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At least 1,081 records · Page 60Linked to original sources
PubMed1981

[The significance of examination of breathing mechanics during general anaesthesia and artificial ventilation for the complex assessment of functional pulmonary conditions in patients with nonspecific respiratory disease (author's transl)].

The results of mechanical examinations of breathing during bronchoscopy in general anaesthesia with various breathing regimens in 140 patients with chronic nonspecific respiratory diseases are given. The variations of breathing mechanics depend on both the extent of the pulmonary changes and the localization of the obstructive syndrome (large and small bronchi) and they correlate with the clinical severity of the respiratory insufficiency. In comparison with the mechanical examinations of breathing in spontaneous breathing we can find a very good coincidence of the results. The results from 42 patients with expiratory stenosis of the trachea and main bronchi are emphasized. The method mentioned guarantees a reliable judgement of the functional condition of the lungs without an additional annoyance of the patient and also without an essential complication of the bronchoscopic examinations. It makes practical clinical conclusions concerning the treatment and the choice of the suitable anaesthesiologic procedure possible. It has the greatest perspective in the modern pulmonologic hospital.

Airway Resistance↗
PubMedDate not supplied

[Hygienic assessment of the influence of climatic factors on the prevalence of respiratory diseases in the Primorye Territory].

A methodology is proposed to assess environmental factors on human health, which is a new type of analyses and helps to substantiate managerial solutions in human health promotion and environmental protection. Stages and an algorithm of calculation of the risk of prevalence of diseases are presented, which has established cause-effect relationships between the climatic parameters and the incidence of respiratory diseases in different age groups and different bioclimatic zones. The established threshold criteria permit a rapid estimation of the influence of environmental factors on morbidity rates and provides a system conception for the development of a complex of therapeutic-and-prophylactic measures.

Adolescent↗
PubMed1996

Plasma concentrations of atrial, brain, and C-type natriuretic peptides and endothelin-1 in patients with chronic respiratory diseases.

We measured plasma concentrations of atrial, brain, and C-type natriuretic peptides (ANP, BNP, and CNP, respectively) and endothelin-1 in 20 patients with chronic respiratory diseases (CRD) to establish whether these peptides are increased in patient groups with CRD (group A, PaO2 > or = 60 mm Hg; group B, PaO2 < 60 mm Hg) and whether a correlation exists between the levels of natriuretic peptides or endothelin-1, and blood gas variables. In patients receiving long-term oxygen therapy (LTOT), plasma ANP, BNP, and endothelin-1 were compared before and after LTOT. We compared the levels of plasma ANP, BNP, and endothelin-1 in the presence or absence of right heart overloading (RHO) found in the ECG. Plasma ANP and BNP levels in group B patients were higher than those in group A and control subjects, and endothelin-1 in group B patients was higher than in control subjects. Inverse correlations were found between PaO2 and levels of plasma ANP, BNP, and endothelin-1. Plasma ANP, BNP, and endothelin-1 decreased significantly 25.4 days after LTOT. In 10 patients with RHO findings in the ECG, plasma ANP and BNP levels were significantly elevated compared with those in patients without RHO. These findings show that plasma ANP, BNP, and endothelin-1 are elevated according to the degree of hypoxemia, and they suggest that decreases in plasma ANP, BNP, and endothelin-1 may be used as indexes of the improvement by LTOT, and that plasma ANP and BNP may represent markers of RHO.

Aged↗
PubMed1986

Bacterial lysate (I.R.S. 19) applied intranasally in the prevention of acute respiratory diseases in children: a randomized double-blind study.

A controlled trial was undertaken to test I.R.S. 19 (a commercial intranasal spray) versus placebo in the prevention of acute respiratory diseases (ARD) in 825 maternity-school children in three cities; another control group of 327 children received neither I.R.S. 19 nor placebo. The spraying was done twice a day for a total of 20 spraying days in each child; sprayings were interrupted on weekends and during absence, the mean spraying period being 34 calendar days. During the 6-month study (1 November to 30 April) the children were monitored for ARD morbidity causing absence from school. A total of 1,585 such ARD cases occurred; their etiology was not investigated. The indices evaluated were: total duration of ARD-associated absence, ARD incidence, and mean duration of one illness. With the administration schedule used, I.R.S. 19 did not, in an overall evaluation, surpass placebo in any of these indices in either normal children or a subgroup of children with presumed enhanced ARD susceptibility.

Acute Disease↗
PubMed2003

TT virus loads and lymphocyte subpopulations in children with acute respiratory diseases.

TT virus (TTV) produces chronic plasma viremia in around 90% of healthy individuals of all ages and has, therefore, been proposed as a commensal human virus. We recently demonstrated that in children hospitalized for acute respiratory diseases high TTV loads were associated with severe forms of disease. Here, we report that in such children TTV loads showed an inverse correlation with the percentage of circulating total T and helper T cells and a direct correlation with the percentage of B cells. Thus, florid TTV replication might contribute to lymphocyte imbalances and, possibly, immunosuppressive effects, thus resembling related animal viruses.

Acute Disease↗
PubMed2006

Use of treatment records and lung lesion scoring to estimate the effect of respiratory disease on growth during early and late finishing periods in South African feedlot cattle.

Growth, morbidity, and slaughter data from 2,036 calves in 2 South African feedlots were used to estimate the effect of bovine respiratory disease (BRD) and of lung lesion type and extent on growth during the early (processing to d 35) and late (d 35 to slaughter) finishing periods. Calves were weighed at processing (d 5 after arrival), on d 35, and at slaughter after a mean of 137 d on feed. All calves were monitored twice daily and were treated for BRD if rectal temperature was > 40 degrees C or if other specific signs of BRD were present. After slaughter, the occurrence and extent of parenchymal bronchopneumonic lesions and pleural adhesions were recorded. Subclinical BRD (never treated but with lung lesions at slaughter) occurred in 29.7% and clinical BRD in 22.6% of calves. Lung lesions were present in 43% of calves at slaughter; 8.6% had parenchymal lesions and 38.8% had pleural adhesions. Using a combined case definition (treated for BRD and/or lung lesions present at slaughter), the incidence of BRD was 52.5%. During the early finishing period, clinical BRD reduced ADG by 216 g (P < 0.001), subclinical BRD reduced ADG by 91 g (P < 0.001), and the combined effect of BRD was a 143 g reduction in ADG (P < 0.001). After d 35, animals treated for BRD tended to grow faster than those with subclinical BRD (P = 0.11), indicating that treatment was generally successful in reducing economic losses. The extent of bronchopneumonic lesions at slaughter was not associated with reduced growth during the early finishing period (P = 0.27), but extensive lesions reduced ADG by 88 g during the late period (P = 0.02). In contrast, the extent of pleural adhesions was not associated with reduced growth rate during the late finishing period (P = 0.37) but was strongly associated with reduced ADG before d 35; there was a 101 g reduction (P < 0.001) and a 220 g reduction (P = 0.01) for adhesions involving < 50% and > 50% of the pleural surfaces, respectively. Thus, although the presence of bronchopneumonic lesions and pleural adhesions at slaughter were both associated with reductions in overall ADG, they were indicative of production losses having occurred at different times during the finishing period. The overall effect of BRD was a 24 g reduction in ADG (P = 0.02) and a 5.1 d increase in days on feed (P < 0.001). The hidden cost of reduced growth rate due to BRD amounted to $3.41 per calf with clinical or subclinical BRD, or $1.79 per animal entering the feedlot.

Animals↗
PubMed1977

Chronic respiratory disease, smoking and prognosis for life. An epidemiological study.

A population group, comprising 653 men and 823 women aged 40-64 years, was surveyed in 1961 to determine the prevalence of chronic respiratory disease. Questionnaire, simple spirometry and thoracic radiography were used. The 10-year mortality of the population has been related to the initial findings. After standardization for age and smoking, men in each of the disease or symptom groups had a higher risk of dying during the 10-year period than men without lung disease; for the total group of men with chronic non-specific lung disease (CNSLD) the standardized risk ratio was 1.3. After standardization for age and presence of CNSLD, men in all smoking groups had a higher risk of dying than male non-smokers. For the total before the age of 15 therisk was 4.1-fold. When men with and without CNSLD were analysed separtely in different smoking groups, the excess mortality of men with CNSLD varied from 10 to 110% (risk ratios from 1.1 to 2.1), being highest among the heaviest smokers. In men without lung disease, the smokers had a 1.8-fold mortality as compared with non-smokers. In women, the CNSLD did not increase mortality, but in female smokers the risk of dying was roughly twice that of female non-smokers although the difference was not significant. It appears from the findings that, as far as the prognosis for life is concerned in the male population surveyed, smoking is more important than CNSLD. The effect of CNSLD seemed to be stronger in men who smoked at least 25 g of tobacco daily, than in men who smoked less. The ex-smokers resembled non-smokers more than smokers in mortality experience which suggests that the deleterious effects of smoking may disappear after smoking has been discontinued.

Adult↗
PubMed1997

Comparison of immune reactivity profiles against various environmental allergens between adult patients with atopic dermatitis and patients with allergic respiratory diseases.

To clarify the pathomechanisms underlying the involvement of different organs by atopic dermatitis (AD) and allergic respiratory disease (ARD), we compared the immune reactivities to various environmental allergens between 46 adult patients who suffered only from AD but were without any history of ARD and 41 patients who had only ARD, using a RAST FEIA (radioallergosorbent test/fluoroenzyme immunoassay) and a scarification patch test. We also studied 42 healthy adult subjects in a similar fashion. Total serum IgE antibody levels were found to be far higher in the AD group than in the ARD and healthy control group, and RAST revealed that the AD group was sensitized to far larger numbers of allergens such as food mix, cereal mix, fungus mix and Candida albicans than were the other groups. The ARD group displayed a high incidence in RAST, comparable to that of the AD group, only against Japanese cedar and grass pollen mix antigen. However, the most remarkable difference in the immune reactivity profiles was that the AD group showed a uniquely higher RAST score and a lower incidence of positive patch test reactions to C. albicans antigen than did the ARD group. The reactivities in the ARD group to C. albicans antigen did not differ from those in the control group. Our present data suggest that a more pronounced shift from Th1 to Th2 cells, reactive against various allergens, takes place in AD patients.

Adolescent↗
PubMed1996

Seasonality of tuberculosis: the reverse of other respiratory diseases in the UK.

BACKGROUND: In Western societies there is a winter peak in mortality, largely accounted for by respiratory and cardiovascular deaths. In view of the known seasonal variation in vitamin D, and of the postulated link between tuberculosis and vitamin D deficiency, a study was undertaken to examine whether the presentation of tuberculosis had the same seasonal rhythm as other pulmonary infections. METHODS: Using cosinor analysis the presence or absence of seasonality was determined for 57,313 tuberculosis notifications for England and Wales. OPCS data in four weekly notifications over a 10 year period (1983-92) were examined as two quinquential sets (1983-7 and 1988-92). These were compared with two groups of acute respiratory illness: 138,992 notifications to OPCS of pneumonia deaths for 1988-92 and all admissions to Scottish hospitals with respiratory disease (252,163 cases) during 1980-4. RESULTS: Analysis of notifications of tuberculosis revealed a summer peak with an amplitude of 10%. This pattern differs markedly from other respiratory disorders in which a winter peak and summer trough is observed. CONCLUSIONS: The unusual seasonality of tuberculosis is currently unexplained. One possibility is that low post-winter trough levels of vitamin D (which are known to affect macrophage function and cell mediated immunity) might result in impaired cellular immunity leading, after a latent period, to reactivation of dormant mycobacterial infection.

Humans↗
PubMed2006

Description of the outbreak of equine influenza (H3N8) in the United Kingdom in 2003, during which recently vaccinated horses in Newmarket developed respiratory disease.

Between March and May 2003, equine influenza virus infection was confirmed as the cause of clinical respiratory disease among both vaccinated and unvaccinated horses of different breeds and types in at least 12 locations in the UK. In the largest outbreak, 21 thoroughbred training yards in Newmarket, with more than 1300 racehorses, were affected, with the horses showing signs of coughing and nasal discharge during a period of nine weeks. Many of the infected horses had been vaccinated during the previous three months with a vaccine that contained representatives from both the European (A/eq/Newmarket/2/93) and American (A/eq/Newmarket/1/93) H3NN8 influenza virus lineages. Antigenic and genetic characterisation of the viruses from Newmarket and elsewhere indicated that they were all closely related to representatives of a sublineage of American viruses, for example, Kentucky/5/02, the first time that this sublineage had been isolated in the uk. In the recently vaccinated racehorses in Newmarket the single radial haemolysis antibody levels in acute sera appeared to be adequate, and there did not appear to be significant antigenic differences between the infecting virus and A/eq/Newmarket/1/93, the representative of the American lineage virus present in the most widely used vaccine, to explain the vaccine failure. However, there was evidence for significantly fewer infections among two-year-old horses than older animals, despite their having similar high levels of antibody, consistent with a qualitative rather than a quantitative difference in the immunity conveyed by the vaccination.

Amino Acid Sequence↗
PubMed1987

Survey of underlying conditions of persons hospitalized with acute respiratory disease during influenza epidemics in Houston, 1978-1981.

The peak occurrence of hospitalizations of persons with acute respiratory disease (ARD), usually pneumonia, has coincided with the peak of influenza virus activity each year. The purpose of this study was to examine the diagnoses other than ARD on the discharge record of patients hospitalized with ARD. We were particularly interested in determining the frequency of high-risk conditions for which influenza vaccine is currently recommended. The risk for ARD hospitalization was 19.7 per ten thousand for persons with high-risk conditions and only 9.3 for persons without. Chronic pulmonary disorders were the most common underlying conditions identified, and persons with pulmonary conditions had the greatest risk for ARD hospitalization. The highest rate occurred among persons older than 65 yr of age with pulmonary conditions (87.5 per ten thousand), and the rate was 27.5 for persons 45 to 64 yr of age. Cardiac conditions were the second most frequent group of underlying disorders of patients hospitalized with ARD. Only for persons younger than 20 yr of age was the risk of ARD hospitalization greater for persons with cardiac conditions than for those with pulmonary conditions (22.9 and 14.9 per ten thousand, respectively). Death, however, was more frequent among persons with underlying heart disease. Intensified effort is needed to fully implement recommendations for prophylaxis of influenza in order to reduce these risks.

Acute Disease↗
PubMed1984

Detection of right ventricular pressure overloading by thallium-201 myocardial scintigraphy. Results in 57 patients with chronic respiratory diseases.

The diagnostic value of thallium 201 (201Tl) myocardial imaging was studied in 57 patients with chronic respiratory diseases, most with COPD (n = 46), by comparing the results to hemodynamic findings. In healthy subjects, the right ventricle (RV) is not visualized; therefore, any recorded activity of the RV was considered as indicating RV hypertrophy due to RV pressure overloading (RVPO). RV activity was graded from 0 (no activity) to 3 (activity greater than or equal to that of the left ventricle). Patients were divided into three groups according to the level of the pulmonary artery mean pressure (PPA): PPA less than or equal to 20 mm Hg (no pulmonary arterial hypertension [PAH] ) = group 1, n = 20; PPA ranging from 21 to 30 mm Hg (mild to moderate PAH) = group 2, n = 20; PPA greater than 30 mm Hg (marked PAH) = group 3, n = 17. RV was visualized in 14 patients in group 3 (82 percent) and in 13 patients in group 2 (65 percent). For all patients with PAH (2 + 3) the sensitivity of 201Tl imaging for the diagnosis of RVPO was of 73 percent, higher than that of ECG and echocardiography (both 51 percent). The sensitivity of 201Tl, even if moderate (65 percent) was better than that of ECG (30 percent) or echo (40 percent) in patients with mild-to-moderate PAH (group 2). A high RV activity (grade 3) was observed in only three patients. The specificity of this method (obtained from results in group 1) was of 80 percent vs 89 percent for echo and 100 percent for ECG. These results suggest that 201Tl myocardial imaging is a rather sensitive method and could be of interest for the noninvasive diagnosis of RVPO in COPD patients.

Adult↗
PubMed1976

[Assessment of working capacity in a group of subjects affected with obstructive respiratory disease (author's transl)].

Ventilatory function was studied by the authors in 43 subjects affected with obstructive respiratory disease. The research was performed both at rest and during two exercise tests -- 60 and 100 watts, respectively. The subjects were divided into three groups on the basis of tidal volume (at 30 1 ventilation) / vital capacity ratio. It was found that during muscular effort subjects with major impairment of spirometric indexes hypoventilated, whereas the opposite occurred in patients with lesser impairment. Moreover, subjects hyperventilating during muscular work were found to have brandypnea, whereas the opposite occurred in hyperventilating patients. It is suggested that progressing and worsening of obstructive emphysema lead to a relative hypoventilation during muscular work, which is due to an "inability" to increase the frequency of breathing.

Adult↗
PubMed2003

[Immunologic aspects of clinical approaches to occupational respiratory diseases].

The authors presented a review on contemporary programs of immunologic examination for patients suffering from occupational respiratory diseases, materials on immunologic mechanisms and on pathogenetic and diagnostic criteria. Comparison covers immunologic parameters proving efficiency of immune modulators inclusion into complex treatment. The authors justify prospects of immunologic studies of receptor-dependent Fas-induced apoptosis, cytokine profiles (inflammatory and anti-inflammatory cytokines) and immune therapy improvement.

B-Lymphocytes↗
PubMed1975

Epidemiology of toluene diisocyanate (TDI)-induced respiratory disease.

This paper describes our experience with the respiratory effects of TDI. Five respiratory reactions attributable to TDI are described with supporting evidence. The reactions are sensitization, irritation from overexposure, acute loss of ventilatory capacity, accelerated loss of pulmonary function and induction of a general asthmatic state. Evidence is presented that suggests a safe exposure level.

Asthma↗
PubMedDate not supplied

Use of hospital discharge data for surveillance of chemical-related respiratory disease.

Hospital discharge data can be useful in the identification of the more severe cases of both work- and nonwork-related chemical-related respiratory disease. The medical records of 329 patients hospitalized in Michigan in 1989 and 1990 for respiratory conditions resulting from chemical fumes and vapors (International Classification of Diseases diagnostic code 506) were reviewed to determine the location and etiology of the exposures. One-third of the discharges were work related. The most common exposures at work were to chlorine and sulfur dioxide and to industrial cleaning agents. Exposure to smoke from house fires and exposure to household cleaners were the most frequent causes of the nonwork-related discharges. Follow-up inspections at the work facilities where the hospitalized patients with work-related disease had become ill revealed that 61 of 261 (23.4%) fellow workers interviewed had new adult-onset asthma or were bothered at work by daily or weekly symptoms of shortness of breath, wheezing, or chest tightness. Nine of the 23 facilities inspected were cited for violating Occupational Safety and Health Administration standards.

Adolescent↗