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PubMed1986

[Use of computed tomography for quantifying Thorotrast and detecting Thorotrast-induced liver tumors].

242 Thorotrast patients were examined by CT. The mean CT-density-values of the whole liver correlate well (0.72) with the measurements of the radioactivity by total-body-counting. Twenty-one of 24 primary liver tumors were correctly diagnosed by CT. The smallest tumor measured 3 cm in diameter. In 8 patients surgical treatment was possible. The sensitivity of CT for the detection of liver tumors, is higher than the sensitivity of echography.

Adenoma, Bile Duct↗
PubMed1986

[Pathomorphological study of thorotrast-related intrahepatic cholangiocarcinoma--a comparison with non-thorotrast cases].

Thirty-five autopsy cases of Thorotrast (TH)-related intrahepatic cholangiocarcinoma were morphologically studied with a comparison to 45 non-TH cases. Latent periods ranged from 25 to 48 years, with a mean of 34.1 +/- 6.6 years. As to tumor location, the peripheral-middle type, in which the main tumor was located in the periphery to middle portion of the liver, was the most common (89.2%) in the TH-related cases, and the hilar type, in which the main tumor was located in the hepatic hilum, was the most common (78.8%) in the non-TH cases. However, there was no close relationship between the distribution of TH deposits and tumor location by soft-X ray examination of the liver slices. Grossly, the massive type with an infiltrative growth was the most common both in the TH- and non-TH cases. Histologically, there were no remarkable differences between the two groups, and tubular adenocarcinoma with varying degrees of fibrous stroma was the most common. In noncancerous areas, proliferation of the bile ducts with slight to moderate atypism and ductular proliferation around Glisson's capsule were found in 30%, and 10%, respectively, of the TH-related cases. However, such changes were also found in the non-TH cases at almost the same incidence.

Adenoma, Bile Duct↗
PubMed1987

[Macroscopic study of cholangiocarcinoma].

Fourty three autopsy cases of cholangiocarcinoma and 18 cases of Thorotrast-related cholangiocarcinoma were macroscopically studied. They were classified into two types, according to the intrahepatic location of the tumors; middle-peripheral type and hilar type. Most Thorotrast-related cases (83%) were middle-peripheral type, while the non-Thorotrast-related cases were hilar type (68%). According to the gross characteristics of the tumor. They were classified into four gross types: infiltrative type (54%), nodular type (21%), periductal type (18%), and diffuse type (7%). Non-specific liver cirrhosis (mixed macro and micronodular type) was associated in 4 of non-Thorotrast related cases, and the association of biliary cirrhosis was found in 3 of the non-Thorotrast cases of the hilar type.

Adenoma, Bile Duct↗
PubMed1987

[Late complications of thorotrast. Experiences from Zurich].

57 cases of late sequelae after diagnostic thorotrast exposure (recorded between 1944 and 1982 in Zurich) are presented. The alpha-ray-emitting contrast medium thorotrast is carcinogenic and fibrogenic. Malignant tumors occurred in about half of our cases after a latency period of 14 to 44 years, comprising 8 primary liver carcinomas, 2 carcinomas of the bile ducts, 3 malignant hemangioendotheliomas of the liver, 10 renal pelvic carcinomas and sarcomas, and one acute myelogenous leukemia. Further, cirrhosis and fibrosis of the liver and paravascular "thorotrastoma" were observed. The late effects of thorotrast are a negative example of avoidable radiation injuries to man.

Adult↗