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At least 1,081 records · Page 60Linked to original sources

Shoe gear for the insensitive foot.

People with insensitive feet have lost most of the natural mechanisms that the rest of us use to protect our feet from injury. With normal sensation, we feel discomfort which causes us to change our gait pattern or to remove our shoes. These incidents which seem so minor are the exact occurrences which are unfelt by the insensate person and are responsible for the vast majority of foot injuries. Since these patients cannot tell where injury is occurring, precise shoe fitting is essential. Also, to effectively maintain the insensitive feet intact, additional objective evaluations should be included during the examination of these patients. Shoe pressure testing and thermometry help to identify regions of excessive pressure on the foot before ulceration occurs. A person with sensory loss in the foot often does not seek consultation for foot care until an open wound or neuropathic fracture is already present. These people need a regular schedule of prophylactic management. Their shoes need to be prescribed and worn, not after an ulcer has occurred, but to prevent it from ever forming.

Diabetic Neuropathies↗

Noninvasive determination of healing of major lower extremity amputation: the continued role of clinical judgment.

Various tests are used preoperatively to differentiate patients who require an above-knee amputation (AKA) from those whose vascular supply is adequate to heal a below-knee procedure (BKA). This 15-month study of 109 amputations compared four of these methods: segmental Doppler systolic pressure measurements, transcutaneous oxygen measurement (tcPO2), fluorescein angiography, and skin thermometry. There were 66 BKAs (85% healed primarily) and 43 AKAs (93% healed primarily). The actual level of amputation was determined by the operating surgeon without consideration of the preoperative test results, and the incidence of healing was then related to the test parameters. The average skin temperature at the amputation site was higher (93.7 degrees F) in the group that healed primarily compared with those who required operative stump revision (89.9 degrees F) (p less than 0.001). The mean midcalf tcPO2 was also higher in the BKA group that healed (PO2 = 36.6 mm Hg) compared with those who failed (PO2 = 16.4 mm Hg) (p less than 0.001). Qualitative skin fluorescence was less successful in differentiating success from failure. Of the 63 BKAs that fluorescein predicted would heal, eight failed (13%). Doppler pressures at the thigh, popliteal, midcalf, or ankle level were unreliable in predicting healing of a BKA. Formulation of indexes relating absolute pressures to the brachial systolic pressure did not improve the value of this examination. From this review it is concluded that the skin temperature and tcPO2 obtained at the site of proposed amputation were the most reliable prognostic noninvasive examinations.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

[Diagnosis and clinical manifestations of dental plexalgia].

The article considers characteristics of clinical manifestations of dental plexalgia, a new form of the disease related to impairment of dental plexuses. In a clinicophysiological study of 56 patients with dental plexalgia conducted at a neurostomatological department the authors used rheofaciography, thermometry and thermography of the face skin, esthesiometry, and electrodiagnosis of the oral mucosa. Electrodiagnosis of the oral mucosa helps to specify the diagnosis of dental plexalgia. The authors describe differential diagnosis criteria reflecting the peculiarities of the clinical picture of dental plexalgia which is characterized by the persistent pain in the area of the damaged plexus with peculiar irradiation which may be used for the diagnosis, rational etiopathogenetic therapy, prophylaxis, and prognosis of the disease.

Adult↗

Comparison of techniques for measuring the local and systemic responses to tuberculin in cattle.

Thermography of tuberculin skin reactions in cattle sensitized with Mycobacterium avium, Mycobacterium bovis, or Mycobacterium paratuberculosis was rapid and sensitive, but was not as specifically related to the homologous sensitization as was increased skin thickness at 48 and 72 hours. Systemic temperature responses were more completely monitored by radiotelemetry of intraperitoneally located temperature transmitters than by rectal thermometry, but the temperatures indicated by the 2 methods were nearly identical. The intraperitoneal transmitters showed that the systemic responses consisted of 1, 2, or 3 temperature peaks, and in 1 animal which had previously been exposed to a heterologous tuberculin, a hypothermic response developed. The systemic temperature responses were more specifically related to homologous sensitization than were dermal responses, but were more cumbersome to measure.

Animals↗

[Current state of the problem of local hyperthermia in Japan].

The author reported the results of local RF hyperthermia in combination with radiotherapy applied to 700 cancer patients used jointly in a group of 7 Japanese institutes, the author being the chief of the group. The author also reported clinical results of thermochemotherapy applied to a limited number of patients in 4 institutes. A conclusion has been made that the use of hyperthermia, especially in combination with radiotherapy, holds promise. However, further optimization of the methods of heating and thermometry is required.

Combined Modality Therapy↗

[Autonomic disorders and thermography using liquid crystals in obesity].

The neurovegetative state was studied by a questionnaire in 70 obese patients. In 61 of them frontal and distal thermometry with liquid crystal cholesterol thermoindicators was performed and the polarization currents of the hands were recorded. In 21.3% of the obese patients deviations in the thermoregulatory state were found. A tendency toward hypothermia of about 2 degrees C, localized predominantly in the medial frontal zone, was registered. Disturbances in the sudomotorics--hypo or hyperhydrosis--were found. The results show mixed and/or parasympathicotonic dystonia in the patients studied. Thermodiagnostics with liquid crystals and registration of the polarization currents are recommended as noninvasive methods for determination of neurovegetative disorders in obesity.

Adolescent↗

Development of controlled Nd:YAG laser for medical applications.

Several medical fields are concerned with applications of thermal lasers such as neodymium-doped, yttrium aluminum garnet (Nd:YAG), argon, and CO2. However, quantification of the necrotic volume of Nd:YAG laser-induced damage is not possible at the time of treatment. Mathematic models and feedback control can help to optimize Nd:YAG laser treatments. We therefore formulated mathematic models for coagulation processes and developed an intelligent Nd:YAG laser system with closed-loop feedback control. Surface temperature evolution proved to be valuable data for real-time control of coagulation and ablation. Infrared thermometry provided the noncontact measurement of temperature. A computer stored the temperature data calculated by the mathematic model. Deviations of surface temperature during the treatment beyond established tolerances causes the Nd:YAG laser system to adjust the laser power automatically.

Animals↗

Effects of a phenylbutazone paste in ponies: model of acute nonimmune inflammation.

In a 12-day treatment schedule, 5 ponies were given orally a paste formulation of phenylbutazone (PBZ) and 5 matched ponies were given equivalent doses of a placebo paste. On day 12, a mild, nonimmune inflammatory reaction was induced subcutaneously in the neck of each pony by inserting sterile, polyester sponge strips soaked in a 2% carrageenan solution. Exudate was collected at 4, 8, 12, and 24 hours by serial removal of sponges. There were no significant (P less than 0.05) differences in exudate protein concentration and leukocyte numbers between the treatment groups, but the group given PBZ had significantly reduced exudate concentrations of eicosanoids 6-keto-prostaglandin F 1 alpha (the stable metabolite of prostacyclin) at 4, 8, and 12 hours; thromboxane B2 at 8, 12, and 24 hours; and bicyclic prostaglandin E2 at 8 hours. The maximal depression of eicosanoid synthesis occurred at times of peak exudate concentrations of PBZ (8 and 12 hours). Phenylbutazone was cleared more slowly from exudate than from plasma. Changes in surface skin temperature were measured by infrared thermometry. Lesional temperatures were recorded 1 cm below the base of the incision line, and mean increases were significantly (P less than 0.05) less in PBZ-treated than in placebo-treated ponies between 4 and 24 hours. The importance of the findings for the clinical efficacy of this dosage schedule is considered.

6-Ketoprostaglandin F1 alpha↗

Effects of local convective cooling and rewarming on skin blood flow.

Local areas of the thighs, palms and fingertips of ten healthy subjects were exposed to cold (10 degrees C) and warm (40 degrees C) air flows of three different velocities, 0.25, 0.50 and 0.75 m/s. The rewarming followed immediately after the cooling. Each climatic condition was applied for 45 min. Skin blood flow and skin temperature were continuously measured by laser Doppler flowmetry and thermometry, respectively. Significant (p less than 0.01 or less) reductions in both skin blood flow and skin temperature, compared to the levels recorded in the room climate, were observed at all the test sites and for all the cooling climates. During cooling no significant differences were obtained between skin blood flow levels reached for the different air velocities, except for the palm (p less than 0.01). Rewarming by the air velocities 0.25 and 0.50 m/s could not even bring the palm skin blood flow back to the precooling levels, while the fingertip (except for the low air velocity) and the thigh showed a hyperaemic reaction. The discrepancies in response pattern between the test sites are interpreted to be due to their different microvasculature and vasomotor innervation. The relationship between skin blood flow and skin temperature was found to be exponential. The correlation coefficients were 0.84, 0.72 and 0.85 for the thigh, palm and fingertip, respectively.

Adolescent↗

A technique for localized tumor hyperthermia in small animals.

Hyperthermia, the intentional elevation of tissue temperature above 41 degrees C, is being intensely researched as a therapeutic modality for cancer, especially when used in combination with radiation therapy and/or chemotherapy. A serious impediment to laboratory progress in this area has been the lack of affordable equipment providing control and reproducibility when faced with highly variable factors including tumor size and shape, blood flow, heat conduction, and tissue dielectric discontinuity. Our solution has been the development of a laboratory microwave hyperthermia system, dedicated to the treatment of small, superficial tumors. This system uses a 2.45-GHz microwave generator and custom applicator to noninvasively heat a mass of tissue about 2 cm in diameter and 1.5 cm in depth. Tissue temperature at up to four locations is measured using miniature. Teflonencased thermocouples. The microwave generator and the thermometry are interfaced to a personal computer which provides fully automated hyperthermia treatment reproducible to +/- 0.2 degrees C.

Animals↗

[Radiologic hyperthermia with microwaves and radio-frequencies. I. Presentation of a multifrequency system].

A computerized system with automatic treatment parameters control for radiological hyperthermia, called Sapic SVO3, is presented. The system has been planned and built by the "Sezione Avionica ed Equipaggiamenti" of the Aeritalia in cooperation with the Radiotherapy Department of the University of Turin. The device is supplied with a multifrequency generator system (915, 433, 2-30 MHz) connected with many kinds of applicators (microstrip antennas, high constant dielectric material loaded antennas, waveguide antennas), with a fiber optic system for temperature control and with a previsional thermometry system.

Computers↗

[Hyperthermia of malignant brain tumors--development of an interstitial microwave hyperthermia system and study of thermodosimetry and heat toxicity in a canine brain model].

Hyperthermia is a promising important adjunct to conventional treatment of malignant brain tumors and available data suggest a strong biological rationale for its use. Hyperthermia has been shown to sensitize tumors to radiation, particularly radiation delivered at low dose rates typical of brachytherapy. To complement our clinical study of interstitial brachytherapy of malignant brain tumors, a microwave interstitial heating system with data acquisition has been constructed at UCSF. This system was evaluated in a phantom and in a series of non-survival and survival experiments for heating patterns and heat toxicity in 24 adult canine brains. A single 2450 MHz microwave heating antenna and 3 fiberoptic thermometry probes were placed stereotaxically into the frontal white matter of 24 dogs. Temperature measurements were made at 1 mm increments along the antenna length 5 mm from the antenna axis and radially away from the antenna junction. For the survival studies, minimum temperatures 43 degrees C, 44 degrees C, and 45 degrees C were maintained at points 5 mm from the antenna junction for 30 minutes. Hyperthermia-induced tissue damage was measured weekly following the heat treatment using CT. In general, it was easy to maintain a steady temperature state for a long time period. Heating patterns tended to be ellipsoidal, corresponding relatively well with those predicted by the phantom trials. Heat toxicity was examined by sequential quantitative CT scans in chronic trials and correlated with histopathology following sacrifice at 1-16 weeks. Neurological deficits were minimal and were restricted to the first day after treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

[Diagnosis and treatment of acute pancreatitis].

In diagnosis of acute pancreatitis of special importance is determination of the activity of transamidinase, phospholipase A, lipase, concentration of copper, calcium and triglycerides in blood serum as well as laparoscopy with biopsy and local thermometry of the pancreas. The dosage of 5-fluoruracil in the complex treatment of patients should be differentiated corresponding to the form of the disease: 3 mg/kg in the endomatous form, 5 mg/kg in the destructive form. The general lethality was 1.4%. In conservative treatment there were no lethal outcomes.

Acute Disease↗

Assessment of current hyperthermia technology.

The current state of the art in techniques for the production and control of whole-body and local hyperthermia is discussed. Techniques of radio-frequency, microwave, and ultrasonic local hyperthermia are considered and compared. Problems of thermometry and control system integration are defined, and requisite biophysical data requirements are established. A bibliography is provided to serve both as an introduction to the hyperthermia literature for researchers from other fields and as a convenient compendium of original sources for scientists currently engaged in hyperthermia research.

Biophysical Phenomena↗

Temperature measurements in normal and tumor tissue of dogs undergoing whole body hyperthermia.

Temperature was measured in the left ventricle, aorta, liver, brain, lung, bone marrow, kidney, and spontaneous solid tumors in dogs undergoing whole body hyperthermia in a radiant heat device. Rectal temperature was found to be a satisfactory indicator of systemic arterial temperature during plateau temperature conditions but rectal temperature underestimated arterial temperature during heating and overestimated it during cooling. Lung temperature, based on small airway temperature, was the same as rectal temperature during plateau temperature conditions. Liver and brain temperatures were slightly higher (0.1-0.2 degree C) than rectal temperature during the plateau phase. During plateau temperature conditions, kidney temperature measurements were higher than rectal temperature when one site/kidney was measured but were lower than rectal temperature when two sites/kidney were measured suggesting invasive thermometry may have affected measured temperature values. Tibial marrow temperature was greater than rectal temperature during heating but fell below rectal temperature during plateau temperature conditions by as much as 1.3 degree C. Femoral marrow temperature was below rectal during heating but gradually exceeded it during steady state conditions, by 0.1-0.4 degree C. Temperature in solid tumors was variable, sometimes exceeding (0.6 degree C) and sometimes being less (1.8 degree C) than rectal temperature.

Animals↗

[Hyperthermia in the treatment of cancer].

The expectation that hyperthermia would be effective in the treatment of cancer is attributable to a theoretical viewpoint based upon biological studies. Cancer cells, which characteristically are hypoxic with poor nutrition and low pH, are sensitive to temperatures over 42.5 degrees C. This is the theoretical basis which assures the effectiveness of hyperthermia when used in combination with radiation therapy. Previous clinical studies have shown that a combination hyperthermia and radiation therapy is an effective treatment for superficial tumors, thus expanding the range of cancer therapy. When used for deeply seated cancer, this combination enhances the efficiency of therapy. It is, however, necessary to improve the heating techniques and methods of thermometry. Fundamental studies are now being actively pursued in respect of combined hyperthermia and chemotherapy. However, inadequacy of clinical material hinders evaluation. The combination of whole-body hyperthermia with anti-cancer agents presents so far, unsolved problems, such as determination of applicable anatomical regions and prevention of complications.

Antineoplastic Agents↗

[OMRON RF hyperthermia treatment system HEH-500 C].

The RF capacitive type hyperthermia system "HEH-500 C" enables regional heating for superficial and deep seated tumors. It consists of a high frequency generator (frequency; 13.56 MHz, out put power; 500 watts), a control unit, a cooling unit for the applicators, an I/F unit (communicate the thermometer to RF generator and plotter printer), a thermometer (thermocouple thermometer or fiber fluorothermometer) and a plotter printer. Heating profile of HEH-500 C was presented with thermographic picture on TX-150 muscle equivalent phantom. Effects of bone and fat layer on heating profile of phantom were also examined. Points to be solved on thermometry, electromagnetic field environment and clinical use were also discussed.

Humans↗