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PubMed2006

Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase.

Previous studies indicate that noise induced hearing loss (NIHL) involves a decrease in glutathione peroxidase (GPx) activity and a subsequent loss of outer hair cells (OHC). However, the cellular localization of this GPx decrease and the link to OHC loss are still poorly understood. In this report, we examined the cellular localization of GPx (GPx1, GPx 3 and GPx 4) in F-344 rat before and after noise exposure and after oral treatment with ebselen, a small molecule mimic of GPx activity. Results indicate that GPx1 is the major isoform within the cochlea and is highly expressed in cells of the organ of Corti, spiral ganglia, stria vascularis, and spiral ligament. Within 5h of noise exposure (4h at 113 dB, 4-16 kHz), significant OHC loss was already apparent in regions coincident with the 8-16 kHz region of the cochlea. In addition, the stria vascularis exhibited significant edema or swelling and a decrease in GPx1 immunoreactivity or fluorescent intensity. Treatment with ebselen (4 mg/kg p.o.) before and immediately after noise exposure reduced both OHC loss and the swelling of the stria vascularis typically observed within 5h post-noise exposure. Interestingly, GPx1 levels increased in the stria vascularis after noise and ebselen treatment vs noise and vehicle-only treatment, and exceeded baseline no noise control levels. These data indicate that ebselen acts to prevent the acute loss of OHCs and reduces the acute swelling of the stria vascularis by two potential mechanisms: one, as a ROS/RNS scavenger through its intrinsic GPx activity, and two, as a stimulator of GPx1 expression or activity. This latter mechanism may be due to the preservation of endogenous GPx1 from ROS/RNS induced degradation and/or the stimulation of GPx1 expression or activity.

Animals↗
PubMed2006

Improved noise reduction in single fiber auditory neural responses using template subtraction.

When recording single-unit responses from neural systems, a common problem is the accurate detection of spikes (action potentials) in the presence of competing unwanted (noise) signals. While some sources of noise can be readily dealt with through filtering or established "template subtraction" techniques, other sources present a more difficult problem. In particular, noise components introduced by power supplies, which contain harmonics of the power-line frequency, can be particularly troublesome in that they can mimic the shape of the desired spikes. The aforementioned standard techniques typically fail to effectively deal with such "noise". In this study, we propose the use of a novel template-subtraction scheme that involves estimating the power-line noise waveform and using cross-correlation techniques to subtract it from the recordings. This technique requires two key steps: (1) cross-correlation analysis of each recorded waveform to extract a robust representation of the power-line noise waveform and (2) a second level of cross-correlation to successfully subtract that representation from each recorded waveform. This paper describes this algorithm and provides examples of its implementation using actual recorded waveforms that were contaminated with these power-line noise signals. An improvement (reduction) in the noise level is reported, as are suggestions for future implementation of this strategy.

Action Potentials↗
PubMed2005

After effects of noise-induced sleep disturbances on inhibitory functions.

The study focuses on possible after effects of noise-induced sleep disturbances on inhibitory brain processes reflecting in performance changes and alternations of inhibition-related components of event-related potentials (ERPs). Following a quiet night and three nights, in which railway noise was presented with different levels, twelve women and ten men (19-28 years) performed a visual Go/Nogo task that contained stimuli either compatible or incompatible with a response. Noise-induced sleep disturbances are highly evident in worsening of subjective sleep quality but did not show up in significant changes of reaction time and error rate. A smaller N2 amplitude and longer latency to incompatible than to compatible stimuli as well as an unspecific attenuation of N2 amplitude under Noise were found. The amplitude of the fronto-central P3 was reduced under Noise compared to baseline only in Nogo trials. The amplitude of the parietal P3 in Go trials was smaller to incompatible than to compatible stimuli but was not affected by Noise. Disturbed sleep was associated with a decreased blink rate during task performance. The results suggest that physiological costs to maintain performance are increased after noisy nights. Decisional processes underlying overt responses (Go-P3) are less vulnerable to noise-disturbed sleep than those related to inhibition (Nogo-N2, NoGo-P3). The deficits may have been compensated by increased on-task concentration and thereby did not become apparent in the performance data. Inhibition-related ERPs may be more sensitive indicators of moderate sleep disturbances caused by noise than performance measures.

Adult↗
PubMed2005

fMRI-acoustic noise alters brain activation during working memory tasks.

Scanner noise during functional magnetic resonance imaging (fMRI) may interfere with brain function and change blood oxygenation level dependent (BOLD) signals, a problem that generally worsens at the higher field strengths. Therefore, we studied the effect of increased acoustic noise on fMRI during verbal working memory (WM) processing. The sound pressure level of scanner noise was increased by 12 dBA from "Quiet" to "Loud" echo planar imaging (EPI) scans by utilizing resonant vibration modes of the gradient coil. A WM paradigm with graded levels of task difficulty was used to further access WM load. Increased scanner noise produced increased BOLD responses (percent signal change) bilaterally in the cerebellum, inferior (IFG), medial (medFG), and superior (SFG) frontal, fusiform (FusG), and the lingual (LG) gyri, and decreased BOLD responses bilaterally in the anterior cingulate gyrus (ACG) and the putamen. This finding suggests greater recruitment of attention resources in these brain regions, probably to compensate for interference due to louder scanner noise. Increased working memory load increased the BOLD signals in IFG and the cerebellum, but decreased the BOLD signals in the putamen and the LG. These findings also support the idea that brain function requires additional attention resources under noisier conditions. Load- and acoustic-noise-related changes in BOLD responses correlated negatively in the WM network. This study demonstrates that MR noise affects brain activation pattern. Future comparisons between studies performed under different acoustic conditions (due to differing magnetic field strengths, pulse sequences, or scanner manufacturers) might require knowledge of the sound pressure level of acoustic noise during fMRI.

Adult↗
PubMed2006

Effect of fMRI acoustic noise on sensorimotor activation examined using optical topography.

Functional magnetic resonance imaging (fMRI) is an important tool for noninvasively imaging the hemodynamic responses accompanying brain activity, but fMRI measurements are accompanied by loud acoustic noises resulting from Lorentz forces that cannot be completely excluded when the present technology is used. We used recorded fMRI acoustic noise and examined its effect on sensorimotor activation in optical topography measurement when subjects were instructed to tap the fingers of the right hand under a 23-dB non-noise condition and 46-, 56-, and 65-dB noise conditions. The results showed that the amplitude of the activation signal (relative change in concentration) for oxygenated hemoglobin in the sensorimotor cortex decreased with increasing noise. The activation signal for deoxygenated hemoglobin did not depend significantly on the noise level but did tend to decrease with increasing noise. These results suggest that fMRI acoustic noise affects the hemodynamics of cortical areas associated with the processing of information other than auditory information.

Adult↗
PubMed1972

Inferences about membrane properties from electrical noise measurements.

Four sources of electrical noise in biological membranes, each with a different physical basis, are discussed; the analysis of each type of noise potentially yields a different sort of information about membrane properties. (a) From the thermal noise spectrum, the passive membrane impedance may be obtained, so that thermal noise measurements are essentially equivalent to the type of since wave analysis carried out by Cole and Curtis. (b) If adequately high frequency measurements could be made, the shot noise spectrum should give information about the average motion of a single ion within the membrane. (c) The number of charge carriers and single ion mobilities within the membrane can possibly be inferred from measurements of noise with a 1/f spectrum. Available data indicate, for example, that increases in axon membrane conductance are not achieved by modulations in the mobility of ions within the membrane. (d) Fluctuations arising from the mechanisms normally responsible for membrane conductance changes can produce a type of electrical noise. Analysis of such conductance fluctuations provides a way to assess the validity of various microscopic models for the behavior of individual channels. Two different probabilistic interpretations of the Hodgkin-Huxley equations are investigated here and shown to yield different predictions about the spectrum of conductance fluctuations; thus, appropriate noise measurements may serve to eliminate certain classes of microscopic models for membrane conductance changes. Further, it is shown how the analysis of conductance fluctuations can, in some circumstances, provide an estimate of the conductance of a single channel.

Analysis of Variance↗
PubMed2000

Upregulation of glial cell line-derived neurotrophic factor (GDNF) in the rat cochlea following noise.

There are endogenous intracellular mechanisms that provide cells with protection from stress, as well as repair from damage. These pathways often involve stress proteins and neurotrophic factors. The present study used Western blot analysis to examine changes in glial cell line-derived neurotrophic factor (GDNF) following noise overstimulation. A noise exposure was utilized which causes a temporary threshold shift and has been previously shown to upregulate heat shock protein 72 in the rat cochlea. This noise exposure also provides protection from a second noise exposure that would otherwise cause a permanent threshold shift. Experimental animals were assessed 2, 4, 8 and 12 h after cessation of noise exposure. Control animals received the same treatment except for the noise exposure and were assessed at the 8 h time point. A moderate expression of GDNF was observed in the normal cochlea. No significant change in GDNF levels was observed at 2 or 4 h following noise overstimulation. However, a significant increase was found at 8 h. At 12 h following noise overstimulation, GDNF levels were no longer significantly elevated from normal. These results suggest that GDNF is involved in the endogenous stress response in the cochlea and are consistent with the protection that exogenously applied GDNF has been shown to provide.

Animals↗
PubMed2000

Effects of industrial noise exposure on distortion product otoacoustic emissions (DPOAEs) and hair cell loss of the cochlea--long term experiments in awake guinea pigs.

Distortion product otoacoustic emissions (DPOAEs), a sensitive detector of outer hair cell (OHC) function, cochlear microphonics (CM), and hair cell loss have been monitored in 12 awake guinea pigs before and after 2 h exposure to specific, played-back industrial noise (105 dB SPL maximal intensity). All animals had stable DPOAE levels before noise exposure. In the first hours after noise exposure DPOAE levels were reduced significantly. In about 70% a partial recovery of the DPOAEs was found within 4 months after noise exposure. In 16% of the investigated ears no recovery of DPOAEs was observed. However, in a few ears increased DPOAEs were observed after noise exposure. Exposure to industrial noise caused both morphological changes in the middle turns of the cochlea and electrophysiological changes in the middle frequency range. A close correlation existed between reduced DPOAE levels, loss in CM potentials, and area of damaged or lost OHCs, but not with the numbers of damaged or lost OHCs in the cochlea. It can be concluded that continuous industrial noise causes a damage to OHCs which differs form the damage caused by impulse noise.

Animals↗
PubMed2002

Effect of noise exposure on blood-labyrinth barrier in guinea pigs.

The influence of noise exposure on the endothelial transport system in the cochlea was investigated using cationic polyethyleneimine (PEI), since systemically administered PEI passes through the capillary endothelial cell and attaches to basal lamina (BL) anionic sites in the cochlea. Under general anesthesia, all guinea pigs were administered an intravenous injection of 0.5% PEI. Thirty minutes later, five animals were exposed to noise (10 kHz, broad band noise, 105 dB SPL) for 30 min, via speakers inserted into the external auditory canal. The remaining five animals (controls) were left without noise exposure for 1 h following PEI injection. All guinea pigs were then immediately sacrificed, and the bony labyrinths were removed. PEI distribution on the BL was assessed in the stria vascularis, spiral ligament, basilar membrane, spiral limbus and Reissner's membrane throughout the cochlea with transmission electron microscopy. Compared to control animals, PEI distribution in the noise-exposed animals was significantly increased in the strial vessels of the basal and second turns and in Reissner's membrane of all turns. In the spiral ligament, basilar membrane and spiral limbus, no significant difference in PEI distribution was observed between the control and noise-exposed animals. These findings indicate that noise exposure increases macromolecular transport in the stria vascularis but not in the spiral ligament, spiral limbus and basilar membrane and that systemically administered macromolecules are more readily transported to Reissner's membrane by noise exposure.

Animals↗
PubMed2000

Regional variations of noise-induced changes in operating range in cat AI.

Regional differences in spectral integration of neurons in cat primary auditory cortex (AI) suggest that regions differ in effects of background noise on operating characteristics of neurons. Therefore, tone-response threshold, best level (peak-rate intensity), dynamic range, and sharpness of tuning in quiet and in continuous broadband noise were mapped for single neurons along the isofrequency domain of AI. Neurons did not show an excitatory response to the noise. Noise invariably increased the tone-response threshold and best levels. Consequently, the dynamic ranges and receptive fields shifted to higher intensity levels without changes of average sharpness of tuning. These shifts were linearly related to noise level and showed little inter-neuronal variability for neurons in the central, mostly sharply tuned part of AI. In more dorsal and ventral parts of AI, neurons were more variable in tone-response threshold, dynamic range and best level, and no systematic relationship between increase in noise level, threshold increase and best-level increase was observed. We conclude that linear shifts in the operating range of neurons in central AI in the presence of continuous noise backgrounds do not affect other response properties and may relate to the unaltered analysis and representation of spectral components of sounds. In contrast, neurons in dorsal and ventral AI change response properties in a non-predictable way in the presence of noise in accordance with the more complex receptive field properties in those areas.

Acoustic Stimulation↗
PubMed2002

Effect of background noise on perception of English speech for Japanese listeners.

OBJECTIVES: To avoid the accidents induced by confusions of non-native speech perception in the presence of noise at work, this study examined the effect of background noise on the discrimination of English speech for Japanese listeners. METHODS: Normal hearing Japanese subjects, who have English learning experience to the level of college graduates, were tested with the CID W-22 word list in quiet settings and in the presence of white, low-frequency weighted (pink noise), or aircraft noise. RESULTS: The discrimination scores were reduced as S/N ratio decreased, and more adversely affected by background white noise than pink or aircraft noise. The individual variability of English word discrimination scores for Japanese listeners was much larger as the S/N ratio decreased. The typical confusions among phoneme were /m/, /n/, and /s/. CONCLUSIONS: The results of this study suggested that ineffective use of speech cues and difference in composition of English phonemes from Japanese could be responsible for degraded speech discrimination of non-native speech in noise. Moreover, it was expected that Japanese workers with age related hearing loss at higher frequencies might have great difficulty in perceiving English speech sounds in the presence of noise.

Adult↗
PubMed2003

Assessment of community noise problem in Greater Beirut Area, Lebanon.

Over the last two decades, urban noise has been increasing rapidly, primarily in urban areas, due to population growth and the increase of certain noise sources. The main objective of this paper is to assess the sources and possible impacts of the community noise problems in Lebanese urban areas, particularly the Greater Beirut Area. The causes and effects of community noise pollution are briefly presented. Sound pressure levels that were measured to define existing noise exposure levels in various locations in the Greater Beirut Area are also presented. The attitudes toward noise pollution and perceived annoyance impact on a sample of 1,038 exposed residents are described. The association between measured noise levels and sources, as well as annoyance, is examined using correlation analysis and linear and multiple linear regressions. A set of recommendations is presented to reduce community noise problem in Greater Beirut Area.

Adult↗
PubMed1976

Effects of noise and perceived control on ongoing and subsequent aggressive behavior.

Two experiments examined the effects of high-intensity (95 dB [A]) noise on ongoing and postnoise aggressive behavior. In Experiment 1, subjects were angered or treated in a neutral manner and given an opportunity to aggress against another subject while being exposed to high-intensity (95 dB) or low-intensity (55 dB) noise. Results indicated that high-intensity noise facilitated aggression for previously angered individuals. Experiment 2 examined postnoise aggression in which subjects completed a math task under high-intensity noise with or without perceived control over the noise. In comparison to a no-noise control, it was found that angered subjects with no control revealed an increase in aggression, whereas perceived-control subjects were no different from no-noise subjects. Results are discussed in terms of the recent Glass and Singer work on noise and task performance and the effects of perceived control on mediating the effects of stressful conditions.

Adaptation, Psychological↗
PubMed1986

A signal-to-noise ratio model for the speech-reception threshold of the hearing impaired.

This paper reviews the results of a series of investigations inspired by a model of the speech-reception threshold (SRT) of hearing-impaired listeners. The model contains two parameters accounting for the SRT of normal-hearing listeners (SRT in quiet and signal-to-noise ratio corresponding to the threshold at high noise levels), two parameters describing the hearing loss (attenuation and threshold elevation in terms of signal-to-noise ratio), and three parameters describing the hearing aid (acoustic gain, threshold elevation expressed in signal-to-noise ratio, and equivalent internal noise level). Experimental data are reported for three different types of hearing impairment: presbycusis, hearing losses with a pathological origin, and noise-induced losses. The model gives an excellent description of the data. It demonstrates that for many hearing-impaired persons speech intelligibility at noise levels beyond 50 to 60 dB(A) is their main problem, whereas hearing aids are most effective below that noise level.

Auditory Threshold↗
PubMed2006

Impact of background noise on reaction time and brain DC potential changes of VDT-based spatial attention.

Background noise is often discussed in terms of mental costs. In this study the effect of background noise on brain activity as reflected by the direct coupled (DC) potential was investigated by a within design in ten participants. During two successive blocks of 7 min each, participants performed 156 trials of a visual display terminal (VDT)-based visual-spatial attention task without noise and two blocks with a mixture of the environmental noises of barking dogs, traffic noise and irrelevant speech of 60 dBA. Brain DC potentials were recorded along the midline and analysed for change by time on task. For noise conditions, reaction time was prolonged and the DC-potential shifted towards positivity, contrary to control condition, independent of block and location. Results suggest reduced cortical resources by widespread inhibitory activation through background noise. It can be concluded that even low intensity background noise is associated with energy consumption and with impaired performance in spatial attention.

Adult↗
PubMed1985

Noise-induced stress in hospital patients: coping and nonauditory health outcomes.

This study found that, for 150 postoperative male patients, degree of objective noise, intrinsic sensitivity of the person to noise, and noise-induced stress were positively related to coping, in the form of exercised control over noise (correlations ranged from r = .207 to r = .468, P less than .01 for all cases). Hierarchical multiple regression confirmed these results. Furthermore, greater sensitivity of the person to noise was positively correlated with ability to cope, regardless of the objective level of noise. Patients who were randomly assigned to an experimental group, where they received instructions for control over noise, showed no difference in coping ability than a control group. There was a lack of support for several hypotheses concerned with the effects of noise-induced stress and coping on health, where stress was measured by self-reports of recovery and average time-out-of-bed in minutes. The meaning of these results is discussed in terms of stress theory.

Adaptation, Psychological↗
PubMed2000

Effects of sample size on the noise floor and distortion product otoacoustic emissions.

This study investigated the effects of sample size on the noise floor and distortion product otoacoustic emissions (DPOAEs) in 55 normal-hearing subjects as a function of intensity. More specifically, we investigated the effects of sample size (12-400 sweeps) as a function of intensity (L1 = L2 = 35, 45 and 55 dB SPL), firstly, on the identifiability of DPOAEs (2F1-F2), secondly, on the noise floor adjacent to DPOAEs, and thirdly, on the magnitude of DPOAEs centred around geometric means of 531 Hz, 1,000 Hz, 2,000 Hz and 4,000 Hz. Testing was conducted with a commercially available system for measuring DPOAEs (Grason-Stadler, GSI-60). A constant F2:F1 ratio of 1.21 was used. As sample size increased from 12 to 400 sweeps, the noise floors decreased by about 13 dB; this closely corresponds to the expected 15 dB reduction based on the square root rule of noise reduction. The highest noise floors were measured at 531 Hz and the lowest noise floors at 2,000 Hz and 4,000 Hz. Identifiability increased as intensity increased from 35 to 55 dB SPL and as sample size increased from 12 to 400 sweeps for all stimulus conditions. Mean DPOAEs for all frequencies (531-4,000 Hz) appeared to decrease as sample size increased, particularly at stimulus levels of 35 dB and 45 dB SPL. These results may be explained by a reduction in the noise levels within the bandwidth of the DPOAE bin. That is, the DPOAE bin is comprised of the DPOAE plus background noise and these two quantities are not separated within the measured bin. Because the magnitude of bin containing DPOAEs is critically dependent on sample size, clinicians should carefully document this variable when collecting normative data. Similarly, clinicians who compare the magnitude of their DPOAEs to published data should note the sample size employed.

Acoustic Stimulation↗
PubMedDate not supplied

Aging but not arousal influences the effect of environmental noise on the span of attention.

In young samples environmental noise acts to reduce attention to low salience events. We asked whether noise would affect old individuals similarly. Furthermore, both aging and noise effects on performance have been attributed to changes in physiological arousal. Therefore, we also asked whether performance changes with noise and aging were necessarily associated with changes in physiological arousal. Young, middle-aged and older individuals (total N = 50) performed a dual task in the presence or absence of 90 dBA white noise. In noise relative to quiet, young and middle-aged but not older participants responded to low salience events less accurately. Neither self-report nor cardiovascular change unequivocally supported the view that general arousal induced the performance changes associated with noise or aging. Cardiovascular changes were controlled by engagement in the task, not by the presence or absence of noise. Age-related changes in preparation for infrequent events were related to vascular change. Alternatives to general arousal explanations were considered.

Adolescent↗