wore their habitual, usually undercorrecting, spectacles, accommodative lags markedly decreased, and a significant correlation was found between residual refractive errors after correcting for the spectacles and accommodative lags. Myopic children with near-point exophoria tended to show smaller lags of accommodation. CONCLUSION: Under binocular viewing conditions, myopic children when viewing the target through fully correcting glasses tend to show larger lags of accommodation than emmetropic children, but the lags of accommodation are usually reduced by their spectacle undercorrection.

Accommodation, Ocular↗
PubMed2000

Microkeratome complications of laser in situ keratomileusis.

PURPOSE: To evaluate the incidence, types, and outcome of microkeratome complications that occur during laser in situ keratomileusis (LASIK). DESIGN: Retrospective, noncomparative, case series. PARTICIPANTS: Three thousand nine hundred ninety-eight eyes that underwent primary LASIK by four surgeons between November 1996 and August 1998 at a university-based refractive center. METHODS: All cases with significant microkeratome complications leading to abandonment of the LASIK procedure were identified and reviewed. MAIN OUTCOME MEASURES: Incidence of complications, change in best corrected visual acuity (BCVA), change in refractive error, and types of complication. RESULTS: There were 27 complications leading to abandonment of the LASIK procedure of 3998 eyes. The overall rate of microkeratome complication was 1 in 150 (0.68%), but it was 1 in 77 (1.3%) in the surgeons' first 1000 eyes, decreasing to 1 in 250 (0.4%) in the last 1000 eyes. Of the 24 planned bilateral cases, 15 complications (63%) happened on the first operated eye. Twenty-six of 27 eyes (96%) recovered to within one line of preoperative BCVA, and one eye lost two lines. At last examination before any repeat refractive procedures, spherical equivalent manifest refraction returned to within 1 diopter (D) of its preoperative value in 18 of 19 eyes (95%), and astigmatism in 16 of 19 eyes (84%) returned to within 1 D of its preoperative value. Sixteen of 27 eyes (59%) had repeat LASIK. Two eyes had complications at repeat LASIK, one of which led to abandonment of the LASIK procedure for a second time. CONCLUSIONS: There is a significant learning curve in the use of the microkeratome. If ablation is not performed, flap complications rarely lead to significant visual loss and generally do not result in a change in refractive error.

Clinical Competence↗
PubMed1996

Sensitivity, specificity, and predictive values of screening tests for eye conditions in a clinic-based population.

PURPOSE: To assess four commonly available visual function tests to detect visually disabling or vision-threatening eye conditions among new patients of a large, urban, public, general ophthalmology clinic. METHODS: Three hundred seventeen patients were tested for contrast sensitivity, Amsler grid abnormalities, and visual acuity at near and at distance. A complete eye evaluation found the prevalence of serious eye diseases, allowing determination of the sensitivity (Sn), specificity (Sp), likelihood ratio (LR), and other characteristics of each test. RESULTS: Of 317 patients, most were Hispanic (77%), women (60%), and middle-aged (44 +/- 17 years). Normal findings were reported in 18%; refractive error in 43%; cataracts in 16%; glaucoma in 7.3%; and macular degeneration in 4.1%. Near visual acuity of 20/40 or worse (Sn = 0.75; Sp = 0.74; LR = 2.8); and distance visual acuity testing of 20/30 or worse (Sn = 0.74; Sp = 0.73; LR = 2.7) correlated significantly with ocular disease, whereas contrast sensitivity testing (Sn = 0.62; Sp = 0.41; LR = 1.1) and Amsler grid test (Sn = 0.19; Sp = 0.92; LR = 2.4) did not. Test performance decreased when refractive errors were excluded and among those younger than 40 years of age relative to those 40 years of age or older. CONCLUSION: Of the four screening tests studied, distance and near threshold visual acuities as defined above were judged to have the best correlations of an abnormal result with ocular disease, both including or excluding refractive error. Different combinations of tests did not result in more accurate detection of ocular disease. More efficient screening tools for detecting ocular disease need to be developed.

Adolescent↗
PubMed2005

A cross-sectional study of Krukenberg spindles and pigmented lens striae in a predominately black population: two highly associated clinical signs of anterior segment pigment dispersal.

PURPOSE: To investigate the relationship of Krukenberg spindles (KS) and pigmented lens striae (PLS), clinical signs related to iris pigment dispersal and possibly glaucoma. METHODS: During a 31-month period, 5 practitioners in an urban, primary eye care setting examined consecutive patients for KS and PLS. Multiple logistic regression was used to evaluate relationships among KS, PLS, and other variables. RESULTS: Krukenberg spindles were present in 65 patients (52 females), comprised of 57 of 2647 (2.2%) blacks, 5 of 303 (1.7%) whites, 2 of 121 (1.7%) Hispanics, and 1 of 55 (1.8%) Asians. PLS were present in 64 subjects (56 females), comprised of 59 (2.2%) blacks, 3 (1.0%) whites, and 2 (3.6%) Asians. KS and PLS were coexistent in 27 subjects. Mean age +/- SD (range) of the KS and PLS subjects was 63.1 +/- 15.0 years (24-88 years) and 67.0 +/- 10.4 years (33-88 years), respectively. Mean refractive error +/- SD (range) of KS and PLS right eyes was +0.55 +/- 2.32D (-6.50 to +5.50D) and +1.34 +/- 2.18D (-6.50 to +7.25D), respectively. Controlling for other variables, PLS were highly predictive (OR = 30.2, P < 0.0001) of KS, and KS were highly predictive (OR = 29.5, P < 0.0001) of PLS. Ignoring presence or absence of PLS, increasing age (in decades) (OR = 1.60, P < 0.0001) was strongly associated with KS. Ignoring presence or absence of KS, age (OR = 1.74, P < 0.0001), female gender (OR = 2.96, P = 0.009), and increasing hyperopic refractive error (OR = 1.30, P < 0.0001) were strongly associated with PLS. CONCLUSIONS: Krukenberg spindles and PLS were strongly associated in our patient population, and the likelihood of both increased with increasing age. Female gender and increasing hyperopic refractive error were highly significant predictors of PLS.

Adult↗
PubMed1991

Variation in axial length and anatomical landmarks in strabismic patients.

The authors calculated axial length measurements in 185 consecutive patients undergoing strabismus surgery and found a mean measurement of 21.98 +/- 1.59 mm (range, 18.75-25.37 mm). Although significant correlation between axial length, refractive error, and age was found, wide variation was present, which indicates that age and refractive error could not accurately predict axial length. Based on a formula derived from a geometric model to determine the equator-limbus distance, given the axial length, the authors found that the equator had a mean distance from the limbus of 11.56 +/- 1.75 mm (range, 9.10-13.76 mm). Based on the variability found at surgery for the insertion-limbus distance, the number of millimeters of recession of the medial rectus from the insertion that would have been necessary to place it at the equator ranged between 3.5 and 8.5 mm in this series, and for the lateral rectus, 3.5 mm to 7.0 mm. The number of millimeters necessary to recess the lateral rectus to its point of tangency with the globe ranged between 9.5 and 14.4 mm.

Adolescent↗
PubMed1997

The Glenn A. Fry Award Lecture (1995). Myopia development in childhood.

PURPOSE: The Orinda Longitudinal Study of Myopia is a 12-year project examining predictive factors for the onset of myopia, the underlying etiologies of myopia, and normal eye growth in school children. METHODS: This paper reports on all measurements made of the ocular components (cycloplegic refractive error, corneal curvature, crystalline lens power, and axial ocular dimensions), parental history of myopia, and near work activity in children participating in the Orinda Longitudinal Study of Myopia between 1989 and 1993. An analysis of the interaction between parental history of myopia and children's near work is conducted on the cross-sectional study data from 1993. RESULTS: The cross-sectional and longitudinal data show a gradual decrease in refractive error from low hyperopia toward emmetropia, no shift in corneal curvature, a gradual decrease in crystalline lens power, thinning of the crystalline lens, and elongation of the eye between the ages of 6 and 14 years. Parental history is more contributory to a statistical model predicting myopia than is near work, but near work is a significant factor as well. We can find no evidence of statistical interaction between parental history and near work in explaining the presence or absence of myopia. CONCLUSIONS: The emmetropization process is evident in the gradual decrease in refractive error toward emmetropia, the axial elongation of the eye, and the compensating decrease in crystalline lens power. Both nature and nurture play a role in the etiology of myopia, although the predominant role appears to belong to a positive parental history of myopia. This role does not appear to be through an interaction between parental myopia status and children's near work activity.

Adolescent↗
PubMed2003

[Topographical evaluation on decentration of orthokeratology lenses].

OBJECTIVE: To evaluate the degree and correlative factors of decentration of orthokeratology lenses and its effect on the visual function. METHODS: Two different kinds of orthokeratology lenses were fitted to 270 eyes of 135 patients [initial mean refractive error: (-3.98 +/- 1.51) D]. Humphery Instruments ATLAS 8.0 was used for the computer-assisted analysis of corneal differential topographical maps. The examination of corneal topography was proceeded on the patients before the fitting of orthokeratology lenses and 6-month later. The distance from center of optic zone to apex of the cornea was measured as the value of decentration of orthokeratology lenses. The factors influenced the value of decentration were analyzed, including the initial refraction error, astigmatism, keratometry values, corneal eccentricity, and the diameter of the lens. The complaints of patients were recorded. Questionnaires, involving the symptoms of monocular diplopia and glare, were used to evaluate the effects of decentration of orthokeratology lenses on the visual function. RESULTS: The mean distance of decentration was (0.49 +/- 0.34) mm after one night fitting, the mean distance of decentration after follow-up for 1 month, 3 months and 6 months was (0.57 +/- 0.41) mm, (0.55 +/- 0.48) mm and (0.59 +/- 0.39) mm, respectively. After one month, the distance of decentration was less than 0.5 mm in 51.1% eyes, 0.5 - 1.0 mm in 35.6% eyes and more than 1.0 mm in 13.3% eyes. The direction of decentration in eyes with more than 0.50 mm decentration was mainly in the temporal side (48.5%). Patients with greater initial astigmatism and smaller diameter of lens showed greater distance of decentration (P < 0.05). There was no statistically significant difference in the distance of decentration between two groups with different corneal eccentricities and keratometry values (P > 0.05). The distance of decentration was greater in patients with monocular diplopia and glare. CONCLUSIONS: The degree of decentration of orthokeratology depends on the degree of initial refractive error, astigmatism and the design of orthokeratology lenses. The degree of decentration can influence the visual function.

Adolescent↗
PubMed2003

Simplified mathematics for customized refractive surgery.

PURPOSE: To describe a simple mathematical approach to customized corneal refractive surgery or customized intraocular lens (IOL) design that allows "hypervision" and to investigate the accuracy limits. SETTING: University eye hospital, Mainz, Germany. METHODS: Corneal shape and at least 1 IOL surface are approximated by the well-known Cartesian conic section curves (ellipsoid, paraboloid, or hyperboloid). They are characterized by only 2 parameters, the vertex radius and the numerical eccentricity. Residual refraction errors for this approximation are calculated by numerical ray tracing. These errors can be displayed as a 2-dimensional refraction map across the pupil or by blurring the image of a Landolt ring superimposed on the retinal receptor grid, giving an overall impression of the visual outcome. RESULTS: If the eye is made emmetropic for paraxial rays and if the numerical eccentricities of the cornea and lens are appropriately fitted to each other, the residual refractive errors are small enough to allow hypervision. Visual acuity of at least 2.0 (20/10) appears to be possible, particularly for mesopic pupil diameters. However, customized optics may have limited application due to their sensitivity to misalignment errors such as decentrations or rotations. CONCLUSIONS: The mathematical approach described by Descartes 350 years ago is adequate to calculate hypervision optics for the human eye. The availability of suitable mathematical tools should, however, not be viewed with too much optimism as long as the accuracy of the implementation in surgical procedures is limited.

Cornea↗
PubMed1982

Effects of radial and circular keratotomy in rabbits.

Nine rabbits underwent radial keratotomy in one eye and circular keratotomy in the other. The follow-up period ranged from 9 to 12 weeks. There was no significant change in the axial length of the eye with either type of surgery, and circular keratotomy produced no significant changes in the curvature or the refractive error of the cornea. However, radial keratotomy produced significant spherical changes in both corneal curvature (mean -3.09 D, P less than 0.01) and refractive error (mean +2.18 D, P less than 0.01); the refractive changes can be explained entirely by the changes in curvature.

Animals↗
PubMed2002

Subclinical inflammation after laser in situ keratomileusis in corneal grafts.

PURPOSE: To evaluate postoperative inflammatory reaction in the eye after laser in situ keratomileusis (LASIK) in corneal grafts. SETTING: Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland. METHODS: Ten eyes of 9 patients with penetrating keratoplasty (PKP) and significant postoperative refractive errors and astigmatism had LASIK 22 months or more after the PKP. All patients were treated with the VISX Star excimer laser and the Bausch & Lomb Hansatome microkeratome. Preoperative and early postoperative inflammation was evaluated by quantifying the aqueous flare intensity with a laser flare photometer (Kowa FM-500). A full ophthalmic assessment was also performed before LASIK and up to 6 months postoperatively. RESULTS: The inflammatory response was mild and limited to the first postoperative hour. The mean anterior chamber flare increased from 6.0 photons/millisecond (ph/ms) preoperatively to 14.0 ph/ms at 1 hour and then decreased to 6.7 ph/ms (hour 3), 6.8 ph/ms (day 1), and 8.2 ph/ms (day 7). The mean spherical equivalent (SE) refraction decreased from -3.81 diopters (D) (range -9.63 to -0.25 D) to -0.46 D (range -1.13 to +0.38 D), and the mean preoperative astigmatism decreased from 3.0 D (range 6.5 to 0.5 D) to 0.7 D (range 0.0 to 2.0 D). At the last examination, 9 eyes were within +/-1.0 D (6 within +/-0.5 D) and all were within +/-1.5 D of the intended SE refraction. Three eyes achieved full cylinder correction, and 7 were within +/-1.0 D of the intended correction. Eight eyes had a best corrected visual acuity of 20/40 or better (unchanged or gain of 1 to 4 lines [6], loss of 1 line [1], and loss of 3 lines [1]), and 8 had an uncorrected visual acuity of 20/50 or better. CONCLUSIONS: Uneventful LASIK induced subtle, short-lasting anterior chamber flare when measured by the laser flare meter. In corneal grafts, LASIK appeared to be a safe and effective procedure for residual refractive errors.

Adult↗
PubMed2006

Anatomical and functional outcome of surgery of primary rhegmatogenous retinal detachment in high myopic eyes.

PURPOSE: To analyse the anatomical and functional outcome of surgery for primary rhegmatogenous retinal detachment (RRD) in highly myopic eyes. METHODS: We retrospectively reviewed the medical records of 111 high myopic patients (111 eyes) with primary RRD treated by scleral buckling or pars plana vitrectomy in a tertiary referral university hospital. The postoperative retinal status and best-corrected visual acuity were recorded. Risk factors including age, refractive error, duration of retinal detachment, preoperative visual acuity, extent of detachment, and intraoperative and postoperative complications were evaluated. Multiple logistic regression analysis was used to determine the independent correlation of each variable on anatomical and functional outcome. RESULTS: Primary surgery resulting in retinal reattachment was achieved in 96 (86.5%) eyes with more than 6 months follow-up (range, 6-60 months). Sixty-eight (61.3%) eyes had postoperative corrected visual acuity 20/50 or more. Postoperative complications in high myopic eyes were variable, and the most common was cataract progression (19.8%). Upon multiple logistic regression analysis, young patients had significantly better anatomical outcome, although the variables including less refraction error, better preoperative visual acuity, scleral buckling procedure, and less surgical intervention showed better functional outcome in our series. CONCLUSIONS: The anatomical outcome of surgery for primary RRD in highly myopic eyes was favourable, and young patients tended to have a higher success rate. Functional outcome was significantly correlated with refractive error, preoperative visual acuity, surgical procedure, and number of vitreoretinal surgery.

Adolescent↗