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PubMed2003

In vitro antagonistic activity of monoterpenes and their mixtures against 'toe nail fungus' pathogens.

The antibiotic effect of the active ingredients in Meijer medicated chest rub (eucalyptus oil, camphor and menthol) as well as the inactive ingredients (thymol, oil of turpentine, oil of nutmeg and oil of cedar leaf) were studied in vitro using the fungal pathogens responsible for onychomycosis, such as the dermatophytes Tricophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, Epidermophyton fl occosum and Epidermophyton stockdale. The zones of inhibition data revealed that camphor (1). menthol (2). thymol (3). and oil of Eucalyptus citriodora were the most efficacious components against the test organisms. The MIC(100) for mixtures of these four components in various carrier solvents revealed that formulations consisting of 5 mg/mL concentrations of each have a potential to be efffective in controlling onychomycosis.

Aged↗
PubMed2007

Antidermatophytic triterpenoids from Syzygium jambos (L.) Alston (Myrtaceae).

Chemical investigation of the EtOAc extract of the stem bark of Syzygium jambos (L.) Alston (Myrtaceae) afforded a number of known triterpenes such as friedelin, beta-amyrin acetate, betulinic acid and lupeol. Friedelin was submitted to a Baeyer-Villiger oxidation, and was also reduced with LiAlH(4) to give the known friedelolactone and friedelanol, respectively. These compounds were identified by comparison of NMR spectral data with those from the literature. The EtOAc extract and the isolated compounds were tested for their antidermatophytic activity against three dermatophyte species: Microsporum audouinii, Trichophyton mentagrophytes and Trichophyton soudanense, commonly found in Cameroon. Betulinic acid and friedelolactone were the most active compounds, and the most sensitive fungi were Trichophyton soudanense and Trichophyton mentagrophytes.

Antifungal Agents↗
PubMed1978

Dermatophytes in a population of bank voles and woodmice.

A population of bank voles (Clethrionomys glareolus) and wood mice (Apodemus sylvaticus) inhabiting an oak wood in Somerset was examined for dermatophytes at monthly intervals for 2 years. The marked animals were frequently retrapped, allowing a study of host fungus relationship over a period of time. Microsporum persicolor (Sabouraud) Guiart er Grigorakis and Trichophyton mentagrophytes (Robin) Blanchard were isolated from both animal species, but M. persicolor predominated in bank voles and T. mentagrophytes in wood mice. In their most favoured host, both dermatophyte species often persisted for several months, but in the less favoured host they were never isolated at more than one sampling. Males of both animal species were infected more often than females. The existing evidence for the geophilic nature of both fungi is reviewed and shown to be very weak, especially for M. persicolor. This is the first report from Great Britain of T. mentagrophytes infection of wood mice not in contact with human habitation.

Animals↗
PubMed1991

Isolation of keratinophilic fungi from soil in Malaysia.

Two hundred and thirty soil samples from different localities were examined for the presence of geophilic keratinophilic fungi. Six species namely Microsporum gypseum--34 isolates, Chrysosporium keratinophilum--29, C. tropicum--20, Keratinophyton terreum--4, Trichophyton terrestre--8 and Chrysosporium species--3--were isolated. Most of these fungi were recovered from garden, field and river bank soil. The importance of these findings is briefly discussed.

Ascomycota↗
PubMed1988

A study of dermatophytoses in Bangkok (Thailand).

A total of 719 cases of dermatophytoses was studied in the Division of Dermatology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, during January to December 1986. Infection caused by fungus comprises 12%, while the incidence of dermatophytoses was 5.5% of skin disorders. The age group commonly infected was 12-21 years old (mean age of 18 years); 40% was female and 47.5% was male. In the female patients the common prevalent infections were tinea corporis 29%, tinea cruris 23%, tinea pedis 16%, while in male patients it was 28%, 39% and 14% respectively. Only 4 species of dermatophytes were isolated. The prevailing ones were: Trichophyton rubrum 66%, T. mentagrophytes 15%, Epidermophyton floccorum 13% and Microsporum gypseum 6%.

Adolescent↗
PubMed1996

Phylogeny of Epidermophyton floccosum and other dermatophytes.

Eleven strains of Epidermophyton floccosum were compared with 5 Microsporum and 5 Trichophyton species with respect to the restriction fragment length polymorphism (RFLP) of the mitochondrial DNA to reveal their phylogenetic relationships. The phylogeny of 11 species showed that the three dermatophyte genera could not be separated from each other and could be considered to be congeneric. This result is not inconsistent with the results from ribosomal RNA sequences.

DNA, Fungal↗
PubMed1990

Dermatophytosis of the scalp: incidence, immune response, and epidemiology.

Tinea capitis remains a common infection among the pediatric population of North America. The 'gray patch' Microsporum audouinii infections of the 1950's have been supplanted by the 'black dot' ringworm of Trichophyton tonsurans. The clinical presentation of T. tonsurans infection is quite variable and may be related to specific host T-lymphocyte response. This dermatophytosis is most frequently incurred from contact with an infected child either directly or via a variety of fomites. Current studies indicate that an asymptomatic adult carrier state may also exist which could contribute to the morbidity of this mycosis.

Humans↗
PubMed1991

Prevalence of superficial mycoses in the Aosta Valley region of Italy from 1984 to 1989.

This report represents the results of the culture tests for fungi carried out in the Aosta Valley region of Italy from 1984 to 1989. The pathological material consisted of cutaneous scales, hair and nails. It was possible to identify 91.8% of the isolates: out of these, 36.1% were dermatophytes, 21% were Aspergillus spp, 15.6% Deuteromycetes, 15% yeasts and 4.1% members of the family Mucoraceae. The resulting data indicate that Microsporum canis was the most wide-spread species (73.7%) among the isolated dermatophytes and keratinophilic fungi (Trichophyton rubrum, T. mentagrophytes, Epidermophyton floccosum and Scopulariopsis brevicaulis): 87.5% were isolated from hair and 65.9% from the glabrous skin. The high prevalence of M. canis as the cause of dermatomycoses is discussed. Lastly the use made of the Regional Hospital's Mycology Department by health workers is discussed.

Arthrodermataceae↗
PubMed1989

Isolation of keratinophilic fungi from floor dust in Arab elementary and preparatory schools in the West Bank of Jordan.

Floor dust collected from classrooms of thirty three elementary schools (16 for girls, and 17 for boys) (children aged 6-11), and twenty four preparatory schools (13 for girls, and 11 for boys) (children aged 12-14) was studied for the occurrence of keratinophilic fungi with respect to human presence and age of children. Tichophyton mentagrophytes was present in 15.4% of the preparatory schools for girls, in 12.5% of elementary schools for girls, and in 11.8% of elementary schools for boys. It was not found in preparatory schools for boys. Microsporum gypseum was found in preparatory schools for girls only (7.7%). Trichophyton terrestre was also only isolated from elementary schools for boys (5.9%). Chrysosporium species were present in 30.3% of all elementary schools (10 schools/33), and in 20.8% of all preparatory schools (5 schools/24). Geotrichum candidum was the most frequent and predominant keratinophilic species in all schools. Pathogenic and potentially pathogenic keratinophilic fungi comprised a large proportion of all fungal isolates recovered from all schools; they comprised 87.2%-89.5% of all fungal isolates in the elementary schools, and 90.4%-93.5% of all fungal isolates in preparatory schools.

Adolescent↗
PubMed1982

Epidemiology of dermatophytosis in the metropolitan area of Turin.

The study here presented deals with the problem of the dermatophytoses in Piedmont, with regard to their etiologic and, more generally, their epidemiologic aspects. From 586 patients who presented themselves at the Dermatology Clinic of the University of Turin, for mycological examinations, between the period of March-November 1979, 100 positive cases were selected. The study was set under way with the filling in of special forms for the epidemiologic investigation and with the classification of some species of fungi which had been isolated beforehand, using the methods of Ajello, Rebell and Taplin (1, 12). From the data collected, it was ascertained that the principal etiologic agents isolated were, in order of frequency: Microsporum canis, Tricophyton rubrum, Epidermophyton floccosum and T. mentagrophytes. The subjects that were affected most by these dermatophytes were the young (babies and schoolchildren) with the location of the infections being mostly in the scalp. As regards the period of manifestation, May - June and September - October were the periods with the highest incidence. It is noteworthy that the diffusion of the principal dermatophytes could be attributed to domestic animals such as cats and dogs.

Adolescent↗
PubMed1986

Serotyping of fungal isolates by precipitating monoclonal antibodies.

Ascites fluid from hybridoma cell lines producing monoclonal antibodies to an exoantigen of Microsporum canis was assayed for its precipitating properties. Three types of monoclonal antibodies were used for serological analysis of heterologous mycelial cultures. Based on specific antigenic determinants, the fungal strains showed different immunodiffusion reactivity within the species. The monoclonal antibodies also proved to be effective reagents for serotyping heterogeneous species. They may also have potential applications in epidemiology.

Animals↗
PubMed1983

Isolation of keratinophilic fungi from floors in Roman primary schools.

Keratinophilic fungi are present in the environment with variable distribution patterns that depend on different factors, one of which, of fundamental importance, is human and or animal presence. The present study was conducted in the environment and classrooms of schools in order to evaluate the relationship between the human presence and the presence of keratinophilic fungi. In order to achieve this goal, a new isolation technique was used. From 20 samples, 253 colonies of keratinophilic fungi were isolated. The results showed that species of the genus Chrysosporium were present in 100% of the samples, while Microsporum and Trichophyton species were present in 40% and 65% of the samples respectively. The percentage of three pathogenic species, M. canis (25), T. mentagrophytes (10) and M. gypseum (10) was significant. The other species isolated were: T. terrestre (55%), Trichophyton sp. (35%), M. cookei (25%) and T. ajelloi (10%). A correlation between the amount of gathered dust and the number of colonies of keratinophilic fungi isolated was not found.

Adolescent↗
PubMedDate not supplied

Mating patterns of dermatophytes of diverse origin in India.

The mating patterns of Trichophyton mentagrophytes var. interdigitale (74 isolates) and the Microsporum gypseum complex (17 isolates) of diverse origin and T. rubrum (25 isolates) and T. tonsurans (10 isolates) of clinical origin were studied. The results of the study showed that the teleomorph of the Indian isolates of T. mentagrophytes belong to Arthroderma vanbreuseghemii, undetermined teleomorphs of T. mentagrophytes var. interdigitale (+) mating types, and undetermined teleomorphs of T. mentagrophytes var. interdigitale indeterminate mating types. All the isolates of T. rubrum and T. tonsurans were found to be of the (-) mating type.

Animals↗
PubMed1986

Fungi on the hair of large mammals in Egypt.

The frequency of occurrence of fungi in 260 hair samples of dog, donkey and cow collected from Veterinary Medicine Hospital of Assiut University was determined. Twenty-three species which belong to fifteen genera were collected. In low frequency, several dermatophytes (Chrysosporium, Microsporum, Arthroderma and Trichophyton) were found as well as some other fungal species pathogenic to man and animals (Aspergillus fumigatus, Stachybotrys chartarum, Scopulariopsis brevicaulis and Cephalosporium acremonium).

Animals↗
PubMed1978

The distribution of geophilic dermatophytes in Kenyan soils.

Two hundred and eighty one soil samples from different provinces of Kenya were examined for dermatophytes by the hair baiting technique. Dermatophytes were recovered from 84 samples. Microsporum gypseum constituted 75.8% of the total isolates while Keratinomyces ajelloi and M. cookei formed 21% and 3.2%, respectively. The distribution of the dermatophytes was influences by soil pH, being more prevalent in acidic than in alkaline soils.

Arthrodermataceae↗
PubMed1981

Antifungal properties of some pyrazolyl-alkyl-sulfides. Electron microscopic evidence in two dermatophytes and Candida albicans.

Four 5-amino-4-alkylthio-pyrazoles were synthesized and their antifungal activity was evaluated in vitro in Trichophyton mentagrophytes, Microsporum cookei and Candida albicans. The compounds slightly influenced the growth kinetics of the yeast, but at concentrations ranging from 20 to 40 micrograms/ml completely prevented the mycelial growth of the two dermatophytes cultivated on Sabouraud's agar medium. An electron microscopic study, undertaken by using the most active compound, showed that in C. albicans mitochondria were the only cell targets affected whereas in the dermatophytes cell wall, plasmalemma and the main cytoplasmic organelles were damaged in various degrees. Since the most remarkable alterations were connected with membrane abnormalities, the cytological changes observed were tentatively interpreted as a consequence of the compound intrusion into the lipid bilayer of the membranes, since the drug is lipophilic in nature.

Antifungal Agents↗
PubMed1991

Review of dermatophytoses in Galicia from 1951 to 1987, and comparison with other areas of Spain.

We have reviewed all the dermatophytoses diagnosed in Galicia during four consecutive 9-year periods 1951-86 and 1987. From 4571 patients, we isolated 3351 fungal strains belonging, in decreasing order of frequency, to the following dermatophyte species: Microsporum canis (25.5%), Trichophyton rubrum (24.6%), T. mentagrophytes (21.4%), Epidermophyton floccosum (11.8%), M. gypseum (5.2%), T. tonsurans (3.9%), T. verrucosum (3.1%), T. schoenlenii (2.5%), T. violaceum (1.2%), T. mengninii (0.3%), M. audouinii (0.2%), T. equinum (0.1%) and T. soudanense (0.1%). Tinea capitis has diminished in frequency since 1951, though there was been a slight increase since 1978; M. canis has always been the most common agent, and between 1951 and 1959 T. schoenleinii was also very frequent but is no longer found. The frequency of tinea corporis, on the other hand, has experienced a considerable increase. Its most common causal agents in the last few years have been T. mentagrophytes, M. canis and T. rubrum. Until 1977 the most common tinea cruris dermatophyte was E. floccosum, but since then it has been T. rubrum. The commonest tinea pedis dermatophytes have been T. rubrum and T. mentagrophytes. Tinea unguium and tinea barbae have been the most frequent dermatophytoses, and their commonest causal agents T. rubrum and T. mentagrophytes respectively. We have documented the distribution of the various causal agents by location of the lesions, age and source of the patients (private or National Health Service patients), and we have compared the results with those obtained in other regions of Spain.

Adolescent↗
PubMed1985

Brief communication: extracellular enzymatic activities of dermatophytes.

Eighty dermatophyte strains belonging to the genera Trichophyton, Microsporum, Epidermophyton and Chrysosporium were screened for their ability to produce extracellular enzymes using a semiquantitative method. The results obtained vary significantly when the studied genera are observed separately, though the enzyme beta-galactosidase was detected in none of the four studied genera.

Chrysosporium↗