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PubMed1989

Relationships between physical exercise and cognitive abilities in older adults.

We investigated relationships between physical exercise and the cognitive abilities of older adults. We hypothesized that the performance of vigorous exercisers would be superior to that of sedentary individuals on measures of reasoning, working memory, and reaction time. We gave a series of cognitive tasks to 62 older men and women who exercised vigorously and 62 sedentary men and women. Multivariate and univariate analyses of variance, with age and education as covariates, indicated that the performance of the exercisers was significantly better on measures of reasoning, working memory, and reaction time. Between-group differences persisted when vocabulary, on which the performance of exercisers was superior, was used as a third covariate. Subsequent analyses showed that neither self-rated health, medical conditions, nor medications contributed to the differences between exercise groups. Results suggest that the possible contribution of physical exercise to individual differences in cognition among older adults should be further investigated.

Adult↗
PubMed1997

Developmental changes in manipulation in tufted capuchins (Cebus apella) from birth through 2 years and their relation to foraging and weaning.

This study examined the contributions of physical and sensorimotor development to manipulation in capuchins (Cebus apella) from birth to 2 years. Between months 1-6 and 7-12, manipulation increased significantly in frequency, in the proportion that was vigorous or required fine motor control, and in the proportion directed at portable objects. Fine motor control, moving objects in relation to the body, and stamina are largely in place by 12 months, after which little changed. All elements of the manipulative repertoire have appeared, and vigorous and dexterous activities have peaked before fully independent foraging. Emergence of permanent dentition and achievement of approximately half of adult body size accompany the attainment of fully independent foraging at 15 months. Thereafter, increasing strength and specific knowledge probably contribute more to changing foraging competence in young capuchins than do stamina and sensorimotor development.

Aging↗
PubMed1996

Signal minus 1: a key factor in immunological tolerance to tissue-specific self antigens?

Recent data suggest that many autoreactive T cells, particularly to tissue-specific self antigens, can escape thymic deletion. The current dogma is that these autoreactive T cells are silenced by the failure of most tissues to provide co-stimulation (signal 2), antigen alone (signal 1) inducing T cell unresponsiveness. However, I propose that activation of autoreactive T cells frequently occurs but autodestruction by effector T cells is tightly regulated. This phenomenon is most evident with lymph node metastasizing tumour cells where the regional lymph node can mount a vigorous response to the invading tumour cells but tumour growth is unimpaired. I suggest that autodestruction is prevented by inhibitory receptors on T cells which recognize class I MHC structures on target cells. These receptors, which I propose deliver 'signal minus 1' to T cells, were recently described on NK cells and a subpopulation of peripheral T cells. They are also strikingly similar to a family of anti-self receptors that my laboratory described on murine T and B cells 15 years ago. In the 'signal minus 1' model, antigen-activated T cells acquire the inhibitory receptors when they become co-stimulation independent and gain the ability to exit lymphoid organs and enter non-lymphoid tissues. Thus, if autoreactive effector T cells encounter autoantigen in tissues they are functionally silenced by inhibitory receptor engagement and signal minus 1 delivery. In contrast, I propose that in response to intracellular infections, cells down-regulate expression of their ligands for inhibitory receptors. Such a model allows infected cells to be selectively eliminated by effector T cells. If correct, the model predicts that effector T cells, whether foreign-antigen- or autoantigen-specific, can selectively respond to infected cells. This apparent 'usefulness' of autoreactive T cells may explain their observed persistence even after an encounter with autoantigen. It is also suggested that signal minus 1 may silence autoreactive B cells specific for tissue-specific cell surface antigens and lack of signal minus 1 may partially explain the vigorous T cell response to allogeneic MHC. Finally, it is hypothesized that, in evolutionary terms, inhibition of autodestruction by the recognition of a 'self marker' and delivery of signal minus 1 is an ancient process which probably emerged in early metazoans.

Animals↗
PubMed1982

Proteinuria in diabetes mellitus: role of spontaneous and experimental variation of glycemia.

The excretion rates of albumin, IgG and beta 2-microglobulin were studied in insulin-dependent diabetic patients with (Albustix positive) and without (Albustix negative) clinical proteinuria and in a group of nondiabetic controls. In patients negative for clinical proteinuria, the mean excretion rate of albumin and IgG was increased but that of beta 2-microglobulin was normal. HbA1, a measure of excess glycemia, was positively correlated with both albumin and IgG urinary excretion rates. Vigorous correction of glycemic control significantly reduced IgG excretion in nine patients. In patients positive for clinical proteinuria, albumin and IgG clearances were inversely correlated with GFR, the filtration of IgG increasing relatively more than that of albumin as GFR declined. A negative hyperbolic correlation was found between GFR and beta 2-micro-globulin excretion. In this group HbA1 was unrelated to excretion rates or clearances of albumin and IgG. In clinically proteinuric patients, long-term correction of hyperglycemia by continuous subcutaneous insulin infusion failed to check the increasing albumin and IgG filtration. The microproteinuria of diabetes is glomerular in origin, is influenced by prevailing glycemia, and is reversible by vigorous glycemic control. In the clinically proteinuric phase, by contrast, selectivity is progressively lost and, as GFR falls, proteinuria becomes of a mixed glomerular and tubular origin. There is no evident association with prevailing glycemia, and metabolic near-normalization dose not appear to affect progression over the period of observation considered. This study suggests that clinical proteinuria denotes the installation of a self-maintaining process, largely independent of the diabetic metabolic disturbance which gave rise to it. Prevention of clinical diabetic nephropathy by metabolic correction may be achievable only in the phase of early microproteinuria.

Adult↗
PubMed2002

Work-related physical activity is not associated with body mass index and obesity.

OBJECTIVE: To analyze the association of work-related physical activity (WRPA) and leisure-time physical activity (LTPA) with body mass index (BMI) and obesity in the Spanish adult population aged 20 to 60 years. RESEARCH METHODS AND PROCEDURES: The data were taken from the 1993 Spanish National Health Survey. We analyzed a sample of 12,044 men and women representative of the Spanish population aged 20 to 60 years. BMI and frequency of obesity (BMI > or = 30 kg/m(2)) were obtained from self-reported weight and height. Multiple linear regression and logistic regression models were constructed, adjusting for the main confounding factors. WRPA and LTPA were measured by two questions to classify subjects into four categories of physical activity. RESULTS: Neither mean BMI nor percentage of obesity varied significantly (p > 0.05) by WRPA. Mean BMI was significantly higher (p < 0.01) in those who were inactive in their leisure time (25.90 kg/m(2) in men and 24.43 kg/m(2) in women) than in those who reported vigorous activity (24.42 kg/m(2) and 22.97 kg/m(2) in men and women, respectively). The odds ration (OR) for obesity decreased with increasing level of LTPA in both men (OR of 0.64 for vigorous activity) and women (OR = 0.68), showing a statistically significant dose-response relation in both men (for linear trend, p = 0.0021) and women (p = 0.0245). DISCUSSION: These results raise questions about the association between WRPA and obesity and suggest the need to reexamine models of the obesity epidemic that point to automation of the workplace as one of the major explanatory factors.

Adult↗
PubMed2004

Physical activity among African-American girls: the role of parents and the home environment.

OBJECTIVES: African-American girls are at increased risk for becoming overweight. Increased physical activity may prevent this. This study examines measurements of girls' physical activity and associations with: BMI, parent's reported self-efficacy and support for helping daughters be active, girl's perceived support from parents for physical activity, parent's and girl's perceived neighborhood safety and access to facilities, and family environment. RESEARCH METHODS AND PROCEDURES: Fifty-two 8- to 10-year-old African-American girls and their primary caregiver in the Minneapolis/St. Paul area participated in the Girls Health Enrichment Multisite Studies pilot intervention to prevent weight gain by promoting healthy eating and physical activity. Data collected included height, weight, physical activity level, and physical activity-related psychosocial measures from girl and parent. Girls wore an activity monitor for 3 days to assess activity level. Correlations were computed among the average minutes per day of moderate to vigorous activity between 12 pm and 6 pm and BMI and psychosocial measures. RESULTS: BMI was inversely correlated with moderate to vigorous activity (r = -0.35, p < 0.01), whereas parent's self-efficacy for supporting daughter to be active was positively correlated with activity (r = 0.45, p < 0.001). There was a trend for parent's reported support of daughter's activity level to be associated with activity (r = 0.26, p < 0.06). Girl's perception of parent's support for physical activity, perceived neighborhood safety and access to facilities, and family environment were not associated with girl's activity levels. DISCUSSION: Interventions to increase physical activity among preadolescent African-American girls may benefit from a parental component to encourage support and self-efficacy for daughters' physical activity.

Black or African American↗
PubMed2004

Covariability in diet and physical activity in African-American girls.

OBJECTIVE: Our goal was to examine 12-week covariability in diet and physical activity changes among 8- to 10-year-old African-American girls and if these changes predicted percent change in BMI. RESEARCH METHODS AND PROCEDURES: Covariability among percent changes [(post - pre)/pre x 100] in nutrients, food groups, and physical activity was assessed among 127 8- to 10-year-old African-American girls. Pearson correlation and hierarchical linear regression analyses were performed. RESULTS: Percent change in percentage kilocalories from carbohydrate was negatively correlated with percent change in both percentage kilocalories from fat (r = -0.85; p < or = 0.01) and protein (r = -0.51; p < or = 0.01). No statistically significant relationships were observed in percent changes among food group variables. Negative relationships were observed between percent changes in fruit/100% juice and percentage kilocalories from fat (r = -0.20; p < or = 0.05) and between percent changes in minutes of moderate-to-vigorous and sedentary activity (r = -0.60; p < or = 0.01). No significant associations were observed between percent change in moderate-to-vigorous physical activity and diet variables or percent change in BMI or waist circumference and percent change in diet or physical activity. DISCUSSION: No relationships were observed between percent changes in physical activity and dietary variables. Percent change in diet and/or physical activity did not predict percent change in BMI. This may have been due to the small sample size, the small changes in diet or physical activity, the short duration of the intervention, or because data from different interventions were combined. Understanding these relationships could have significant implications for addressing the obesity epidemic.

Black or African American↗
PubMed2005

Sedentary behaviors, physical activity, and metabolic syndrome in middle-aged French subjects.

OBJECTIVE: To study the relationships of time spent in sedentary occupations with the National Cholesterol Education Program-defined metabolic syndrome (MS), taking into account the habitual level of physical activity (PA). RESEARCH METHODS AND PROCEDURES: This was a cross-sectional analysis in 1902 men and 1932 women 50 to 69 years of age participating in the French Supplementation with Antioxidant Vitamins and Minerals study. We assessed past-year PA, television watching or computer use, and reading during leisure with the Modifiable Activity Questionnaire. Subjects who performed at least 150 min/wk of moderate-intensity PA (3 to 6 metabolic equivalent tasks) or 60 min/wk of vigorous PA (>6 metabolic equivalent tasks) were considered as meeting recommended levels. RESULTS: The frequency of most MS components increased with time spent in front of a screen and decreased with increasing PA levels. The likelihood to have MS, adjusted for age, education, and smoking, was decreased by one-third in subjects meeting moderate PA guidelines and by two-thirds in subjects meeting vigorous PA recommendations [odds ratio (95% CI), 0.34 (0.17 to 0.66) in women, 0.44 (0.28 to 0.68) in men] compared with those with insufficient PA. Independently of PA levels, time spent in front of a screen was positively associated with the likelihood to have the MS in women [odds ratio (95% CI), 3.30 (2.04 to 5.34)], whereas in both sexes, no association was found with time spent reading. DISCUSSION: The relationship of the MS with a sedentary lifestyle differs according to sex and type of sedentary occupation. These results suggest the need to assess selected indicators of sedentary behavior in preventive programs.

Aged↗
PubMed2005

Relationships of age and weekly running distance to BMI and circumferences in 41,582 physically active women.

OBJECTIVE: To assess in women whether age-related increases in adiposity are dependent on exercise, and, contrariwise, whether exercise-related declines in adiposity are dependent on age. RESEARCH METHODS AND PROCEDURES: Cross-sectional analyses were conducted of 41,582 female runners. RESULTS: Age affected the relationships between vigorous exercise and adiposity. The decline in BMI per kilometer per week run was linear in 18 to 23 year olds and became increasingly non-linear (convex) with age. Waist, hip, and chest circumferences declined significantly with running distance across all age groups, but the declines were significantly greater in older than younger women, particularly among shorter distance runners. The relationships between body circumferences and running distance became increasingly convex in older women. Conversely, vigorous exercise diminished the apparent increase in adiposity with age. The increase in average BMI with age was greatest in women who ran <8 km/wk, intermediate in women who ran 8 to 15 km/wk or 16 to 31 km/wk, and least in those who averaged over 32 km/wk. Before age 45, waist circumference rose for those who ran 0 to 7 km/wk, showed no significant relationship to age for those who ran 8 to 39 km/wk, and declined in those who ran 40 to 55 and 56 km/wk and more. Age related-increases in hip and chest circumferences before 45 years old were significantly less in women who ran longer weekly distances. DISCUSSION: These cross-sectional associations are consistent with the hypothesis that exercise may mitigate age-related increases in adiposity and that age affects exercise-induced reductions in adiposity (although causality remains to be determined experimentally).

Adiposity↗
PubMed2006

Validation and calibration of an accelerometer in preschool children.

OBJECTIVE: Obesity rates in young children are increasing, and decreased physical activity is likely to be a major contributor to this trend. Studies of physical activity in young children are limited by the lack of valid and acceptable measures. The purpose of this study was to calibrate and validate the ActiGraph accelerometer for use with 3- to 5-year-old children. RESEARCH METHODS AND PROCEDURES: Thirty preschool children wore an ActiGraph accelerometer (ActiGraph, Fort Walton Beach, FL) and a Cosmed portable metabolic system (Cosmed, Rome, Italy) during a period of rest and while performing three structured physical activities in a laboratory setting. Expired respiratory gases were collected, and oxygen consumption was measured on a breath-by-breath basis. Accelerometer data were collected at 15-second intervals. For cross-validation, the same children wore the same instruments while participating in unstructured indoor and outdoor activities for 20 minutes each at their preschool. RESULTS: In calibrating the accelerometer, the correlation between Vo(2) (ml/kg per min) and counts was r = 0.82 across all activities. The only significant variable in the prediction equation was accelerometer counts (R(2) = 0.90, standard error of the estimate = 4.70). In the cross-validation, the intraclass correlation coefficient between measured and predicted Vo(2) was R = 0.57 and the Spearman correlation coefficient was R = 0.66 (p < 0.001). Cut-off points for moderate- and vigorous-intensity physical activity were identified at 420 counts/15 s (Vo(2) = 20 mL/kg per min) and 842 counts/15 s (Vo(2) = 30 mL/kg per min), respectively. When these cutpoints were applied to the cross-validation data, percentage agreement, kappa, and modified kappa for moderate activity were 0.69, 0.36, and 0.38, respectively. For vigorous activity, the same measures were 0.81, 0.13, and 0.62. DISCUSSION: Accelerometer counts were highly correlated with Vo(2) in young children. Accelerometers can be appropriately used as a measure of physical activity in this population.

Acceleration↗
PubMed2002

The efficacy of prophylactic outpatient antibiotics for the prevention of neutropenic fever associated with high-dose etoposide (VP-16) for stem cell mobilization.

High-dose etoposide (2 g/m(2)) plus G-CSF is a very effective regimen for peripheral blood progenitor cell (PBPC) mobilization. Unfortunately, neutropenia is common. The infectious complications associated with high-dose etoposide have not been previously described. After noting a high incidence of hospitalizations for neutropenic fever, we began a vigorous prophylactic antibiotic regimen for patients receiving high-dose etoposide plus G-CSF, attempting to reduce infectious complications. Ninety-eight patients underwent etoposide mobilization between December 1997 and June 2000. Three chronological patient groups received: (1) no specific antibiotic prophylaxis (n = 44); (2) vancomycin i.v., cefepime i.v., clarithromycin p.o., and ciprofloxacin p.o. (n = 27); and (3) vancomycin i.v., clarithromycin p.o., and ciprofloxacin p.o. (n = 27). The patients not receiving antibiotic prophylaxis had a 68% incidence of hospitalization for neutropenic fever. In the patients receiving prophylaxis, the incidence was reduced to 26% and 15% respectively, for an overall incidence of 20% (P < 0.001 for comparison between prophylaxed and unprophylaxed groups). We conclude that etoposide mobilization is associated with a significant incidence of neutropenic fever, which can be substantially reduced by a vigorous antimicrobial prophylactic program.

Ambulatory Care↗
PubMedDate not supplied

The HIV epidemic in China: history, response, and challenge.

The first case of AIDS was reported in 1985 in China, but by the early 21st century, the government estimated that there were 840,000 citizens living with HIV/AIDS. The number is increasing rapidly. The major risk groups are injection drug users (IDUSs; 43%) and former plasma donors (27%), but rates among heterosexual groups are rising rapidly. Sentinel surveillance was initiated in 1986, and now includes IDUs, men-who-have-sex-with-men, sexually transmitted disease clinic attendees, antenatal women, long-distance truck drivers, and sex workers. Although the government was slow to respond to the epidemic in the late 20th century, it has made a vigorous response in the early 21st century. Components of that response include implementation and evaluation of harm reduction programs for IDUs, education to increase knowledge and reduce stigma, treatment and social support for rural and poor HIV/AIDS patients, widespread testing, and increased funding for HIV/AIDS programs. International agencies have been generous in their support of the government initiatives. To successfully combat the epidemic, China needs to develop and train the necessary infrastructure to implement its intervention programs, particularly in the rural areas, to vigorously combat stigma and discrimination, support research especially in the universities and research institutions other than the China Centers for Disease Control, develop a system for efficient exchange of research and program information, and update legislation to reflect the current situation.

Acquired Immunodeficiency Syndrome↗
PubMed2006

Within- and between-individual variability in estimated energy expenditure and habitual physical activity among young adults.

OBJECTIVE: To examine the within- and between-individual variability in the estimated total energy expenditure (TEE) and habitual physical activity (PA) in free-living young adults. We were specifically interested in the day-to-day variation. DESIGN: Cross-sectional. SETTING: University. SUBJECTS: A total of 277 (125 males, 152 females) participants aged 18-24 years. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Subjects recorded their daily PA with the Bouchard 3-day diary. Descriptive statistics for TEE, moderate-to-vigorous physical activity (MVPA), inactivity (IA), and activity energy expenditure (AEE) were calculated and presented as a frequency distribution. Within- and between-individual variability were tested by RMANOVA and also presented as the coefficient of variation (CV). RESULTS: Mean values for TEE, MVPA, AEE, and IA were comparable between males and females; however, considerable between-individual variability existed. Only MVPA showed a significant difference between sexes (P<0.05), due to slightly greater vigorous PA in males compared to females (8.0 and 6.8 kcal/kg/day, respectively; P=0.12). Results from the RMANOVA revealed no significant day-to-day variability in any TEE or PA variable and the CVs were not significantly different between males and females. TEE and IA displayed mean CVs of approximately 12% while mean CVs for AEE and MVPA approximated 32 and 84%, respectively. CONCLUSIONS: Results from this study suggest (1) a limited day-to-day variability in TEE and (2) a large degree of between-individual variation for TEE and PA exist. This study highlights the importance of understanding the variability associated with TEE, which is important for PA measurement and proper PA and nutritional recommendations. SPONSORSHIP: None.

Adolescent↗
PubMed1999

Parent-child relationship of physical activity patterns and obesity.

OBJECTIVE: To study differences in physical activity between normal-weight and obese children, as well as parent-child associations of obesity and physical activity. DESIGN: Cross-sectional study. SUBJECTS: 129 obese children (67 girls and 62 boys), 142 normal-weight controls (81 boys and 61 girls), and mothers (n = 245) and fathers (n = 222) of the children. METHODS: Physical activity was assessed by a 3-day physical activity record (children and parents), by a questionnaire (children), and by one question on habitual physical activity (parents). The data were analysed by stepwise linear and logistic regressions. Obesity was assessed from relative weight (children) and BMI (parents). RESULTS: Parent inactivity was a strong and positive predictor of child inactivity (beta-coefficients 0.25 and 0.16, P<0.001, for mother and father inactivity, respectively). Scores of parent activity were somewhat weaker predictors of child vigorous activity hours and total physical activity level (beta-coefficients 0.13-0.25, P = 0.003-0.08). Child obesity was negatively associated with child habitual physical activity (odds ratio 0.88, P<0.001). In addition, parent obesity (body mass index > or =30 kg/m2) was another strong predictor of child obesity (odds ratio 2.38-3.50, P<0.002). CONCLUSIONS: The present study underscores the parents' role in childhood activity patterns and obesity. A novel finding was that the parent-child relationship of inactivity appeared to be stronger than that of vigorous activity. Hence, parents who want to reduce their children's inactivity may have to pay attention to their own lifestyle.

Adult↗
PubMed2001

Relationship of leisure-time physical activity and occupational activity to the prevalence of obesity.

OBJECTIVE: To assess the interaction between leisure-time physical activity (LTPA) and occupational activity (OA) on the prevalence of obesity. DESIGN: Secondary data analysis of a population based cross-sectional US national sample (NHANES III). SUBJECTS: A total of 4889 disease-free, currently employed adults over age 20 y. MEASUREMENTS: Subjects body mass index (BMI) was categorized as (1) obese (BMI> or =30 kg/m(2)), or (2) non-obese (BMI<30 kg/m(2)). LTPA was divided into four categories: (1) no LTPA; (2) irregular LTPA; (3) regular moderate intensity LTPA; and (4) regular vigorous intensity LTPA. OA was grouped as (1) high OA and (2) low OA. Age, gender, race-ethnicity, smoking status, urbanization classification, alcohol consumption and income were statistically controlled. RESULTS: In all, 16.8% (s.e. 0.7) of the total subject population were obese (15.1% (s.e. 1.1) of men and 19.1% (s.e. 1.1) of women). Logistic regression revealed that compared to those who engage in no LTPA and have low levels of OA, the likelihood of being obese is 42% (95% CI 0.35, 0.96) lower for those who engage in no LTPA and have high OA, 48% (95% CI 0.32, 0.83) lower for those who have irregular LTPA and have high levels of OA, and about 50% lower for all those who have regular LTPA through moderate or vigorous activity levels regardless of OA level. CONCLUSION: When considering disease free adults above 20 y of age employed in high and low activity occupations, a high level of occupational activity is associated with a decreased likelihood of being obese.

Adult↗
PubMed2001

Physical activity and determinants of physical activity in obese and non-obese children.

OBJECTIVE: To compare the physical activity (PA) patterns and the hypothesized psychosocial and environmental determinants of PA in an ethnically diverse sample of obese and non-obese middle school children. DESIGN: Cross-sectional study. SUBJECTS: One-hundred and thirty-three non-obese and 54 obese sixth grade children (mean age of 11.4+/-0.6). Obesity status determined using the age-, race- and gender-specific 95th percentile for BMI from NHANES-1. MEASUREMENTS: Objective measurements were collected of PA over a 7-day period using the CSA 7164 accelerometer: total daily counts; daily moderate (3-5.9 METs) physical activity (MPA); daily vigorous physical activity (> or =6 METs; VPA); and weekly number of 5, 10 and 20 min bouts of moderate-to-vigorous physical activity (> or =3 METs, MVPA). Self-report measures were collected of PA self-efficacy; social influences regarding PA, beliefs about PA outcomes; perceived PA levels of parents and peers, access to sporting and/or fitness equipment at home, involvement in community-based PA organizations; participation in community sports teams; and hours spent watching television or playing video games. RESULTS: Compared to their non-obese counterparts, obese children exhibited significantly lower daily accumulations of total counts, MPA and VPA as well as significantly fewer 5, 10 and 20 min bouts of MVPA. Obese children reported significantly lower levels of PA self-efficacy, were involved in significantly fewer community organizations promoting PA and were significantly less likely to report their father or male guardian as physically active. CONCLUSIONS: The results are consistent with the hypothesis that physical inactivity is an important contributing factor in the maintenance of childhood obesity. Interventions to promote PA in obese children should endeavor to boost self-efficacy perceptions regarding exercise, increase awareness of, and access to, community PA outlets, and increase parental modeling of PA.

Australia↗
PubMed2006

The effects of changing exercise levels on weight and age-related weight gain.

OBJECTIVE: To determine prospectively whether physical activity can prevent age-related weight gain and whether changing levels of activity affect body weight. DESIGN/SUBJECTS: The study consisted of 8,080 male and 4,871 female runners who completed two questionnaires an average (+/-standard deviation (s.d.)) of 3.20+/-2.30 and 2.59+/-2.17 years apart, respectively, as part of the National Runners' Health Study. RESULTS: Changes in running distance were inversely related to changes in men's and women's body mass indices (BMIs) (slope+/-standard error (s.e.): -0.015+/-0.001 and -0.009+/-0.001 kg/m(2) per Deltakm/week, respectively), waist circumferences (-0.030+/-0.002 and -0.022+/-0.005 cm per Deltakm/week, respectively) and percent changes in body weight (-0.062+/-0.003 and -0.041+/-0.003% per Deltakm/week, respectively, all P<0.0001). The regression slopes were significantly steeper (more negative) in men than women for DeltaBMI and Delta%body weight (P<0.0001). A longer history of running diminished the impact of changing running distance on men's weights. When adjusted for Deltakm/week, years of aging in men and years of aging in women were associated with increases of 0.066+/-0.005 and 0.056+/-0.006 kg/m(2) in BMI, respectively, increases of 0.294+/-0.019 and 0.279+/-0.028% in Delta%body weight, respectively, and increases of 0.203+/-0.016 and 0.271+/-0.033 cm in waist circumference, respectively (all P<0.0001). These regression slopes suggest that vigorous exercise may need to increase 4.4 km/week annually in men and 6.2 km/week annually in women to compensate for the expected gain in weight associated with aging (2.7 and 3.9 km/week annually when correct for the attenuation due to measurement error). CONCLUSIONS: Age-related weight gain occurs even among the most active individuals when exercise is constant. Theoretically, vigorous exercise must increase significantly with age to compensate for the expected gain in weight associated with aging.

Adolescent↗
PubMed2000

The effect of frequency and mode of sports activity on the psychological status in tetraplegics and paraplegics.

OBJECTIVE: To examine whether the psychological benefits of sports activity differ between tetraplegics and paraplegics with spinal cord injury, and investigate the effect of frequency and modes of sports activity on the psychological benefits. METHODS: The Self-rating Depression Scale (SDS), State-Trait Anxiety Inventory (STAI) and Profiles of Mood States (POMS) were administered to 169 male individuals with spinal cord injury (mean age=42.7 years) including 53 tetraplegics and 116 paraplegics. The subjects were divided into four groups according to their frequencies of sports activity; High-active (more than three times a week; n=32), Middle-active (once or twice a week, n=41), Low-active (once to three times a month, n=32), and Inactive (no sports participation, n=64). RESULTS: Analysis of variance revealed significant differences in depression for SDS, trait anxiety for STAI and depression and vigor for POMS among the groups. High-active group showed the lowest scores of depression and trait anxiety and the highest score of vigor among the four groups. In contrast, no significant difference was found for any psychological measurements between tetraplegics and paraplegics. In addition, there was no significant difference for any psychological measurements among modes (wheelchair basketball, wheelchair racing, wheelchair tennis and minor modes). CONCLUSIONS: These findings demonstrated that sports activity can improve the psychological status, irrespective of tetraplegics and paraplegics, and that the psychological benefits are emphasized by sports activity at high frequency.

Adolescent↗