Vascular tumors of the salivary glands in children.
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Digital subtraction techniques used in the examination of eight patients with salivary and nasolacrimal disease are described. Pleomorphic adenoma, ductal stricture, extrinsic masses, parotid-otic fistula, and a radiolucent calculus were demonstrated. The procedures are more easily performed than film techniques, and pathology is better demonstrated by digital ductography than on a film examination. Image subtraction, reregistration, and window manipulation allowed clear demonstration of ducts about the head and neck, overcoming limitations imposed by inherently high object contrast. Digital subtraction ductography is an important nonvascular application of digital imaging technology.
In an attempt to determine whether radiation therapy leads to an increased density of salivary glands on subsequent contrast-enhanced CT, 109 CT scans from 78 patients with head and neck tumors were reviewed. The density of parotid and submandibular glands was subjectively evaluated (compared with adjacent muscle) and correlated with treatment including surgery, chemotherapy, and radiation. Density of the parotid and/or submandibular glands was found to be significantly associated with previous irradiation on contrast-enhanced scans (p less than .05). One or both glands were denser than normal in seven (44%) of 16 patients who received only radiation therapy and in eight (38%) of 21 who received chemotherapy and radiation therapy, compared with only two (10%) of 20 patients who received chemotherapy alone and two (4%) of 52 patients who received neither. The type or amount of irradiation, type of chemotherapy, or timing of the CT scan after the initiation of treatment was not found to be significant. We conclude that the density of the parotid and/or submandibular glands on contrast-enhanced CT is frequently increased after radiation therapy for tumors of the head and neck.
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In 111 patients with idiopathic peripheral facial paralysis (Bell's palsy) the prognosis was established during the first days of the disease, using sialometry and the stapedius reflex test in 102 patients. A poor prognosis was indicated in 36 patients. Treatment with adrenocorticotrophic hormone (ACTH) was commenced within 10 days (in the majority within 5 days) of the onset of the paresis in 31 of those patients with a poor prognosis. The recovery rate in the ACTH-treated group was superior compared with the untreated control group of patients with a poor prognosis. The difference is statistically significant. Those patients with a good prognosis were not treated but merely followed up. Some factors which could influence the result of the treatment are considered.
A 65-year-old woman with facial erythema and hypergammaglobulinemia developed excessive fatigability. A diagnosis of Lambert-Eaton myasthenic syndrome (LEMS) was made from electrophysiological studies. She had symptoms and laboratory data compatible with probable Sjögren's syndrome. Skin biopsy revealed the histological findings of discoid lupus erythematosus. Treatment with 3,4-diaminopyridine resulted in the improvement of fatigability. LEMS should be recognized as a treatable complication of systemic autoimmune diseases.
Autonomic nervous function was evaluated by deep breathing [expiration/inspiration (E/I) ratio] and tilt table tests [acceleration (AI) and brake indices (BI)] in 19 patients with primary Sjögren's syndrome (pSS) and in 56 age matched controls. The E/I-ratio and systolic blood pressure (at rest, 1, and 8 min after tilt) were found to be significantly reduced (p < 0.001, p < 0.05, p < 0.01, p < 0.01 respectively) in patients with pSS whereas neither AI, BI nor diastolic blood pressure did differ significantly between patients and controls (NS). The van Bijsterveld's score correlated negatively with the AI (r = -0.77, p < 0.001) as well as the BI (r = -0.60, p < 0.01). No correlations were found between the 3 autonomic nerve function parameters (E/I-ratio, AI, BI) and unstimulated whole sialometry or salivary gland scintigraphy. We conclude that autonomic disturbances, mainly affecting the parasympathetic nerves are associated with pSS.
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